• 대한한방내과학회지
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• 제28권4호
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• pp.681-693
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• 2007

Background and Objective : Atractylodes japonica (AJ) is a commonly-used herbal medicine in Asian countries such as Korea, China and Japan. The present study was designated to evaluate the direct effects of AJ on helper T cell activities and on Th1/Th2 lineage development in vitro. Materials and Methods : Spleen cells from 8-week BALB/c mice were cultured in CR extracts containing medium without activation for 24 hours and with activation for 48 hours. CD4+ T cells were isolated and analyzed for mRNA expression levels of INF-$\gamma$, IL-4, T-bet and GATA-3 by RT-PCR and secretion cytokines levels of INF-$\gamma$, IL-2, IL-4, IL-5 and IL-10 by ELISA. Results : The results demonstrated that AJ had no mitogenic effects on unstimulated CD4+ T cells, but augmented CD4+T-cell proliferation upon activation with anti-CD3/anti-CD28 antibodies in a dose-dependent manner. AJ treatment significantly increased CD4+ T cell population and IFN-$\gamma$ expression was significantly enhanced, while IL-4 expression significantly decreased. In addition, in vitro Th1/Th2 polarization experiments revealed that AJ enhanced IFN-$\gamma$ secretion in Th1 cells, but reduced the IL-4 in Th2 cells in dose-dependent manner. Conclusion : These results suggest that AJ treatment could be a desirable alternative therapy for the prevention or correction of Th2 dominant pathological disorders, such as allergy and asthma.

• 대한한방소아과학회지
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• 제11권1호
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• pp.227-248
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• 1997

In order to study the effects of Chungpyesagantang(淸肺瀉肝湯) on the diabetic rats induced by streptozotocin, during 15 days rats were administered Chungpyesagantang extract after streptozotocin injection (50mg/kg) (sample group). On 2nd, 9th, and 15th day, I investigated the levels of body weight, serum glucose, serum total cholestrol, serum triglyceride. The last day, I killed rats and investigated hepatic lipid peroxidase. The results were obtained as follows: 1. Body weight of the diabetic rats induced by streptozotocin and Chungpyesagantang, as compared with the control group on the 15th day, increased effectively. (p〈0.05 respectively) 2. Glucose levels in serum of the diabetic rats induced by streptozotoc in and Chungpyesagantang, as compared with the control group on the 9th and 15th day, decreased effectively.(p〈0.05 respectively) 3. Total cholesterol levels in serum of the diabetic rats induced by streptozotocin and Chungpyesagantang, as compared with the control group on the 9th and 15th day, decreased effectively.(p〈0.05 respectively ) 4. Triglyceride levels in serum of the diabetic rats induced by streptozotocin and Chungpyesagantang, as compared with the control group on the 9th and 15th day, decreased effectively.(p〈0.05 respectively) 5. On hepatic lipid peroxidethe of the diabetic rats induced by streptozotocin and Chungpyesagantang, as compared with the control group on the 9th and 15th day, decreased effectively.(p〈0.01 respectively)

• 복식
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• 제58권5호
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• pp.71-86
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• 2008

The Purpose of this article is to study the excavated women's costume of the Joseon Dynasty, and to help identify the period of those costumes with the time of the burial unknown. The excavated women's costume is concentrated in 16th to 17th century, and the reason is due to the method of the burial. The characteristics of costumes from each period is as follows. The special features about 15th century costumes are the women's Dan-ryeong(round-collared jacket), Dae-gum style shirt(shirt with the squared collar facing each other), and skirt with horizontal dart. The 16th century costumes are the women's Dan-ryeong, wide Jegori with various length, skirt with horizontal dart, skirt with its hem folded, and pants with shoulder strap. In the 17th century, the formal dress changes to Won-sam from Dan-ryeong. The collar changes from the squared shape to the cut Dang-ko collar, and the skirt with its hem folded is not seen after the early 17th century. The long jacket changes to Dang-ui and gets settled, and the clothes becomes smaller and tighter. In the 18th century, the women's formal dress gets settled to Won-sam and Dang-ui, and the pants with shoulder strap is no longer seen. Jegori becomes shorter and smaller compared to those from the 17th century, and again gets wider and bigger in the late 18th century, and it leads to the change of making a big sized shroud.

