• The Korean Journal of Physiology and Pharmacology
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• v.25 no.4
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• pp.273-280
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• 2021

Lung cancer despite advancement in the medical field continues to be a major threat to human lives and accounts for a high proportion of fatalities caused by cancers globally. The current study investigated vanillin oxime, a derivative of vanillin, against lung cancer cells for development of treatment and explored the mechanism. Cell viability changes by vanillin oxime were measured using MTT assay. Vanillin oxime-mediated apoptosis was detected in A549 and NCI-H2170 cells at 48 h of exposure by flow cytometry. The CEBP homologous protein (CHOP) and death receptor 5 (DR5) levels were analysed by RT-PCR and protein levels by Western blotting. Vanillin oxime in concentration-dependent way suppressed A549 and NCI-H2170 cell viabilities. On exposure to 12.5 and 15 μM concentrations of vanillin oxime elevated Bax, caspase-3, and -9 levels in A549 and NCI-H2170 cells were observed. Vanillin oxime exposure suppressed levels of Bcl-2, survivin, Bcl-xL, cFLIP, and IAPs proteins in A549 and NCI-H2170 cells. It stimulated significant elevation in DR4 and DR5 levels in A549 and NCI-H2170 cells. In A549 and NCI-H2170 cells vanillin oxime exposure caused significant (p < 0.05) enhancement in CHOP and DR5 mRNA expression. Vanillin oxime exposure of A549 and NCI-H2170 cells led to significant (p < 0.05) enhancement in levels of phosphorylated extracellular-signal-regulated kinase and c-Jun N-terminal kinase. Thus, vanillin oxime inhibits pulmonary cell proliferation via induction of apoptosis through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated pathway. Therefore, vanillin oxime may be studied further to develop a treatment for lung cancer.

• Korean Journal of Agricultural Science
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• v.49 no.1
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• pp.121-128
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• 2022

Fusarium wilt disease caused by Fusarium species is a major problem affecting cultivated cucurbit plants worldwide. Fusarium species are well-known soil-borne pathogenic fungi that cause Fusarium wilt disease in several cucurbit plants. In this study, we aimed to identify and classify pathogenic Fusarium species from cultivated Korean cucurbit plants, specifically watermelon and cucumber. Thirty-six Fusarium isolates from different regions of Korea were obtained from the National Institute of Horticulture and Herbal Science Germplasm collection. Each isolate was morphologically and molecularly identified using an internal transcribed spacer of ribosomal DNA, elongation factor-1α, and the beta-tubulin gene marker sequence. Fusarium species that infect the cucurbit plant family could be divided into three groups: Fusarium oxysporum (F. oxysporum), Fusarium solani (F. solani), and Fusarium equiseti (F. equieti). Among the 36 isolates examined, six were non-pathogenic (F. equiseti: 15-127, F. oxysporum: 14-129, 17-557, 17-559, 18-369, F. solani: 12-155), whereas 30 isolates were pathogenic. Five of the F. solani isolates (11-117, 14-130, 17-554, 17-555, 17-556) were found to be highly pathogenic to both watermelon and cucumber plants, posing a great threat to cucurbit production in Korea. The identification of several isolates of F. equiseti and F. oxysporum, which are both highly pathogenic to bottle gourd, may indicate waning resistance to Fusarium species infection.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.6 no.5
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• pp.337-345
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• 2016

There is an increasing attention on the sustainable energy in the world as the problem of fossil energy exhaustion and environmental issues appear. This paper addresses technologies and industries related to hydrogen energy in the literature, and develops strategy for the preparation of hydrogen energy infrastructure in Korea by extracting several factors suitable for SWOT analysis after reviewing literature. Research articles and reports about the practical application of hydrogen energy in the literature were investigated and seventy evaluation factors were extracted. Then, survey to eliminate the unsuitability problems of duplication, disproportion and objectivity was performed by scholars and experts in research institutes. Finally, sixteen factors consisting of 4 strength factors, 4 weakness factors, 5 opportunity factors and 4 threat factors were determined as the strategic factors for the infrastructure of hydrogen energy industry.

