• Genomics & Informatics
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• 제20권2호
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• pp.23.1-23.9
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• 2022

A survival prediction model has recently been developed to evaluate the prognosis of resected nonmetastatic pancreatic ductal adenocarcinoma based on a Cox model using two nationwide databases: Surveillance, Epidemiology and End Results (SEER) and Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP). In this study, we applied two machine learning methods-random survival forests (RSF) and support vector machines (SVM)-for survival analysis and compared their prediction performance using the SEER and KOTUS-BP datasets. Three schemes were used for model development and evaluation. First, we utilized data from SEER for model development and used data from KOTUS-BP for external evaluation. Second, these two datasets were swapped by taking data from KOTUS-BP for model development and data from SEER for external evaluation. Finally, we mixed these two datasets half and half and utilized the mixed datasets for model development and validation. We used 9,624 patients from SEER and 3,281 patients from KOTUS-BP to construct a prediction model with seven covariates: age, sex, histologic differentiation, adjuvant treatment, resection margin status, and the American Joint Committee on Cancer 8th edition T-stage and N-stage. Comparing the three schemes, the performance of the Cox model, RSF, and SVM was better when using the mixed datasets than when using the unmixed datasets. When using the mixed datasets, the C-index, 1-year, 2-year, and 3-year time-dependent areas under the curve for the Cox model were 0.644, 0.698, 0.680, and 0.687, respectively. The Cox model performed slightly better than RSF and SVM.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2431-2440
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• 2015

Background: Registry data from four major public hospitals indicate trends in clinical care and survival from colorectal cancer over three decades, from 1980 to 2010. Materials and Methods: Kaplan-Meier productlimit estimates and Cox proportional hazards models were used to investigate disease-specific survival and multiple logistic regression analyses to explore first-round treatment trends. Results: Five-year survivals increased from 48% for 1980-1986 to 63% for 2005-2010 diagnoses. Survival increases applied to each ACPS stage (Australian Clinico-Pathological Stage), and particularly stage C (an increase from 38% to 68%). Risk of death from colorectal cancer halved (hazards ratio: 0.50 (0.45, 0.56)) over the study period after adjusting for age, sex, stage, differentiation, primary sub-site, health administrative region, and measures of socioeconomic status and geographic remoteness. Decreases in stage were not observed. Survivals did not vary by sex or place of residence, suggesting reasonable equity in service access and outcomes. Of staged cases, 91% were treated surgically with lower surgical rates for older ages and more advanced stage. Proportions of surgical cases having adjuvant therapy during primary courses of treatment increased for all stages and were highest for stage C (an increase from 5% in 1980-1986 to 63% for 2005-2010). Radiotherapy was more common for rectal than colonic cases. Proportions of rectal cases receiving radiotherapy increased, particularly for stage C where the increase was from 8% in 1980-1986 to 60% in 2005-2010. The percentage of stage C colorectal cases less than 70 years of age having systemic therapy as part of their first treatment round increased from 3% in 1980-1986 to 81% by 1995-2010. Based on survey data on uptake of adjuvant therapy among those offered this care, it is likely that all these younger patients were offered systemic treatment. Conclusions: We conclude that pronounced increases in survivals from colorectal cancer have occurred at major public hospitals in South Australia due to increases in stage-specific survivals. Use of adjuvant therapies has increased and the patterns of change accord with clinical guideline recommendations. Reasons for sub-optimal use of radiotherapy for rectal cases warrant further investigation, including the potential for limited rural access to impede uptake of treatments at metropolitan-based radiotherapy centres.

• 한국소음진동공학회논문집
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• 제20권10호
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• pp.923-930
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• 2010

Finite element models of dynamic systems can be updated in two stages. In the first stage, mass and stiffness matrices are updated neglecting damping, and in the second stage, damping matrices are estimated with the mass and stiffness matrices fixed. Three methods to estimate damping matrices for this purpose are proposed in this paper. The methods include one for proportional damping systems and two for non-proportional damping systems. Method 1 utilizes orthogonality of normal modes and estimates damping matrices using the modal parameters extracted from the measured responses. Method 2 estimates damping matrices from impedance matrices which are the inverse of FRF matrices. Method 3 estimates damping using the equation which relates a damping matrix to the difference between the analytical and measured FRFs. The characteristics of the three methods are investigated by applying them to simulated discrete system data and experimental cantilever beam data.