• 대한한방부인과학회지
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• 제15권4호
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• pp.32-44
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• 2002

Onsinhwan(OSH : 溫腎丸) is used in female infertility, especially due to lack of kidney yang or Sinyanghe(腎陽虛). An attempt was made to evaluate the influences of OSH on the serum concentrations of FSH and LH, Estrogen, Progesterone and the histological and optical changes of ovary, ovary weight of rats. The results of the study were as follows : 1. Blood FSH level increased in experimental group as compared with control group on 7th day and 14th day, which showed no efficacy. 2. Blood LH level decreased in experimental group as compared with control group on 14th day, which showed no efficacy. 3. Blood Estrogen level increased in experimental group as compared with control group on 7th day and 14th day, which showed no efficacy. 4. Blood Progesterone level decreased in experimental group as compared with control group on 7th day and 14th day, which showed no efficacy. 5. In histological observations of ovary, ovulation increased in experimental group as compared control group on 7th and on 14th day, which showed no efficacy. 6. In optically observations of ovary, size and weight of ovary increased in experimental group on 7th day and on 14th day, which showed no efficacy. According to these results, OSH did not influence on the ovulation of ovary in rats.

• 동아시아식생활학회지
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• 제8권3호
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• pp.235-245
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• 1998

The purpose of this research was to determine the dishes most commonly served during various festive days. This research studied the habits of housewives in Seoul and In the Choongchung province who have children in high school. 1. Most of the housewives in Seoul graduated from high school. On the other hand. those in the Choongchung province graduated from elementary school in their education backgrounds. The monthly income ranged from 1,550,000 won to 1,190,000won to 1,190,000 won for the housewives of Seoul, and from 1,000,000 won to 1,490,000 for those of Choongchung. The nuclear family system was dominated in both areas and 63.8% of the housewives had a full-time job. 2. "Sulnal(The New Year's Day), Chusuk(Thanksgiving Day), Jungwol-daeborum(The 1st Full-Moon Day)" are among the festive days celebrated in 85% of the both areas, and "Yuwol-Yudu(6th, June), Chungyangjul(9th, September), Naphyang(8th, September)" were celebrated in 0.5%. 3. Traditional festive dishes with respect to the festive days were as follows. Tuckuk(rice cake soup) was a favorite food in Sulnal(The New Year's Day), Burum(Peanut,pine-nut, walnut, etc) in Jungwol-daeborum(The 1st Full-Moon Day), Samgyetang(chicken soup) in Dongji Songpyen(rice cake) in Chusuk(Thanksgiving day) and Patjuk(small red beans soup) in Dongji (22th, December). No significance was found in the number of dishes. 4. The Regional differences the festive days such as Sulnal(The New Year's Day), Ipchun(4th, February), Jungwol-daeborum(The 1st Full-Moon Day), Samwol-samjit(3th, March) Sawolchopail(Budda's birthday), Tano(5th, May), Yuwol-yudu(6th, March) Sawolchopail Budda's birthday), Tano(5th, May), Yuwol-yudu(6th, June), Chilwol-chilsok(7th, July), Suddal -gumum (The year's last day) were very significant 5. The festive days should continue. On the other hand, the menu(dishes) of the festive days should be simplified.hould be simplified.

• 대한수학교육학회지:수학교육학연구
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• 제24권3호
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• pp.409-428
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• 2014

본 연구는 조선산학의 내용적 변화가 관찰되는 17-18세기에 초점을 맞추어 조선산학의 교육과정적 특징을 살펴보고 그 교육적 의미를 탐색하였다. 문헌분석 결과, 17-18세기의 조선 산학교육에서는 실용적 차원뿐 아니라 심성함양 차원의 목적이 존재하였으며, 교수 학습방법과 평가 항목에서는 15-16세기와 비교하여 큰 변화가 없었다. 반면 내용 체계에서는 위계성이 강화되고 기하 영역의 비중이 높아지는 변화를 보였다. 또한 이 시기의 조선산학서에서 유럽수학의 유입을 확인하였으며, 중국산학의 영향권에서 조금씩 벗어난 조선산학의 고유성의 면모를 관찰하였다. 이와 같이 이전 시기와 차별화되는 교육과정적 특징들이 다수 관찰되는 17-18세기는 중국산학에 대한 비판적 수용과 조선산학의 고유한 발전이 있었던 시기라고 할 수 있다.

