• Journal of Veterinary Clinics
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• v.20 no.1
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• pp.74-78
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• 2003

We executed this experiment to observe side effects of warfarin, the anticoagulant that is used for preventing thrombus in cardiovascular surgery for calves. The 6 calves(70-130 kg) were used in this experiment regardless of sexes. We administered warfarin at 0.07 mg/kg daily for 25 days. Blood was collected before warfarin administration, every five days for 30 days. PCV, RBC, WBC, fibrinogen, total protein and platelet as blood test, prothrombin time (PT) as blood coagulation test, and AST, SDH, total bilirubin, BUN and creatinine as serum biochemical tests were measured. As the result of the experiment, PT has been gradually increased after warfarin administration. It has been gradually increased and remains within the therapeutic range from the third day to the 28th day. PCV and RBC were decreased significantly from the value before the administration (p < 0.05). In the serum biochemical test, SDH shows significant increase comparing the value before the administration (p < 0.05). AST and total bilirubin were increased gradually from the value before the administration. Considering the result of the experiment, to give wafarin to prevent thrombus in cardiovascular surgery, we can get anticoagulation effect with minimal administration(0.07 mg/kg, PO) from the third day of the administration. However because of the decreased PCV and RBC, it may cause anemia. It may cause damage to liver based on the result of serum biochemical test.

• Women's Health Nursing
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• v.15 no.1
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• pp.24-31
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• 2009

Purpose: This study was to examine the change of stress and nursing needs in preterm labor women after hospitalization. Method: Forty seven women with preterm labor who were admitted in two university hospitals participated in the survey and they were completed the questionnaires on admission day and 5th day after admission. Questionnaires included in modified Antepartum Hospital Stressor Inventory (AHSI) and Nursing Needs for Preterm Labor. The collected data were analyzed by paired t-test and Pearson correlation test. Result: The stress level was not decreased significantly after hospitalization. Among them, the stresses about fetus and medical staff were decreased significantly after hospitalization, but those about pregnant women, husband and environment were increased significantly after hospitalization. The difference in the level of nursing needs between the two different days was not significant except the physical needs. The total level of stress and nursing needs were correlated significantly on the 5th day after hospitalization. Conclusion: These results indicate that stress and nursing needs of preterm labor women undergo changes after hospitalization. Therefore, development of the program being followed by stressors which change from day to day and further studies are required in order to examine the decreasing of the stress.

• The Journal of Korean Academic Society of Nursing Education
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• v.9 no.1
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• pp.94-102
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• 2003

The purpose of this study was to identify the effects of foot-bath on fatigue of nursing students in clinical practice. method: The research design was a nonequivalent control group pretest-posttest design. The subjects were randomly assigned to one of four groups and data collection was conducted from June to August 2001. For the experimental group the foot-bath was performed once a day for 3 days. The instrument was subjective fatigue scale and 150mm graphic rating scale. For four groups pretest was done on first day and posttest was done on third day. The data was analyzed by the t-test and paired t-test. results: The subjective fatigue scale score was not significantly after the foot-bath in day duty but significantly lower after the foot-bath in evening duty. The graphic rating scale score was significantly lower after the foot-bath. The subjective fatigue scale score and graphic rating scale score on 1st, 3rd foot-bath day were significantly lower in experimental group. conclusion: On the basis of the above findings, this study suggests that foot-bath can be an effective fatigue relieving method.

• Biomolecules & Therapeutics
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• v.3 no.1
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• pp.38-46
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• 1995

DA-125, a new anthracycline antitumor antibiotic, was administered at dose levels of 0, 0.04, 0.2 and 1.0 mg/kg/day intravenously to pregnant and subsequently delivered Sprague-Dawley rats from day 17 of gestation to day 21 of lactation. Effects of test agent on general toxicity of dams and growth, behaviour and mating performance of F1 offspring were examined. At 1 mg/kg, one out of the twentytwo dams showed difficult delivery, characterized by a stillbirth. Reduction in body weight, loss in food intake, and decrease in spleen weight were also observed in dams. In addition, the lower rates of successful performances in memory test (28.6%) and necrosis of tail end (9.5%) were seen in F1 offspring. At 0.04 and 0.2 mg/kg, no toxic effect on dams and F1 offspring was observed. There were no malformed Fl and F2 fetuses in all groups. The results indicate that the no effect dose levels(NOELs) of DA-125 are 0.2 mg/kg/day for dams and Fl offspring, and over 1 mg/kg/day for F2 fetuses.

