• 대한간호학회지
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• 제53권4호
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• pp.453-467
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• 2023

Purpose: This study investigated the cumulative effects of depressive symptoms on cognitive function over time in community-dwelling older adults. Methods: Data were investigated from 2,533 community-dwelling older adults who participated in the Korean Longitudinal Study of Aging (KLoSA) from the 5th (2014) to the 8th wave (2020). The association between cumulative depressive symptoms and cognitive function was identified through multiple regression analysis. Results: When the multiple regression analysis was conducted from each wave, the current depressive symptoms scores and cognitive function scores were negatively associated, regardless of the waves (B5th = - 0.26, B6th = - 0.26, B7th = - 0.26, and B8th = - 0.27; all p < .001). Further, when all the previous depressive symptoms scores were added as explanatory variables in the 8th wave, the current one (B8th = - 0.09, p < .001) and the previous ones (B5th = - 0.11, B6th = - 0.09, and B7th = - 0.13; all p < .001) were also negatively associated with the cognitive function score. The delta R², which indicates the difference between the model's R² with and without the depressive symptoms scores, was greater in the model with all the previous and current depressive symptoms scores (6.4%) than in the model with only the current depressive symptoms score (3.6%). Conclusion: Depressive symptoms in older adults have a long-term impact. This results in an accumulated adverse effect on the cognitive function. Therefore, to prevent cognitive decline in older adults, we suggest detecting their depressive symptoms early and providing continuous intervention to reduce exposure to long-term depressive symptoms.

• Korean Journal of Acupuncture
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• 제27권4호
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• pp.59-72
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• 2010

Objectives : In the study on the waveform analysis of radial artery pulse diagnosis, we need to establish fundaments of contemporary pulse diagnosis research, and to find the change of pulse waveform parameter with applied variation pf pressure. Methods : As we will to do experimental research on the difference of pulse waveform on the radial artery with applied variations of pressure(5 stage-pressure) and measuring position(left KWAN). In this research, we analyzed the change of the waveform according to five stage pressure. Results : The results were as follows; When we analyzed the change of the waveform according to pressure in the left KWAN, E, hl, h2 and A were the difference between 8ths pressure grades in 95% trust section. And t2, t4 were the difference between 8ths pressure grades in 95% trust section. W was the difference between 8ths pressure grades in 95% trust section. And h2/h1 was the difference between 6ths pressure grades in 95% trust section. There is the difference between 1st and 2nd grade & between 2nd and 5th grade in the case of t4/t2 in 95% trust section. And there is the difference between 1st and 5th grade, between 3rd and 4th grade, between 3rd and 5th grade & between 4th and 5th grade in the case of W/A in 95% trust section. And there is the difference between 1st and 2nd grade, between 2nd and 3rd grade, between 2nd and 4th grade, between 3rd and 4th grade, between 3rd and 5th grade & between 4th and 5th grade in the case of A/E in 95% trust section. Conclusions : We found the statistically resonable differences between each pulse depending on the applied pressure. And Analysing the radial pulse(left KWAN) at 5 applied pressure levels may be useful to study on the pulse waveform diagnosis.

• IMMUNE NETWORK
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• 제11권6호
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• pp.416-419
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• 2011

Dextran sodium sulfate (DSS) is a widely used chemical model for inflammatory bowel disease (IBD). It is thought that imbalances in the T helper (Th) cell subsets contribute to IBD. Recent studies suggest that the acute DSS-colitis model is polarized toward a Th1/Th17 profile based on RT-PCR analysis of colonic tissues. In the current study we determined whether colonic Th cells from DSS-colitis mice were skewed toward the Th17 profile. Mice were treated with 5% DSS for 7 days and colonic T cells isolated and examined for production of IFN-${\gamma}$ (Th1 cell), IL-4 (Th2 cell) and IL-17 (Th17 cell) by intracellular flow cytometry. We found that the percentage of colonic Th17 cells were similar to non-treated controls but the percentage of Th1 cells were elevated in DSS-colitis mice. These results suggest that in the acute DSS-colitis model the colonic Th cells exhibit a Th1 profile and not a Th17 profile.

• 대한수의학회지
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• 제15권2호
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• pp.251-257
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• 1975

In order to investigate the effects of high ambient temperature on the thyroid, a total of 50 rabbits (mean weight, 1,294g) reared under $7^{\circ}C$ were alloted to two groups. Rabbits in one group served as controls and the others, after reared under $30^{\circ}C$ for 16 days, were returned to the normal temperature for 16 days. The results obtained in this work were summerized as follows: 1. The weight of the thyroid gland was decreased severely from the 2nd day and increased to normal range on the 4th day after returned to normal temperature. 2. Thyroid follicles were atrophied significantly from the 1/2 day and then enlarged gradually from the 4th day, while their colloid substance also manifested poor staining, coagulation, and disappearence, being reappeared from the 8th day. 3. Hypertrophied follicular epithelial cells showed more enlarged size, degeneratien, necrosis, and mitosis from the 1/2 day in accordance with experimental term and those changes were diminished from the 8th day. 4. Histologically thyroid manifested-hypothyroidism on the 16th day but showed mild hyperthyroidism on the 2nd day and euthyroidism from the 4th day of returned roaring.

