• 한국임상수의학회지
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• 제32권6호
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• pp.486-490
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• 2015

이차원 초음파는 심장 기능의 평가에 있어 널리 이용되어지고 있다. 심혈관계 질환의 진단을 위해서는 좌심실 내강의 영상화가 필수적이다. SonoVue$^{TM}$는 육불화황 가스로 안정화된 새로 나온 조영제이다. 현재 이 초음파 조영제를 이용하여 활발한 연구가 진행되고 있으나, 개에서 진단을 위한 가장 효율적인 용량에 대한 연구가 없었다. 이 연구의 목적은 SonoVue$^{TM}$ 조영제를 이용하여 좌심실 내강의 영상화에 있어 효율적인 용량을 찾는데 있다. 열 마리의 건강한 비글 성견을 실험에 이용하였다. 본 연구에서는 조영제의 용량을 각 0.03 ml/kg, 0.05 ml/kg 그리고 0.1 ml/kg 으로 사용하여 각 용량에서의 좌심실 내강의 영상화 되는 시간을 비교하였다. 내강이 영상화되는 시간의 측정은 segmental score를 이용하였다. Segmental score법은 좌심실 내강을 6개의 가상의 구역으로 나누고 각 구역이 영상화되는 것을 수치화 하는 방법이다. 본 연구에서는 일반적으로 유의성이 있다고 할 수있는 segmental score가 5이상일 때의 시간을 측정하였다. 그리고 재연성의 평가를 위해 3명의 관찰자가 실험에 동참하였다. 측정치의 통계분석은 SPSS 14.0버전에서 일원배치 분산분석과 Scheffe 다중 비교를 이용하였다. 각 용량에서(0.03 ml/kg, 0.05 ml/kg, 0.1 ml/kg) 좌심실이 영상화 되는 평균 시간은 3.54초, 6.15초, 24.39초로 나타났다. 표준편차는 각 용량별 2.14124, 2.61205, 11.09802로 나타났다. 실험에 참여한 모든 동물에서 과민 반응, 심마진, 혈관 부종 등의 부작용이 나타나지 않았다. 결론적으로 소노뷰 조영제를 이용하여 좌심실 내강의 영상화시 가장 효율적인 조영제의 용량은 단위체중당 0.1 ml/kg이며, 이 용량에서 재연성 역시 가장 높았다.

• Tuberculosis and Respiratory Diseases
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• 제67권6호
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• pp.545-550
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• 2009

Background: Endobronchial ultrasonogram (EBUS) has increased the diagnostic yield of a bronchoscopic biopsy of peripheral pulmonary lesions (PPL). This study evaluated the diagnostic yield of EBUS-guided transbronchial biopsy (TBB) and the visibility of EBUS PPL. Methods: Between August 2007 and November 2008, 50 patients (32 men and 18 women, median age, 61.1${\pm}$10 yrs; range, 16 to 80 yrs) whose PPL lesions could not be detected with flexible bronchoscopy were enrolled in this study. Among the 50 patients, 40 cases were malignant lesions (adenocarcinoma 25, squamous cell carcinoma 10, small cell carcinoma 5) and 10 cases were benign lesions (tuberculoma 7, fungal ball 1, other inflammation 2). Results: The mean diameter of the target lesion was 35.4${\pm}$4.3 mm. Of the 50 patients examined, the overall diagnostic yield by EBUS-TBLB was 46.0% (23/50). The visualization yield of EBUS was 66.0% (33/50). A definitive diagnosis of PPL localized by EBUS was established using EBUS-TBLB in 69.6% (23/33) of cases. The diagnostic yields from washing cytology and brushing cytology from a bronchus identified by EBUS were 27.0% and 45.4% respectively. The diagnostic yields reached 78.7% when the three tests (washing cytology, brushing cytology and EBUS-TBLB) were combined. The visualization yield of EBUS in lesions <20 mm was significantly lower than that in lesions ${\geq}$20 mm (p=0.04). The presence of a bronchus leading to a lesion (open bronchus sign) on the chest CT scan was associated with a high visualization yield on EBUS (p=0.001). There were no significant complications associated with EBUS-TBLB. Conclusion: EBUS-TBLB is a safe and effective method for diagnosing PPL. The lesion size and open bronchus signs are significant factors for predicting the visualization of EBUS.

