• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4397-4402
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• 2011

The NF-${\kappa}B$ system of transcription factors plays a crucial role in inflammatory diseases, making it an important drug target. We combined quantitative structure activity relationships for predicting the activity of new compounds and quantitative dynamic models for the NF-${\kappa}B$ network with intracellular concentration models. GFA-MLR QSAR analysis was employed to determine the optimal QSAR equation. To validate the predictability of the $IKK{\beta}$ QSAR model for an external set of inhibitors, a set of ordinary differential equations and mass action kinetics were used for modeling the NF-${\kappa}B$ dynamic system. The reaction parameters were obtained from previously reported research. In the IKKb QSAR model, good cross-validated $q^2$ (0.782) and conventional $r^2$ (0.808) values demonstrated the correlation between the descriptors and each of their activities and reliably predicted the $IKK{\beta}$ activities. Using a developed simulation model of the NF-${\kappa}B$ signaling pathway, we demonstrated differences in $I{\kappa}B$ mRNA expression between normal and different inhibitory states. When the inhibition efficiency increased, inhibitor 1 (PS-1145) led to long-term oscillations. The combined computational modeling and NF-${\kappa}B$ dynamic simulations can be used to understand the inhibition mechanisms and thereby result in the design of mechanism-based inhibitors.

• Journal of the Korean Institute of Intelligent Systems
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• v.16 no.6
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• pp.759-765
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• 2006

In this paper, it is proposed an effective face expression recognition LDA mixed mode using a triangularity membership fuzzy function and wavelet basis. The proposal algorithm gets performs the optimal image, fuzzy wavelet algorithm and Expression recognition is consisted of face characteristic detection step and face Expression recognition step. This paper could applied to the PCA and LDA in using some simple strategies and also compares and analyzes the performance of the LDA mixed model which is combined and the facial expression recognition based on PCA and LDA. The LDA mixed model is represented by the PCA and the LDA approaches. And then we calculate the distance of vectors dPCA, dLDA from all fates in the database. Last, the two vectors are combined according to a given combination rule and the final decision is made by NNPC. In a result, we could showed the superior the LDA mixed model can be than the conventional algorithm.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.11 no.1
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• pp.19-27
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• 1993

For the design of a large-scale landfill, the future utilization plan of the landfill ought to precede based on the analysis of existing facility. Analysis for the present condition of reclamation must include accurate assesment of volume and other consideration such as urban scenery. In this study an optimum data interpolation scheme area/volume determination method based on the classification of topography were combined for the correct assessment of sweeping volume. Combined model was compared with the real data of Digital Elevation Model constructed by aero photography. The new model aims at providing basic information for the design and utilization of a new landfill. A a result of this study, we made an algorithm to perform the classification of the topography in the area of interest objectively. In addition, we decided optimal data interpolation scheme and area/volume calculation method for given topography. Finally, we applied the developed methodology to Nangido Landfill to assess current landfill situation and potential capacity when landfilling is resumed.

• Health Policy and Management
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• v.24 no.1
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• pp.35-46
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• 2014

Background: This paper describes the relationship and effect of health examination on personal medical cost by identifying the difference of the cost for medical care in physician visit between the population without and with health examination. Methods: After classifying into three cohorts in which, independent variables were designed according to the Andersen's behavioral model, the association of personal medical cost for medical care and prescription drugs which is dependent variable was analyzed by t-test and Mann-Whitney test for description and gamma regression model for inference. Results: In personal average medical cost, the population with health examination paid significantly more than without health examination, 11.6% more in cohort 2008, 26.6% more in cohort 2009, and 48.0% more in combined cohort. The odds ratio on medical expenditure of outpatients with health examination was 1.067, 1.126, 1.398 significantly in cohort 2008, 2009, and combined cohort respectively, comparing to the group without health examination. In independent variables, that is female, the elderly, never married, non-working, non-metropolitan, the higher family income, the smaller family size, people with disability, the people with chronic disease, and people with health examination have significantly being paid more tendency showing positive association with medical cost. Conclusion: This result showed that medical expenditure in physician visit has been increased after taking a health examination. Therefore reasonable limitation of getting preventive medical service is suggested to avoid medical shopping around and reduce being repeated health examination by unifying control to find out easily the clinical results from various medical facilities.

• Journal of the Korean Society of Propulsion Engineers
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• v.20 no.6
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• pp.83-90
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• 2016

Ramjet mode combustion test was performed for a dual-mode ramjet engine model. The engine model consists of an air intake, a combustor and a nozzle. The combustor in the model has a large backward-facing step, designed to be used as a part of a rocket-based combined cycle engine. The test was performed at the flight speed of Mach 5 and the altitude of 24 km. Strong combustion was established only when the fuel was injected from both of the bottom-side and cowl-side wall. When the total fuel stoichiometric ratio was 1.0, distributed as 0.5 on the cowl side and 0.5 on the bottom side, the flow became subsonic at some portion in the combustor by thermal choking, i.e., ramjet mode was established for this condition.

