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Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety

  • Najib, Fateme Sadat;Poordast, Tahereh;Mahmudi, Monireh Sufi;Shiravani, Zahra;Namazi, Niloofar;Omrani, Gholamhossein Ranjbar
    • Journal of Pharmacopuncture
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    • v.25 no.2
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    • pp.106-113
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    • 2022
  • Objectives: Herbal medicine is a worldwide health topic. Vitex agnus-castus L. (VAC) is a popular plant used for gynecologic problems due to its hormonal effects. The aim of this study is to reveal VAC extract effect on fetus when this herb is used started from antenatal period or during pregnancy. Methods: Performed from starting day of January 2019 till February 2019, 48 rats were assigned in randomly divided eight-member six groups: control (C1), treated group with 365 mg/kg VAC from initiation of insemination (T1) and 30 days prior to pregnancy (T2), control that underwent caesarean section on 15th day of gestational age (C2) and treated group with 365 mg/kg VAC from initiation of insemination (T3) and 30 days prior to pregnancy (T4) that underwent caesarean section. Weight, sex and number of fetuses, abortion and still birth rate and estradiol level were evaluated using t-test by SPSS software. Results: We showed increased weight among T1 group considering totally and sex-dependent which is significant (all p-value < 0.05). We also detected significantly decreased weight in T2 in total (p-value < 0.0001) and when considering female fetuses (0.043) but not males (0.17). Although the results showed slightly non-significant increased weight among fetuses of T3 (totally or based on the fetus sex) compared to the control group (C2), T4 group had statistically decreased weight compared to control group. Pregnancy rate and pregnancy outcome were affected by VAC usage. The time of VAC initiation also affected live birth and abortion rates. Conclusion: VAC extract may affect pregnancy rate, live birth rate, abortion and stillbirth rates. Its effect on the weight and the sex showed dual pattern depends on the time of initiation and pregnancy trimester of evaluation. Prescribing this medicinal plant for patients being prone to pregnancy should be with caution. Further study is recommended.

A study on the effect of corporate working environment on job enthusiasm (기업의 근로 환경이 직무 열의에 미치는 영향 분석 연구)

  • Ryu, Sung-Yong;Lim, Sang-Ho
    • Industry Promotion Research
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    • v.7 no.4
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    • pp.17-23
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    • 2022
  • This study is a study to analyze the effect of corporate working environment on job enthusiasm. Based on the 6th work environment survey conducted between 2020 and 2021 among data from the National Statistical Office, some 440 data were used for analysis. The analysis results are summarized as follows. First, the job satisfaction that the working environment had on job enthusiasm had a statistically significant effect with a β value of .307. Second, it was analyzed that there was a statistically significant difference in job enthusiasm according to general characteristics in employment type and income level. The significance probabilities were .028 and .012, respectively, and there was a significant difference between the groups of temporary workers and daily workers in employment type. was analyzed to exist. Third, there was no significant relationship between gender and work environment satisfaction. However, in Satisfied, 148 men and 181 women, out of a total of 329 respondents, 45% male and 55% female in satisfaction. could know a little more. This study is considered to be necessary to provide opportunities and resources so that members of the organization can demonstrate their abilities by creating a working environment that workers can be satisfied with.

A Study on the Social Exclusion Types of Middle-aged Single-person Households (중년1인가구의 사회적 배제 잠재집단 유형과 영향요인)

  • Chang, On Jeong
    • Journal of Family Resource Management and Policy Review
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    • v.26 no.3
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    • pp.1-17
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    • 2022
  • This study focused on the heterogeneity of groups in single-person households, to identify how middle-aged single-person households is categorized by sub-groups and to come up with policy measures to overcome social exclusion by examining predictive factors for the type of social exclusion. Potential class analysis and multinomial logistic regression analysis were conducted on a total of 361 middle-aged single-person households using the 14th Korea Replication Panel data. The social exclusion index of these households was measured consisting of 10 six-dimensional indicators. The results showed that middle-aged single-person households had five different types: "non-exclusion"(29.6%), "health restriction"(14.3%), "interact restriction and middle-risk multiple-exclusion" (12.0%), "income and health exclusion"(14.1%), and "high-risk multiple-exclusion"(30.0%). More than 70% of the respondents experienced social exclusion, and most of the exclusion types were multiple exclusion. When examining the factors affecting each exclusion type, the 'subjective health level' was a common major predictor, and family interact, age and leisure activity satisfaction variables were significant predictors of the 'high-risk multiple exclusion type' and 'the interact restriction and middle-risk multiple-exclusion type'. Based on these results, a multidimensional intervention strategy is an effective measure to solve the social exclusion problem of middle-aged single-person households, and practical measures should be considered by strengthening 'health' and exchanges.

