• Title/Summary/Keyword: The Combined Model

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An Experimental Study on the Quality of Concrete with Municipal Solid Waste Incineration Ash (쓰레기 소각재 사용 콘크리트의 품질특성에 대한 실험적 연구)

  • Kim, Jae-Woo;Choi, Jae-Jin;Moon, Dae-Joong
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.2 no.4
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    • pp.335-344
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    • 2014
  • The Quality of municipal solid waste incineration ash (incineration ash) was analyzed for the purpose of the reusing for concrete material. The folwability and strength properties of concrete mixed with incinerator ash were investigated. CaO component was included more than 50% in chemical component of incinerator ash, mean size of 50% accumulated particle distribution of incinerator ash was about $25{\mu}m$. Particle shape of incinerator ash ($IA_1$) was massed the round shape with fine particle, particle shape of incinerator ash ($IA_2$) was piled up the sheet shape according to manufacture procedure. The Quality of concrete was effected by use of incinerator ash. When the incinerator Ash ($IA_2$) was used, slum of concrete was increased and dosage of high range water reducing agent was reduced. However, strength development of concrete was decreased. Dosage of high range water reducing agent was increased by combined use of incinerator ash ($IA_2$) and diatomite powder, but strength development of concrete was improved. Ratio of compressive strength and tensile strength was in the range 85%~105% of CEB-FIP model code.

The effect of retinoic acid on radiosensitivity analyzed by linear-quadratic model and apoptosis in head and neck squamous carcinoma cell lines (두경부 편평세포암종세포주에서 retinoic acid가 linear-quadratic 모델을 적용한 방사선감수성과 apoptosis 유발에 미치는 영향)

  • Lee Eun-Sook;Kang Bum-Hyun;Heo Min-Suk;Lee Sam-Sun;Choi Hyun-Bae;Choi Soon-Chul;Park Tae-Won
    • Imaging Science in Dentistry
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    • v.31 no.3
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    • pp.135-143
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    • 2001
  • Purpose : To evaluate the effect of all-trans-retinoic acid on radiosensitivity and radiation-induced apoptosis in NHOK, HEp-2 and FaDu cell lines. Material and Methods: We measured the changes in survival fraction at 2 Gy (SF2), α and β after treatment of retinoic acid (1μM) prior to irradiation with doses of 2, 4, 6 and 10 Gy and correlated the radiosensitizing effect of retinoic acid with them. Also, apoptosis induction was assayed with the flow cytometry on days 1,2, 3, 4 and 5 after irradiation (2, 10 and 20 Gy) combined with retinoic acid. Results and Conclusion: SF2 values for NHOK, HEp-2 and FaDu cell lines were 0.54, 0.64 and 0.41, respectively and the cell line of FaDu was the most radiosensitive. For cell lines of NHOK and HEp-2, pretreatment of cells with retinoic acid resulted in a significant decrease of the SF2 values. The α/β ratios of x-ray survival curve were 8.714 (NHOK), 4.098 (HEp-2) and 11.79 (FaDu). The α/β ratio for NHOK decreased on pretreatment with retinoic acid, whereas those for HEp-2 and FaDu increased. Radiation induced apoptosis in all cell lines but, retinoic acid did not affect the apoptosis.

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Curcumin-loaded PLGA Nanoparticles Conjugated with Anti-P-glycoprotein Antibody to Overcome Multidrug Resistance

  • Punfa, Wanisa;Suzuki, Shugo;Pitchakarn, Pornsiri;Yodkeeree, Supachai;Naiki, Taku;Takahashi, Satoru;Limtrakul, Pornngarm
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.21
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    • pp.9249-9258
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    • 2014
  • Background: The encapsulation of curcumin (Cur) in polylactic-co-glycolic acid (PLGA) nanoparticles (Cur-NPs) was designed to improve its solubility and stability. Conjugation of the Cur-NPs with anti-P-glycoprotein (P-gp) antibody (Cur-NPs-APgp) may increase their targeting to P-gp, which is highly expressed in multidrugresistance (MDR) cancer cells. This study determined whether Cur-NPs-APgp could overcome MDR in a human cervical cancer model (KB-V1 cells) in vitro and in vivo. Materials and Methods: First, we determined the MDR-reversing property of Cur in P-gp-overexpressing KB-V1 cells in vitro and in vivo. Cur-NPs and Cur-NPs-APgp, in the range 150-180 nm, were constructed and subjected to an in vivo pharmacokinetic study compared with Cur. The in vitro and in vivo MDR-reversing properties of Cur-NPs and Cur-NPs-APgp were then investigated. Moreover, the stability of the NPs was determined in various solutions. Results: The combined treatment of paclitaxel (PTX) with Cur dramatically decreased cell viability and tumor growth compared to PTX treatment alone. After intravenous injection, Cur-NPs-APgp and Cur-NPs could be detected in the serum up to 60 and 120 min later, respectively, whereas Cur was not detected after 30 min. Pretreatment with Cur-NPs-APgp, but not with NPs or Cur-NPs, could enhance PTX sensitivity both in vitro and in vivo. The constructed NPs remained a consistent size, proving their stability in various solutions. Conclusions: Our functional Cur-NPs-APgp may be a suitable candidate for application in a drug delivery system for overcoming drug resistance. The further development of Cur-NPs-APgp may be beneficial to cancer patients by leading to its use as either as a MDR modulator or as an anticancer drug.

