• 한국자원식물학회지
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• 제23권6호
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• pp.498-502
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• 2010

The immune system may play an important role in aging and the changes in the immune status are associated with treatment of various immunomodulators. This study examined the effects of $\beta$-glucans isolated from mushroom fungi, Coriolus versicolor on macrophages functions in young (8-weeks-old) and aged (82-weeks-old) male C57BL/6 mice. When peritoneal macrophages were treated with various concentrations of $\beta$-glucan ($1-100\;{\mu}g/ml$) for 24 hrs, tumoricidal activity, NO production and phagocytic activity were significantly increased in the young mice, whereas there are no effects in the aged mice. These results suggest that $\beta$-glucans has differential effects on the macrophage functions in young and aged mice and age nutrition might need to be considered to select proper immunomodulator. In addition, $\beta$-glucan could be used clinically for the treatment of diseases such as cancer therapy in the young.

• 한국노년학
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• 제36권3호
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• pp.751-763
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• 2016

본 연구에서는 인지노화와 그에 영향을 미치는 사회심리학적 요인에 대해 개관하였다. 노화로 인한 인지기능의 변화는 세부 기능별로 상이함에도 인지노화는 쇠퇴의 관점으로 주로 해석되고 있다. 인지노화에 대한 부정적인 시각은 노화 고정관념(age stereotype)과 같은 사회심리학적 요인이 반영된 결과로 볼 수 있다. 노화 고정관념은 문화권에 따른 차이는 있으나 보통 부정적인 측면이 강하게 나타나는데, 더 부정적인 고정관념을 보일수록 기억 수행이 저하되는 것으로 나타났다. 노화 고정관념을 실험적으로 활성화시키는 경우, 긍정적인 고정관념을 제시받은 노인이 부정적인 고정관념을 제시받은 노인에 비해 더 높은 기억 수행을 보였다. 자신의 인지기능에 대한 평가인 자기신념(self-referent belief)도 인지기능에 영향을 미치는 것으로 나타난다. 보통 노인의 자기신념이 청년의 자기신념보다 낮게 나타나고, 자기기억신념의 수준은 실제 기억 수행과 관련되는 것으로 나타난다. 이상의 사회심리학적 요인이 인지기능에 미치는 영향에 대한 이론적 설명과 시사점이 논의되었다.

• 건설안전기술
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• 통권55호
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• pp.10-17
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• 2012

Aging society may approached to our society during snatch very, and enter in super aging society for more span. Investment that we which live 21th century are many in people's quality of life elevation meantime did not consist, but stand in visual point that must improve many portions forward. For front, repletions for many equipments that consider aged on our society must consist, and much researches may have to be gone for this. According to traffic accident result, percentage of older pedestrian deaths was 46.5% as much in Korea. In particular, the crossing accidents by 59% or more of the older pedestrian traffic safety measures that target is an urgent situation. Therefore, in this study was to identify the domestic status and problem on no-sidewalk region for older pedestrians. In addition, side walk the installation and maintenance plan presented to prepare for aging society.

• 대한의생명과학회지
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• 제4권2호
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• pp.87-101
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• 1998

장기간 체중부하운동이 흰쥐의 심근에 미치는 효과를 규명하기 위하여 생후 3개월, 10개월 및 20개월된 흰쥐를 5개월간 운동시킨 후 각각의 비운동군과 비교하여 심근의 조직학적ㆍ세포학적 변화를 관찰하고, 심근세포내 미세구조적 변화를 입체해석학적으로 비교 분석하였다. 운동 15개월군부터 노화색소의 양이 현저히 증가되었고 사립체의 변성, 공포화 현상 그리고 간질조직의 증식이 뚜렷하였으며, 25개월군에서는 윤반분리, 근원섬유의 소실 및 과수축대 출현빈도가 증가되었다. Glucose-6-phosphatase의 활성도는 15개월 운동군에서 감소하여 25개월 운동군에서는 활성도가 거의 나타나지 않았다. 입체해석학적 결과에서도 장기간 체중부하운동으로 인해 15개월, 25개월군에서 모두 사립체와 근원섬유의 체적밀도는 감소되었고, 간질조직의 체적밀도는 증가되었다. 본 연구의 결과로 볼 때 장기간 체중부하운동은 3개월군에 있어서 심장에 미치는 역효과가 없으나 10개월군과 20개월군에서는 심근기능강화에 역효과를 초래 할 우려가 큰 것으로 판단된다.

