• 한국구조물진단유지관리공학회 논문집
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• 제18권6호
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• pp.82-89
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• 2014

이 연구의 목적은 다양한 혼화재의 치환과 양생온도를 고려한 콘크리트의 압축강도 발현을 평가할 수 있는 단순모델의 제시이다. 이를 위해 ACI 209의 포물선 식을 성숙도 함수를 기반으로 하여 수정하였으며, 압축강도 발현 상수 A, B 그리고 재령 28일 압축강도는 264개의 기존 실험결과들의 회귀분석으로부터 결정하였다. 제시된 모델의 검증을 위하여 혼화재 치환과 양생온도를 변수로 3그룹의 실험을 수행하였다. 콘크리트의 28일 압축강도는 양생온도가 표준양생온도(20도시)보다 높을수록 또는 낮을수록 감소하였다. 초기 재령3일동안 표준온도에서 양생을 한 콘크리트의 압축강도 발현은 그 이후 양생온도 변화에 영향을 거의 받지 않았다. 제안된 모델의 예측값과 실험값의 비의 평균과 표준편차는 각각 1.00와 0.08로서 실험결과와 잘 일치하였다.

• 지역사회간호학회지
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• 제18권4호
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• pp.611-623
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• 2007

Purpose: To evaluate a reducing alcohol intervention program for workers. Method: The intervention program employed one-group pretest-post-test design with repeated measuring by quasi-experimental study. The program was developed from literature review based on the Transtheoretical Model, and evaluated from April 6 to June 22, 2006. Sixteen white collar male workers participated. At the beginning, the subjects were at the pre-contemplation stage (50%) and contemplation stage (50%). The intervention was applied personally or in group twice a week for 9 weeks. Results: The scores of each stage of change in the post-test increased significantly compared with those in the pretest. The scores of process (cognitive and behavioral) of change in the post-test increased significantly compared with those in the pretest. The score of self-efficacy of change in the post-test increased significantly compared with that in the pretest. The score of pros-cons for drinking in the post-test decreased significantly compared with that in the pretest. The consumption of alcohol a week and a day in the post-test decreased significantly compared with that in the pretest. The levels in ALT, AST, GGT, total cholesterol, triglyceride, B.P. and BMI in the post-test did not decrease significantly compared with those in the pretest, but the level of FBS decreased significantly compared with that in the pretest. Conclusion: The above result informs us that a stage-based reducing alcohol intervention program for workers has the effect of increasing the stages of change, the process of change (cognitive and behavioral) and self-efficacy, and decreasing pros-cons for drinking alcohol consumption and FBS, and it also has a value as an effective means of nursing for workers.

• Journal of Korean Neurosurgical Society
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• 제48권5호
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• pp.391-398
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• 2010

Objective : This study was designed to validate the cell trafficking efficiency of the in vivo bioluminescence image (BLI) study in the setting of transplantation of the luciferase expressing bone marrow-derived mesenchymal stem cells (BMSC), which were delivered at each different time after transient middle cerebral artery occlusion (MCAO) in a mouse model. Methods : Transplanting donor BMSC were prepared by primary cell culture from transgenic mouse expressing luciferase (LUC). Transient focal infarcts were induced in 4-6-week-old male nude mice. The experiment mice were divided into five groups by the time of MSC transplantation : 1) sham-operation group, 2) 2-h group, 3) 1-day group, 4) 3-day group, and 5) 1-week group. BLI for detection of spatial distribution of transplanted MSC was performed by detecting emitted photons. Migration of the transplanted cells to the infarcted area was confirmed by histological examinations. Differences between groups were evaluated by paired t-test. Results : A focal spot of bioluminescence was observed at the injection site on the next day after transplantation by Signal intensity of bioluminescence. After 4 weeks, the mean signal intensities of 2-h, 1-day, 3-day, and 1-week group were $2.6{\times}10^7{\pm}7.4{\times}10^6$. $6.1{\times}10^6{\pm}1.2{\times}10^6$, $1.7{\times}10^6{\pm}4.4{\times}10^5$, and $8.9{\times}10^6{\pm}9.5{\times}10^5$, respectively. The 2-h group showed significantly higher signal intensity (p<0.01). The engrafted BMSC showed around the infarct border zones on immunohistochemical examination. The counts of LUC-positive cells revealed the highest number in the 2-h group, in agreement with the results of BLI experiments (p<0.01). Conclusion : In this study, the results suggested that the transplanted BMSC migrated to the infarct border zone in BLI study and the higher signal intensity of LUC-positive cells seen in 2 hrs after MSC transplantation in MCAO mouse model. In addition, noninvasive imaging in real time is an ideal method for tracking stem cell transplantation. This method can be widely applied to various research fields of cell transplantation therapy.