• Journal of Preventive Medicine and Public Health
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• 제16권1호
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• pp.19-24
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• 1983

In order to study the effects of iron and zinc on the lead poisoning of rats, lead with iron and zinc, or lead alone were administered orally to a total of 98 adult rats of Sprague-Dawley Species. The concentrations of lead, zinc, and iron were measured by atomic absorption spectrophotometer at every 20 days intervals of 20th, 40th, 60th, 80th and 120th day as a final measurement. Those datas were analysed and compared with those of control groups. The results were summarized as follows; 1. The concentration of lead in blood, bone. and liver tissues kept increasing in case of lead exposure group whereas it started decreasing at 60-80th day when concentration of zinc started increasing in case of combined exposure group. However, in kidney tissue, the concentration of lead in combined exposure group kept increasing up to the end of observation showing special high concentration at the final measurement at 120th day. 2. Concentration of zinc in blood and liver tissues had increased from 60-80th day in case of combined exposure group. 3. Concentration of iron in blood showed decreasing from $44.15{\pm}9.67\;to\;32.44{\pm}2.69{\mu}g/ml$ in case of lead exposure group, whereas it showed constant level of $47.50{\sim}45.65{\mu}g/ml$. However, in liver tissue it kept constant as control did from 40th to 60th days, but from 100th day on it started increasing to show much higher concentration than control.

• 한국의상디자인학회지
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• 제22권4호
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• pp.1-16
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• 2020

This study focused on front-blouse-type skirts from the 15th and 16th centuries and aimed to investigate their formative characteristics and wearing patterns. Previous studies, literature, records, paintings, and excavated clothing items were used as research materials. The researcher categorized front-blouse-type skirts into three types based on the construction method. The first has the front-center portion of the skirt folded up, the second has the center portion cut short, and the third has horizontal dart pleats on either side. An examination of 48 items from 18 excavation sites of front-blouse-type skirts showed that only the front-center portion folded up type appeared in the 15th century, and it was only in the 16th century that the other forms of skirts were worn. Finally, based on the analysis, the pattern of wearing front-blouse-type skirts and their changing factors was deduced. Front-blouse-type skirts were identified as ceremonial skirts that were popular in the 15th and 16th centuries among the types of long skirts available. The popularity and usage of this type of skirt began to spread gradually in the 15th century. In the 16th century, various types of front-blouse-type skirts were brought into vogue by the royal family and the external register. It can be inferred that the popularity of front-blouse-type skirts gradually declined in the 17th century as other types of long skirts, folding skirts, and Sran type skirts emerged.

• 대한간호학회지
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• 제53권4호
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• pp.453-467
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• 2023

Purpose: This study investigated the cumulative effects of depressive symptoms on cognitive function over time in community-dwelling older adults. Methods: Data were investigated from 2,533 community-dwelling older adults who participated in the Korean Longitudinal Study of Aging (KLoSA) from the 5th (2014) to the 8th wave (2020). The association between cumulative depressive symptoms and cognitive function was identified through multiple regression analysis. Results: When the multiple regression analysis was conducted from each wave, the current depressive symptoms scores and cognitive function scores were negatively associated, regardless of the waves (B5th = - 0.26, B6th = - 0.26, B7th = - 0.26, and B8th = - 0.27; all p < .001). Further, when all the previous depressive symptoms scores were added as explanatory variables in the 8th wave, the current one (B8th = - 0.09, p < .001) and the previous ones (B5th = - 0.11, B6th = - 0.09, and B7th = - 0.13; all p < .001) were also negatively associated with the cognitive function score. The delta R², which indicates the difference between the model's R² with and without the depressive symptoms scores, was greater in the model with all the previous and current depressive symptoms scores (6.4%) than in the model with only the current depressive symptoms score (3.6%). Conclusion: Depressive symptoms in older adults have a long-term impact. This results in an accumulated adverse effect on the cognitive function. Therefore, to prevent cognitive decline in older adults, we suggest detecting their depressive symptoms early and providing continuous intervention to reduce exposure to long-term depressive symptoms.

• 아동학회지
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• 제28권4호
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• pp.289-304
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• 2007

Subjects of this study on reading motivation were 300 2nd, 4th, and 6th grade elementary school children. Instruments were the Motivation for Reading Questionnaire (Wigfield and Guthrie 1997; Kwun, 2002) and a School Reading Environment questionnaire developed by the researcher. Results showed that (1) the school reading environment (SRE) of 2nd graders was better than the SRE of 4th and 6th graders. (2) The reading motivation (RM) of 2nd graders was higher than the RM of 4th graders on external purposes; the RM of 4th graders was higher than 6th graders on self-efficacy and social interaction. (3) RM correlated positively with all aspects of SRE. (4) RM was affected by grade in school followed by school library environment and classroom library environment.