• Nutrition Research and Practice
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• 제18권1호
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• pp.46-61
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• 2024

BACKGROUND/OBJECTIVES: An increasing life expectancy in society has burdened healthcare systems substantially because of the rising prevalence of age-related metabolic diseases. This study compared the effects of animal protein hydrolysate (APH) and casein on metabolic diseases using aged mice. MATERIALS/METHODS: Eight-week-old and 50-week-old C57BL/6J mice were used as the non-aged (YC group) and aged controls (NC group), respectively. The aged mice were divided randomly into 3 groups (NC, low-APH [LP], and high-APH [HP] and fed each experimental diet for 12 weeks. In the LP and HP groups, casein in the AIN-93G diet was substituted with 16 kcal% and 24 kcal% APH, respectively. The mice were sacrificed when they were 63-week-old, and plasma and hepatic lipid, white adipose tissue weight, hepatic glucose, lipid, and antioxidant enzyme activities, immunohistochemistry staining, and mRNA expression related to the glucose metabolism on liver and muscle were analyzed. RESULTS: Supplementation of APH in aging mice resulted in a significant decrease in visceral fat (epididymal, perirenal, retroperitoneal, and mesenteric fat) compared to the negative control (NC) group. The intraperitoneal glucose tolerance test and area under the curve analysis revealed insulin resistance in the NC group, which was alleviated by APH supplementation. APH supplementation reduced hepatic gluconeogenesis and increased glucose utilization in the liver and muscle. Furthermore, APH supplementation improved hepatic steatosis by reducing the hepatic fatty acid and phosphatidate phosphatase activity while increasing the hepatic carnitine palmitoyltransferase activity. Furthermore, in the APH supplementation groups, the red blood cell (RBC) thiobarbituric acid reactive substances and hepatic H₂O₂ levels decreased, and the RBC glutathione, hepatic catalase, and glutathione peroxidase activities increased. CONCLUSIONS: APH supplementation reduced visceral fat accumulation and alleviated obesity-related metabolic diseases, including insulin resistance and hepatic steatosis, in aged mice. Therefore, high-quality animal protein APH that reduces the molecular weight and enhances the protein digestibility-corrected amino acid score has potential as a dietary supplement for healthy aging.

• 한국안전학회지
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• 제33권1호
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• pp.148-161
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• 2018

A traffic fatality by young people marked average annual decrease of 4.5% since 2011. Meanwhile, a traffic fatality by senior over 65 years old marked average annual increase of 7.9% for the last five years which means that the annual increase of traffic fatality by senior will be a serious problem. This study started questioning that senior drivers over 65 years old did not retain the same causal factor of fatal traffic accidents and thus extensively analyzed a risk of it by age group quantitatively, dividing the senior driver group into the early, middle and latter stages. Depending on the aging level, the risk of traffic fatality showed a wide difference in seven different types of traffic accidents generally, and happened to increase with latter and middle parts of the senior driver more than the early part. Therefore, this study proposes four policy suggestions: 1) The senior driver need to be offered customized driving educations and the improvement of road environment is also recommended. 2) Political assistance is needed to support and guide a safety related technology installation for the new or existing car. 3) Renewal of driving license and an aptitude test(physical examination, cognitive test) for drivers over 75 years old should take in a less than 3 years and an additional road test is needed as occasion demands. 4) Like the United States and Europe, development and extension of customized treatment guidebook for medical teams who examine senior drivers is needed and establishment of education and administration system that a supervisor of driving license renewal can impose safety restriction and American anonymity reporting system is considered to institutionalize in the medium to longer term.