• Journal of Korean Neurosurgical Society
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• 제49권2호
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• pp.83-91
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• 2011

Objective : Minocycline, a second-generation tetracycline-class antibiotic, has been well established to exert a neuroprotective effect in animal models and neurodegenerative disease through the inhibition of microglia. Here, we investigated the effects of minocycline on motor recovery and neuropathic pain in a rat model of spinal cord injury. Methods : To simulate spinal cord injury, the rats' spinal cords were hemisected at the 10th thoracic level (T10). Minocycline was injected intraperitoneally, and was administered 30 minutes prior surgery and every second postoperative day until sacrifice 28 days after surgery. Motor recovery was assessed via the Basso-Beattie-Bresnahan test Mechanical hyperalgesia was measured throughout the 28-day post -operative course via the von Frey test Microglial and astrocyte activation was assessed by immunohistochemical staining for ionized calcium binding adaptor molecule 1 (lba1) and glial fibrillary acidic protein (GFAP) at two sites: at the level of hemisection and at the 5th lumbar level (L5). Results : In rats, spinal cord hemisection reduced locomotor function and induced a mechanical hyperalgesia of the ipsilateral hind limb. The expression of lba1 and GFAP was also increased in the dorsal and ventral horns of the spinal cord at the site of hemisection and at the L5 level. Intraperitoneal injection of minocycline facilitated overall motor recovery and attenuated mechanical hyperalgesia. The expression of lba1 and GFAP in the spinal cord was also reduced in rats treated with minocycline. Conclusion : By inhibiting microglia and astrocyte activation, minocycline may facilitate motor recovery and attenuate mechanical hyperalgesia in individuals with spinal cord injuries.

• Journal of Animal Science and Technology
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• 제55권6호
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• pp.489-500
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• 2013

Daily milk yields on test days were estimated using morning or afternoon partial milk yields collected by official agencies and the accuracy of the estimates was determined. Test-day data for milk yields consisted of 3,156,734 records of AM/PM partial milking measurements of 255,437 milking Holstein cows from 3,708 farms collected from December 2008 to April 2013. A linear regression model (LRM) was applied to estimate daily milk yields using alternate AM/PM milk yield records within lactation stages, milking intervals, and parities on every daily milk yield. The alternate statistical approach was a non-linear hierarchical model (NHM) in which Brody's growth function was implemented by reflecting an animal's physiological milk production cycle. When compared with LRM, daily milk yields predicted by the NHM were assumed to be functionally related to day in milk (or lactation) stage, milking intervals, and partial milk yields. Since the results were in terms of accuracies based on comparisons of different statistical models, accuracies of estimates of daily milk yields by NHM were close to those determined by the LRM. The average of these accuracies was 0.94 for AM partial milk yields and 0.93 for PM partial milk yields for first calving cows. However, the accuracies of AM/PM milk yield estimations from cows under a calving stage higher than the first parity were 0.96 and 0.95, respectively. Correlations between the estimated daily milk yields and the actual daily milk yields ranged from 0.96~0.98. These accuracies were lower for unbalanced AM/PM milking intervals and the first calving cows. Overall, prediction of daily milk yields by NHM would be more appropriate than by LRM due to its flexibility under different milk yield-related circumstances, which provides an idea of the functional relationship between milking intervals and days in milk with daily milk yields from statistical viewpoints.

• 자원환경지질
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• 제26권4호
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• pp.541-549
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• 1993

The main goal of this paper is to determine hydraulic properties and to predict drawdown for the efficient and stable development of groundwater in the Daejong-Chun area, North of Kyungsang-Do. Based on geological survey and analysis of well logging data conducted in 1991, it is found that the type of aquifer of this area is considered to be an anisotropic unconfined aquifer with saturated thickness of 19.8 m. In order to characterize this aquifer pumping test was conducted, and the resulting drawdown data were utilized for the analysis by applying both type curve matching technique and semi-log straight line method. As a result, the average specific yield of this aquifer is estimated as 32.3%, and the average ratio of $K_H$ to $K_V$ is only 2.7, which means that gravitational effect is not significant factor for this type of aquifer. For the validation of the estimated hydraulic properties, the analytical model which was developed with Newton-Raphson iteration procedure in this study, was employed to generate the drawdown. And, the resulting drawdown was compared against actual drawdown data and it shows the excellent matches. The actual drawdown data for 9 hours of pumping were used for history matching purposes and relatively satisfactory matches were achieved in this match. Then, the model was run by using the tuned parameters that are obtained during history matching stage, and the drawdown was predicted for the next 30 years of pumping with $3,000m^3/day$ of constant pumping rate. Its result indicates that the drawdown was stabilized as 1.41 m from 20 days with $3,000m^3/day$ of constant pumping rate, which is the required amount of water to be safely supplied to this area.