A Study on Next-Generation Data Protection Based on Non File System for Spreading Smart Factory (스마트팩토리 확산을 위한 비파일시스템(None File System) 기반의 차세대 데이터보호에 관한 연구)

  • Kim, Seungyong;Hwang, Incheol;Kim, Dongsik
    • Journal of the Society of Disaster Information
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    • v.17 no.1
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    • pp.176-183
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    • 2021
  • Purpose: The introduction of smart factories that reflect the 4th industrial revolution technologies such as AI, IoT, and VR, has been actively promoted in Korea. However, in order to solve various problems arising from existing file-based operating systems, this research will focus on identifying and verifying non-file system-based data protection technology. Method: The research will measure security storage that cannot be identified or controlled by the operating system. How to activate secure storage based on the input of digital key values. Establish a control unit that provides input and output information based on BIOS activation. Observe non-file-type structure so that mapping behavior using second meta-data can be performed according to the activation of the secure storage. Result: First, the creation of non-file system-based secure storage's data input/output were found to match the hash function value of the sample data with the hash function value of the normal storage and data. Second, the data protection performance experiments in secure storage were compared to the hash function value of the original file with the hash function value of the secure storage after ransomware activity to verify data protection performance against malicious ransomware. Conclusion: Smart factory technology is a nationally promoted technology that is being introduced to the public and this research implemented and experimented on a new concept of data protection technology to protect crucial data within the information system. In order to protect sensitive data, implementation of non-file-type secure storage technology that is non-dependent on file system is highly recommended. This research has proven the security and safety of such technology and verified its purpose.

Effects of Physical Activity in the Elderly with Osteoarthritis on Stress and Health-related Quality of Life (EQ-5D) : Using Data from the 2018 National Health and Nutrition Survey (골관절염 노인의 신체활동이 스트레스 및 건강관련 삶의 질(EQ-5D)에 미치는 영향 : 2018 국민건강영양조사 자료 이용)

  • Paek, Hyun-Hee;Jeong, Min
    • Journal of Korea Entertainment Industry Association
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    • v.14 no.5
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    • pp.267-276
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    • 2020
  • The purpose of this study was to investigate the effects of physical activity in the elderly with osteoarthritis on stress and health-related quality of life (EQ-5D). This study performed data analysis using the SPSS 17.0 program in 104 elderly people with osteoarthritis over 65 years old using raw data from the 7th National Health and Nutrition Survey. The main results of this study are as follows: Males exercised more strength than women, and the better the subjective health status, the higher the rate of walking and aerobic activity. The group that felt stress showed a higher rate of walking and aerobic activity than the group that had no stress, and one group that felt a little stress practiced walking more than 3 days. The exercise ability of the elderly with osteoarthritis was better in the group who practiced walking, strength training, and aerobic activity than in the group without physical activity, and in self-management, the group practicing exercise and aerobic activity had problems with self-management. There was no daily activity, and the group that practiced walking and strength training also showed a high level of daily activity. In the area of pain/discomfort, the group practicing walking showed less pain/discomfort, and in the area of anxiety/depression, the group practicing walking showed less anxiety/depression. In conclusion, it is considered that in order to increase the quality of life of the elderly with osteoarthritis and to manage the stress, active efforts to increase the level of physical activity are necessary.

Projection of Cancer Incidence and Mortality From 2020 to 2035 in the Korean Population Aged 20 Years and Older

  • Youjin, Hong;Sangjun, Lee;Sungji, Moon;Soseul, Sung;Woojin, Lim;Kyungsik, Kim;Seokyung, An;Jeoungbin, Choi;Kwang-Pil, Ko;Inah, Kim;Jung Eun, Lee;Sue K., Park
    • Journal of Preventive Medicine and Public Health
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    • v.55 no.6
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    • pp.529-538
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    • 2022
  • Objectives: This study aimed to identify the current patterns of cancer incidence and estimate the projected cancer incidence and mortality between 2020 and 2035 in Korea. Methods: Data on cancer incidence cases were extracted from the Korean Statistical Information Service from 2000 to 2017, and data on cancer-related deaths were extracted from the National Cancer Center from 2000 to 2018. Cancer cases and deaths were classified according to the International Classification of Diseases, 10th edition. For the current patterns of cancer incidence, age-standardized incidence rates (ASIRs) and age-standardized mortality rates were investigated using the 2000 mid-year estimated population aged over 20 years and older. A joinpoint regression model was used to determine the 2020 to 2035 trends in cancer. Results: Overall, cancer cases were predicted to increase from 265 299 in 2020 to 474 085 in 2035 (growth rate: 1.8%). The greatest increase in the ASIR was projected for prostate cancer among male (7.84 vs. 189.53 per 100 000 people) and breast cancer among female (34.17 vs. 238.45 per 100 000 people) from 2000 to 2035. Overall cancer deaths were projected to increase from 81 717 in 2020 to 95 845 in 2035 (average annual growth rate: 1.2%). Although most cancer mortality rates were projected to decrease, those of breast, pancreatic, and ovarian cancer among female were projected to increase until 2035. Conclusions: These up-to-date projections of cancer incidence and mortality in the Korean population may be a significant resource for implementing cancer-related regulations or developing cancer treatments.

