• Journal of Korean Physical Therapy Science
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• v.24 no.2
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• pp.27-35
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• 2017

Purpose: This study aimed to investigate the effect of shoes sole form on fatigue of lower extremity during treadmill gait. Method: Thirty healthy young adults (15 males and 15 females) were recruited. They performed treadmill gait in two different conditions: double sole(DS) and flat sole(FS). Result: lower extremity fatigue were signficantly decreased in double sole condition(p<.05). Conclusion: These findings suggest that double sole contributes to reduction of lower extremity muscle fatigue.

• Physical Therapy Korea
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• v.5 no.3
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• pp.56-62
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• 1998

The nature of entrainment between the locomotor and the respiratory rhythm was investigated while normal human subjects were walked or running on a treadmill. The purpose of this study was to analyze the incidence and type of coordination between the locomotor and the respiratory rhythm during running at different work load. The experiments were carried out on 12 untrained volunteers exercising at 3 work loads (2 METs, 3 METs, 4 METs in randomized order). The gait cycle was measured by electromyography (EMG) signal of gastrocnemius firing and the respiratory cycle was measured by a thermometer. We found that the ratio between the locomotor and the respiratory rhythm existed and 2:1 ratio between the locomotor-respiratory coupling was dominant at 2 METs and 3 METs.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.15 no.2
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• pp.35-43
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• 2009

Purpose : The purpose of this study was to measure the change of strength of trunk flexion and extension on abdominal and back muscles. Methods : Each taping group 1(n=14), taping group 2(n=14), taping group 3(n=14) and control group(n=15) were measured a muscle strength by Biodex at first test, second test, third test and forth test in 3 days. Results : The strength of trunk flexion and extension was significantly different among the experimental groups (p<.05). It also shows that significant increasing of muscle strength at 48 hours after application of taping (p<.05). Conclusion : In conclusion, we were found that taping technique base on taping type show immediately assistance of muscle strength and enduring effect for 48 hours.

• Journal of Chest Surgery
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• v.53 no.4
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• pp.160-167
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• 2020

Surgical resection is the mainstay of treatment for locally advanced esophageal cancer. Neoadjuvant therapy is recommended to improve survival, based on the results of several randomized trials and meta-analyses. However, controversy remains regarding how to combine surgery, radiotherapy, and chemotherapy. Moreover, in East Asia, the predominant histological type is esophageal squamous cell carcinoma, which has a different epidemiology and tumor biology from esophageal or gastroesophageal junctional adenocarcinoma. As such, the management of esophageal cancer in East Asia seems to be different from that in Western countries. Thus, this article reviews the current evidence on neoadjuvant therapy and considers the optimal combinations and ongoing strategies of multimodal therapy for esophageal squamous cell carcinoma.

• BMB Reports
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• v.52 no.1
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• pp.35-41
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• 2019

Cellular senescence, a permanent state of cell cycle arrest, is believed to have originally evolved to limit the proliferation of old or damaged cells. However, it has been recently shown that cellular senescence is a physiological and pathological program contributing to embryogenesis, immune response, and wound repair, as well as aging and age-related diseases. Unlike replicative senescence associated with telomere attrition, premature senescence rapidly occurs in response to various intrinsic and extrinsic insults. Thus, cellular senescence has also been considered suppressive mechanism of tumorigenesis. Current studies have revealed that therapy-induced senescence (TIS), a type of senescence caused by traditional cancer therapy, could play a critical role in cancer treatment. In this review, we outline the key features and the molecular pathways of cellular senescence. Better understanding of cellular senescence will provide insights into the development of powerful strategies to control cellular senescence for therapeutic benefit. Lastly, we discuss existing strategies for the induction of cancer cell senescence to improve efficacy of anticancer therapy.

• Journal of Hospice and Palliative Care
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• v.26 no.3
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• pp.140-144
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• 2023

Many terminally ill cancer patients grapple with a range of physical, psychological, and social challenges. Therefore, it is critical to offer effective psychological interventions to assist them in managing these issues and enhancing their quality of life. This brief communication provides a concise overview of acceptance and commitment therapy (ACT), along with empirical evidence of its application for patients, caregivers, and healthcare professionals in hospice and palliative care settings and an overview of future directions of ACT interventions in South Korea. ACT, a third-wave type of cognitive behavioral therapy, is a model of psychological flexibility that promotes personal growth and empowerment across all life areas. Currently, there is substantial evidence from overseas supporting the effectiveness of ACT on health-related outcomes among patients with various diseases, caregivers, and healthcare professionals. The necessity and significance of conducting ACT-based empirical research in hospice and palliative care settings in South Korea are discussed.

