• Korean Circulation Journal
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• 제53권12호
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• pp.795-810
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• 2023

Background and Objectives: Myocarditis is a potentially fatal disease, but curative treatments have not yet been established. Myocardial inflammation is an important pathogenesis of this disease, and immunosuppressants such as methylprednisolone and immunoglobulin have been used for treatment; however, the effectiveness needs to be improved. Thalidomide and dipeptidyl peptidase (DPP) 4 inhibitors were recently investigated regarding their immunomodulatory properties. This study aimed to test whether thalidomide or a DPP4 inhibitor (evogliptin) can improve the effectiveness of myocarditis treatment using a rat model of experimental autoimmune myocarditis (EAM). Methods: Rats with or without myocarditis were administered thalidomide at 100 mg/kg/day and DPP4 inhibitor at 10 mg/kg/day orally. Measurement of echocardiography, serum inflammatory cytokines, myocardial histopathological examination, and immunohistochemical staining for leukocytes, macrophages, CD4+ T cells, and cytoskeleton were performed after 3 weeks, and the fibrosis area was measured after 3 and 6 weeks. Results: Thalidomide and DPP4 inhibitor did not reduce the severity of myocarditis compared with the EAM without treatment rats by comparing the echocardiographic data, myocardial CD4⁺, macrophages, neutrophil infiltrations, and the heart weight/body weight ratio in 3 weeks. The levels of inflammatory cytokines were not lower in the thalidomide and DPP4 inhibitor-treated group than in the untreated group in 3 weeks. In 6 weeks, thalidomide and DPP4 inhibitors did not reduce the fibrosis area compared to untreated groups. Conclusions: Although thalidomide and the DPP4 inhibitor had an immunomodulatory effect and are used against inflammatory diseases, they did not ameliorate myocardial inflammation and fibrosis in this rat model of EAM.

• 한국태양에너지학회 논문집
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• 제24권2호
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• pp.51-62
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• 2004

Architects may evaluate building models to see how a building will shadow itself and its neighbors at various times. A heliodon, a tilt-table which is a machine that imitates the rotation and orbit of the Earth, helps architects wanting to analyze patterns of shadow patch, passive solar heating options, site solar panels, or control solar heat gain. The heliodon swivels in three directions for setting latitude, season, and time of day. Using the device, an architect first clamps a model to the tabletop, then turns the table to the coordinates of interest. Usually, the winter and summer solstices receive strong attention, for they represent extreme cases, A more recent installation at a university adds to its heliodon a set of lamps to recreate the illumination level and more accurate patterns of shadow patch. The table holds the building model at various angles to a spotlight, which mounts in the pole. The set of scale model measurement describes the validity of various electric lamps as an artificial sun to approximate the sun's parallel rays, helping designers to distinguish between illuminated areas in and around a building and those regions falling in the shadows.

• 대한건축학회논문집:구조계
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• 제34권7호
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• pp.19-26
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• 2018

This study tested 25 lightweight aggregate concrete (LWAC) mixtures using the expanded bottom ash and dredged soil granules to examine the compressive strength gain of such concrete with different ages. The test parameters investigated were water-to-cement ratios and the natural sand content for the replacement of lightweight fine aggregate. The compressive strength gain rate in the basic equation specified in fib model code was experimentally determined in each mixture and then empirically formulated as a function of the water-to-cement ratio and oven-dried density of concrete. When compared with 28-day compressive strength, the tested LWAC mixtures exhibited relatively low gain ratios (0.49~0.82) at an age of 3 days whereas the gain ratios (1.16~1.41) at 91 days were higher than that (1.05~1.15) of the conventional normal-weight concrete. Thus, the fib model equations tend to overestimate the early strength gain of LWAC but underestimate the long-term strength gain. The proposed equations are in good agreement with the measured compressive strength development of LWAC at different ages, indicating that the mean and standard deviation of the normalized root mean square errors determined in each mixture are 0.101 and 0.053, respectively.

• 자원환경지질
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• 제56권1호
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• pp.65-73
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• 2023

As one of the most vulnerable countries to floods, there should be an increased necessity for accurate and reliable flood forecasting in Indonesia. Therefore, a new prediction model using a machine learning algorithm is proposed to provide daily flood prediction in Indonesia. Data crawling was conducted to obtain daily rainfall, streamflow, land cover, and flood data from 2008 to 2021. The model was built using a Random Forest (RF) algorithm for classification to predict future floods by inputting three days of rainfall rate, forest ratio, and stream flow. The accuracy, specificity, precision, recall, and F1-score on the test dataset using the RF algorithm are approximately 94.93%, 68.24%, 94.34%, 99.97%, and 97.08%, respectively. Moreover, the AUC (Area Under the Curve) of the ROC (Receiver Operating Characteristics) curve results in 71%. The objective of this research is providing a model that predicts flood events accurately in Indonesian regions 3 months prior the day of flood. As a trial, we used the month of June 2022 and the model predicted the flood events accurately. The result of prediction is then published to the website as a warning system as a form of flood mitigation.