Percentile-Based Analysis of Non-Gaussian Diffusion Parameters for Improved Glioma Grading

  • Karaman, M. Muge;Zhou, Christopher Y.;Zhang, Jiaxuan;Zhong, Zheng;Wang, Kezhou;Zhu, Wenzhen
    • Investigative Magnetic Resonance Imaging
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    • v.26 no.2
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    • pp.104-116
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    • 2022
  • The purpose of this study is to systematically determine an optimal percentile cut-off in histogram analysis for calculating the mean parameters obtained from a non-Gaussian continuous-time random-walk (CTRW) diffusion model for differentiating individual glioma grades. This retrospective study included 90 patients with histopathologically proven gliomas (42 grade II, 19 grade III, and 29 grade IV). We performed diffusion-weighted imaging using 17 b-values (0-4000 s/mm2) at 3T, and analyzed the images with the CTRW model to produce an anomalous diffusion coefficient (Dm) along with temporal (𝛼) and spatial (𝛽) diffusion heterogeneity parameters. Given the tumor ROIs, we created a histogram of each parameter; computed the P-values (using a Student's t-test) for the statistical differences in the mean Dm, 𝛼, or 𝛽 for differentiating grade II vs. grade III gliomas and grade III vs. grade IV gliomas at different percentiles (1% to 100%); and selected the highest percentile with P < 0.05 as the optimal percentile. We used the mean parameter values calculated from the optimal percentile cut-offs to do a receiver operating characteristic (ROC) analysis based on individual parameters or their combinations. We compared the results with those obtained by averaging data over the entire region of interest (i.e., 100th percentile). We found the optimal percentiles for Dm, 𝛼, and 𝛽 to be 68%, 75%, and 100% for differentiating grade II vs. III and 58%, 19%, and 100% for differentiating grade III vs. IV gliomas, respectively. The optimal percentile cut-offs outperformed the entire-ROI-based analysis in sensitivity (0.761 vs. 0.690), specificity (0.578 vs. 0.526), accuracy (0.704 vs. 0.639), and AUC (0.671 vs. 0.599) for grade II vs. III differentiations and in sensitivity (0.789 vs. 0.578) and AUC (0.637 vs. 0.620) for grade III vs. IV differentiations, respectively. Percentile-based histogram analysis, coupled with the multi-parametric approach enabled by the CTRW diffusion model using high b-values, can improve glioma grading.

Changes in the Global Citizenship of Participants in Overseas Volunteer Activities for University Students (대학생 해외자원봉사활동 참여학생의 세계시민의식 변화)

  • Song, Byung-Chul;Kim, Min-Kyung;Oh, Chang-Seok;Shin, Soo-Jin;Han, Jin-A;Kim, Soo-Jeong
    • Journal of The Korean Society of Integrative Medicine
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    • v.10 no.1
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    • pp.157-168
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    • 2022
  • Purpose : The purpose of this study is to determine the effect of the overseas volunteer activities of university students on changes in global citizenship. Methods : This study was conducted as a one-group pre-posttest design. The study's subjects were students who participated in the 37th World Friends Korea Youth Volunteer Corps in 2018. Among them, 158 students who completed the survey were included in the analysis. The tool for measuring global citizenship was comprised of knowledge, skill, attitude, and willingness to practice. The data were analyzed using the SPSS 26.0 program, and the statistical significance was set to p<.05. Results : Among the study's participants, there were 123 females (77.85 %). By grade, there were the most juniors, with 68 (43.04 %). There were 53 (33.55 %) seniors, 28 (18.35 %) sophomores, and eight freshmen (5.06 %). Among all participants, 52.53 % had experience in global citizenship education, and 63.92 % had experience in activities related to global citizenship. Because of analyzing the changes in global citizenship before and after overseas volunteer activities, "skill" increased the most, from 3.51±.65 points to 4.34±.56 points (p< .001). Due to analyzing changes in global citizenship before and after overseas volunteerism, the knowledge and attitude of freshmen were statistically significantly positive, with 1.17± 1.23 (p=.011) and 1.41±1.22 (p=.008), respectively. Participants with global citizenship experience had a significant change in attitude (p=.018). Conclusion : It was confirmed that the overseas volunteer activities of undergraduate students in the university brought a positive change to global citizenship. Providing opportunities for global citizenship education and activities in elementary, middle, and high schools in the future will maximize the effects of overseas volunteer activities to improve global citizenship.