• The Korean Journal of Franchise Management
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• v.9 no.2
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• pp.17-29
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• 2018

Purpose - The environment surrounding the franchise industry in recent years is a big threat to the franchise business. In this perspective, this study examines the effect of franchise CEO's Innovation, CSR Passion, and customer orientation(CO) on customers' perceived service quality(PSQ), affection, and commitments in the context of food-service franchise industry. This study suggests the guidelines on how franchisor uses their passion and customer orientation on customer to maintain and increase the commitments. Research design, data, and methodology - In order to achieve these purposes, research model and hypotheses were developed. Out of 500 respondents received through online survey, 449 respondents were used, because of 51 incomplete respondents. The data were analyzed using frequency analysis, confirmatory factor analysis, correlation analysis, and structural equational modeling with SPSS 23.0 and AMOS 23.0 statistical program. Result - The results of the study are as follows. First, innovation passion has a significant impact on PSQ and customer affection. And CSR passion have a significant impact on PSQ. Second, customer orientation has a significant impact on PSQ and customer affection. Third, PSQ has a significant impact on customer affection and sustainable commitment. Fourth, customer affection has a significant impact on behavioral commitment. Fifth, behavioral commitment has a significant impacts on sustainable commitment. Conclusions - The implications of this study are following as: Restaurants franchisor and CEOs should have a passion for innovation to continuously identify consumer needs and develop new menus and services that meet their needs. Second, franchisor and CEOs need to demonstrate the importance of creating the right environment, creating a fair business, and trying to create products in a given environment. Finally, franchisor and CEOs should demonstrate how to build relationships with customers and how to maintain positive feelings. In addition, it is necessary to appeal to the customers with enthusiasm and a customer-oriented tendency of the entrepreneur of the franchise head office in order to maintain the relationship with the customer and feelings.

• Convergence Security Journal
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• v.22 no.1
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• pp.129-134
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• 2022

A smart platform is defined as an evolved platform that realizes physical and virtual space into a hyper-connected environment by combining the existing platform and advanced IT technology. The hyper-connection that is the connection between information and information, infrastructure and infrastructure, infrastructure and information, or space and service, enables the realization and provision of high-quality services that significantly change the quality of life and environment of users. In addition, it is providing everyone with the effect of significantly improving the social safety net and personal health management level by implementing smart government and smart healthcare. A lot of information produced and consumed in these processes can act as a factor threatening the basic rights of the public and individuals by the informations themselves or through big data analysis. In particular, as the smart platform as a core function that forms the ecosystem of a smart city is naturally and continuously expanded, it faces a huge security burden in data processing and network operation. In this paper, platform components as core functions of smart city and appropriate security threats and countermeasures are studied.

• Nuclear Engineering and Technology
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• v.55 no.7
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• pp.2628-2641
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• 2023

Nuclear safety is the lifeline for the development and application of nuclear energy. In severe accidents of pressurized water reactor (PWR), aerosols, as the main carrier of fission products, are suspended in the containment vessel, posing a potential threat of radioactive contamination caused by leakage into the environment. The gas-phase aerosols suspended in the containment will settle onto the wall or sump water through the natural deposition mechanism, thereby reducing atmospheric radioactivity. Aiming at the low accuracy of the aerosol model in the ISAA code, this paper improves the natural deposition model of aerosol in the containment. The aerosol dynamic shape factor was introduced to correct the natural deposition rate of non-spherical aerosols. Moreover, the gravity, Brownian diffusion, thermophoresis and diffusiophoresis deposition models were improved. In addition, ABCOVE, AHMED and LACE experiments were selected to validate and evaluate the improved ISAA code. According to the calculation results, the improved model can more accurately simulate the peak aerosol mass and respond to the influence of the containment pressure and temperature on the natural deposition rate of aerosols. At the same time, it can significantly improve the calculation accuracy of the residual mass of aerosols in the containment. The performance of improved ISAA can meet the requirements for analyzing the natural deposition behavior of aerosol in containment of advanced PWRs in severe accident. In the future, further optimization will be made to address the problems found in the current aerosol model.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.443-449
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• 2022

