• Journal of the Korean Home Economics Association
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• v.42 no.7
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• pp.145-164
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• 2004

The purpose of this study is to understand how late middle-aged women in our society view and adapt to “aging”. This is a crucial step forward linking two stages, the growing young age and the declining old age, which eventually improves the qualify of life in old a9e. This qualitative study used Personal narratives extracted from tape-recorded interviews of 20 late middle-aged women in their fifties and analyzed key experiences of late middle-aged women in their transition to old age. Participants were observed to perceive not only many limitations but also alternative potentialities. First, the major challenges due to the closing young era were ‘physical declines’, including health problems and wrinkles, and ‘leaving children’. Second, the potentialities to start a new era also could be found. Many participants found themselves to be generous enough to assist others in need. In addition, they looked to adapt to new challenges. It was likely that the many adversities that they had faced made them resilient. These results show that late middle-aged women were actively negotiating with themselves and their surroundings in order to overcome their losses, maintain their potentialities, and, in the process, acknowledge their impending old age for better preparation.

• The Korean Journal of Physiology
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• v.23 no.1
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• pp.51-66
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• 1989

Mammalian cardiocytes secrete atrial natriuretic peptides (ANPs) into plasma, which cause marked natriuresis, diuresis, vasorelaxation and inhibition of hormone secretions. Aging influences the ability of the kidney both to conserve and to excrete sodium; i.e., in old animals, the excretory capacity of sodium is reduced and the time required to excrete sodium load is prolonged. Therefore, it is possible that animals differing in ages may respond differently to ANP. In the present study, we determined whether the renal, hormonal and vascular effects of ANP may be influenced by aging in conscious rabbits. The plasma renin concentration decreased with aging but plasma ANP concentration was significantly lower only in 24-month-old rabbits. Plasma aldosterone concentration and atrial ANP content did not change by aging. In 1-month-old rabbits, ANP (atriopeptin III, 3 ug/kg) administered intravenously caused hypotension and decreased in plasma renin and aldosterone concentrations, but did not cause diuresis and natriuresis. In 2 to 5 month-old rabbits, ANP caused hypotension, decreases in Plasma renin and aldosterone concentrations and marked renal effects. However, in 24-month-old rabbits, all the above effects of ANP was blunted. With hydration of physiological saline at a rate of 15 ml/kg/h for 2hr, urine volume and glomerular filtration rate did not change but the electrolyte excretion as well as fractional excretion of sodium significantly increased. The plasma concentrations of active renin and aldosterone were decreased but plasma inactive renin and ANP concentrations were increased. The changes in renal function and plasma level of hormone showed no differences in different ages. These results suggest that the peripheral vascular receptors to ANP may develop earlier than those in the kidney, and the attenuated vascular and renal responses to ANP in the old age may be due to age-related modifications in renal function and blood vessel.

• (The)Study of the Eastern Classic
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• no.49
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• pp.109-136
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• 2012

'Old man' or 'old age' was not the parts of academic discipline in the Joseon era but Yeoheon put it in the philosophical 'problematization' of the learning of the Confucianism. He was argued that the old man or old age is not merely biological decline but it has the goal to achieve. The completion of self is the meaning and end of the life throughout the subjective realization and procedure of attaining the goal step by step. Well-aged old man is affirming the getting old and making the positive changing of old life time in his one sake. This essay is showing the Yeoheon's thought of old aging as the self-realizing well-ageing. Next, it is argued that the predicament of old age or old man is not just social welfare or biological aspects but it is serious philosophical problems. If it was just social or biological aspects then it is just a social phenomenon to approach the view of scientists. However, this is not only life and death and flux of time and relativities but also it is problematizing the self-identification subjectivities. Obviously, it is the significant that the old and or old age is fundamentally philosophical subject rather than social or biological materials. In the third chapter, we are dealing with the views of the life and death of Yeoheon. He was insisted that quite interesting opinion that is the all the lives in the universe include himself is 'a wayfarer'. It looks like a time traveler in the universe; we are just one who stays in a body for awhile. When we follow him, we are living in this universe in a time (disposable) but the same theorem is applying to the whole universe as well myriad creatures. Therefore, man has a job to do as an entity of the universe. Yeoheon was called it is the business as a job and we have to do the Dao till you end. The fourth, Yeoheon was suggested that the old man has his work and business. There are two kind of works for an old man, the former is self control as an old age that is call the old man's job and the latter is staying with the Dao that is called the old man's business. According to Yeoheon, man has charged to realize the law of the universe that means we are the moral entity; therefore we are business to complete ourselves. Old age is decline of physical activities rather than vigorous, therefore, we have to follow our body and self-affirmation of declination is the Dao. The final, Yeoheon was advised that the old man better saved in the current of the Dao, because the physical function is declining but the shining Dao is within the mind in the body. It is motivation of the self-dignity of old man and one who recognizes the work to do even in the old body that he will be the significant among all the society not a lonely old man anymore. Old aging is biological twilight but the considerable real size expertise and self-affirmation is the Dao of old age. We are meditating nowadays in Yeoheon's philosophical context on old man or old aging. By him, the old age is man of dignity as long as he realizes in his Dao through the business and self-affirmation.

