• Tuberculosis and Respiratory Diseases
• /
• 제83권2호
• /
• pp.107-115
• /
• 2020

Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functions in the living system. Recently, our understanding of the molecular mechanisms underlying aging biology has significantly advanced. Interestingly, many of the pivotal molecular features of aging biology are also found to contribute to the pathogenesis of chronic lung disorders such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, for which advanced age is the most crucial risk factor. Thus, an enhanced understanding of how molecular features of aging biology are intertwined with the pathobiology of these aging-related lung disorders has paramount significance and may provide an opportunity for the development of novel therapeutics for these major unmet medical needs. To serve the purpose of integrating molecular understanding of aging biology with pulmonary medicine, in this review, recent findings obtained from the studies of aging-associated lung disorders are summarized and interpreted through the perspective of molecular biology of aging.

• 한국산업정보학회논문지
• /
• 제23권6호
• /
• pp.67-77
• /
• 2018

최근 학령인구 감소에 따라 많은 문제점들이 나타나고 있다. 우리나라는 인구대비 가장 많은 대학을 보유하고 있기 때문에 각 대학의 생존에 필요한 최소한의 학생 유지율 관리가 점점 더 중요해 지고 있다. 따라서 본 연구는 계속되는 학력인구의 감소에 따라 각 대학들이 생존 방안으로 학생 유지율의 적절한 관리 방안을 모색한다. 이를 위하여 특정 대학에 입학한 학생들을 대상으로 성별, 출신고, 출신지역, 성적, 졸업여부 등의 데이타를 분석하여, 학생들이 입학에서 졸업에 이르기까지 지속적으로 유지될 수 있는 학생 유지율을 관리하기 위한 기본적인 방향이 어떤 것인지 알아본다. 또한, 최적의 입력 변수를 파악하고, 최적의 입력 파라메터를 기초로 apriori 알고리즘을 이용하여 연관 분석을 실행하여 유지율 관리에 가장 적합한 자료를 수집할 수 있도록 한다. 이를 바탕으로 각 대학들이 학생들을 모집하고 유지하는데 도움이 되도록 가장 효율이 높은 딥러닝(Deep Learning) 모듈을 개발하기 위한 기초 자료로 만들고자 한다. 의사결정트리를 활용하여 졸업여부를 측정한 결과는 딥러닝의 정확도 보다 낮은 75%로 나타났다. 의사결정트리에서 졸업여부를 결정하는 요인은 일반고를 졸업하고, 도시지역에 거주하면서 여성이면서 성적이 높은 학생들이 졸업확율이 높은 것으로 나타났으며 결과적으로 의사결정트리 보다는 개발된 딥러닝듈이 더 효율적으로 학생들의 졸업여부를 평가할 수 있는 모델로 나타났다.

• 한국건축시공학회:학술대회논문집
• /
• 한국건축시공학회 2021년도 봄 학술논문 발표대회
• /
• pp.259-260
• /
• 2021

Currently, the school-age population continues to decline in Korea due to social factors. On the other hand, the dormitory facilities are constantly being built and renovated. There are many problems such as construction period and on-site waste when constructed with reinforced concrete structures, which are existing construction methods. Accordingly, dormitory facilities shall be constructed using appropriate construction methods. Therefore, in this study, we will collect and organize basic data on the use status and modular system of dormitory facilities and study efficient maintenance and management when modular construction method is applied to dormitory facilities with changing demand.

• 보건행정학회지
• /
• 제31권1호
• /
• pp.100-113
• /
• 2021

Background: This study aims to figure out the gaps in health status by estimating amenable mortality rate by region, reflecting the characteristics of Korea, and estimating the years of life lost (YLL) per capita by disease. Methods: People who died from amenable diseases between 2008 and 2018 were extracted from the cause of death statistics provided by Statistics Korea. The age-standardized amenable mortality rates were estimated to compare the health status of 229 regions. YLL per capita was calculated to compute the burden of diseases caused by treatable deaths by region. The YLL per capita by region was calculated to identify the burden of disease caused by amenable deaths. Results: First, while the annual amenable mortality rate in Korea is on a steady decline, but there is still a considerable gap between urban and rural areas when comparing the mortality rates of 229 areas. Second, YLL per capita due to the amenable deaths is approximately 14 person-years during the analysis period (2008-2018). Conclusion: Although the health status of Koreans has continuously improved, there is still a gap in health status region by region in terms of amenable mortality rates. Amenable death accounts for a loss of life equivalent to 14 person-years per year. Since the amenable mortality rate is an indicator that can measure the performance of the health care system, efforts at each local area are required to lower it.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권10호
• /
• pp.5003-5006
• /
• 2012

Objective: Yanting County is a high risk area for esophageal cancer (EC) in China. The purpose of this study was to describe the mortality and mortality change of EC from 2004 to 2009 in Yanting County. Methods: EC mortality data from 2004 to 2009 obtained from the Cancer Registry in Yanting were analyzed. Annual percentage changes (APC) were calculated to assess the trends in EC mortality. Age-standardized mortality was calculated based on world standard population of 2000. Results: The average EC mortality was 54.7/$10^5$ in males and 31.6/$10^5$ in females over the 6 years. A decline in EC mortality with time was observed in both genders, with a rate of -8.70% per year (95% CI: -13.23%~-3.93%) in females and -4.11% per year (95%CI: -11.16%~3.50%) in males. Conclusion: EC mortality decreased over the six years in both genders, although it remained high in the Yanting area. There is still a need to carry out studies of risk factors for improved cancer prevention and further reduction in the disease burden.

