• Journal of the Korean Regional Science Association
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• v.34 no.1
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• pp.3-17
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• 2018

This paper empirically investigates time-varying regression parameter of hedonic price model for Seoul office rental market in distinct periods of a market cycle. Office rental index is constructed and the index indicates that the global financial crisis differentiates the analysis period into decline stage and recovery stage. Pre-crisis period is classified into decline stage and post-crisis is classified into recovery stage. Structural break-point test suggests structural change of hedonic model of rent determinants occurred in 2008. Evidence indicates that individual regression parameters of hedonic price model for decline stage are significantly different from those for recovery stage. Changes in the regression parameters of land price, distance to metro, building size, building age, and conversion rate are consistent. In recovery stage, the effect of locational advantage on office rent decreases whereas the effect of building characteristics on the rent increases.

• Journal of the Korea institute for structural maintenance and inspection
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• v.14 no.4
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• pp.86-93
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• 2010

The wear of railway track affects loss of rough ride, noise or vibration of train and traveling safety. Moreover as the track is worn away, this promotes destruction of structural mechanism of rail track which can bring about increasing of rail track maintenance cost drastically. For this reason, it is very important and interested research subject to design railway track structure and to analyse train movement mechanism based on systematic analysis of the reasons causing rail wear possible in real field. In this research, for the efficient maintenance, Life Cycle Performance of rail track and maintenance characteristics are computed considering some track components such as track type, contracting type, sleeper type and roadbed type. Time - Wear probabilistic distribution relationship as well as multiple regression analysis based on time, curvature and wear data are computed to predict the service life remainder of railway track and to be adapted to safety assessment.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.42 no.12
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• pp.31-36
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• 2005

In this paper, we propose a new optical switching system as a infrastructure of the BcN, in which the high traffic volume will be expected due to the multimedia service, like P2P services. Because the JET protocol, the most popular protocol in OBS (Optical Burst Switching) research area, has high blocking probability for burst, it prevents commercialization in real network for its low throughput in TCP layer. To improve high blocking rate in OBS network, we segment large network into small network and perform burst scheduling to avoid burst loss. By using proposed scheme, Internet provider can reduce network deployment cost in Metro network as well as large mesh core networks

• Journal of the Health Care and Life Science
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• v.9 no.1
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• pp.103-115
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• 2021

The purpose of this study is to understand the annual trend of patients with cervical vertebrae disability and improve their health service utilization in the general description (200 TABLE) of patients with cervical vertebrae disability.The main results of this study are as follows. All patients with cervical vertebrae disability were women aged 50 to 59. Compared to 2010, the proportion of patients with disease increased year by year in all subjects in 2018, with men under 30-39 years of age and women under 19 years of age increasing the highest.

• Psychiatry investigation
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• v.15 no.11
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• pp.1064-1070
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• 2018

Objective Several cell line studies have demonstrated thioridazine's anticancer, multidrug resistance-reversing and apoptosis-inducing properties in various tumors. We conducted this nationwide population-based study to investigate the association between thioridazine use and cancer risk among adult patients with schizophrenia. Methods Based on the Psychiatric Inpatient Medical Claim of the National Health Insurance Research Database of Taiwan, a total of 185,689 insured psychiatric patients during 2000 to 2005 were identified. After excluding patients with prior history of schizophrenia, only 42,273 newly diagnosed patients were included. Among them, 1,631 patients ever receiving thioridazine for more than 30 days within 6 months were selected and paired with 6,256 randomly selected non-thioridazine controls. These patients were traced till 2012/12/31 to see if they have any malignancy. Results The incidence rates of hypertension and cerebrovascular disease were higher among cases than among matched controls. The incidence of hyperlipidemia, coronary artery disease and chronic pulmonary disease did not differ between the two groups. By using Cox proportional hazard model for cancer incidence, the crude hazard ratio was significantly higher in age, hypertension, hyperlipidemia, cerebrovascular disease, coronary artery disease and chronic pulmornary disease. However, after adjusting for other covariates, only age and hypertension remained significant. Thioridazine use in adult patients with schizophrenia had no significant association with cancer. Conclusion Despite our finding that thioridazine use had no prevention in cancer in adult patients with schizophrenia. Based on the biological activity, thioridazine is a potential anticancer drug and further investigation in human with cancer is warranted.