• BMB Reports
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• v.48 no.11
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• pp.595-596
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• 2015

Skeletal muscle exhibits a loss of muscle mass and function with age. Decreased regenerative potential of muscle stem/progenitor cells is a major underlying cause of sarcopenia. We analyzed microRNAs (miRNA) that are differentially expressed in young and old myoblasts, to identify novel intrinsic factors that play a degenerative role in aged skeletal muscle. miR-431, one of decreasing miRNAs in old myoblasts, improved the myogenic differentiation when overexpressed in old myoblast, but suppressed their myogenic capability in knockdowned young myoblasts. We found that miR-431 directly binds to 3` untranslated regions (UTR) of Smad4 mRNA, and decreases its expression. Given that SMAD4 is one of the downstream effectors of TGF-β, a well-known degenerative signaling pathway in myogenesis, the decreased miR-431 in old myoblast causes SMAD4 elevation, thus resulting in defective myogenesis. Exogenous expression of miR-431 greatly improved the muscle regeneration in the cardiotoxin-injured hindlimb muscle of old mice by reducing SMAD4 levels. Since the miR-431 seed sequence is conserved in human SMAD4 3'UTR, miR-431 regulates the myogenic capacity of human skeletal myoblasts in the same manner. Our results suggest that age-associated miR-431 is required for the maintenance of the myogenic capability in myoblasts, thus underscoring its potential as a therapeutic target to slow down muscle aging.

• The Journal of Internal Korean Medicine
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• v.26 no.2
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• pp.379-389
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• 2005

Objectives: It is well known that aging and aging-related diseases are linked to the increased level of oxidative stress caused by reactive oxygen species(ROS) and reactive nitrogen species(RNS). Nonprotein-SH decreases during aging, while substances such as ROS, nitric oxide(NO), peroxynitrite($ONOO^-$), myeloperoxidase(MPO), and dityrosine show a significant increase. This study investigated the effect of Ichungwhan on the aging process by examining its effect on the generation of the above-mentioned substances. Methods: Four comparison groups of SD rats were used. They were 6 month-old rats, 24 month-old rats, and 24 month-old rats fed with food containing 0.1% and 0.3% of Ichungwhan extract. The amount of NO, $ONOO^-$, and ROS in the rats' kidneys were examined using a fluorescence microplate reader. The reagents used for this purpose include: dihydrorhodamine 123 (DHR 123), 2',7' -dichlorodihydrofluorescein, diacetate(DCFDA), and 4,5-diaminofluorescein(DAF-2). A spectrophotometer was used to investigate the reactivity of nonprotein-SH and myeioperoxidase(MPO), using reagents such as trichloroacetic acid(TCA) and tetramethylbenzidine(TMB). The amounts of MPO protein and dityrosine were measued by western blot. Results: The observed effects of Ichungwhan on rats were as follows: increase of nonprotein-SH; effective decrease of RNS level by suppression of the generation system of $ONOO^-$ and NO; decrease of ROS level; decrease of the MPO reactivity and the subsequent reduction of amount of MPO protein; retardation of dityrosine formation. It can be hypothesized, therefore, that Ichungwhan affects both the earlier and later phases of the molecular inflammatory process, and retards the aging process. Conclusions: Empirical evidence in this study supports a role for Ichungwhan in generation mechanisms of aging process-linked substances ROS, NO, $ONOO^-$, nonprotein-SH, MPO and dityrosine. Affects contrary to the aging process observed in rats beg further empiricism to investigate potential application of Ichungwhan as a medication for age-related diseases in humans.