• 약학회지
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• 제56권6호
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• pp.366-371
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• 2012

In this present study, we determined whether or not there is an immunoadjuvant effect of ochnaflavone, a biflavone isolated from Lonicera japonica. As an antigenic source, the cell wall (CACW) of Candida albicans, a fungal pathogen, was used. CACW consists of 95% carbohydrate (mannan). In the experiments, BALB/c mice were immunized with emersion forms of CACW combined with or without ochnaflavone (Och) in the presence of IFA containing mineral oil or CACW alone. Then, the amounts of antisera collected from these mice groups were measured by the ELISA method. Data from these experiments showed that CACW combined with Och (CACW/Och/IFA) provoked the production of antisera app. 2.2 or 5 times more than the corresponding CACW/IFA or CACW alone (CACW/DPBS), respectively, in mice (P<0.05). We further examined the immune response type induced by Och. Analysis of the values of the IgG1/IgG2a ratios obtained from IgG isotyping revealed that Och induced Th2-immunity more dominantly than Th1. This finding was confirmed by cytokine profile. CACW/Och/IFA formulation induced IL-4 (Th2-type cytokine) more than IFN${\gamma}$ (Th1-type cytokine) as compared with CACW/IFA and CACW/DPBS formulations (P<0.05). All data combined, Och appears to have an immunoadjuvant activity that may convert Th1 immunity into Th2 immunity.

• Journal of Acupuncture Research
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• 제24권1호
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• pp.13-28
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• 2007

Objectives : Clinical character of chronic tension-type headache is bilateral, moderate intensity, persistent and chronic, repeating disease and CTTH is a common prevalent disease, but pathophysiology and likely mechanism remain unclear. It impedes subjective quality of life. The purpose of this research is to examine the effect of sa-am acupuncture method for chronic tension-type headache. Methods : In this randomized, single blind, placebo-controlled study, we compared active acupuncture with sham acupuncture for the treatment of chronic tension-type headache. Volunteers who satisfied the requirements were enrolled in study. Evaluation of chronic tension-type headache was measured by VAS and Headache Disability Inventory(HDI), Six point Linkert Scale before and after treatments. Results : 26 subjects finished study. There were not difference between two groups on age, sex, weight, height, blood pressure, pulse, respiratory rate, Byeonjeung, sunrise of treatment. In change of VAS, there were not difference between two groups on before treatment. Before treatment per visit, VAS of 6th and 7th visit were significantly decreased in active acupuncture(each p=0.039, p=0.008) and were not decreased in sham acupuncture. In change of VAS on a withdrawing needling after treatment, VAS of 1st, 2nd, 6th and 7th visit were significantly decreased in active acupuncture (each p=0.001, 0.038, 0.035, 0.008) and VAS of 2nd, 4th and 5th, 6th visit were significantly decreased in sham acupuncture(each p=0.033, 0.032, 0.035, 0.031). In change of VAS on 2hrs after treatment, VAS of 4th and 5th, 6th visit were significantly decreased in active acupuncture(each p=0.014, 0.023, 0.027) and 5th visit were significantly decreased in sham acupuncture(each p=0.004, 0.009). In change of VAS on 4hrs after treatment, VAS of 4th and 5th, 6th visit were significantly decreased in active acupuncture(each p=0.018, 0.011, 0.015) and 5th, 6th visit were significantly decreased in sham acupuncture(each p=0.020, 0.015). In change of VAS on the next day after treatment, VAS of 3th and 4th and 5th, 6th visit were significantly decreased in active acupuncture(each p=0.032, 0.011, 0.005, 0.012) and 4th, 5th visit were significantly decreased in sham acupuncture(each p=0.001, 0.012). In change of VAS according to a current time(before treatment, after a withdrawing needling, 2hrs, 4hrs, the next day), total score of VAS was decreased more active acupuncture group than sham acupuncture group, but there were no statistical significance compared with sham acupuncture group. In change of HDI score, after treatment was decreased than before treatment in two group, but there were no statistical significance compared with two group. In change of Six point Linkert scale score, after treatment was decreased than before treatment in two group on 6th, 7th visit(active acupuncture 6th 7th each p=0.002, 0.003, sham acupuncture 6th 7th each 0.003, 0.009), but there were no statistical significance compared with tow group. Conclusion : Sa-am acupuncture treatment is effective to improve the symptoms and quality of life in patients with chronic tension-type headache.