• 한국발생생물학회지:발생과생식
• /
• 제21권4호
• /
• pp.417-424
• /
• 2017

Alzheimer's disease (AD) is neurodegenerative disease, characterized by the progressive decline of memory, cognitive functions, and changes in personality. The major pathological features in postmortem brains are neurofibrillary tangles and amyloid beta ($A{\beta}$) deposits. The majority of AD cases are sporadic and age-related. Although AD pathogenesis has not been established, aging and declining mitochondrial function has been associated. Mitochondrial dysfunction has been observed in AD patients' brains and AD mice models, and the mice with a genetic defect in mitochondrial complex I showed enhanced $A{\beta}$ level in vivo. To elucidate the role of mitochondrial complex I in AD, we used SH-SY5Y cells transfected with DNA constructs expressing human amyloid precursor protein (APP) or human Swedish APP mutant (APP-swe). The expression of APP-swe increased the level of $A{\beta}$ protein in comparison with control. When complex I was inhibited by rotenone, the increase of ROS level was remarkably higher in the cells overexpressing APP-swe compared to control. The number of dead cell was significantly increased in APP-swe-expressing cells by complex I inhibition. We suggest that complex I dysfunction accelerate amyloid toxicity and mitochondrial complex I dysfunction in aging may contribute to the pathogenesis of sporadic AD.

• The Journal of Asian Finance, Economics and Business
• /
• 제4권4호
• /
• pp.17-26
• /
• 2017

Many workers today encounter the problem of overemployment which occurs when actual working hours exceed preferred or desired working hours. Overemployed workers desire to work fewer hours although this may entail a concomitant decline in earnings. This research is conducted to examine the likelihood of overemployment among employees in a particular state in Malaysia, that is, Penang. This study uses primary data that was collected in a survey encompassing a total of 525 employees in the state. A logit model is used to analyse the relationship between the likelihood of overemployment and various socio-demographic, household and work-related variables. The factors that are significantly related to overemployment are ethnicity, age, education, number of children in the household, occupation, hours of work and control over work schedule. Based on the findings of this paper, it is suggested that policies such as offering part-time jobs or job-sharing options to older workers, implementing family-friendly policies, adopting decent working time measures and strategies that give workers more control over their work schedule are some possible ways to deal with the issue of overemployment.

• Journal of Information Technology Applications and Management
• /
• 제27권3호
• /
• pp.37-54
• /
• 2020

In response to the recent decline in the school-age population, universities have made attracting foreign students a major policy task for universities. As a result, the number of foreign students increased rapidly in terms of quantity, but in terms of quality, the risk is inevitable. Accordingly, the government presented education and internationalization competency certification system indicators on the basis of which quality control of students was systematized. Based on the above certification system, this study focused on analyzing the multiple factors that are actually given to the academic adaptation (performance) of the 2200 students who entered a certain university. In addition, factors other than the certification system index were discovered to comprehensively track how they affect the academic performance of students studying abroad. The researcher found the multi-reciprocal model analysis showed that the difference between the learner and the moderator was significant, and whether or not they had the Korean proficiency test (TOPIK) was significant. It also said that it could have a direct impact on Chinese University Entrance Exams (高考) are significant. If a model that is very effective in selecting students is established by each university and used as an indicator through this study, it will serve as a basis for efficient selection of students.

• 천문학논총
• /
• 제30권2호
• /
• pp.355-358
• /
• 2015

We have conducted a near-infrared monitoring campaign at the UK InfraRed Telescope (UKIRT), of the Local Group galaxy M33. The main aim was to identify stars in the very final stage of their evolution, and for which the luminosity is more directly related to the birth mass than the more numerous less-evolved giant stars that continue to increase in luminosity. The pulsating giant stars (AGB and red supergiants) are identified and their distributions are used to derive the star formation rate as a function of age. These stars are also important dust factories; we measure their dust production rates from a combination of our data with Spitzer Space Telescope mid-IR photometry. The mass-loss rates are seen to increase with increasing strength of pulsation and with increasing bolometric luminosity. Low-mass stars lose most of their mass through stellar winds, but even super-AGB stars and red superginats lose ~40% of their mass via a dusty stellar wind. We construct a 2-D map of the mass-return rate, showing a radial decline but also local enhancements due to agglomerations of massive stars. By comparing the current star formation rate with total mass input to the ISM, we conclude that the star formation in the central regions of M33 can only be sustained if gas is accreted from further out in the disc or from circum-galactic regions.

• 한국디지털건축인테리어학회논문집
• /
• 제2권1호
• /
• pp.32-38
• /
• 2002

Hanyang woman's college educational facility general planning presents "Long-term and expansive space organization plan" of Hanyang woman's collage to correspond to sudden decline and "Globalization specialization" of "Matriculation competition rate by school age decrease in population" but there is primary purpose. To detailed item, secure "Flexibility of campus space by learning environment change" and studies and examines "Campus ashes construction plan by step by new earth purchase" we wish to propose "Long-term and systematic synthesis master plan" and "Newly-appointed official and present official new construction plan".