With climate change and the global population growth, the frequency and scope of wildfires are constantly increasing, which threatened people's lives and property. For example, according to California Department of Forestry and Fire Protection, in 2020, a total of 9,917 incidents related to wildfires were reported in California, with an estimated burned area of 4,257,863 acres, resulting in 33 fatalities and 10,488 structures damaged or destroyed. At the same time, the ongoing development of technology provides new tools to simulate and analyze the spread of wildfires. How to use new technology to reduce the losses caused by wildfire is an important research topic. A potentially feasible strategy is to simulate and analyze the spread of wildfires through computing technology to explore the impact of different factors (such as weather, terrain, etc.) on the spread of wildfires, figure out how to take preemptive/responsive measures to minimize potential losses caused by wildfires, and as a result achieve better management support of wildfires. In preparation for pursuing these goals, the authors used a powerful computing framework, Spark, developed by the Commonwealth Scientific and Industrial Research Organization (CSIRO), to study the effects of different weather factors (wind speed, wind direction, air temperature, and relative humidity) on the spread of wildfires. The test results showed that wind is a key factor in determining the spread of wildfires. A stable weather condition (stable wind and air conditions) is beneficial to limit the spread of wildfires. Joint consideration of weather factors and environmental obstacles can help limit the threat of wildfires.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.4
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• pp.323-333
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• 2024

Polychlorinated biphenyls (PCBs) were once used throughout various industries; however, because of their persistence in the environment, exposure remains a global threat to the environment and human health. The Kv1.3 and Kv1.5 channels have been implicated in the immunotoxicity and cardiotoxicity of PCBs, respectively. We determined whether 3,3',4,4'-tetrachlorobiphenyl (PCB77), a dioxin-like PCB, alters human Kv1.3 and Kv1.5 currents using the Xenopus oocyte expression system. Exposure to 10 nM PCB77 for 15 min enhanced the Kv1.3 current by approximately 30.6%, whereas PCB77 did not affect the Kv1.5 current at concentrations up to 10 nM. This increase in the Kv1.3 current was associated with slower activation and inactivation kinetics as well as right-shifting of the steady-state activation curve. Pretreatment with PCB77 significantly suppressed tumor necrosis factor-α and interleukin-10 production in lipopolysaccharide-stimulated Raw264.7 macrophages. Overall, these data suggest that acute exposure to trace concentrations of PCB77 impairs immune function, possibly by enhancing Kv1.3 currents.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.2
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• pp.21-33
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• 2016

This paper aims to investigate the relations among the entrepreneurship, SWOT factors, and performance in Korean hidden champion firms. 112 potential Korean hidden champions were drawn at random from the hidden champion candidates of Export-Import Bank of Korea. For analyzing the relationship of them, the entrepreneurship factors categorized with organizational risk taking, innovativeness, and proactiveness from previous researches(Khandwalla, 1977; Miller, 1983; Miller & Friesen, 1978, 1982). Also, four SWOT factors classified into strength, weakness, opportunities, and threat by confirmatory factor analysis. As a result, we found some statistically significant effects between the SWOT factors and entrepreneurship factors, and they sequentially affects to performance. That is, as a presented with previous research, there is verified that entrepreneurship is caused by organizational risk taking, innovativeness, and proactiveness. Also, SWOT factors significantly affect to business performance. Some guidelines for practicing potential Korea hidden champions as a result of this would include; first of all, it is important to support the potential hidden champions consulting approach in global perspectives; secondly, effective governmental support programs for hidden champions should be developed for positive impacts of according to these results.

• Journal of the Korean Applied Science and Technology
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• v.38 no.3
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• pp.735-749
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• 2021

There is true that the evaluation of non-face-to-face swimming classes currently offered by universities due to the COVID-19 outbreak is generally negative. For this reason, the quality of non-face-to-face swimming classes at universities is bound to depend on the expertise of the instructor. However, whether or not of students who lack of practices of swimming could experience exercise flow and could continuously last the swimming exercise after semester or even graduation is difficult to confirm. This is considered to be a significant threat in the future not only for swimming, but also for all liberal arts and lifestyle sports. This study aimed at 281 non-athletic college students with experience of taking both swimming classes, and the need for a study on the structural relationship between exercise flow and participation intention by university swimming class leaders' expertise in non-sports majoring college students. And the results were empirically analyzed. The research results derived in this process are summarized as follows. First, the effect of swimming class leader's expertise (personality, lecture skills, student management, practical skills, basic knowledge) perceived by non-athletic college students on exercise flow (cognitive flow, behavior flow) affects cognitive flow. As a factor influencing, it was found that lecture skills had a statistically positive (+) effect, and as factors influencing behavioral commitment, the positive (+) effect was statistically significant in personality, lecture skills, student management, and basic knowledge. Second, as for the effect of exercise commitment (cognitive commitment, behavior commitment) perceived by non-athletic college students on continuous participation intention, the behavioral commitment factor was found to have a statistically positive (+) effect.