• 한국농림기상학회지
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• 제2권2호
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• pp.41-46
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• 2000

본 시험은 다산벼를 공시하여 작물시험장 수도재배 포장에서 1998~1999년에 단위면적당 수수화보를 위하여 5월10일부터 10일 간격으로 6월 19일까지 5회 이앙을 하여 생육환경 변화에 따른 경수증가와 재식본수를 1, 3, 5본 및 7본으로 하였을 때 출수기의 변화를 구명하고 재배 기술 개발의 기초자료로 활용하고자 시험하여 몇 가지 결과를 얻었기에 보고하고자한다. 1. 다산벼는 초기 생육기온이 높을수록 분얼에 유리하여 이앙 후 30일 경수가 5월 10일 이앙 9.7개 보다 6월 19일 이앙이 18.3개로 8.6개가 많았다. 2. 재식묘수에 따른 경수는 7묘까지 많을수록 많았으며, 수수는 분얼 경수가 많을수록 많은 경향이었다. 3. 출수기는 이앙기가 늦어질수록 6월 9일 까지는 출수일수가 단축되었으나 6월 19일 이앙은 늦어졌다. 주당묘수에 따른 변화는 y = 2.65$x^2$-31.36x+1957.5 ($R^2$=0.9795)관계로 변화하였다. 4. 경당 건물중은 평균기온의 변화에 따라 y = -0.1285$x^2$+6.6717x-83.423($R^2$=0.9223$^{**}$ ) 관계가 있고, 경당 건물중이 가장 높은 최적 기온은 26$^{\circ}C$이었다. 5. 수수와 수량과의 관계는 수수가 증가하면 수량은 증가하였고, 그 관계는 y=1.6292x+11.701($R^2$=0.6342$^{**}$ )이었다.

• 디지털산업정보학회논문지
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• 제11권2호
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• pp.141-152
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• 2015

Our agriculture and rural villages have faced negative conditions in many reasons. To overcome this situation, a new change is needed by the 6th industrialization. Many agriculture and rural villages in Korea are pursuing the 6th industrialization through the convergence of the primary, secondary, and tertiary industries to vitalize agriculture and rural villages. But there are several problems with the 6th industrialization. There is a limit to the capacity building of the members of the rural organization and Korean agricultural base primary, secondary, and tertiary industries are weak all. In addition, it has been insufficient research for value chain management of the region as a whole; there has been no study of information sharing across the region for the 6th industrialization. This study is about value chain management model for successful the 6th industry with Quick Response System and the big data technology. In this study to provide the efficiency of 6th industry value chain management with customer's needs analysis using big data and research for the information share between the industries in the region through the information pipeline theory of the QR System. We hope that our study is helped to proceed successfully on the 6th industrialization in Korea.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.344-347
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• 2005

Helper T(Th) cells regulate immune response by producing various kinds of cytokines in response to antigen stimulation. The regulatory functions of Th cells are promoted by their differentiation into two distinct subsets, Th1 and Th2 cells. Th1 cells are involved in inducing cellular immune response by activating cytotoxic T cells. Th2 cells trigger B cells to produce antibodies, protective proteins used by the immune system to identify and neutralize foreign substances. Because cellular and humoral immune responses have quite different roles in protecting the host from foreign substances, Th cell differentiation is a crucial event in the immune response. The destiny of a naive Th cell is mainly controlled by cytokines such as IL-4, IL-12, and IFN-${\gamma}$. To understand the mechanism of Th cell differentiation, many mathematical models have been proposed. One of the most difficult problems in mathematical modeling is to find appropriate kinetic parameters needed to complete a model. However, it is relatively easy to get qualitative or linguistic knowledge of a model dynamics. To incorporate such knowledge into a model, we propose a novel approach, fuzzy continuous Petri nets extending traditional continuous Petri net by adding new types of places and transitions called fuzzy places and fuzzy transitions. This extension makes it possible to perform fuzzy inference with fuzzy places and fuzzy transitions acting as kinetic parameters and fuzzy inference systems between input and output places, respectively.

• 대한한방소아과학회지
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• 제10권1호
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• pp.221-244
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• 1996

In order to study the effects of Jamyong-oil(蠶?油) on the diabetic rats induced by streptozotocin, during 15days rats were administered Jamyong-oil after streptozotocin injection(50mg/kg). On 2nd, 9th and 15th day, I investigated the levels of serum glucose, serum total cholesterol, serum triglyceride, serum amylase, and body weight. The last day, I killed rats and investigated hepatic lipid peroxide, tissue amylase. The results were obtained as follows: 1. Serum glucose levels of the sample group decreased effectively (p < 0.05) at the 15th day as compared with the control group. 2. Serum total cholesterol levels of the sample group decreased effectively (p < 0.05) at the 9th and 15th day as compared with the control group. 3. Serum triglyceride levels of the sample group decreased effectively (p < 0.05) at the 15th day as compared with the control group. 4. Activities of the serum amylase of the sample group increased respectively at the 9th (p < 0.05) and 15th (p < 0.01) day as compared with the control group. 5. Body weights of the sample group increased effectively (p < 0.05) at the 15th day as compared with the control group. 6. Hepatic lipid peroxide levels of the sample group decreased significantly (p < 0.01) as compared with the control group. 7. Tissue amylase levels of the sample group increased but not effective as compared with the control group.