Analyzing Effects on Improving Infrastructures for the Development of Maritime Tourism Combined Fishing Ports - Focusing on ports in Gijang, Busan - (해양관광 복합형어항 개발에 따른 인프라정비의 파급효과 분석 - 부산시 기장지역 어항을 중심으로-)

  • Kim, Gyeong-Su
    • Journal of the Korean Association of Geographic Information Studies
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    • v.10 no.1
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    • pp.146-157
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    • 2007
  • Fishing villages have rich potential on account of serving as a base of fishing activities with various maritime ecosystem, culture and maritime resources as well. The object of the study is ports located in Gijang, Busan and it presents the overall development direction in ports within this area. Through systematic and well-planned developing small-sized ports, this research analyzes regional economic implications by improving settlement conditions for fishing villagers scattered around this area taking the ports' natural traits into consideration. The research correlates regional input output analysis by fishing port arrangement project with connection between inter-industries and inter-regions according to the model of input-output analysis and attempts to systematically analyze regional economic structure with the economic implication divided into production, employment and income, influenced upon by the change of political exogenous variable.

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A Study of the Causal Relationship between Organizational Trust and Error Management Culture across Social Service Agencies (조직신뢰와 오류관리문화와의 관계에 대한 연구 - 사회복지이용시설을 중심으로 -)

  • Lee, Sangchul
    • Korean Journal of Social Welfare
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    • v.67 no.3
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    • pp.83-105
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    • 2015
  • This study has two objectives. First, it examines the relationship between organizational trust and error management culture. Second, it also examines the effect of social workers' perceived work value on the combined model by considering the unique characteristics of social work profession and social desirability. This study employs the stratified sampling method on social workers with more than two year work experiences in their current social service agencies that are located in Seoul and Kyungki province; finally it analyzes the responses from 564 social workers by using the method of multiple regression modeling. This study has the following results: (1) there is a causal relationship between social desirability and organizational trust perceived by social workers; (2) there is a positive causal relationship between social workers' perceived work value and organizational trust; and (3) there is also a positive causal relationship between factor structure of error management culture and organizational trust. This study discusses the theoretical and practical implications of the results.

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Development of Robot Performance Platform Interoperating with an Industrial Robot Arm and a Humanoid Robot Actor (산업용 로봇 Arm과 휴머노이드 로봇 액터를 연동한 로봇 공연 플랫폼 개발)

  • Cho, Jayang;Kim, Jinyoung;Lee, Sulhee;Lee, Sang-won;Kim, Hyungtae
    • Journal of Broadcast Engineering
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    • v.25 no.4
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    • pp.487-496
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    • 2020
  • For the purpose of next generation technology for robot perfomances, a RAoRA (Robot Actor on Robot Arm) structure was proposed using a robot arm joined with a humanoid robot actor. Mechanical analysis, machine design and fabrication were performed for motions combined with the robot arm and the humanoid robot actor. Kinematical analysis for 3D model, spline interpolation of positions, motion control algorithm and control devices were developed for movements of the robot actor. Preliminary visualization, simulation tools and integrated operation of consoles were constructed for the non-professionals to produce intuitive and safe contents. Air walk was applied to test the developed platform. The air walk is a natural walk close to a floor or slow ascension to the air. The RAoRA also executed a performance with 5 minute-running time. Finally, the proposed platform of robot performance presented intensive and live motions which was impossible in conventional robot performances.

Synergistic Effect of Notopterygium incisum and Saposhnikovia divaricata in the Anti-inflammatory Activity (강활과 방풍의 항염증 상승작용에 관한 연구)

  • Lee, Do-Yeon;Choi, Go-Ya;Yoon, Tae-Sook;Cheon, Myeong-Sook;Kim, Seung-Ju;Yasukawa, Ken;Yu, So-Yeon;Kim, Ho-Kyoung
    • The Korea Journal of Herbology
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    • v.23 no.4
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    • pp.39-44
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    • 2008
  • Objectives: Notopterygium incisum(N. incisum) and Saposhnikovia divaricata(S. divaricata) have been clinically used in traditional oriental medicine for treatment of inflammatory diseases. Also, a herbal mixture prepared with N. incisum and S. divaricata has been strongly linked to the anti-inflammatory effect. In this study, we evaluate the synergistic anti-inflammatory effect of N. incisum and S. divaricata. Methods: For evaluating the anti-inflammatory activity of a herbal mixture of N. incisum and S. divaricata in vivo, we measured the changed ear thickness in 12-O-tetradecanoyl-phorbol-13-acetate(TPA)-induced mouse ear edema model after topical application of herbal mixture. In addition, the levels of markers for inflammation, such as tumore necrosis factor (TNF)-${\alpha}$, interleukin (IL)-1${\beta}$, and nitric oxide(NO), were determined by ELISA assay in lipopolysaccharide-stimulated Raw 264.7 cells. Results: We reported that water extracts of N. incisum and S. divaricata combination significantly inhibited the mouse ear edema induced by TPA. Moreover, the water extracts of N. incisum and S. divaricata combination exhibited synergistic effects in down-regulating IL-1${\beta}$ level, but not TNF-${\alpha}$ and NO. Conclusions: These results suggest that combined treatment of N. incisum and S. divaricata, based on seven methods in prescription compatibility, has a synergistic effect in down-regulating inflammatory response both in vivo and in vitro models. Especially, it seems that IL-1${\beta}$ is a one of main target of the mixture of N. incisum and S. divaricata on anti-inflammatory activity.

