• Journal of Pharmaceutical Investigation
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• v.34 no.2
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• pp.139-145
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• 2004

The purpose of the present study was to evaluate the bioequivalence of two risperidone tablets, Risperdal (Janssen Korea Co., Ltd.) and Rispen (Myung In Pharm. Co., Ltd), according to the guidelines of Korea Food and Drug Administration (KFDA). The risperidone release from the two risperidone formulations in vitro was tested using KP VIII Apparatus II method with various of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four healthy male subjects, $23.33\;{\pm}2.10$ years in age and $69.24{\pm}8.05\;kg$ kg in body weight, were divided into two groups and a randomized $2\;{\times}\;2$ cross over study was employed. After one tablet containing 2 mg as risperidone was orally administered, blood was taken at predetermined time intervals and the concentrations of risperidone in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t$,$C_{max},\;and\;T_{max}$ were calculated and ANOVA test was utilized for the analysis of the parameters using logarithmically transformed $AUC_t$,$C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the Risperdal were 0.20, -1.29 and -11-09% for $AUC_t$,$C_{max},\;and\;T_{max}$, respectively There were no sequence effects two formulations in parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g.,$log(0.90){\sim}log(1.30)$ and $log(0.84){\sim}log(1.09)$ for$AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Rispen tablet and Risperdal tablet were bioequivalent.

• Journal of Pharmaceutical Investigation
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• v.34 no.2
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• pp.147-153
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• 2004

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tablets, $Amaryl^{\circledR}$ (Handok/Aventis Pharm. Co., Ltd.) and Glimed (Kuhn II Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The glimepiride release from the two glimepiride formulations in vitro was tested using KP VIII Apparatus II method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB 80 into each dissolution medium). Twenty six healthy male subjects, $22.65{\pm}2.19$ years in age and $66.55{\pm}8.85$ kg in body weight, were divided into two groups and a randomized $2\;{\times}\;2$ cross-over study was employed. After one tablet containing 2 mg as glimepiride was orally administered, blood was taken at predetermined time intervals and the concentrations of glimepiride in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the Amaryl were -3.70, -8.28 and 0.61% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., $log(0.84){\sim}log(1.04)$ for $log(0.82){\sim}log(1.03)$ for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Glimed tablet and Amaryl tablet were bioequivalent.

• Journal of Korean Society of Environmental Engineers
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• v.22 no.1
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• pp.141-148
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• 2000

In this study, effects of substrates and nitrate on biological phosphorus release in EBPR(enhanced biological phosphorus removal) process were examined using batch test apparatus at anaerobic conditions. The sludge used in this experiments was taken from SBR(sequencing batch reactor) treating swine wastewater at aeration period. Phosphorus release rates obtained with substrates of FSW(fermented swine wastewater), acetate, propionate, domestic wastewater and methanol were 6.19, 5.99, 1.52, 1.2 and $1.03mgP/gVSS{\cdot}hr$, respectively. Those observed with acetate and FSW were 4~5 times greater than those with propionate, methanol and domestic wastewater. Therefore phosphorus release rates were significantly affected by type of substrate added at anaerobic condition. Phosphorus release was greatly affected by concentration of nitrate in anoxic condition. Comparing to acetate, propionate and FSW, phosphorus release was observed after almost completely depletion of nitrate concentration with methanol and domestic wastewater added as substrate. In the cases supplied with acetate, propionate and FSW, phosphorus release rates were less influenced by a nitrate concentration than those with methanol and domestic wastewater.

• Magazine of the Korean Society of Agricultural Engineers
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• v.28 no.4
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• pp.66-76
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• 1986