• International Journal of Aeronautical and Space Sciences
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• 제16권4호
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• pp.571-580
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• 2015

In this paper, a computational study was conducted in order to investigate the rotor blade sweep effect on the aerodynamics of a small axial supersonic impulse turbine stage. For this purpose, three-dimensional unsteady RANS simulations have been performed with three different rotor blade sweep angles ($-15^{\circ}$, $0^{\circ}$, $+15^{\circ}$) and the results were compared with each other. Both NTG (No tip gap) and WTG (With tip gap) models were applied to examine the effect on tip leakage flow. As a result of the simulation, the positive sweep model ($+15^{\circ}$) showed better performance in relative flow angle, Mach number distribution, entropy rise, and tip leakage mass flow rate compared with no sweep model. With the blade static pressure distribution result, the positive sweep model showed that hub and tip loading was increased and midspan loading was reduced compared with no sweep model while the negative sweep model ($-15^{\circ}$) showed the opposite result. The positive sweep model also showed a good aerodynamic performance around the hub region compared with other models. Overall, the positive sweep angle enhanced the turbine efficiency.

• Geomechanics and Engineering
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• 제13권6호
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• pp.893-906
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• 2017

Automatic large scale soil model generation is very critical stage for earthquake hazard simulation of urban areas. Manual model development may cause some data losses and may not be effective when there are too many data from different soil observations in a wide area. Geographic information systems (GIS) for storing and analyzing spatial data help scientists to generate better models automatically. Although the original soil observations were limited to soil profile data, the recent developments in mapping technology, interpolation methods, and remote sensing have provided advanced soil model developments. Together with advanced computational technology, it is possible to handle much larger volumes of data. The scientists may solve difficult problems of describing the spatial variation of soil. In this study, an algorithm is proposed for automatic three dimensional soil and velocity model development of southern part of the European side of Istanbul next to Sea of Marmara based on GIS data. In the proposed algorithm, firstly bedrock surface is generated from integration of geological and geophysical measurements. Then, layer surface contacts are integrated with data gathered in vertical borings, and interpolations are interpreted on sections between the borings automatically. Three dimensional underground geology model is prepared using boring data, geologic cross sections and formation base contours drawn in the light of these data. During the preparation of the model, classification studies are made based on formation models. Then, 3D velocity models are developed by using geophysical measurements such as refraction-microtremor, array microtremor and PS logging. The soil and velocity models are integrated and final soil model is obtained. All stages of this algorithm are carried out automatically in the selected urban area. The system directly reads the GIS soil data in the selected part of urban area and 3D soil model is automatically developed for large scale earthquake hazard simulation studies.

• Structural Engineering and Mechanics
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• 제47권6호
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• pp.881-898
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• 2013

This paper describes analytical investigation into a new dual function system including a couple of shear links which are connected in series using chevron bracing capable to correlate its performance with magnitude of earthquakes. In this proposed system, called Chevron Knee-Vertical Link Beam braced system (CK-VLB), the inherent hysteretic damping of vertical link beam placed above chevron bracing is exclusively utilized to dissipate the energy of moderate earthquakes through web plastic shear distortion while the rest of the structural elements are in elastic range. Under strong earthquakes, plastic deformation of VLB will be halted via restraining it by Stopper Device (SD) and further imposed displacement subsequently causes yielding of the knee elements located at the bottom of chevron bracing to significantly increase the energy dissipation capacity level. In this paper first by studying the knee yielding mode, a suitable shape and angle for diagonal-knee bracing is proposed. Then finite elements models are developed. Monotonic and cyclic analyses have been conducted to compare dissipation capacities on three individual models of passive systems (CK-VLB, knee braced system and SPS system) by General-purpose finite element program ABAQUS in which a bilinear kinematic hardening model is incorporated to trace the material nonlinearity. Also quasi-static cyclic loading based on the guidelines presented in ATC-24 has been imposed to different models of CK-VLB with changing of vertical link beam section in order to find prime effectiveness on structural frames. Results show that CK-VLB system exhibits stable behavior and is capable of dissipating a significant amount of energy in two separate levels of lateral forces due to different probable earthquakes.