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Analysis of the Effect of Temperature on the Pesticide Efficacy and Simulation of the Change in the Amount of Pesticide Use (온도가 농약효과에 미치는 영향분석 및 농약사용량 예측 모의실험)

  • Mo, Hyoung-ho;Kang, Ju Wan;Cho, Kijong;Bae, Yeon Jae;Lee, Mi-Gyung;Park, Jung-Joon
    • Korean Journal of Environmental Biology
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    • v.34 no.1
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    • pp.56-62
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    • 2016
  • Pest population density models are very important to monitor the initial occurrence and to understand the continuous fluctuation pattern of pest in pest management. This is one of the major issues in agriculture because these predictions make pesticides more effective and environmental impact of pesticides less. In this study, we combined and predicted the mortality change of pest caused by pesticides with temperature change and population dynamic model. Sensitive strain of two-spotted spider mite (Tetranychus urticae Koch) with kidney bean leaf as host was exposed to mixed acaricide, Acrinathrin-Spiromesifen and organotin acaricide, Azocyclotin, at 20, 25, 30, and $35^{\circ}C$, respectively. There was significant difference in mortality of T. urticae among pesticides and temperatures. We used DYMEX to simulate population density of T. urticae and predicted that the initial management time and number of chemical control would be changed in the future with climate change. There would be implications for strategies for pest management and selection process of pesticide in the future corresponding climate change.

Modeling of Elastodynamic Problems in Finite Solid Media (유한 고체내 탄성동역학 문제의 모델링)

  • Cho, Youn-Ho
    • Journal of the Korean Society for Nondestructive Testing
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    • v.20 no.2
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    • pp.138-149
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    • 2000
  • Various modeling techniques for ultrasonic wave propagation and scattering problems in finite solid media are presented. Elastodynamic boundary value problems in inhomogeneous multi-layered plate-like structures are set up for modal analysis of guided wave propagation and numerically solved to obtain dispersion curves which show propagation characteristics of guided waves. As a powerful modeling tool to overcome such numerical difficulties in wave scattering problems as the geometrical complexity and mode conversion, the Boundary Element Method(BEM) is introduced and is combined with the normal mode expansion technique to develop the hybrid BEM, an efficient technique for modeling multi mode conversion of guided wave scattering problems. Time dependent wave forms are obtained through the inverse Fourier transformation of the numerical solutions in the frequency domain. 3D BEM program development is underway to model more practical ultrasonic wave signals. Some encouraging numerical results have recently been obtained in comparison with the analytical solutions for wave propagation in a bar subjected to time harmonic longitudinal excitation. It is expected that the presented modeling techniques for elastic wave propagation and scattering can be applied to establish quantitative nondestructive evaluation techniques in various ways.

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Determination of Calibration Curve for Total Nitrogen Contents Analysis in Fresh Rice Leaves Using Visible and Near Infrared Spectroscopy (벼 생체엽신 질소함량 측정을 위한 근적외선분광분석의 검량식 작성)

  • Kwon Young-Rip;Baek Mi-Hwa;Choi Dong-Chil;Choi Joung-Sik;Choi Yeong-Geun
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.50 no.6
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    • pp.394-399
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    • 2005
  • Near Infrared Spectroscopy (NIRS) has been used as a tool for the rapid, accurate and nondestructive assay of the fresh rice leaf in nitrogen content. NIRS used in this study was visible and near infrared spectroscopy type instrument, Foss model 6500. To obtain a useful calibration equation, standard regression between the data was analyzed by chemical analysis and by NIRS method. Accuracy of calibration equation for nitrogen content on fresh leaf of rice were 0.879, 0.858 and 0.819, respectively. Accuracy of calibration equation after outlier treatment increased as 0.017, 0.02 and 0.061 improved each with 0.896, 0.878 and 0.880, respectively. Calibration equation combined using merge function after accuracy of calibration equation more increased by 0.911. Difference analysis value between calibration equation and lab value by kjeldahl showed $0.001\%$. With this as same result is the possibility of closing the deterioration of the sample in order to omit a construction and pulverization process it is judged with the fact that the nitrogen content measurement of the fresh rice leaf which the possibility of reducing an hour and an expense is by a near infrared spectroscopy technique will be possible.