• 한국추진공학회지
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• 제8권3호
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• pp.37-43
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• 2004

증기발생기 슬러지 세정을 위한 고압분사 실험의 분류궤적에 대한 가시화 및 속도분포를 측정함으로써 최적의 노즐형상을 찾기 위하여 플랜져방식의 고압펌프(사용압력 : 200 kg/$\textrm{cm}^2$, 15HP, 11kW. 토출유량 Q : 301/min)를 이용하였다. 가시화를 통하여 정성적인 분포를 비교분석할 수 있었고, 분류의 속도분포등을 통하여 노즐 형상비에 따른 유동의 차이를 2차원 PDPA 광학 계측장비를 사용하여 분석하였다. 고압 분사시 형상비에 관계없이 모든 경우에 있어서 중심축을 따라 모든 궤적들은 거의 유사함을 보였으나, 분류 중심에서 벗어난 외곽영역에서는 많은 차이가 있음을 알 수 있었다 이는 형상 비에 따른 주변 공기와의 마찰 및 분류 유입현상 때문이라 여겨진다.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2005년도 추계 학술대회 논문집
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• pp.134-142
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• 2005

지하매질에서 핵종이동현상을 가시적으로 관찰할 수 있는 실험실규모 실험장치를 개발하여 이동실험을 수행하였다. 이 실험장치는 $50{\times}50cm$ 규모 화강암과 아크릴상층부로 구성되어있다. 실험에는 삼중수소, 음이온, 수착성양이온 뿐만 아니라 이동경로를 관찰할 수 있는 유기염료도 포함하였다. 시간에 따른 물질이동양태를 사진을 찍어 컴퓨터에 저장하였다. 또. 이동과정을 모사하고 단위공정별로 분석해 볼 수 잇는 이동모델도 개발하였다. 컴퓨터모사를 통해 균열내 흐름장에서 압력과 유속분포를 계산하고, 균열내 이동양태와 유출곡선을 계산해 실험결과와 비교 평가하였다.

• 한국가시화정보학회지
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• 제7권2호
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• pp.17-21
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• 2010

This paper presents the fabrication and performance measurement of a temperature sensor array on a flexible substrate attachable to a curved surface using MEMS technology. Specifically, the fabrication uses the well-developed printed circuit board fabrication technology for complex electrode definition. The temperature sensor array are lifted off with a $10{\times}10$ matrix in a $50\;mm{\times}50\;mm$ to visualize temperature distribution. Copper is used as temperature sensing material to measure the change in resistances with temperature increase. In a thermal oven with temperature control, the temperature sensor array is Characterized. The constant slope of resistance change is obtained and temperature distribution is measured from the relationship between resistance and temperature.

• Translational and Clinical Pharmacology
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• 제25권3호
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• pp.147-152
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• 2017

This study focused on the role of cytochrome P450 2D6 (CYP2D6) genotypes to predict phenotypes in the metabolism of dextromethorphan. CYP2D6 genotypes and metabolic ratios (MRs) of dextromethorphan were determined in 201 Koreans. Unsupervised clustering algorithms, hierarchical and k-means clustering analysis, and color visualizations of CYP2D6 activity were performed on a subset of 130 subjects. A total of 23 different genotypes were identified, five of which were observed in one subject. Phenotype classifications were based on the means, medians, and standard deviations of the log MR values for each genotype. Color visualization was used to display the mean and median of each genotype as different color intensities. Cutoff values were determined using receiver operating characteristic curves from the k-means analysis, and the data were validated in the remaining subset of 71 subjects. Using the two highest silhouette values, the selected numbers of clusters were three (the best) and four. The findings from the two clustering algorithms were similar to those of other studies, classifying $^*5/^*5$ as a lowest activity group and genotypes containing duplicated alleles (i.e., $CYP2D6^*1/^*2N$) as a highest activity group. The validation of the k-means clustering results with data from the 71 subjects revealed relatively high concordance rates: 92.8% and 73.9% in three and four clusters, respectively. Additionally, color visualization allowed for rapid interpretation of results. Although the clustering approach to predict CYP2D6 phenotype from CYP2D6 genotype is not fully complete, it provides general information about the genotype to phenotype relationship, including rare genotypes with only one subject.