• Environmental Mutagens and Carcinogens
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• v.22 no.2
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• pp.97-105
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• 2002

Nowadays a huge variety of products that aim to assist to quit smoking or reduce addictive symptoms are developed and manufactured with safety evaluation, but the safety of the most recent products of interest which do not contain tobacco and nicotine, and shape cigarettes is not evaluated and guaranteed relatively. This study was carried out to evaluate the single and repeated dose inhalation toxicity and genotoxicity of H menthol (Nicotine free-tobacco free) herbal cigarettes provided by Cigastop Ltd. in ICR mice. In this study, doses which we determined to expose to mice were 40 cigarettes for 6 hours a day to mice in single dose and 20 (high dose), 10 (middle dose) and 5 cigarettes (low dose) a day for 28 days in repeated dose inhalation toxicity, in vivo chromosome aberration test and micronucleus test. The particulate substances from H menthol herbal cigarettes also were gathered and used in the Salmonella typhimurium/microsome assay (Salmonella test; Ames test). We could find neither significant changes between control and treatment groups nor dose-response effects of test material at all except serum Ca level of female middle dose treatment group in repeated dose inhalation toxicity test. In conclusion, H menthol herbal cigarettes, when applied clinically intended dose we used, might not show any toxic and/or mutagenic effect.

• Nuclear Engineering and Technology
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• v.32 no.1
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• pp.10-16
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• 2000

Preliminary experiment was peformed to investigate the leaching characteristics of paraffin waste forms that had been recently generated in large quantities at domestic nuclear power plants. At first, waste simulants whose compositions were different in mixing ratio of paraffin to boric acid were prepared. Their compressive strengths were measured and ninety-day leaching test of specimen including cobalt was carried out according to ANSI/ANS-16.1 test procedure. Water immersion test was also conducted keeping pace with leaching test and the weight change and the compressive strength of specimen were observed after ninety days. The compressive strength of waste form exhibited 666 psi (4.53 MPa) in the case where mixing ratio of boric acid to paraffin was 78/22, which was adopted in concentrate waste drying system of domestic nuclear power plants. The leaching test resulted in about 50% of the cumulative fraction leached for boric acid and cobalt, respectively. The specific gravity of waste form was 0.87 ［g/g］whose value was less than that of water because the weight loss of about 39% occurred after the water immersion test of ninety days. It was also observed that the waste form which had undergone ninety-day water immersion test exhibited the compressive strength of 203 psi (1.38 MPa).

• Korean Journal of Child Studies
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• v.18 no.2
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• pp.5-18
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• 1997

The purpose of the current study was to determine whether preschoolers' attachment relationships with their parents and socioemotional behaviors are related to their day care experiences in infancy and at the present time. The participants consisted of 59 preschoolers and their mothers from 2-parent, white, middle-class dual earner families in Madison, Wisconsin. Preschoolers' attachment quality was measured by two representational instruments: the Separation Anxiety Test and "My Family and Friends". Mothers completed questionnaires about their family background and their children's day care history. The quality of current day care was obtained from directors' reports about regulatable features of the day care centers. Teachers completed the Preschool Behavior Questionnaire. Data was analyzed by hierarchical multiple regression analysis. The results showed that the quality of preschoolers' attachment relationships with parents were significantly related to the amount of day care during infancy, the quality of current care, and children's gender. In addition, the amount of infant day care appeared to have negative relations with children's socioemotional behavior problems as evaluated by teachers.

