• Journal of Chest Surgery
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• 제28권9호
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• pp.861-864
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• 1995

We experienced a case of benign clear cell tumor, a very rare form of lung tumor. A forty-year-old male complained of non-specific right flank pain for 1 month prior to admission. Under the suspicion of a benign lesion, an exploratory thoracotomy was done. Since the first case was reported in 1963 by Leibow and Castleman, about 40 cases have been reported worldwide by 1993. Basically it was believed to be a benign lesion but in certain cases, it showed malignant behavior. Simple surgical excision is satisfactory to this benign lesion. But close long-term follow up is mandatory. We report this first case in Korea with the review of literature.

• Journal of Chest Surgery
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• 제54권6호
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• pp.535-538
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• 2021

Schwannomas are rare benign tumors that develop in Schwann cells lining peripheral nerves. Schwannomas of the brachial plexus are especially rare, accounting for 5% of all cases. Although several treatments can be considered, the exact method of treatment is unclear owing to the scarcity and sporadic occurrence of schwannomas. Tumor resection is performed in most cases, and nerve damage is inevitable in cases of neuroinvasive schwannoma. In this case series, we present our successful use of transposition of cable-grafted nerves for the treatment of schwannomas. We performed cable-grafted nerve interposition in addition to tumor resection, leading to increased recovery of nerve damage. To relieve postoperative symptoms and minimize sequelae, precise surgical tumor resection followed by nerve interposition using a cable-grafted nerve may be recommended.

• Journal of Chest Surgery
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• 제42권4호
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• pp.540-542
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• 2009

사구종양은 정상 사구체에서 볼 수 있는 특화된 평활근 세포를 닳은 세포로 이루어진 종양으로 손가락의 손톱 아래 부위가 호발 부위이지만, 손바닥, 팔, 다리에도 잘 생기며 이외에도 무릎골, 흉벽, 골, 위, 대장, 신경 등에도 드물게 생긴다. 그러나, 기관에 생긴 사구 종양은 매우 드문데, 저자들은 기관에 생긴 1예의 사구 종양을 경험하였기에 이를 문헌 고찰과 함께 보고하고자 한다.

• Journal of Chest Surgery
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• 제44권1호
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• pp.39-43
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• 2011

Background: Pulmonary sclerosing hemangioma is a rare thoracic tumor, and pathophysiology or clinical course of this tumor is not yet fully described. Furthermore, there is no consensus on the standard operative procedure for this tumor. Material and Methods: Medical records of thirty-two patients, who underwent surgical resection of pulmonary sclerosing hemangioma from 1996 to 2007, were retrospectively reviewed. Results: Nineteen patients underwent lobectomy and thirteen patients underwent limited resection. Video-assisted thoracoscopic surgery was performed in 9 patients in the latter group. Lymph node dissection was done in 21 patients, and one patient was found to have lymph node metastasis of the tumor. There was no postoperative complication, no early death and no tumor-related late mortality. The mean follow-up duration was 39.3 months (2 months~129 months), and all patients were free of local recurrence and distant metastasis during this period. There was no significant difference in patient's characteristics between the two groups, except that the mean hospital stay was shorter in limited resection group than in lobectomy group (p=0.0031). Conclusion: Pulmonary sclerosing hemangioma usually requires surgical resection for both diagnosis and treatment. Limited resection can decrease hospital stay with a surgical outcome comparable to lobectomy, and may be preferred to lobectomy if sufficient resection margin can be achieved.

• 대한기관식도과학회지
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• 제15권1호
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• pp.60-63
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• 2009

The photodynamic therapy (PDT) is a new treatment modality of destroying malignant tumors and pre-malignant lesions based on the use of photodynamical damage to tumor cells under the photochemical reactions. But the clinical reports of photodynamic application on the benign tumor of the internal organs were extremely rare. So we decribed our experience of one case of benign tracheal tumor successfully treated by PDT.