• Journal of Korean Public Health Nursing
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• v.29 no.1
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• pp.29-39
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• 2015

Purpose: The purpose of this study was to investigate the aging anxiety, factors of successful aging, and preparation for aging in early and late middle-aged people. Methods: The study subjects were 140 middle-aged people aged from 40 to 59. Data were collected using a self-administered questionnaire from August 16 to September 30, 2013. The collected data were analyzed with descriptive statistics, t-test, ${\chi}^2$-test and Pearson correlation coefficient using IBM SPSS 21.0 program. Results: Between early and late middle age, there were statistically significant differences in the subcategories of aging anxiety: fear of loss (t=2.93, p=.004), fear of old people (t=-2.33, p=.021), physical appearance (t=2.32, p=.022), and psychological concerns (t=2.04, p=.043). A statistically significant difference was found between two groups in one subscale of preparation for aging: physical preparation (t=-2.02, p=.045). In early midlife, significant associations were observed between preparation for aging and both aging anxiety (r=.56, p<.001) and factors of successful aging (r=.54, p<.001). In late midlife, preparation for aging and factors of successful aging showed positive correlation (r=.50, p<.001) Conclusion: Results of this study indicate that programs for successful transition to old age in middle-aged people should consider their aging anxiety level and preparation for aging at their stage of life.

• Proceedings of the Korea Society of Design Studies Conference
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• 2000.11a
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• pp.134-135
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• 2000

컴퓨터와 인간의 관계는 몇 단계를 거쳐 오늘날 우리가 일상적으로 사용하는 데까지 이르러, 컴퓨터의 사용 계층이 점점 일반화, 다양화되어 전문가들이나 젊은층 뿐만아니라 노인들이나 어린이들도 일상생활에서 많이 사용하는 도구가 되어 업무수행에 있어서 쉽게 인지하고 편리하게 사용하고자 하는 맡은 연구들이 행해져 오고 있다. (중략)

• KIEAE Journal
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• v.11 no.5
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• pp.119-127
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• 2011

The aging population has been increasing in Korea so that it is difficult for people to understand the change of the future society. This study aimed to analyze the characteristics of preliminary retiree's alternative housing preference by providing an accurate information about residential current issues and the seriousness brought by the aging society. It explained the visual information about the aspect of the residential change due to the aging society to 104 preliminary retirees who live in the apartment in Seoul. It surveyed the characteristics of the alternative housing preference following 4 situations of the Old age type(couple/healthy, couple/ill, single/healthy, single/ill). It analyzed the difference of housing preference before and after providing information. The results are as follows: First, a previous apartment is not enough to prepare the aging society and UIBS(unit insertion building system) for the elderly was expected to be a great help to the frail after 2026. Second, the preference of UIBS was increased after providing information of the aging society. Third, in the case of the illness, a big city with medical facilities was preferred not to move in the suburb. Fourth, after providing information, a small size of apartment was preferred but the preferred change of housing ownership was not founded. Last, there was considerable difference before and after providing information under 4 situation of Old age type. These results showed the feasibility of coping with more accurate future society only if a survey should be taken with providing sufficient information about the aging society.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.713-716
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• 2002

Aging effect on the cardiovascular circulation is simulated by lumped parameter model. Aging phenomena can be hemodynamically explained as (1) the increase of flow resistance induced by remodeling of artery vessels and increased viscosity of blood and (2) the reduction of the vessel capacitance caused by arteriosclerosis. Appropriate physiological parameters are evaluated from the clinical data of adults and old men. Simulation results well explain the hypertension with aging of cardiovascular system.

• Journal of Digital Convergence
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• v.11 no.12
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• pp.121-144
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• 2013

The purpose of this study is to explore the effects of the middle aged's perception of successful aging on their preparations for the old age. We used data from 350 participants, aged 35-64 in Seoul-Gyonggi region. The hierachial regression analysis estimated the relation between the middle aged's perception on successful aging and their preparations for the old age. The findings indicate that the middle aged's level of preparations for the old age was slightly higher than average. The level of their emotional preparation appeared highest and the level of economical preparation showed lowest. The perception of successful aging indicated relatively high, and especially the level of comfortable everyday life showed highest. The results also showed that personal characteristics influencing on preparations for the old age were sex, age, marriage status, religion, occupation, monthly income, health condition, level of plan for the old age, and social activities frequency, and demonstrated that the perception of successful aging effected on preparations for the old age positively.