• Journal of Pharmaceutical Investigation
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• v.31 no.4
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• pp.281-287
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• 2001

Rebamipide is a novel anti-gastric ulcer agent that has been reported to increase the synthesis of mucus, to increase the mucosal concentration of prostaglandin, and to promote rapid ulcer healing. The purpose of the present study was to evaluate the bioequivalence of two rebamipide tablets, $Mucosta^{TM}$ (Otsuka Korea Pharmaceutical Co., Ltd.) and $Rebamide^{TM}$ (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The rebamipide release from the two rebamipide tablets in vitro was tested using KP VII Apparatus II method at pH 6.8 dissolution media. Twenty normal male volunteers, $24.20{\pm}2.26$ years in age and $66.19{\pm}9.41\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 100 mg of rebamipide was orally administered, blood was taken at predetermined time intervals and the concentrations of rebamipide in serum were determined using HPLC method with fluorescence detector. The dissolution profiles of two rebamipide tablets were very similar at pH 6.8 dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t$, $C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t$, $C_{max}\;and\;T_{max}$ between two tablets based on the $Mucosta^{TM}$ were -2.57%, 5.77% and -1.47%, respectively. Minimum detectable differences $({\Delta})$ at ${\alpha}=0.05$ and $1-{\beta}=0.8$ were less than 20% (e.g., 12.62% and 17.63% for $AUC_t,\;and\;C_{max}$, respectively). The powers $(1-{\beta})$ at ${\alpha}=0.05$, ${\Delta}=0.2$ for $AUC_t\;and\;C_{max}$ were above 99.00% and 88.56%, respectively. The 90% confidence intervals were within ${\pm}20%$ (e.g., $-9.96{\sim}4.82$ and $-4.54{\sim}16.09$ for $AUC_t\;and\;C_{max}$, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that $Rebamide^{TM}$ tablet is bioequivalent to $Mucosta^{TM}$ tablet.

• The Journal of Engineering Geology
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• v.22 no.2
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• pp.173-183
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• 2012

The nature of surface deformation of Tono granite was investigated using a confocal laser scanning microscope (CLSM) under water-saturated stress relaxation conditions. A new apparatus was developed for this experiment, enabling continuous measurements of stress-strain and simultaneous observations of surface deformation by CLSM. The amounts of grain contact deformation and intra-granular surface deformation were calculated using a finite element method. The results reveal that intense grain contact deformation and intra-granular surface deformation occurred during the period of stress relaxation, and that the intensity of this deformation increased with increasing applied stress. Finite element method (FEM) results show that the strain of grain boundary was greater than strain of inter-granular surface. Contour maps of these local strains were compiled for individual grains and their boundaries, revealing intense deformation at the boundaries between biotite and quartz under compressional stress. This result was a consequence of the mechano-chemical effect of biotite and quartz minerals. Biotite in granite has a layered structure of iron-magnesium-aluminum silicate sheets that are weakly bonded together by layers of potassium ions. In contrast, quartz occurs as stable spherical grains.

• Journal of the Institute of Convergence Signal Processing
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• v.19 no.2
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• pp.68-76
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• 2018

In this paper, we describe the correlation processing method of multi-polarization observation data of the Daejeon Correlator. VLBI observations include single or multiple polarized observations depending on the type of object. Polarization observations are performed to observe the characteristics of the object. During the observations of the celestial object, polarization measurements are also performed to determine the delay values and causes of changes in the object. Correlation processing of polarization observation data of the Daejeon correlator is proposed by OCTAVIA of a synchronous reproduction processing apparatus that outputs data input to each antenna unit by using an output bit selection function to convert bits and the order of the data streams is changed, And the input of the Daejeon correlator is configured to perform the polarization correlation processing by conducting correlation processing by setting the existing stream number to be the same. Correlation processing is conducted on the test data observed for the polarization correlation processing and it is verified through experiments that the polarization correlation processing method of the proposed Daejeon correlator is effective.

• Korean Journal of Food Science and Technology
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• v.16 no.1
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• pp.83-89
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• 1984

In order to study the feasibility of industrial application of Kimchi juice separation-pasteurization method, a pilot scale Kimchi pasteurizer was designed and fabricated. The apparatus consisted of five sections: Kimchi juice separation-mixing, holding, precooling and cooling sections. Stainless steel pipelengths required for the heat exchanging sections were determined based on an equation, $W{\;}C_p{\;}T{\;}={\;}U(2{\;}RL){\;}T_{1m}$. Overall heat transfer coefficients in preheating, holding, precooling and cooling sections were 875, 1398, 2036, and $288{\;}kcal/m^2h^{\circ}C$ at the flow rate of 4 l/min, respectively, and temperature profiles of each section were in good agreement with those predicted from design criteria. A preliminary test using Chinese radish Kimchi demonstrated that this method can effectively be used in commercial processing of kimchi.