This study was attempted to investigate the effects of delayed compaction on the unconfined compressive strengh and dry density of Soil-cement mixtures. Soil-cement construction is a time-consuming procedure. Time-delay is known as a detrimental factor to lower the quality of soil-cement layer. A laboratory test was performed using coarse and fine weathered granite soils. The soils were mixed with 7% cement at optimum moisture content and excess moisture content in part. Socondary additives such as lime, gypsum-plaster, flyash and sugar were tried to counteract the detri-mental effect of delayed compaction. The specimens were compacted by Harvard Miniature Compaction Apparatus at 0,1,2,4,6 hors after mixing. Two kinds of compactive efforts(9 kgf and 18 kgf tamper) were applied. The results were summarized as follows: 1.With the increase of time delay, the decrease rate of dry density of the specimen compacted by 9 kgf tamper was steeper than that of the specimen compacted by 18kgf tamper. In the same manner, soil-B had steeper decreasing rate of dry density than soil-A. 2.Based on the results of delayed compaction tests, the dry density and unconfined compressive sterngth were rapidly decreased in the early 2 hours delay, while those were slowly decreased during the time delay of 2 to 6 hours. 3.The dry density and unconfined compressive strength were increased by addition of 3% excess water to the optimum moisture content during the time delay of 2 to 6 hours. 4.Without time delay in compaction, the dry densities of soil-A were increased by adding secondary additives such as lime, gypsum-plaster, flyash and sugar, on the other hand, those of soil-B were decreased except for the case of sugar. 5.The use of secondary additives like lime, gypsum-plaster, flyash and sugar could reduce the decrease of unconfined compressive strength due to delayed compaction. Among them, lime was the most effective. 6.From the above mentioned results, several recommendations could be suggested in order to compensate for losses of unconfined compressive strenght and densit v due to delayed compaction. They are a) to use coarse-grained granite soil rather than fined-grained one, b) to add about 3% excess compaction moisture content, c) to increase compactive effort to a certain degree, and d) to use secondary additives like line gypsum-plaster, flyash, and sugar in proper quantity depending on the soil types.

• Food Engineering Progress
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• v.13 no.4
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• pp.308-313
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• 2009

This study was conducted to design and fabricate a heat pump that can produce some weather conditions similar to those of the dry season of the rough rice in Korea, and to investigate basic performances of the apparatus. During the drying test, the amount of energy consumption and drying characteristics were measured at four different temperature levels ranging between 20$^{\circ}C$ and 50${^{\circ}C}$. In the psychrometric chart, the freezing capacity and refrigerant circulation ratio of the heat pump were 173 kJ/kg and 49.6 kg/hr, respectively. Therefore, coefficient of performance was 5.5, which was superior to that of refrigerant R-22 (4.0) in standard refrigeration cycle. In addition, the time to reach target drying temperature (30${^{\circ}C}$) and relative humidity (40%) were 6 minutes and 7 minutes, respectively. Temperature differences between the drying temperature and the rice were 1.5${^{\circ}C}$ and 8.5${^{\circ}C}$ at the drying temperatures of 21.9${^{\circ}C}$ and 48.7${^{\circ}C}$, respectively. This result demonstrated that the increased temperature of the rice in the drying section decreased sufficiently in the tempering section. At the drying temperatures of 21.9, 30.7 38.8, and 48.7${^{\circ}C}$, drying rates were 0.29, 0.61, 0.85, and 1.26%/hr, respectively, which were similar to those of commercial dryer. In addition, the amounts of energy consumption were 325, 667, 692, and 776 kJ/kg, respectively. These results showed that this dryer saved up to 86% of energy consumption compared with the commercial dryer, which uses 4,000-5,000 kJ/kg of fossil fuel.

• Geomechanics and Engineering
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• v.24 no.2
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• pp.115-127
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• 2021

This paper investigates the effects of soaking on a lime stabilized high plasticity clay and evaluates the implications for pavement design. In this context, the soil was stabilized by 4%, 6% and 9% hydrated lime. The soil was pulverized in two different gradations so that representative field gradations could be simulated. Both soil pulverization levels passed the relevant field gradation criteria. Curing durations were chosen as 7 days, 28 days and 56 days. Two groups of samples were prepared and were tested in unconfined compression test apparatus to measure the strength and secant modulus at failure values. One of the groups was tested immediately after curing. The other group of samples were first cured and then subjected to soaking for ten days before testing. Visual observations were made on the samples during the soaking period. The results showed the superiority of fine soil pulverization over coarse soil pulverization for unsoaked conditions in terms of strength and modulus values. Soaking of the samples affected the unconfined compressive strength and modulus values based on lime content, curing duration and soil pulverization level. In soaked samples, fine soil pulverization resulted in higher strength and modulus values compared to coarse soil pulverization. However, even with fine soil pulverization, effects of soaking on modulus values were more significant. A new term named as "Soaking Influence Factor (SIF)" was defined to compare the reduction in strength and modulus due to soaking. The data was compared with the relevant design guidelines and an attempt was made to include Soaking Influence Factors for strength and modulus (SIFS and SIFM) into pavement design processes. Two equations which correlated secant modulus at failure to unconfined compressive strength were proposed based on the samples subjected to soaking. The results of this study showed that in order to decrease the diverse effects of soaking for lime stabilized soils, soil pulverization level should be kept as fine as possible in the field. Importance of proper drainage precautions in the pavements is highlighted for better performance of the pavements.