• Journal of The Geomorphological Association of Korea
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• v.26 no.2
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• pp.1-14
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• 2019

This study analyzed the relativity between block stream and talus distributions by employing a likelihood ratio approach. Possible distribution sites for each debris slope landform were extracted by applying a spatial integration model, in which we combined fuzzy set model, Bayesian predictive model, and logistic regression model. Moreover, to verify model performance, a success rate curve was prepared by cross-validation. The results showed that elevation, slope, curvature, topographic wetness index, geology, soil drainage, and soil depth were closely related to the debris slope landform sites. In addition, all spatial integration models displayed an accuracy of over 90%. The accuracy of the distribution potential area map of the block stream was highest in the logistic regression model (93.79%). Eventually, the accuracy of the distribution potential area map of the talus was also highest in the logistic regression model (97.02%). We expect that the present results will provide essential data and propose methodologies to improve the performance of efficient and systematic micro-landform studies. Moreover, our research will potentially help to enhance field research and topographic resource management.

• Journal of the Korea Safety Management & Science
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• v.9 no.2
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• pp.49-57
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• 2007

This Study is to suggest a method of effect evaluation of forest fire on governor station in shrub land. Theoretically, to evaluate effects of forest fire, it is combined that Spread Rate of Forest Fire, Flame Model, and Thermal Radiation Effects Model; i.e. a travel time of forest fire is calculated by Spread Rate of Forest Fire, fire-line intensity is calculated by Flame Model, and effects of fire-line intensity is affected by Thermal Radiation Effects Model. With the aforementioned method, we could carry out the effect evaluation of forest fire on governor station in shrub land and could distinguish scenarios to need protection plan from all scenarios.

• Journal of Korean Society on Water Environment
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• v.22 no.6
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• pp.1068-1074
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• 2006

For receiving water quality protection a control systems of urban drainage for CSOs reduction is needed. Examples in combined sewer systems include downstream storage facilities that detain runoff during periods of high flow and allow the detained water to be conveyed by an interceptor sewer to a centralized treatment plant during periods of low flow. The design of such facilities as storm-water detention storage is highly dependant on the temporal variability of storage capacity available as well as the infiltration capacity of soil and recovery of depression storage. For the continuous long-term analysis of urban drainage system this study used analytical probabilistic model based on derived probability distribution theory. As an alternative to the modeling of urban drainage system for planning or screening level analysis of runoff control alternatives, this model has evolved that offers much ease and flexibility in terms of computation while considering long-term meteorology. This study presented rainfall and runoff characteristics of the subject area using analytical probabilistic model. Runoff characteristics manifested the unique characteristics of the subject area with the infiltration capacity of soil and recovery of depression storage and was examined appropriately by sensitivity analysis. This study presented the average annual CSOs, number of CSOs and event mean CSOs for the decision of storage volume.

• International Journal of Control, Automation, and Systems
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• v.6 no.5
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• pp.639-650
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• 2008

Electricity price forecasting has become an integral part of power system operation and control. In this paper, a wavelet transform (WT) based neural network (NN) model to forecast price profile in a deregulated electricity market has been presented. The historical price data has been decomposed into wavelet domain constitutive sub series using WT and then combined with the other time domain variables to form the set of input variables for the proposed forecasting model. The behavior of the wavelet domain constitutive series has been studied based on statistical analysis. It has been observed that forecasting accuracy can be improved by the use of WT in a forecasting model. Multi-scale analysis from one to seven levels of decomposition has been performed and the empirical evidence suggests that accuracy improvement is highest at third level of decomposition. Forecasting performance of the proposed model has been compared with (i) a heuristic technique, (ii) a simulation model used by Ontario's Independent Electricity System Operator (IESO), (iii) a Multiple Linear Regression (MLR) model, (iv) NN model, (v) Auto Regressive Integrated Moving Average (ARIMA) model, (vi) Dynamic Regression (DR) model, and (vii) Transfer Function (TF) model. Forecasting results show that the performance of the proposed WT based NN model is satisfactory and it can be used by the participants to respond properly as it predicts price before closing of window for submission of initial bids.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.12
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• pp.5905-5926
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• 2017

Sentiments can profoundly affect individual behavior as well as decision-making. Confronted with the ever-increasing amount of review information available online, it is desirable to provide an effective sentiment model to both detect and organize the available information to improve understanding, and to present the information in a more constructive way for consumers. This study developed a unified phrase-based topic and sentiment detection model, combined with a tracking model using incremental hierarchical dirichlet allocation (PTSM_IHDP). This model was proposed to discover the evolutionary trend of topic-based sentiments from online reviews. PTSM_IHDP model firstly assumed that each review document has been composed by a series of independent phrases, which can be represented as both topic information and sentiment information. PTSM_IHDP model secondly depended on an improved time-dependency non-parametric Bayesian model, integrating incremental hierarchical dirichlet allocation, to estimate the optimal number of topics by incrementally building an up-to-date model. To evaluate the effectiveness of our model, we tested our model on a collected dataset, and compared the result with the predictions of traditional models. The results demonstrate the effectiveness and advantages of our model compared to several state-of-the-art methods.