• Archives of Pharmacal Research
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• 제26권3호
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• pp.197-201
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• 2003

Novel $\beta$-hydroxy propenamides as analogues of the active metabolite of leflunomide (A 771726) were synthesized and evaluated for their inhibitory activity on dihydroorotate dehydrogenase (DHODH) in an investigation into their immunosuppressive activity. Compounds 2a, 3a, and 3h were approximately 4-40 times more potent than leflunomide in their activity while they were-less active than A 771726.

• Archives of Pharmacal Research
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• 제17권5호
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• pp.323-326
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• 1994

Three new sesquiterpene lactone glucosides named dentatins A, B and C were isolated from lxeris dentata and the structures were elucidated as $3{\betha}, {\;}8{\betha}-dihydroxy-(1{\alpha}, 5{\alpha})guainan-10(14)-ene-6{\alpha}, {;\}12-olide-3-O-{\betha}-D-giucopyuranoside{\;}(1), {\;}3{\betha}, {\;}8{\betha}-dihydroxy-(1{\alpha}, {\;}5{\alpha})-guaian-4(15), {\;}10(14)-diene-6{\alpha}, {\;}12-plide-3-O-{\betha}-D-glucopyranoside{\;}(3)$, respectively, on the basis of spectral evidence.

• Archives of Pharmacal Research
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• 제24권5호
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• pp.385-389
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• 2001

Twelve 4-substituted cyclopenta[c]quinoline derivatives were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The compounds 6c and 6e bearing p-anisidine and pyrrolidine side chain were more active than the others.

• Archives of Pharmacal Research
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• 제26권11호
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• pp.887-891
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• 2003

Novel trans-2,2-dimethylcyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate, 3, was synthesized via five steps from ethyl chrysanthemate and condensed with purine bases using the Mitsunobu reaction to give six cyclopropyl nucleosides. These synthesized nucleosides did not show any significant antiviral activity against HSV-1, HSV-2, EMCV, Cox B3, or VSV, at concentrations up to 100 $\mu M$.

• Archives of Pharmacal Research
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• 제13권2호
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• pp.207-210
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• 1990

The position of interglycosidic linkages of two acylated flavonol glucorhamnosides from Ginkgo biloba leaves was unambiguously determined as 1 $\longrightarrow$ 2 linkages rather than 1 $\longrightarrow$ 4 ones on the basis of spectroscopic and chemical evidence.

• Archives of Pharmacal Research
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• 제27권10호
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• pp.1034-1036
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• 2004

Four compounds were isolated from Salicornia herbacea by repeated column chromatography. Their structures were identified as ${\beta}$-sitosterol (1), stigmasterol (2), uracil (3), and isorhamnetin-3-O-${\beta}$-D-glucopyranoside (4) by spectral analysis and comparison with the published data.

• Archives of Pharmacal Research
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• 제3권2호
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• pp.75-78
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• 1980

Potential antinumor activity of sixteen Korean medicinal plants was tested against leukemia SN 36, murine tomor model. Survival studies by measuring life span indicated that Morus alba (Moraceae), Verbascum phlomoides (Scrophulariaceae), Curcuma longa (Zingbieraceae), Torilis japonica (Umbelliferae), Bupleurum falcatum (Umbelliferae) and Codonopsis pilosula (Campanulaceae) exhibited significant antitumor activity with the dose-schedule employed in the experiment. Methanol (70%) extracts of Platycodon gradiflorum (Campanulaceae), Bupleurum longeradiatum (Umbelliferae) and Asiasarum sieboldii (Aristolochiaceae) showed rather potent toxicity.

• Archives of Pharmacal Research
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• 제16권4호
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• pp.265-270
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• 1993

6, 10, 14, 18-Tetramethyl-5, 9, 131, 17(E, E, E)-nonadecatetraen-2-one was synthesized from geraniol or 6-methyl-5(E)-hepten-2-one in 6 steps, repectively. The key step in both syntheses, was the condensation of phenyl sulfone compound and allylic chloride.

• 펄프종이기술
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• 제45권2호
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• pp.1-12
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• 2013

The annals of Joseon Dynasty designated as a national treasure No. 151 and a UNESCO World Memory are among the greatest archives that should be preserved permanently and inherited to future generations through the proven scientific conservation method. The annals of Joseon Dynasty in the custody of the National Archives of Korea as the sole original archive, has been restricted from the direct physical and chemical approaches. In this study, it is to develop a systematic conservation management scheme, based on the conservation state of the annals. Four books from the annals were selected out of 848 books and their moisture contents and optical property profiles were measured through the books. All the defects previously and newly found were pictured in 10~100 magnifications. The wire marks left on the Hanji's of the annals were analyzed. It was found that water damages and paper molds were prevalent in all four annals selected, and it was recommended to conduct more research for the conservation of those damaged areas. It turned out that various qualities of Hanji's were used for the time of publishing the annals because moisture content, optical properties, and wire mark intervals were quite different between papers even within one book.

• 정보관리연구
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• 제41권1호
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• pp.173-200
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• 2010

정부 주도하에 정책적으로 이루어지는 국책 건설사업은 국가의 사회간접자본시설에 주로 집중되며 상당한 국가예산이 투입되고 관련 분야의 전문적 역량이 총체적으로 투입되는 장기적 사업이다. 일반적으로 사회기반시설은 반영구 혹은 영구적 국가 자산으로 유지하게 되며 그에 따른 기록물 또한 해당 시설물의 수명기간 동안 보존 활용되어야 한다. 또한 국책사업 특성상 다양한 이해관계자 간의 유기적 협의체계를 지원하고 오랜 기간 동안 일관된 문서 및 기록관리체계를 유지하기 위해서는 기관별 특성을 최대한 배제한 사업 역무 위주의 표준화된 분류체계의 수립이 필요하다. 따라서 국책사업 기록물의 분류체계는 사업 자체 업무 분석을 근거로 사업 업무분류체계(WBS : Work Breakdown Structure)를 기반으로 수립되어야 한다. WBS는 프로젝트 관리(PM) 분야에서 통상적인 사업관리 기법으로 업무구분을 위해 사업초기에 수립되며, 프로젝트 목표를 달성하고 필요한 인도물을 산출하기 위하여 프로젝트 팀이 실행할 작업을 인도물 중심으로 분할한 계층 구조체계이다. 따라서 본 연구는 WBS에 기반한 국책사업 기록물 분류체계 수립에 대한 구체적인 사례와 방안을 제시함으로써 현 관리, 행정기록물 중심의 기록물 분류 체계에 대한 새로운 시각을 제시하는 데 목적이 있다.