• Child Health Nursing Research
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• v.8 no.1
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• pp.5-19
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• 2002

The purpose of this study was to identify therapeutic play need and the degree of the nurses's therapeutic play performances perceived by hospitalized children's mothers, and then to compare the difference between the degree of the need and perceived performances. The subjects of this study consist of 121 hospitalized children's mothers. A questionaire for this study was 29 item likert type 4 point scale developed on the basis of literature review, hospitalized children's mother interview and researcher's clinical experiences. Data was analyzed by Paired t-test, t-test, ANOVA & Duncan's comparison. Results of this study are summarized as follows : 1. The degree of the therapeutic play need was measured to be high (3.20). The degree of perceived therapeutic play need by five components were followed as : physiologic suffering relief & enhancing play (3.39), growth & development facilitating play (3.26), instructional play (3.24), emotional well-being promoting play (3.18) and providing play tool & environment(2.97). 2.The degree of the nurse's therapeutic play performances perceived by mothers was measured to be low (1.60). The degree of perceived performances of the therapeutic play by the five components were followed as : physiologic suffering relief & enhancing play (1.87), instructional play (1.74), emotional well-being promoting play (1.64), providing play tool & environment (1.44) and growth&development facilitating play (1.42). 3. The difference between the degree of the therapeutic play need and nurese's perfor- mances perceived by hospitalized children's mothers were significant statistically (t= 38.54, p=.0001). Also, five components of therapeutic play were significant statistically (p=.0001). Therapeutic play has unique benefits among health care intervention for children. These findings will help in building of the theoretical framework of therapeutic play and enhancing the quality of nursing care for hospitalized children. Therapeutic play program for hospitalized children according to child growth & development and physiologic status are recommended to be developed.

• Journal of Families and Better Life
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• v.33 no.5
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• pp.103-115
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• 2015

The purpose of this study is, first, to develop a Therapy Competency Enhancement Program for Novice Play-therapists Using Traditional Play to enhance therapy Competency and second, to examine the program's effectiveness. The program consists of 10 sessions and each session employs a variety of traditional plays. The Therapeutic relationship Scale and Playfulness Scale were used as a pre-test and post-test respectively. The data were analyzed by the SPSS 18.0 program, which applied the Mann-Whiteney U test and Wilcoxon rank sum test. Twelve novice play therapists participated in ten sessions of the Therapy Competency Enhancement Program, and were compared with the control group of twelve novice play therapists who did not receive treatment. The treatment group statistically showed significant enhancement in therapeutic relationships, and playfulness in comparison to the control group. It was concluded that the Therapy Competency Enhancement Program for Novice Play-therapists Using Traditional Play was effective for enhancing therapeutic relationships and playfulness. This study has significance in its attempt to develop a Therapy Competency Enhancement program to improve the therapeutic relationship, and playfulness of novice play therapists by Traditional Play.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.11 no.2
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• pp.161-178
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• 2000

The author reviewed history and development of variable approaches of play psychotherapy. To understand basic concepts and practical factors of play, the functions of play behavior and it's clinical application were summarized. As major therapeutic approaches, both theoretical concepts and practical techniques of psychoanalytic approach and those of nondirective approach were presented. For clinician it is important to know developmental theories which can be applied to various therapeutic technics and to apply these theories to play therapy situations. So, to know the developmental approach in play psychotherapy, play as a developmental process, its' therapeutic application, play in the perspective of cognitive development and the therapeutic process of play psychotherapy were reviewed. With the knowledge of developmental concept therapists can increase their abilities to prescribe an appropriate type of play therapy.

• Korean Parent-Child Health Journal
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• v.12 no.2
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• pp.119-130
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• 2009

Purpose: This study was designed to examine the effects of Therapeutic Play Program on the pre-operative anxiety of the preschoolers. The design of this study is a quasi experimental study of non-equivalent control group pre-test/post-test design. Method: The subjects of this study were the hospitalized preschoolers receiving an operation in C University Hospital. These totalled 60 and were divided into a 30-person-control-group and a 30-person-experimental-group. The data was collected from June 1 to October 5, 2002. The Experimental treatment was carried out according to Therapeutic Play Program developed by Researcher. The instruments used in this study were the observational records for Hospitalized preschooler's Anxiety behavior response, pulse rate, and respiration rate of the preschooler's. The collected data were analyzed with real numbers, percentage, t-test, and $X^2$-test, using SPSS WIN 11.0 program. Result: Hypothesis, "The experimental group provided with a Therapeutic Play Program would show a lower score of the pre-operative anxiety behavior(t=13.79, p=.00), pre-operative pulse(t=4.50, p=.00) and pre-operative respiration rate(t=4.29, p=.00) response than when the control group was not provided", was supported. Conclusion: Therapeutic Play Program is determined to be useful for reducing Pre-operative anxiety of the preschoolers.