• Korean Journal of Radiology
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• 제20권1호
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• pp.50-57
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• 2019

In pediatric thoracic CT, respiratory motion is generally treated as a motion artifact degrading the image quality. Conversely, respiratory motion in the thorax can be used to answer important clinical questions, that cannot be assessed adequately via conventional static thoracic CT, by utilizing four-dimensional (4D) CT. However, clinical experiences of 4D thoracic CT are quite limited. In order to use 4D thoracic CT properly, imagers should understand imaging techniques, radiation dose optimization methods, and normal as well as typical abnormal imaging appearances. In this article, the imaging techniques of pediatric thoracic 4D CT are reviewed with an emphasis on radiation dose. In addition, several clinical applications of pediatric 4D thoracic CT are addressed in various thoracic functional abnormalities, including upper airway obstruction, tracheobronchomalacia, pulmonary air trapping, abnormal diaphragmatic motion, and tumor invasion. One may further explore the clinical usefulness of 4D thoracic CT in free-breathing children, which can enrich one's clinical practice.

• BMB Reports
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• 제46권5호
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• pp.252-257
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• 2013

Fibroblast activation protein (FAP) is a specific serine protease expressed in tumor stroma proven to be a stimulatory factor in the progression of some cancers. The purpose of this study was to investigate the effects of FAP knockdown on tumor growth and the tumor microenvironment. Mice bearing 4T1 subcutaneous tumors were treated with liposome-shRNA complexes targeting FAP. Tumor volumes and weights were monitored, and FAP, collagen, microvessel density (MVD), and apoptosis were measured. Our studies showed that shRNA targeting of FAP in murine breast cancer reduces FAP expression, inhibits tumor growth, promotes collagen accumulation (38%), and suppresses angiogenesis (71.7%), as well as promoting apoptosis (by threefold). We suggest that FAP plays a role in tumor growth and in altering the tumor microenvironment. Targeting FAP may therefore represent a supplementary therapy for breast cancer.

• Journal of Chest Surgery
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• 제53권6호
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• pp.361-367
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• 2020

Background: Malignant primary cardiac tumors are extremely rare, but have a poor prognosis. This study evaluated the surgical outcomes of patients with this disease. Methods: Forty patients who underwent surgery for malignant primary cardiac tumors between January 1998 and December 2018 were enrolled. Participants were divided into 3 groups based on resection margins (R0, 14 patients; R1, 11 patients; and R2, 11 patients) and their surgical outcomes were compared. Heart transplantation was performed in 4 patients with unresectable tumors. Results: Early mortality was reported in 2 cases (5%) due to postoperative bleeding and cerebral hemorrhage secondary to brain metastasis. The 1- and 2-year survival rates were 67.5% and 42.5%, respectively. The median survival time of the patients was 20.3 months (range, 9.2-37.6 months). The median survival time was 48.7, 20.3, and 4.8 months in patients with R0, R1, and R2 resections, respectively (p=0.023). Tumor recurrence occurred in 21 patients (61.7%), including 4 cases of local recurrence and 17 cases of distant metastasis. In patients who underwent heart transplantation, the median survival time was 29.5 months, with 3 cases of distant metastasis. Conclusion: Although surgery for malignant primary cardiac tumors has a poor prognosis, complete resection of the tumor may improve surgical outcomes.

• Journal of Chest Surgery
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• 제40권2호
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• pp.147-150
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• 2007

결합조직형성 소원형세포 종양(desmoplastic small round cell tumor)은 최근에 발생 빈도가 증가하는 추세인 희귀한 종양으로 주로 복강 내에서 발생하는 것으로 알려져 있다. 저자들은 15세 여자 화자의 종격동에 발생한 결합조직형성 소원형세포 종양에 대해 적극적인 항암화학요법, 수술, 방사선치료 및 자가 말초혈 조혈모세포 이식 등의 복합요법으로 만족스러운 결과를 얻었기에 이를 국내 최초로 보고하고자 한다.

• Journal of Chest Surgery
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• 제26권6호
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• pp.510-512
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• 1993

We report rare cases of myxoid chondrosarcoma and meningomyelocele mimicking as neurogenic tumor in the posterior mediastinum. This lesions clinically mimicked neurogenic tumor due to its location and dumbbell shape appearance. The histogenesis of myxoid chondrosarcoma is discussed as skeletal origin from the thoracic vertebrae, and meningomyelocele is ectopic harmatoma lesion of C.N.S. or meningx. This lesions is concluded that distinguished for the differential diagnosis among Neurogenic tumor arising in the posterior mediastinum.