• The Korean Journal of Pain
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• 제20권2호
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• pp.190-194
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• 2007

Complex regional pain syndrome (CRPS), which is a syndrome that is defined by pain and sudomotor and/or vasomotor instability, is usually resistant to conventional treatment. Here, a case involving a 30-year-old male patient with CRPS type I who showed severe intractable right shoulder pain with allodynia and hyperalgesia despite being treated with oral medications, nerve blocks including thoracic sympathetic neurolysis, and spinal cord stimulation is described. The patient frequently visited the emergency room due to severe uncontrollable breakthrough pain. Although a favorable effect was observed in response to intermittent ketamine infusion therapies that were performed on an outpatient basis, acute exacerbation of pain occurred frequently during the night and could not be controlled. Therefore, subcutaneous ketamine infusion therapy using a patient-controlled analgesic system was attempted and found to effectively control acute exacerbation of pain during 6 weeks of infusion without serious complications.

• 대한방사성의약품학회지
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• 제1권2호
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• pp.104-108
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• 2015

Human serum albumin (HSA) has potential for diagnosis and therapy in clinical setting. The purpose of experiments was to develop and evaluate $^{68}Ga$-HSA as a PET agent for diagnosis of acute inflammation. NOTA-HSA was synthesized by conjugating 2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid to HSA in 0.1 M sodium carbonate buffer (pH 9.5) and then purified using a PD-10 size-exclusion column. NOTA-HSA was labeled with $^{68}Ga$ at room temperature for 10 min, and 8.4% sodium hydrogen carbonate buffer was added for neutralization. $^{68}Ga$-NOTA-HSA was purified using alumina N plus light cartridge and $0.22{\mu}m$ syringe filter. Labeling efficiency and radiochemical purity were determined by ITLC-SG with 0.1 M citric acid. Biodistribution study was performed in a male BALB/c mice model of Carrageenan-induced acute inflammation. Animal PET study was performed in acute inflammation mice model after tail vein injection of $^{68}Ga$-HSA. This radiotracer showed high labeling efficiency (>99%) around pH 7. Biodistribution study showed higher inflamed footpad uptake than control footpad uptake. Animal PET study revealed 2 times higher uptake on inflamed footpad compared to control footpad. In these experiments, we developed $^{68}Ga$-HSA for acute inflammation PET imaging and evaluated it in a mouse disease model. The results demonstrated that $^{68}Ga$-HSA has potential as a PET imaging agent for diagnosis of acute inflammation.

• Nuclear Medicine and Molecular Imaging
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• 제42권4호
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• pp.261-266
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• 2008

We established a model to calculate radioactive waste from sewage disposal tank of hospitals to optimize the number of patients receiving inpatient radioiodine therapy within the safety guideline in our country. According to this model and calculation of radioactivity concentration using the number of patients per week, the treatment dose of radioiodine, the capacity and the number of sewage tanks and the daily amount of water waste per patient, estimated concentration of radioactivity in sewage waste upon disposal from disposal tanks after longterm retention were within the safety guideline (30 Bq/L) in all the hospitals examined. In addition to the fact that we could increase the number of patients in two thirds of hospitals, we found that the daily amount of waste water was the most important variable to allow the increase of the number of patients within the safety margin of disposed radioactivity. We propose that saving the water amount be led to increase the number of patients and they allow two patients in an already furnished hospital inpatient room to meet the increasing need of inpatient radioiodine treatment for thyroid cancer.

• 방사선산업학회지
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• 제5권3호
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• pp.197-202
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• 2011