• 동의생리병리학회지
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• 제25권2호
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• pp.300-305
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• 2011

The present study was investigated the neuroprotective effects of acupuncture at ST36 on learning and memory deficits after transient cerebral ischemia in a gerbil model. The animals were randomly divided into three groups (n=7 in each group): the sham operation group (SHAM), ischemia-induced and ST36 acupuncture group (ISC + ST36), and the ischemia-induced and Tail-acupuncture group (ISC + TAIL). For the acupuncture stimulation, stainless steel needles, 0.3 mm in diameter, were inserted bilaterally into the ST36 locus or the tail and stimulated for 1 min/day for 14 days. Using the Morris water maze test, the animals were tested on spatial learning and memory. In addition, the effects of acupuncture on memory storage and the choline acetyltransferase (ChAT) activity, in the hippocampal CA1 area, were investigated by ChAT immunohistochemistry. Transient cerebral ischemia produced impaired performance on the MWM test (DAY 5: p<0.01 and retention test: p<0.05) and severely decreased ChAT immunoreactivity in the CA1 hippocampal area compared to the SHAM group (p<0.05). However, improved learning and memory were observed (DAY 5: p<0.05 and retention test: p<0.01) as well as a significantly reduced loss of ChAT immunoactivity in the hippocampal CA1 region (p<0.001) after acupuncture stimulation at ST36 were observed. These results show that acupuncture at ST36 ameliorated the learning and memory deficits at least in part through the cholinergic system. The findings of this study provide potential data that acupuncture is useful for the treatment of some of the behavioral impairs of transient cerebral ischemia.

• Journal of Acupuncture Research
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• 제24권5호
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• pp.137-150
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• 2007

Objectives : To find effects of acupuncture, electro-acupuncture, low level He-Ne laser therapy(LLLT) at $TE_5$, $GB_{41}$ in the neuropathic pain. We made experiment on rats ligated L5 spinal nerve like general herniation of nucleus pulposus(HNP). Methods : A model of neuropathic pain was made by isolating Left 5th lumbar spinal nerve of rats. Three days after the neuropathic surgery, acupuncture and LLLT, electro-acupuncture was injected at $TE_5$, $GB_{41}$ one time a day for a week. Each group was divided two. one is opposite side performed the surgery which is right, another is left side performed the surgery. After that, the author examined the withdrawal response of neuropathic rats' legs by van Frey filament and acetone stimulation. And also the author examined c-Fos, Nociceptin and KOR-3 in the midbrain central gray of neuropathic rats. Results : As we have observed the effect of mechanical allodynia, LT-R group were diminished on 6th day compared with control group, EA-L group, EA-R group and LT-L group were diminished on 7th day compared with control group. As we have observed the effect of cold allodynia, EA-R group were diminished on 6th day, 7th day compared with control group. As we have observed the effect of activity of c-Fos in the central gray part, EA-R group and LT-R group were diminished compared with control group. As we have observed the effect of activity of Nociceptin in the central gray part, EA-R group were a little increased compared with control group but it is not reliability. As we have observed the effect of activity of KOR-3 in the central gray part, EA-R group were significantly increased compared with control group. Conclusions : We have noticed that effect of acupuncture at opposite side of sickness and powerful stimulation could be more effective, because of EA-R group have more controllable effect all test we have done on the other hand EA-L group have only effect on mechanical allodynia. This study can be used in clinical therapy for neuropathic pain. But it is not reliability that Nociceptin have effectively to control pain. Therefore We have to follow up about that.

• 대한가정학회지
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• 제45권2호
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• pp.1-22
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• 2007

The purpose of this study was to investigate the effect of mother's characteristics, mediated by disciplinary methods and young children's emotional regulation, on young children's aggression. Subjects of this study consisted of 342 young children drawn from seven preschools in Cheongju city. The pilot study was used to examine the applicability of survey instrument. Data were analyzed by the method of frequency, percentage, Cronbach' ${\alpha}$, factor analysis, T-test. F-test, and Duncan post-hoc test using SPSSWIN program. The test of model was done with analysis of correlational matrix in LISREL VII package using a maximum likehood estimation. The results of this research were as follows: First, there were statistically significant differences in mother's characteristics consisting of neurosis symptom and extroversions, disciplinary methods consisting of coercive-punishment and indifferent-irresponsibility, young children's emotional regulation, and young children's aggression consisting of relation and overtness according to some socio-demographic variables. Girls had the higher emotional regulation than boys. Second, the direct effects of disciplinary methods and emotional regulation on boys' aggression were different in between relational and overt aggression. Third, the variables predicting boys' emotional regulation directly were the same in both relational and overt aggression. Forth, the direct effect of mother's characteristics on disciplinary methods was different in between coercive-punishment and indifferent-irresponsibility. Fifth, the indirect effects of mother's characteristics, mediated by disciplinary methods and young children's emotional regulation, on young children's aggression were partly supported in this study. Sixth, the theoretical model of the impact of mother's characteristics, disciplinary methods, and young children's emotional regulation on young children's aggression was different according to gender.

