• 제목/요약/키워드: Thioflavones

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Synthesis and iNOS Inhibitory Activities of Thioflavones

  • Dao Tran Thanh;Tuyen Truong Ngoc;Park Haeil
    • Archives of Pharmacal Research
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    • 제28권6호
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    • pp.652-656
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    • 2005

  • A number of thioflavones has been synthesized and evaluated for their iNOS inhibitory activities. Thiowogonin (6) was obtained from naturally occurring chrysin in 5 steps. Other thioflavones were prepared from the corresponding flavones in a single step by the reaction with Lawesson's reagent. The biological activities of thioflavones were not enhanced by the functional group conversion from carbonyl to thiocarbonyl. Compounds 11 and 13 showed potent. NO inhibitory activity at high concentration (40 uM), leading to the possible development of novel neuroprotective agents based on wogonin.

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