• Toxicological Research
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• 제17권3호
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• pp.203-213
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• 2001

We investigated the toxic effects of propylthiouracil (PTU) In Sprague-Dawley (SD) rats to develop and validate an enhanced Protocol for Test Guideline 407 as OECD Project. Twenty male and female SD rats,7 weeks old, were treated with PTU in corn oil at levels of 0, 0.1, 1 and 10 mg/kg/day for 4 weeks orally. Clinical observation, body weight changes, food uptake, water consumption, urinalysis, estrus cycle and sperm analysis, serum chemist교, autopsy findings and histopathological findings were evaluated in this study. No clinical signs and mortality were observed in the study. The body weights and food uptakes in the group treated with 10 mg/kg/day were reduced from 3 weeks after the initiation of the treatment. The levels of 3,5,3'-triiodothyronine (T3) and thyroxine (T4, 3,5,3',5'-tetraiodothyrosine) were also significantly decreased in the group treated with 10 mg/kg/day. Also, the relative and absolute organ weights of thymuses were decreased. Thyroid glands of rats in the group treated with PTU 10 mg/kg/day were bigger than those of rats in the control group. In the histopathological examination, diffuse hyperplasia and hypertrophy of thyroid follicular cells were observed in all treatment groups, leading to the reduction of lumen size and papillary enfolding of lining epithelium. The degree of lesion was increased in a dose-dependent manner. The results suggested that PTU would cause toxicity in thyroid gland and decrease the levels of T3 and T4 in SD rats. However there were no effects on the other organ including testis and uterus especially in spermatogenesis and estrus cycle. On the basis of the results, enhanced protocol for Test Guideline (TG) 407 may be sensitive and reliable to detect endocrine-active substances like PTU.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.128-128
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• 2002

In association with the international validation project to establish a test protocol for the "Enhanced OECD Test Guideline 407", we performed a 28-day repeated-dose toxicity study of vinclozolin (VCZ), an androgen antagonist, and ketoconazole (KCZ), a biosynthesis inhibitor of testosterone (T), and assessed the sensitivity of new parameters for detecting endocrine-related effects of endocrine-disrupting chemicals.(omitted)

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2002년도 Current Trends in Toxicological Sciences
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• pp.128-128
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• 2002

• 한국산학기술학회논문지
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• 제17권3호
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• pp.509-517
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• 2016

본 연구는 종합병원 간호사를 대상으로 환자안전문화에 대한 인식과 안전간호활동에 미치는 영향을 파악하고 변인을 규명하기 위함이다. D시와 G시에 위치한 종합병원의 간호사 178명을 대상으로 하였다. 자료는2015년 6월 20일부터 7월 30일까지 수집하였으며, Kim 등이 수정 보완 한 환자안전문화에 대한 인식과 Lee가 개발한 안전간호활동을 연구도구로 사용하였다. 수집된 자료는 t-test, One-way ANOVA, Pearson correlation coefficients와 단계적 중다회귀분석하였다. 환자안전문화에 대한 인식은 환자안전간호활동과 양의 상관관계가 있었다(r=.407, p<.001) 본 연구 결과 대상자의 병원 근무 환경은 안전간호활동에 43.3%의 영향력이 있는 것으로 나타났으며, 병원간호사의 안전간호활동에 병원근무환경이 가장 중요한 변인으로 볼수 있다. 안전간호의 질 향상을 위하여 환자안전문화에 대한 인식을 높일 수 있는 구체적인 방안과 안전간호 지침이 필요하다.