• 농촌의학ㆍ지역보건
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• 제46권2호
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• pp.89-97
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• 2021

대상자의 인구사회학적 특성에 따른 성공적 노화의 차이는 나이에 따라서 차이가 있었고, 대상자의 성공적 노화는 기억과 정적관계가 있고, 심리사회적 스트레스와 부적관계가 있었다. 심리사회적 스트레스와 기억 간에 부적 관계가 있었다. 성공적 노화에 영향을 주는 요인은 심리사회적 스트레스로 나타났다. 따라서 본 연구의 결과는 지역사회 노인의 심리사회적 스트레스가 성공적 노화를 예측하는 중요한 변인임을 입증했다는 점에서 의미가 있다. 따라서 노인의 성공적 노화를 위한 스트레스 개입 프로그램의 경험적 근거자료가 될 수 있다.

• 한국간호교육학회지
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• 제27권4호
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• pp.392-401
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• 2021

Purpose: This study was conducted to identify the relationship of health status, aging anxiety, social networking, generativity, and happiness and to investigate the main factors influencing happiness of late middle-aged adults. Methods: The study collected data from a total of 153 middle-aged men and women aged 50 to 64 years old from a consumer panel of Macromill-Embrain, the biggest online survey provider in Korea. The data were analyzed using descriptive statistics, Pearson's correlation coefficient and a stepwise multiple regression using the SPSS 22.0 program. Results: The subjects' happiness mean score was 16.17±9.29. Statistically significant differences in happiness were found according to education (F=4.38, p=.014), economic status (t=5.13, p<.001), and religion (t=2.18, p=.031). Happiness was correlated significantly with health status (r=.41, p<.001), aging anxiety (r=-.62, p<.001), family support (r=.43, p<.001), friend support (r=.36, p<.001) and generativity (r=.63, p<.001). The factors influencing happiness of late middle-aged adults were generativity (𝛽=.37, p<.001), aging anxiety (𝛽=-.35, p<.001), family support (𝛽=.20, p<.001), and economic status (𝛽=.13, p=.033). The explanatory power of the model was 58.0%. Conclusion: This study will be used as basic data when developing a nursing intervention program for successful aging by identifying factors that affect the happiness of late middle-aged adults.

• 한국방사선학회논문지
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• 제14권7호
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• pp.947-956
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• 2020

인간의 신체는 노화가 진행됨에 따라 구조 및 기능이 저하되어 다양한 질병에 취약해지게 된다. 특히 뇌구조의 변화는 혈관 및 대사성 뇌 질환과 같은 질병에 대한 면역 체계가 취약해지고 신경정신질환에 쉽게 노출되게 된다. 본 연구에서는 이러한 뇌 구조를 비침습적으로 관찰할 수 있는 자기공명영상 기법을 이용하여 65세에서 85세까지의 여성을 대상으로 뇌 부피, 회백질, 백질, 피질하부 영역의 부피가 노화에 따라 어떻게 변화 하는지 패턴을 조사하였으며, 연구결과로 피질하부영역에서 선형적으로 유의미하게 감소하는 변화 패턴을 확인 할 수 있었다. 이러한 결과는 뇌 구조 영역의 노화로 인한 변화가 노년기 신경정신질환과 밀접한 관련이 있음을 시사하고 있으며, 노년기 뇌 발달에 대한 이해를 도울 수 있는 정보를 제공할 수 있다.

• 한국의류산업학회지
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• 제21권5호
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• pp.586-596
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• 2019

Ageism, attitudes toward aging, and body satisfaction play significant roles in determining older women's perceptions of successful aging. In addition, subjective socioeconomic and health status can act as major identifiers in determining the overall level of physical and social well-being in old age. Research for this exploratory study includes: 1) exploring the overall levels of ageism perception, attitudes toward aging, and body satisfaction among older women and 2) identifying the differences in ageism, attitudes toward aging, and body satisfaction between high and low subjective socioeconomic and health status of older women. Data for this study were collected through an online questionnaire of 221 older women. The results revealed that older women's perceptions of ageism, aging attitudes, and body satisfaction were significantly different based on subjective socioeconomic and health status. In general, older women with higher levels of subjective socioeconomic and health status reported more positive perceptions and attitudes toward aging along with higher levels of body satisfaction. The results implied that subjective health status was a more powerful indicator differentiating the aging-related perceptions of older women than the subjective socioeconomic status. This study supports the need for a conscious effort to reduce ageism that ultimately improves the overall well-being of all members in society.