• Journal of the Korean Home Economics Association
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• v.49 no.3
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• pp.39-53
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• 2011

The purpose of this study was to develop a 'Solution-Focused Brief Play Therapy' and analyze children's responses to its various therapeutic techniques. The participants were three boys and three girls, all aged between 11 and 10 years, living in an orphanage on the outskirts of Seoul. Each child received 7-10 therapy sessions, each lasting 90 minutes. All sessions were video-taped and recorded verbatim. These data, along with the observational notes recorded by the researcher, were subjected to a qualitative data analysis(Creswell, 2002). The results showed not only that children set their goals and evaluated themselves objectively but also suggested solutions to meet their goals by doing something meaningful to themselves.

• Korean Journal of Human Ecology
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• v.17 no.3
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• pp.439-455
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• 2008

The purpose of this study is to find the sand play therapeutic effect for a middle-aged woman who shows the depression because of her husband's debauchery. The client showed psychological conflict, also her children appeared the schoolwork problem and regression. For the pre-test, HTP, KED, SCT and MMPI were used. As a result of analysis she was under heavy stress and chose to sleep as a mean to forget herself. The sand play total sessions were 19. The subject of the sand play therapy were analysed the sessions into the chaos stage, the struggle stage, ego/self axis stage and the adaptation stage. Sand play therapy helps the client's positive change and accept in the sand play. The sand play therapy was effective and significant to cure to middle-aged woman with depression.

• Journal of Plant Biotechnology
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• v.37 no.3
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• pp.292-304
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• 2010

High value-added therapeutic proteins have been leading the biologics industry and occupied major portion of the market. More than 60% of the currently available protein therapeutics are glycoproteins attached with glycans which play crucial roles for the protein folding, therapeutic efficacy, in vivo half-life and immunogenecity. This review introduces the process of glycosylation and the impacts of glycans in the aspects of therapeutics. The important glycan structures in therapeutic performances were also summarized focusing on three representative categories of glycoproteins, cytokines, therapeutic antibody and enzyme. Currently, mammalian expression systems such as Chinese hamster ovary cells are preferred for the production of therapeutic glycoproteins due to their ability to synthesize glycans having similar structures with human type glycans. However, recent advances of plant glycoengineering to overcome the limitation originating from different glycan structures will soon allow to develop more efficient and economic plant-based production systems for therapeutic glycoproteins.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.467-471
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• 2016

Gallstones constitute one of the more common and relatively costly conditions of the gastrointestinal system and are a major risk factor for gallbladder cancer. Most gallstone cases involve individuals younger than 60 years of age, those older representing 9% of the total in one series. There are many risk factors for gallstones and Lith and Mucin genes, for example, play important roles in their formation. Surgery is one therapeutic approach but in the future it is to be expected that drugs for prevention of gallstones will be developed in the future. This will have clear implications for gallbladder cancer control.

• Child Health Nursing Research
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• v.12 no.4
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• pp.486-494
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• 2006

Purpose: This study was done to analyze children's play during hospitalization. Method: Data were collected from 36 play situations of hospitalized children, ages 2 to 6, hospitalized at 4 general hospitals, one in each city, Seoul, Suwon, Daejeon and Daegu. All observations were made in pediatric units during free-play periods. Each child was observed for 5 minutes at each observation and observed three times at each play session. Results: Of the children, 83.3% played on the bed. Play partners were mainly mothers. While 75.0% of children actively took part in play activity and 70.0% played with joy, 63.9% of play partners were more passive in the play. The most frequent play material was a small toy. The level of play was early stage of social and cognitive play, and dramatic play was observed in a few children over the age of 3 years. The play activities were conversional play, reflections of therapeutic procedures, imagination, and exploratory play. In the conversional play, children converted hospital equipments into play materials. Conclusion: It is recommended that health care team members should pay attention and actively participate in play of hospitalized children in order to help them have some control over the stress of the situation.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.4
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• pp.219-226
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• 2000

The application of recombinant DNA technology to restructure metabolic net-work can change metabolite and protein products by altering the biosynthetic pathways in an organism. Although some success has been achieved, a more detailed and thorough investigation of this approach is certainly warranted since it is clear that such methods hold great potential based on the encouraging results obtained so far. In last decade, there have been tremendous advances in the field of glycobiology and the stage has been set for the biotechnological production of glycoproteins for therapeutic use. Today glycoproteins are one of the most important groups of pharmaceutical products. In this study the attempt was made to focus on identifying technologies that may have general application for modifying glycosylation pathway of the yeast cells in order to produce glycoproteins of therapeutic use. The carbohydrates of therapeutic recombinant glycoproteins play very important roles in determining their pharmacokinetic properties. A number of biological interactions and biological functions mediated by glycans are also being targeted for therapeutic manipulation in vivo. For a commercially viable production of therapeutic glycoproteins a metabolic engineering of a host cell is yet to be established.