• Nutrition Research and Practice
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• 제16권2호
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• pp.173-193
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• 2022

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is one of the most representative neurodegenerative disease mainly caused by the excessive production of amyloid beta (Aβ). Several studies on the antioxidant activity and protective effects of Populus tomentiglandulosa (PT) against cerebral ischemia-induced neuronal damage have been reported. Based on this background, the present study investigated the protective effects of PT against cognitive impairment in AD. MATERIALS/METHODS: We orally administered PT (50 and 100 mg/kg/day) for 14 days in an Aβ_25-35-induced mouse model and conducted behavioral experiments to test cognitive ability. In addition, we evaluated the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and measured the production of lipid peroxide, nitric oxide (NO), and reactive oxygen species (ROS) in tissues. RESULTS: PT treatment improved the space perceptive ability in the T-maze test, object cognitive ability in the novel object recognition test, and spatial learning/long-term memory in the Morris water-maze test. Moreover, the levels of AST and ALT were not significantly different among the groups, indicating that PT did not show liver toxicity. Furthermore, administration of PT significantly inhibited the production of lipid peroxide, NO, and ROS in the brain, liver, and kidney, suggesting that PT protected against oxidative stress. CONCLUSIONS: Our study demonstrated that administration of PT improved Aβ_25-35-induced cognitive impairment by regulating oxidative stress. Therefore, we propose that PT could be used as a natural agent for AD improvement.

• 생물환경조절학회지
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• 제29권3호
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• pp.209-218
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• 2020

ET_c 손실을 보상하는데 필요한 물의 양을 작물 용수 요구량(Crop water requirement, CWR)로 정의되며, ET_c 평가는 작물 필요 요구량을 정확하게 정량화하는 데 필요하며, 물 균형 계산에서 중요한 역할을 한다. 토마토와 파프리카의 실제 관수 요구량(Actual crop water, ACW)이 적절한 CWR인지 평가하였다. 토마토와 파프리카 재배에 적정한 AWC 예측 및 추정을 위하여 온실 내부 환경데이터를 Penman-Monteith을 이용하여 기준 작물 증발산(ET)을 계산한 후, 기준 증발산은 작물 상수(Kc;토마토-1.15, 파프리카-1.05)계수로 조정하였다. 토마토와 파프리카의 CWR과 ACW를 계산하여 비교 평가한 결과 ACW가 CWR을 대체할 수 있지만 파프리카의 ACW는 필요 이상으로 높게 나타났다. 또한, 토마토의 ACW는 1일 100 ~ 1,200 ml이고, 파프리카의 ACW는 1일 100 ~ 500 ml가 적절한 것으로 나타났다. 그러나, 스마트 온실에서 ET_c의 정밀도를 높이려면, ET_c가 CWR로 변환되고 ACW와 비교하기 위해서 클래스 A팬 설정이 필요하다. 향후 실시간으로 CWR을 측정하기 위한 시뮬레이션 프로그램 연구가 필요하다.

• 한국치위생학회지
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• 제15권4호
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• pp.649-659
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• 2015

Objectives: The purpose of the study is to investigate the musculo-skeletal pain prevalence and severity in the dental hygienists based on PRECEDE model. Methods: A self-reported questionnaire was completed by 483 dental hygienists in Gwangju from September 13 to October 12, 2013. Data were analyzed by frequency analysis, chi-square test, t-test, and multiple logistic regression analysis using SPSS 18.0 program. Musculo-skeletal pain severity was classified from 1 to 5 by PRECEDE model. The questionnaire consisted of six questions of the general characteristics of the subjects, one question of musculo-skeletal pain prevalence, one question of body part musculo-skeletal pain prevalence, one question of subjective health status, three questions of activities of daily living, six questions of working environment, one question of musculoskeletal system diseases knowledge, two questions of social support, two questions of education experience and data use method, and five questions of necessity of health education. Results: The prevalence rate of musculo-skeletal pain within a year was 83.9% and 22.8% of the dental hygienists complained of severe pain. The odds ratio of moderate pain severity was 1.99(95% CI, 1.10-3.60) and the odds ratio of unhealthiness was 3.27 (95% CI, 1.35-7.94). The odds ratio of pain severity in those working for 4-6 years was 0.21(95% CI, 0.08-0.57). The odds ratio of pain severity in those practicing 6-10 scaling cases per day was 0.33(95% CI, 0.17-0.65). The odds ratio of pain severity in wrist turning and bending was 3.56(95% CI, 1.19-10.62). Conclusions: The muscolu-skeletal pain severity in the dental hygienists was closely associated with subjective health condition, work duration, the number of scaling practice activity, and a treatment posture. Regular physical checkup for the dental hygienists will improve the musculo-skeletal pain due to scaling practice.