• Journal of Platform Technology
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• v.10 no.4
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• pp.25-38
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• 2022

Recently, it is reported that the Korean Unmanned Aerial Vehicle (UAV) interface protocol (K-4586) based on STANAG-4586 is being developed to secure interoperability between UAVs. The core elements of the K-4586-based Unmanned Aircraft System (UAS) are the Core UAV Control System (CUCS), Vehicle Specific Module (VSM), Data Link Interface (DLI), and C4I systems. In UAS based on K-4586, the DLI function for transmitting and receiving messages to link UAVs is included in VSM and CUCS respectively. The Generator/Analyzer (G/A) tool is an apparatus that is developed for protocol conformance verification for VSM and CUCS, and G/A tools with DLI message transmitting and receiving should be developed separately. Core applications (VSM, CUCS, DLI) and G/A tools based on K-4586 may be developed independently depending on the developers. If the DLI message modules are different for each developer, the scope and results of protocol conformance verification will be dissimilar, and some problems may happen during system integration. In this study, common DLI message module based on the API was designed to provide the DLI message transmitting and receiving function necessary to the development of core applications and the protocol conformance verification tool of based on K-4586. When applying the proposed common DLI message module, it can be expected to shorten the UAS system development period and reduce costs, and ensure conformance of protocol. In this paper, the design and implementation method for the common DLI message module based on API was proposed and the results of functional test was described.

• Journal of the Korean Geotechnical Society
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• v.24 no.5
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• pp.117-127
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• 2008

The volumetric pressure plate extractor (VPPE) was modified for the measurement of shear wave velocity ($V_s$) at various levels of matric suction as well as soil water characteristic curve (SWCC). A non-destructive technique with a pair of bender element (BE) was employed in order to measure the $V_s$ and the corresponding maximum shear modulus ($G_{max}$) of unsaturated soil specimens. Three types of soil were collected from different road construction sites in Korea. For all test soils, the variations in $G_{max}$ with the various levels of water content and matric suction were investigated using the developed apparatus. Compared with the preceding results from the suction-controlled torsional shear (TS) testing system and in-situ seismic tests, the feasibility fur evaluating modulus characteristics of unsaturated compacted soils with the developed VPPE-BE system was assessed. It was confirmed that the newly developed system would be potentially helpful in modeling seasonal variation of modulus.

• Journal of Korean Tunnelling and Underground Space Association
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• v.12 no.4
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• pp.295-306
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• 2010

Contrary to an intact rock, the jointed rock mass shows strain-dependent deformation characteristics (elastic modulus and damping ratio). The maximum elastic modulus of a rock mass can be obtained from an elastic wave-based exploration in a small strain level and applied to seismic analyses. However, the assessment and application of the non-linear characteristics of rock masses in a small to medium strain level ($10^{-4}{\sim}0.5%$) have not been carried out yet. A non-linear dynamic analysis module is newly developed for FLAC3D to simulate strain-dependent shear modulus degradation and damping ratio amplification characteristics. The developed module is verified by analyzing the change of the Ricker wave propagation. Strain-dependent non-linear characteristics are obtained from disks of cored samples using a rock mass dynamic testing apparatus which can evaluate wave propagation characteristics in a jointed rock column. Using the experimental results and the developed non-linear dynamic module, seismic analyses are performed for the intersection of a shaft and an inclined tunnel. The numerical results show that vertical and horizontal displacements of non-linear analyses are larger than those of linear analyses. Also, non-linear analyses induce bigger bending compressive stresses acting on the lining. The bending compressive stress concentrates at the intersection part. The fundamental understanding of a strain-dependent jointed rock mass behavior is achieved in this study and the analytical procedure suggested can be effectively applied to field designs and analyses.

• Journal of the Korean Institute of Gas
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• v.27 no.4
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• pp.62-69
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• 2023

The use of low-grade coal is continuously increasing with the development of combustion technology and cost reduction for coal used in thermal power plants . During combustion, the latent heat of evaporation due to moisture is large, and there is a risk of spontaneous combustion and dust explosion during the process of storing and pulverizing coal. This study compared and evaluated the minimum explosive concentration and explosive strength of four types of coal dust-fine, coal dust-coarse, wood pallet+organic dust, and wood chip with coal powder collected from domestic power plant D. The minimum explosive concentration of coal dust was measured according to JIS Z 8818:2002, and the explosion strength was tested according to ASTM E1226 using a Siwek 20 L Chamber Apparatus. As a result of the minimum explosive concentration test, it was found that coal dust-fine has a risk of dust explosion, and since an explosion occurs at a dust concentration of 130 g/m³ of wood chips, it was found that there is a risk of explosion at the lowest dust concentration. According to the dust explosion class standard, Kst is less than 200 bar m/s, and all samples fall under the explosion class St 1, and the dust has a low risk of explosion.