• Journal of The Korean Society For Urban Railway
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• v.6 no.4
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• pp.427-436
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• 2018

HADAX is a serial communication converter of train control computer. It is connected with various signal equipments such as wayside signal equipments, station signal equipments, train control computers, and transmits control information and signal condition information for train control. And transmits information to several electronic interlocking devices through a splitter interface. Since HADAX interfaces with many signaling devices through serial communication, frequent communication connection faults necessitate improvement of performance such as dual system configuration, integration of external splitter, and multi-channelization of communication card. The improved HADAX device should have compatibility with the dimensions of existing enclosure and enclosure, and verify the performance of dual system and splitter integration. Therefore, we verified the performance of HADAX through the route control test, dual system test, and multi-channel communication test with splitter integrated connection by connecting with the existing signal equipment.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7995-8001
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• 2014

Interferon-gamma (IFN-${\gamma}$) has been used to treat various malignant tumors. However, the molecular mechanisms underlying the direct anti-proliferative activity of IFN-${\gamma}$ are poorly understood. In the present study, we examined the in vitro antitumor activity of IFN-${\gamma}$ on two human non-small-cell lung carcinoma (NSCLC) cell lines, H322M and H226. Our findings indicated that IFN-${\gamma}$ treatment caused a time-dependent reduction in cell viability and induced apoptosis through a FADD-mediated caspase-8/tBid/mitochondria-dependent pathway in both cell lines. Notably, we also postulated that IFN-${\gamma}$ increased indoleamine 2,3-dioxygenase (IDO) expression and enzymatic activity in H322M and H226 cells. In addition, inhibition of IDO activity by the IDO inhibitor 1-MT or tryptophan significantly reduced IFN-${\gamma}$-induced apoptosis and death receptor 5 (DR5) expression, which suggests that IDO enzymatic activity plays an important role in the anti-NSCLC cancer effect of IFN-${\gamma}$. These results provide new mechanistic insights into interferon-${\gamma}$ antitumor activity and further support IFN-${\gamma}$ as a potential therapeutic adjuvant for the treatment of NCSLC.

• Journal of the Korean Society of Safety
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• v.30 no.6
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• pp.139-147
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• 2015

This study deals with actual commuting distance and influence of risk factors depending on commuting distance and mode in order to reestablish actual commuting zone of primary school students. Data mining analysis(CHAID) was applied for this reestablishment using survey results from 6,927 primary school students in Seoul Metro. Six risk factors; convenience level of commuting path condition, convenience level of road crossing condition, vehicle speed on commuting path, segregation level between commuter and vehicle, congestion level of commuting path, and public security level and two mode; walking and cycle are considered in the analysis. As the results of CHAID analysis, commuting distance was divided into four zones; Internal Zone(0.491km under), External Zone(0.492 ~ 1.492km, 1.493 ~ 2.699km), Commutable Zone(2.70km over), and awareness level on safety is declined as commuting distance is increased. The risk factor affecting on safety is recognized differently by students depending on commuting distance and mode. For students commuting by walking, vehicle speed on commuting path and convenience level of commuting path condition are recognized as the prime risk factor within Internal Zone and Commutable Zone, respectively. For students commuting by cycle, convenience level of road crossing condition and vehicle speed on commuting path are recognized as the prime risk factor within Commutable Zone. Analysis results show that improved plan and program for commuting path for primary school students are required considering actual commuting distance and method.

• Radiation Oncology Journal
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• v.36 no.4
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• pp.276-284
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• 2018

Purpose: Traditionally, three-dimensional conformal radiation therapy (3D-CRT) is used for neoadjuvant chemoradiation in locally advanced rectal cancer. Intensity-modulated radiation therapy (IMRT) was later developed for more conformal dose distribution, with the potential for reduced toxicity across many disease sites. We sought to use the National Cancer Database (NCDB) to examine trends and predictors for IMRT use in rectal cancer. Materials and Methods: We queried the NCDB from 2004 to 2015 for patients with rectal adenocarcinoma treated with neoadjuvant concurrent chemoradiation to standard doses followed by surgical resection. Odds ratios were used to determine predictors of IMRT use. Univariable and multivariable Cox regressions were used to determine potential predictors of overall survival (OS). Propensity matching was used to account for any indication bias. Results: Among 21,490 eligible patients, 3,131 were treated with IMRT. IMRT use increased from 1% in 2004 to 22% in 2014. Predictors for IMRT use included increased N stage, higher comorbidity score, more recent year, treatment at an academic facility, increased income, and higher educational level. On propensity-adjusted, multivariable analysis, male gender, increased distance to facility, higher comorbidity score, IMRT technique, government insurance, African-American race, and non-metro location were predictive of worse OS. Of note, the complete response rate at time of surgery was 28% with non-IMRT and 21% with IMRT. Conclusion: IMRT use has steadily increased in the treatment of rectal cancer, but still remains only a fraction of overall treatment technique, more often reserved for higher disease burden.

• Journal of the Korean Society for Railway
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• v.15 no.6
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• pp.609-615
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• 2012

TPS (Train Performance Simulation) based on ATO (Automatic Train Operation) is required for driverless LRT (Light Rail Transit) operation plan instead of typical TPS based on driver operation. In this paper, new TPS model using ATO pattern is proposed and compared with the automatic train operation result in a test line of Seoul Metro Line 6 and in a whole line of Busan-Gimhae LRT. The actual ATO pattern can be very accurately simulated by new TPS model with the introduction of 4 parameters such as commercial braking rate, jerk, station stop profile and grade converted distance. The commercial scheduled time for driverless automatic train operation can be proposed to have "Fast" mode TPS trip time plus 3 seconds/km margin recommended by Korean standard LRT specification in this paper.