• 산업공학
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• 제12권3호
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• pp.395-400
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• 1999

Shipbuilding process is composed of hull construction, in which the structural body of a ship is formed, and outfitting, in which all the non-structural parts such as pipes, derricks, engines, machinery, electrical cable, etc. are manufactured, added and assembled. Hull construction can be classified into parts fabrication, block assembly and hull erection. Among them, the parts fabrication is the first manufacturing stage that produces components or zones needed for block assembly and hull construction. More specifically, the parts fabrication is performed through machining processes including marking, cutting, pressing, and/or forming. When material is entering into the parts fabrication stage, it is important for achieving the total efficiency of production to select one of production division, so-called 'bay,' as well as machine tools on which the part is fabricated. In this paper, given production quantities of parts in the fabrication stage, the problem is to optimally select machine tools and production division, such that the total flow-time is minimized as well as the workload among machines is balanced. Specifically, three mathematical models for flow-time minimization, load balance, and simultaneously considering both objectives, and a numerical example are analyzed and presented.

• 한국조사연구학회지:조사연구
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• 제8권1호
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• pp.1-30
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• 2007

본 연구에서는 6시그마에서 기대한 성과를 얻으려면 도입과정에서 일련의 단계를 거쳐야 한다는 가정을 하였으며 특히 조직성숙이 성과에 미치는 영향을 분석하고 있다. 6시그마에서 성과를 얻는 단계를 준비단계, 수용단계, 성숙단계로 정의하여 단계적 모형을 제시하였다. 준비단계는 다시 조직변화오인, 추진시스템요인으로 세분하였고, 결과변수인 성과는 시장경쟁력성과, 조직구성원성과, 재무성과로 구분하였다. 6시그마를 도입하여 기대한 성과를 얻으려면 이 단계를 순차적으로 거쳐야 한다는 가정을 토대로 단계모형과 경쟁모형을 설정하여 구조방정식 모형을 통하여 비교 분석하였다. 기업을 표본단위로 한 판단표집(judgement sampling)을 통해 설문자료를 수집 처리하였다. 최종적인 분석에는 281 업체에서 수집된 자료가 사용되었다. 6시그마를 도입하고자 하는 기업은 준비단계, 수용단계, 그리고 성숙단계까지 도달해야만 기대한 성과를 얻을 수 있다는 것을 분석결과로 제시한다. 즉, 준비와 수용만 되었다고 큰 성과를 얻는다기보다는 성숙단계까지 가야만 성과를 제대로 얻을 수 있음을 시사하고 있다.

• 대한기계학회논문집B
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• 제22권11호
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• pp.1591-1602
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• 1998

Simple spanwise distribution models of deviation angle and pressure loss coefficient due to the tip leakage flow are formulated for use in association with the streamline curvature method as a flow analysis. Combining these new models with the previous deviation and loss models due to secondary flow, a robust streamline curvature method is established for flow analysis of single-stage, subsonic axial turbines with wide ranges of turning angle, aspect ratio and blading type. At the exit from rotor rows, the flow variables are mixed radially according to a spanwise transport equation. The proposed streamline curvature method is tested against a forced vortex type turbine as well as a free vortex type one. The results show that the spanwise variations of flow angle, axial velocity and loss coefficients at rotor exit are predicted with good accuracy, being comparable to a steady three-dimensional Navier-Stokes analysis. This simple and fast flow analysis is found to be very useful for the turbine design at the initial design phase.

• International Journal of Naval Architecture and Ocean Engineering
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• 제6권4호
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• pp.1182-1196
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• 2014

In problems of global hydroelastic ship response in severe seas including the whipping problem, we need to know the hydrodynamic forces acting on the ship hull during almost arbitrary ship motions. In terms of ship sections, some of them can enter water but others exit from water. Computations of nonlinear free surface flows, pressure distributions and hydrodynamic forces in parallel with the computations of the ship motions including elastic vibrations of the ship hull are time consuming and are suitable only for research purposes but not for practical calculations. In this paper, it is shown that the slamming forces can be decomposed in two components within three semi-analytical models of water entry. Only heave motion is considered. The first component is proportional to the entry speed squared and the second one to the body acceleration. The coefficients in these two components are functions of the penetration depth only and can be precomputed for given shape of the body. During the exit stage the hydrodynamic force is proportional to the acceleration of the body and independent of the body shape for bodies with small deadrise angles.