A Study on the 「Gyobeob」 of 『Jeon-gyeong』 : Focused on Comparison with Chapter 「Words of Law」 of 『Daesoon Jeon-gyeong』 6th Edition (『전경』 「교법」편 연구 - 『대순전경』 6판 「법언」장과의 비교를 중심으로 -)

  • Ko, Nam-sik
    • Journal of the Daesoon Academy of Sciences
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    • v.26
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    • pp.1-41
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    • 2016
  • The script of the Fellowship of Daesoon Truth, 『Jeongyeong』 consists of seven sectors and 17 chapters. The seven sectors include 「Life of Sangje」, 「Reordering of the Universe」, 「Passing on of Teaching」, 「Law of Teaching」, 「Wisdom」, 「Cure of the Sick」, and 「Foreseeing」. The chapter 「Reordering of the Universe」 has the most records about Sangje, while the 「Law of Teaching」 has the most variety of materials in many passages about Sangje. This shows that the chapter 「Reordering of the Universe」 puts emphasis on the unique religious activities of Sangje and 「Law of Teaching」 is important for its edifying elements. "Law of teaching" is 敎法(Gyobeop) in Chinese character. 敎 means "teaching" and 法 "laws". What is law? A law becomes the rules for maintaining order of a society. In the view of religion, the law is ethical rules set by Kang Jeungsan to keep an order in the world. The first and second chapters of 「Law of Teaching」 have writings on 1. What Sangje said in person to the disciples, 2. The teachings Sangje gave to the disciples in certain occasions, 3. Reality of the society in late Joseon Dynasty, 4. Teachings related to the historical figures and old stories, and 5. Literatures. The third chapter has two special types of writing, which is about Taoism myths and statements written only in Chinese characters. In 『Daesoon Jeongyeong Volume 6』, the chapter 「Words of Law」 has more contents on edification for disciples, Cheok and resolving grudges with more detailed expression of woman resolving their piled up grudges. This chapter also has writings about discriminating old evil customs of Confucianism, emphasizing virtue and act of reciprocating for offered graces while training of one's mind and working on one's daily practice (shown in Sangje's saying about certain historical figures, quoting the Song of Suwun, statements in Chinese characters), Sangje's opinion about Japan, China, ancestral beings, eating raw foods, Byeokgok and others. In comparison with 「Words of Law」 in 『Daesoon Jeongyeong Volume 6』, which was issued in 1965 as the previous generation literature, 「Law of Teaching」 in 『Jeongyeong』 has many additional statements made to existing passages. Also, some passages were combined of two previous passages, some words were corrected, and in some passages, additional statements were made about the same person mentioned in another passage. And some passages were dropped. For the contents, 『Jeongyeong』 has additional statements about spiritual training of one's mind and practicing the teaching in daily lives, which indicates that 『Jeongyeong』 is focusing more on actual daily practice and the idea of overcoming hardships during the practice and realizing the principle of Resolution of all grudges.

Family-Friendly Community Characteristics and Life Satisfaction of Working Mothers with Elementary School-Age Children: Mediation Effects of Work-Family Conflict and Facilitation (가족친화적 지역사회 특성과 초등학령기 자녀를 둔 취업모의 삶의 만족도 : 일-가족 갈등 및 촉진의 매개효과)

  • Park, In-Sook
    • Journal of Family Resource Management and Policy Review
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    • v.27 no.2
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    • pp.1-17
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    • 2023
  • This study examined the relationship between family-friendly community characteristics and the life satisfaction of working mothers with elementary school children, and investigated whether the relationship was mediated by work-family conflict and facilitation of working mothers. For the analysis, the study used the response data of 627 working mothers from the 11th wave of the Panel Study on Korean Children (PSKC, 2019) and multi-mediation effect analyses were conducted using PROCESS. The main results are as follows. First, the higher neighbor support, the higher the work-family facilitation, which significantly increased life satisfaction. Second, the appropriateness of parenting environment and community service infrastructure satisfaction showed significant indirect effects with life satisfaction through increasing work-family facilitation and lowering work-family conflict. Moreover, the appropriateness of parenting environment was positively related with life satisfaction and it was a only variable that was directly associated with life satisfaction. On the other hand, the convenient access to community service infrastructure was found to lower work-family facilitation and lower life satisfaction, confirming the need for follow-up studies. This study shows that the family-friendly characteristics of the community are important for working mothers with elementary school-age children and provides empirical evidence to improve the family-friendly community characteristics.