In this study, an Ag-polyaniline-silica (Ag-PANI-silica) nanoparticle was evaluated as a radioisotope carrier. An Ag-PANI-silica nanoparticle was incubated in the $^{125}I$ solution for a duration of 24 hr to test its radioisotope absorptivity. During the incubation, radioactivity of the nanoparticle was measured at 3, 6, 12, and 24 hr. After a 24 hr incubation, $^{125}I$-Ag-PANI-silica nanoparticle was incubated in a fresh saline for a duration of 48 hr to check its stability. Additionally, the $^{125}I$-Ag-PANI-silica nanoparticle was injected to the ICR mouse to investigate its in-vivo distribution characteristics. The $^{125}I$ absorption yield of the Ag-PANI-silica nanoparticle was higher than 95% after a 6 hr incubation period in the $^{125}I$ solution. And $^{125}I$-Ag-PANI-silica was stable for 48 hr at 80% yield at room temperature. The SPECT/CT image of a mouse that received $^{125}I$-Ag-PANI-silica complex showed that the $^{125}I$-Ag-PANI-silica complex was distributed in the lung, stomach and thyroid at 30 min post injection. From these results, the Ag-PANI-silica nanoparticle has good radio-iodine carrying property and can be applicable for the purpose of diagnosis and therapy.

• Tuberculosis and Respiratory Diseases
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• 제84권3호
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• pp.217-225
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• 2021

Background: Despite the proven benefits of dexamethasone in hospitalized coronavirus disease 2019 (COVID-19) patients, the optimum time for the administration of dexamethasone is unknown. We investigated the progression of COVID-19 pneumonia based on the timing of dexamethasone administration. Methods: A single-center, retrospective cohort study based on medical record reviews was conducted between June 10 and September 21, 2020. We compared the risk of severe COVID-19, defined as the use of a high-flow nasal cannula or a mechanical ventilator, between groups that received dexamethasone either within 24 hours of hypoxemia (early dexamethasone group) or 24 hours after hypoxemia (late dexamethasone group). Hypoxemia was defined as room-air SpO₂ <90%. Results: Among 59 patients treated with dexamethasone for COVID-19 pneumonia, 30 were in the early dexamethasone group and 29 were in the late dexamethasone group. There was no significant difference in baseline characteristics, the time interval from symptom onset to diagnosis or hospitalization, or the use of antiviral or antibacterial agents between the two groups. The early dexamethasone group showed a significantly lower rate of severe COVID-19 compared to the control group (75.9% vs. 40.0%, p=0.012). Further, the early dexamethasone group showed a significantly shorter total duration of oxygen supplementation (10.45 days vs. 21.61 days, p=0.003) and length of stay in the hospital (19.76 days vs. 27.21 days, p=0.013). However, extracorporeal membrane oxygenation and in-hospital mortality rates were not significantly different between the two groups. Conclusion: Early administration of dexamethasone may prevent the progression of COVID-19 to a severe disease, without increased mortality.

• Pediatric Infection and Vaccine
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• 제25권3호
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• pp.170-175
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• 2018

방선균은 피부, 구강, 위장관 및 하부 여성 생식기에 정상균무리로 존재하며 증식속도가 느린 사상체의 형태를 한 혐기 그람 양성균이다. 방선균증은 방선균 감염에 의한 질환으로 대부분 경부 안면 감염증, 복부, 골반 감염증, 그리고 흉부 감염증의 임상 형태로 나타난다. 저자들은 급성 충수염으로 충수절제술을 받은 건강한 6세 남아에서 수술 후 조직검사에서 복부 방선균증을 진단하고 장기간 항생제 치료한 1예를 경험하고 보고하는 바이다. 복부 방선균증은 소아에서는 드문 질환이고 증상이 비특이적이며 균동정을 위한 배양검사가 까다로운 점이 있어 초기 진단이 잘 되지 않고 주로 임상 검체에서 특징적인 조직소견으로 진단되는 경우가 많다. 이를 통해 방선균의 특징을 이해하고 복통을 주소로 내원한 환자에서 정상균무리가 체내로 침입할 수 있는 선행 요인 등을 가진 경우 감별진단에 복부 방선균증도 염두에 두는 것이 바람직하겠다.