• 한국가시화정보학회지
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• 제4권1호
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• pp.56-61
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• 2006

A change of three-dimensional vortical structures on the wake behind a road vehicle has been investigated according to the existence of an air spoiler. To reconstruct the three-dimensional velocity fields, two-dimensional PIV(particle image velocimetry) measurements were performed for lots of the x-y, y-z and z-x planes. Since the isovorticity surface does not represent exactly the vortical structures within the recirculation region due to strong shear flows, the velocity component normal to the x-y plane is obtained by interpolating those velocities in the z-x plane. Then, the ${\lambda}_2-definition$ is applied to visualize the vortices in the recirculation region. As a result, it is found that the air spoiler weakens C-pillar vortices and produces strong wing-tip vortices. Inside the recirculation region, the height and volume of coherent vortices are increased relatively when an air spoiler is equipped. On the other hand, two small coherent vortices are observed in case that an air spoiler is absent.

• Journal of Advanced Marine Engineering and Technology
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• 제32권7호
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• pp.1019-1029
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• 2008

In this study, visual investigation of sprays and flames has been performed and soot formation in Diesel and GTL fuels has been compared in a specially designed Rapid Charging Combustion Vessel (RCCV) under various ambient gas $O_2$ concentrations and two injection pressures. It has been concluded that soot in the mixing-controlled combustion of Diesel and GTL fuels has similar tendency to be formed in the leading portion of the jet boundaries. Auto-ignition delay for GTL fuel is shorter than that for diesel fuel. The temporal and special variation of soot concentration in the diesel flame jets at various $O_2$ concentrations was correlated with the heat release rate. Soot concentration appears in the regions when diffusion combustion starts, and its concentration reaches maximum at the peak of heat release curve and then decreases due to oxidation. Visualization by shadowgraph method showed that soot decreases with lower $O_2$ concentration, and higher injection pressure.

• 한국가시화정보학회지
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• 제3권2호
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• pp.71-78
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• 2005

Uncertainty introduced by a cross-correlation algorithm based on FFT has been investigated using PIV standard images. The standard images were generated by the Monte Carlo simulation method. Both bias and random errors from the velocity vector have been analyzed with regard to the particle diameter, displacement, and the number of particles. The uncertainty of velocity is evaluated based upon the IS0/IEC standard. As a result, a total error of $0.26\%$ is included in the PIV cross-correlation algorithm. In addition, the uncertainty budget is presented, where the effect of the above three variables is examined. According to the budget, the variation of the number of particles within the interrogation window mainly contributes to the combined standard uncertainty of the real measured velocity field when excluding the effect of errors by the experiments itself. Finally, the expanded uncertainty is found to be about $12\%$ at the $95\%$ confidence level.

• 대한기계학회논문집B
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• 제22권7호
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• pp.1013-1021
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• 1998

Various vortical structures are investigated by using three kinds of flow visualization methods in branch pipe flows. There are two typical flow patterns when a jet from the branch pipe with various angles is injected to the main pipe cross flow. The velocity range of cross flow of the main pipe is 0.2 m/s ~ 1.2 m/s and the corresponding Reynolds number, R$_{p}$ is of the range 1.5 * 10$^{3}$ ~ 9.02 * 10$^{3}$. The velocity ratio(R), jet velocity/cross flow velocity, is chosen from 1.3 to 4. The subsequent behavior and development of the ring vortices which are created at the jet boundary mainly depend on the velocity ratio. An empirical relation for the shedding frequency of the ring vortices is derived. It is also found that there are two different vortex shedding mechanism in the mixing of two fluid streams.s.