• The Journal of Korean Physical Therapy
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• v.15 no.1
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• pp.38-60
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• 2003

The purpose of this study was to observe the effects of Far-infrared on mice rheumatoid arthritis induced by type II collagen. The author peformed several experimental tests which were the hematoxylin-eosin tissue stain, the hind paw thickness, and ELSIA of cytokines(TNF-$\alpha$, IL-1$\beta$). On day 14 and 21, FIR-Tx. group decreased in synovial membrane thickness more than control II group FIR-Tx group decreased in hind paw thickness more than control II group. In the ELISA test of TNF-$\alpha$ concentration, control II group significantly increased in the concentration more than normal and FIR-Tx. group on day 7, 14, and 21. In the ELISA test of IL-$\beta$ concentration, FIR-Tx. group decreased in the concentration more than control II group on day 14 and 21. With J's Linear Function Data Process Program, researchers can get the estimated the concentration or the hind paw thickness from this experiment. The estimated results would be a good guide to therapists and researchers, planning Far-infrared application on the rheumatoid arthritis. These results indicated that far-infrared irradiating appeared to reduce the concentration of TNF-$\alpha$ and IL-1$\beta$ at mouse model of autoimmune arthritis. It would be considered that Far-infrared has an effect on relieving rheumatoid arthritis.

• PNF and Movement
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• v.16 no.3
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• pp.365-376
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• 2018

Purpose: This study investigates research trends in the Proprioceptive Neuromuscular Facilitation (PNF) and Movement journal. Methods: This study analyzes the frequency of keywords and their coincidences with medical subject headings (MeSH) over 15 years in 315 papers from volume 1, issue 1 to volume 15, issue 3 of a journal published by the Korean Proprioceptive Neuromuscular Facilitation Association. The research types and levels are also analyzed, and the journals are classified by subject, diagnosis, application of PNF, and technique used when PNF is applied. All of the variables are classified in five-year units and their trends are examined. Results: A total of 315 papers were published in 40 issues, and 1190 keywords were used over 15 years. The most frequently used keyword was "PNF." For the keywords that coincided with the MeSH, there were 235 (19.74%) complete coincidence words, 167 (14.03%) incomplete coincidence words, and 788 (66.21%) complete incoincidence words. Thus, the number of complete incoincidence words was the largest. For research types, there were 196 (61.90%) experimental studies, which was the most studied research type. For research levels, there were 155 (49.21%) Level 3 studies (non-randomized trial), which was the research level with the largest number of papers. Normal people were the most common subjects (121 cases, 38.41%), and the number of papers that did not use PNF was 187 (59.37%), which was larger than those that used PNF. The most frequently used combination technique was isotonics when PNF was used. Conclusion: Basic data on PNF-related research was obtained by analyzing papers published over the past 15 years. This information can be used to suggest future directions for PNF research.

• Journal of Genetic Medicine
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• v.17 no.2
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• pp.62-67
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• 2020

Purpose: Eliglustat is an oral substrate reduction therapy (SRT) approved for adults with Gaucher disease type I (GD1) who are extensive, intermediate, or poor CYP2D6 metabolizers. Here we report one-year experience of eliglustat switch therapy from long-term enzyme replacement therapy (ERT) in three adult patients with GD1. Materials and Methods: Medical history, clinical (hemoglobin concentration, platelet count, and bone mineral density) and biochemical parameters (angiotensin converting enzyme, total acid phosphatase, and lyso-gb1) of the patients were collected and evaluated by retrospective review of medical records at every 3, 6, or 12 month after switch to SRT. Results: Patient 1 was a 43-year old female diagnosed GD1 and her clinical and biochemical parameters were stabilized for more than 20 years by ERT. Due to the burden of regular hospital visit, she switched to SRT. During one-year of SRT, clinical parameters and biomarkers were maintained stable. However, after suffering acute febrile illness during SRT, she decided to re-switch to ERT due to concerns about drug interaction. Patient 2 was 41-year old male, younger brother of patient 1 and Patient 3 was 31-year old male. They switched to SRT in clinically stable condition with long-term ERT. The one-year SRT was tolerable without specific safety issue and the clinical parameters were maintained stable. Conclusion: One-year eliglustat therapy in three adult patients with GDI was generally tolerable and effective for maintaining the clinical parameters and biomarkers. However, the drug compliance, concurrent drug interactions, and long-term safety of eliglustat should be carefully monitored.

• Physical Therapy Rehabilitation Science
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• v.12 no.1
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• pp.1-11
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• 2023

Objective: This study aimed to investigate the effects of squat posture, band position, and contraction type on the muscle activity of the hip abductors during resisted lateral band walking. Design: A cross-sectional survey study Methods: 24 healthy male subjects were recruited, and surface electromyography was used to measure the muscle activity of the gluteus maximus, gluteus medius, and tensor fascia lata of the dominant leg during lateral walking exercises. Resistance bands were applied to the knees, ankles, and feet in semi-squat and squat postures, and exercises were randomly performed under six different conditions. Results: The results showed significant differences in muscle activity in the gluteus maximus, gluteus medius, and tensor fascia lata according to posture, band position, and contraction type (p<0.05). The muscle activity of the hip abductors increased in the squat posture and with the band placed on the distal joint compared to the proximal joint (p<0.05). Additionally, muscle activity was higher in the eccentric contraction phase than in the concentric contraction phase (p<0.05). Contrary to previous studies, moving the resistance band from the ankle to the foot increased the muscle activity of the tensor fascia lata while the activity of the gluteus maximus and gluteus medius also increased. Conclusions: According to the results, squat posture with a resistance band placed on the feet and using an eccentric contraction phase were found to be the most effective methods for strengthening the hip abductors.