• 비만대사연구학술지
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• 제1권2호
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• pp.78-82
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• 2022

Liraglutide (Saxenda^R) is prescribed to induce and sustain weight loss in obese patients. The starting dose of liraglutide is 0.6 mg/day for 1 week, which is increased by 0.6 mg/day every week until the full maintenance dose of 3 mg/day is achieved. Such dose titration is needed to prevent side effects, which primarily include gastrointestinal problems such as nausea, diarrhea, constipation, vomiting, dyspepsia, and abdominal pain. A 35-year-old, reportedly healthy obese man receiving liraglutide treatment for obesity visited the emergency room complaining of generalized weakness and dizziness accompanied by repeated diarrhea and vomiting. He reported over 20 episodes of diarrhea starting the day after liraglutide dose escalation from 1.2 mg/day to 1.8 mg/day. Laboratory findings suggested pre-renal acute kidney injury, including serum creatinine 4.77 mg/dl, blood urea nitrogen (BUN) 37 mg/dl, estimated glomerular filtration rate (eGFR) 15 ml/min/1.73 m², and Fractional excretion of sodium 0.08. After volume repletion therapy, his renal function recovered to a normal range with laboratory values of creatinine 1.08 mg/dl, BUN 14 mg/dl, and eGFR 88 ml/min/1.73 m². This case emphasizes the need for caution when prescribing glucagon-like peptide-1 receptor agonists, including liraglutide, given the risk of serious renal impairments induced by volume depletion and dehydration through severe-grade diarrhea and vomiting.

• 문화기술의 융합
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• 제7권2호
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• pp.297-302
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• 2021

본 연구는 뇌졸중 후 노인의 우울정도를 확인하고, 수면의 질과 우울의 관련성을 파악하기 위해 시행되었다. 연구대상자는 뇌졸중 후 물리치료실을 내원하는 60세 이상의 노인 110명이며, 설문조사는 2020년 8월부터 11월까지 시행하였다. 자료분석은 기술적 통계, t-test, ANOVA, Pearson's correlation coefficients, multiple regression analysis를 이용하였다. 연구결과 참여대상자의 77.3%(85명)이 우울한 것으로 나타났으며, 일반적 특성에 따른 우울은 뇌졸중 마비측에 따라 차이를 보였다. 대상자의 우울에 영향을 미치는 요인은 수면의 질이었으며, 설명력은 27.8%로 뇌졸중 후 노인의 수면의 질은 우울에 주요한 영향요인임이 확인되었다. 따라서 뇌졸중 후 노인의 우울을 감소시키기 위해 수면의 질을 개선하기 위한 방안들이 마련되어야 할 것으로 생각된다.

• 임상간호연구
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• 제29권1호
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• pp.67-74
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• 2023

Purpose: This study aimed to identify the effect of warm scarf on xerostomia and sore throat in postoperative colon cancer patients. Methods: A total of 40 participants with colon cancer who underwent colon cancer operation over 2hours were included from C University hospital in Seoul. The number of experimental group and control group is each 20 calculated by G*Power, and they were assigned by using nonequivalent control group no-synchronized design. In the experimental group, a warm scarf was applied to the neck for 120 minutes from entering the recovery room after the colorectal cancer surgery was completed. In the experimental group and the control group, xerostomia and sore throat were measured twice at 60-minute intervals. The degree of xerostomia was measured through the degree of wetness of the absorbent paper in mm, and the degree of sore throat was measured through the NRS (Numeral Rating Scale). Data were collected using self-administered questionnaires from August 2018 to September 2020 and were analyzed using IBM SPSS/WIN 21.0 Descriptive statistics, x² test, Fisher's exact test, t-test were used to determine the participant's characteristics. The effect of warm scarf on xerostomia and sore throat were separately estimated by Repeated Measures ANOVA. Results: The experimental group showed significant decrease of xerostomia and sore throat as time goes (p<.001). Conclusion: Results indicate that warm scarf on xerostomia and sore throat in postoperative colon cancer patients is helpful method for relieving side effect of tracheal intubation.

• Journal of Digestive Cancer Research
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• 제3권1호
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• pp.39-41
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• 2015

HER2 양성인 진행성 위암에서 어떤 치료 약제를 선택하는가에 대하여는 진료지침이 정립되어 있지만, 그 유지기간에 대하여는 아직 정립된 진료 지침은 없다. 저자들은 진행성 위암 환자에서 36개월 동안 trastuzumab을 기반으로 한 항암화학 요법을 하여 유지하고 있는 사례를 문헌 고찰과 함께 보고하는 바이다.