• Korean Journal of Veterinary Service
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• v.24 no.1
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• pp.21-29
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• 2001

To compare of serum antibody titers using ELISA and HI, serum samples were collected from 100 breeders and their progeny 550 broilers. The breeders and broilers were vaccinated with infectious bronchitis(IB)- and Newcastle disease(ND)-viruses according to general vaccination program. The antibodies in serum samples against IB and ND viruses were detected by enzyme-linked immunosorbent assay(ELISA) using commercial ELISA kit and hemagglutination inhibition(HI) test. Geometric mean titer(GMT) of ELISA and In titers were monitored from 1-day-old to 35-day-old broilers and compared to those of breeder chickens. The antibody titers of breeders vaccinated with ]B virus showed 47,800, ELISA and 7.2, HI, respectively. Progeny chicks, 1-day-old, vaccinated with IBV showed high antibody titers than those of breed chickens. Those chicks were maintained protective antibody levels until 11-day-old. From 14-day-old, the antibody level decreased below protective levels. In ND, breeders serum antibody titers ELISA and Eiu were 30,200 GMT and 8.7 HI titer, respectively. On 1-day-old chicks, antibody levels was decreased to half in ELISA(16,270) compared with those of breeders, but In titers was 7.4. Progeny broilers, protective antibody level was maintained until 14- day-old by ELISA, but at 11-day-old by HI titers. After then, ND antibody titer was continuously decreased underdefense level. These result indicated that the ELISA method be more sensitive than HI titration to detect serum antibody level for IBV and NDV.

• Journal of Pharmacopuncture
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• v.19 no.3
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• pp.231-238
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• 2016

Objectives: This study used repeated intravenous injections of Saeng Maek San (SMS) injection in Sprague-Dawley (SD) rats to assess the toxicity and the stability of SMS. Methods: Six-week-old male and female SD rats reared by Orient bio Inc were chosen for this pilot study. They were randomly split into four groups: Group 1 (G1), the control group (0.3 mL of normal saline solution/day/animal), and Groups 2, 3 and 4 (G2, G3 and G4), the experimental groups (0.1, 0.2 and 0.3 mL/day/animal of SMS), respectively. Each animal received an intravenous injection of SMS once a day for four weeks. Clinical signs, body weight changes, and food consumption were monitored during the observation period, and urinalysis and hematology were conducted after four weeks of SMS or saline administration. Results: No deaths occurred in any of the four groups during the observation period. Compared to the control group, male and female rats in groups 3 and 4 (0.2 and 0.3 mL/animal/day) showed hemoglobinuria, but the low-dosage group (G2, 0.1 mL/animal/day) showed no significant changes in the clinical signs test. No significant changes due to SMS were observed in the experimental groups regarding body weight changes, food consumption urinalysis, or hematology. Conclusion: During this study, no mortalities were observed in any of the experimental groups and no hemoglobinuria was observed in the low dosage group (0.1 mL/animal/day) while it was intermittently observed in groups 3 and 4 (0.2 and 0.3 mL/animal/day). Thus, we suggest that the no-observed adverse-effect level (NOAEL) is 0.1 mL/animal/day in male and female SD rats.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.5
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• pp.49-55
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• 2017

In the seventies, a number of researchers carried out experiments on pullout tests with prototype equipment, and the pullout test was certified as a reliable nondestructive testing(NDT) method for determining the strength of concrete. To estimate the strength of high-strength concrete, we propose a simplified pullout test that uses as a break-off bolt a standard 10mm bolt with a groove on the shaft, an insert nut, and a pullout instrument that includes a hydraulic oil pump without a load cell. To verify the advantages of the simplified pullout test(low cost, simplicity, and convenience), four wall specimens were tested with two levels of concrete strength, 30 MPa and 50 MPa, using a simplified pullout tester with a load cell. The pullout load and concrete compressive strength were measured every day until day 7, day 14, day 21 and day 28. It was found that the pullout load was very similar to the compressive strength. Therefore, we have verified that a simplified pullout test can be used to evaluate the in-place strength of high-strength concrete in structures. The prediction equation of the groove diameter of the break-off bolt(y) with the concrete strength(x) was derived as y=0.05x+3.79, with a coefficient of determination of 0.88 found through regression analysis.