• Asian-Australasian Journal of Animal Sciences
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• 제32권3호
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• pp.334-340
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• 2019

Objective: The objective of this study was to investigate the genetic components of daily milk yield and to re-rank bulls in South Korea by estimated breeding value (EBV) under heat stress using the temperature-humidity index (THI). Methods: This study was conducted using 125,312 monthly test-day records, collected from January 2000 to February 2017 for 19,889 Holstein cows from 647 farms in South Korea. Milk production data were collected from two agencies, the Dairy Cattle Genetic Improvement Center and the Korea Animal Improvement Association, and meteorological data were obtained from 41 regional weather stations using the Automated Surface Observing System (ASOS) installed throughout South Korea. A random regression model using the THI was applied to estimate genetic parameters of heat tolerance based on the test-day records. The model included herd-year-season, calving age, and days-in-milk as fixed effects, as well as heat tolerance as an additive genetic effect, permanent environmental effect, and direct additive and permanent environmental effect. Results: Below the THI threshold (${\leq}72$; no heat stress), the variance in heat tolerance was zero. However, the heat tolerance variance began to increase as THI exceeded the threshold. The covariance between the genetic additive effect and the heat tolerance effect was -0.33. Heritability estimates of milk yield ranged from 0.111 to 0.176 (average: 0.128). Heritability decreased slightly as THI increased, and began to increase at a THI of 79. The predicted bull EBV ranking varied with THI. Conclusion: We conclude that genetic evaluation using the THI function could be useful for selecting bulls for heat tolerance in South Korea.

• Journal of Astronomy and Space Sciences
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• 제22권3호
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• pp.273-282
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• 2005

주간에 활용될 수 있는 별 센서의 성능을 알아보기 위해, 주간 별 센서 관측 모델을 개발하였다. 주간 동안 별 센서가 감지하게 될 별들에 대한 중심찾기 오차는 그 모델을 사용해서 계산되었다. 별 센서가 운용되는 주간 환경의 대기 물리량을 계산하기 위해 표준 대기 모델(LOWTRAN7)이 사용되었다. 주간 별 센서 관측 모델에는 별과 태양 사이의 다양한 분리각, 중심찾기 알고리즘, 그리고 별 센서의 다양한 시스템 특성이 고려되었다. 개발된 별 센서 모델은 벡터 관측을 통한 자세결정 성능의 예측에 있어서 보다 현실적인 오차 정보를 제공하게 될 것이다.

• The Journal of Korean Physical Therapy
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• 제15권1호
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• pp.38-60
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• 2003

The purpose of this study was to observe the effects of Far-infrared on mice rheumatoid arthritis induced by type II collagen. The author peformed several experimental tests which were the hematoxylin-eosin tissue stain, the hind paw thickness, and ELSIA of cytokines(TNF-$\alpha$, IL-1$\beta$). On day 14 and 21, FIR-Tx. group decreased in synovial membrane thickness more than control II group FIR-Tx group decreased in hind paw thickness more than control II group. In the ELISA test of TNF-$\alpha$ concentration, control II group significantly increased in the concentration more than normal and FIR-Tx. group on day 7, 14, and 21. In the ELISA test of IL-$\beta$ concentration, FIR-Tx. group decreased in the concentration more than control II group on day 14 and 21. With J's Linear Function Data Process Program, researchers can get the estimated the concentration or the hind paw thickness from this experiment. The estimated results would be a good guide to therapists and researchers, planning Far-infrared application on the rheumatoid arthritis. These results indicated that far-infrared irradiating appeared to reduce the concentration of TNF-$\alpha$ and IL-1$\beta$ at mouse model of autoimmune arthritis. It would be considered that Far-infrared has an effect on relieving rheumatoid arthritis.

• 한국세라믹학회지
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• 제40권10호
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• pp.936-942
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• 2003

In order to develop glass formulations for vitrifying Low-and Intermediate-Level radioactive Wastes (LILW) from nuclear power plants of Korea Hydro & Nuclear Power (KHNP) Co., Ltd., promising glass formulations were selected based on glass property model predictions for viscosity, electrical conductivity and leach resistance. Laboratory measurements were conducted to verify the model predictions. Based on the results, the models for electrical conductivity, US DOE 7-day Product Consistency Test (PCT) elemental release, and pH of PCT leachate are accurate for the LILW glass formulations. However, the model for viscosity was able to provide only qualitative results. A leachate conductivity test was conducted on several samples to estimate glass leach resistance. Test results from the leachate conductivity test were useful for comparison before PCT elemental release results were available. A glass formulation K11A meets all the KHNP glass property constraints, and use of this glass formulation on the pilot scale is recommended. Glass formulations K12A, K12B, and K12E meet nearly all of the processing constraints and may be suitable for additional testing. Based on the comparison between the measured and predicted glass properties, existing glass property models may be used to assist with the LILW glass formulation development.