• Journal of the Korean Wood Science and Technology
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• v.22 no.4
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• pp.19-25
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• 1994

The purpose of this study was to determine the technical feasibility of making 3-dimensional thin hardboard panels for overlay substitutes of low grade particleboard and plywood panels. Experimental studies were directed at assembling bench-top apparatus, learning the characteristics of different types of lignocellulosic waste papers, for making thin hardboard with several combinations of them with and without resin addition. The raw materials used are waste corrugated cartons, cereal boxes, and old magazines which contain substantial amount of lignin in it. The experimental results showed that satisfactory thin(0.21~0.16cm) hardboard could be made from the residential mixed waste papers that have selected properties comparable to commercial 0.32cm hardboard. The significant mixing ratio effect of the waste papers was present on the thickness swelling, water absorption, linear expansion, and modulus of elasticity including Taber abrasion tests of the thin hardboard made. The mixing ratio of waste papers and resin in the thin hardboard prominently affected the specific gravity of it, which led to affect modulus of elasticity and those physical properties sensitively. And it was shown that the hardboard containing those physical properties can be used for overlay substitutes of low grade plywood and particleboard panels.

• Journal of Pharmaceutical Investigation
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• v.38 no.6
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• pp.413-419
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• 2008

Carvedilol, is a nonselective $\beta$-blocking agent and it also has vasodilating properties that are attributed mainly to its blocking activity at ${\alpha}_1$-receptors. The purpose of the present study was to evaluate the bioequivalence of two carvedilol tablets, $Dilatrend^{(R)}$ tablet 12.5 mg (Chong Kun Dang Pharmaceutical Co., Ltd.) and Cadilan tablet 12.5 mg (KyungDong Pharmaceutical. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of carvedilol from the two carvedilol formulations in vitro was tested using KP VIII Apparatus II method with pH 4.5 dissolution medium. Thirty two healthy male subjects, $25.00{\pm}3.09$ years in age and $70.71{\pm}11.35\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single tablet containing 12.5 mg as carvedilol was orally administered, blood samples were taken at predetermined time intervals and the concentrations of carvedilol in serum were determined using HPLC with fluorescence detector. The dissolution profiles of two formulations were similar in the tested dissolution medium. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Dilatrend^{(R)}$ tablet 12.5 mg, were 4.66%, 8.33% and -7.45% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., $\log\;0.9823{\sim}\log\;1.1042$ and $\log\;1.0132{\sim}\log\;1.1875$ for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Cadilan tablet 12.5 mg was bioequivalent to $Dilatrend^{(R)}$ tablet 12.5 mg.

• Journal of the Korean Geotechnical Society
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• v.32 no.11
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• pp.73-81
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• 2016

Recently, the construction of onshore waste landfill sites has been studied due to the increase of waste and geosynthetics are widely utilized to enforce and protect waste landfill. Geosynthetics comprises the interface with soil and the seismic behavior and stability mostly depend on the dynamic shear behavior of the geosynthetic-soil interface. Therefore, the understanding of dynamic shear behavior and dynamic relative displacement of the interface is critical. The dynamic shear behavior of the interface is affected by surrounding conditions and loading and shows very complicated response, and, it is difficult to study theoretically. In this study, laboratory test to investigate dynamic relative displacement is performed under chemical condition. Dynamic interface apparatus is utilized and cyclic simple shear tests are conducted under short term (60 days of submerging period) and long term (840 days of submerging period) conditions. Consequently, relative displacement of the interface shows the largest values under acid condition, which means more severe damage of the interface.

• Clean Technology
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• v.13 no.2
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• pp.151-158
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• 2007

An experimental study to investigate the condensing heat transfer characteristics of small diameter horizontal double pipe heat exchangers with R-22 and R-410A was performed. Experimental facility was constructed to calculate and observe HTC(heat transfer coefficients), flow patterns and pressure drop. The main components include a liquid pump, an evaporator, a condenser(test section), a sight-glass, pressure taps and measurement apparatus. Two pipes of different diameters are tested; One 5.35 mm ID 0.5 mm thick, the other 3.36 mm ID 0.7 mm thick. The mass flow rate ranged from 200 to $500\;ks/m^2{\cdot}s$ and heating capacity were form 1.0 to 2.4 kW. The flow patterns of R-22 and R-410A were observed with a high speed camera through the sight-glass. The tests revealed that HTC of R-410A was higher than that of R-22 by maximum 5%. Annular pattern was observed for the most cases but stratified flow was also detected when x<0.2. The pressure drop in 3.36 mm ID pipe was higher than that of 5.35 mm by $30{\sim}50%$. Comparing with previous correlations such as Shah, Fujii and Soliman's, Fujii' showed the best good agreement with my data with a maximum deviation of 40%.

• YAKHAK HOEJI
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• v.47 no.5
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• pp.339-344
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• 2003

Atenolol is a water soluble, ${\beta}_1$ selective adrenoceptor antagonist used in the treatment of angina and hypertension. It is primarily eliminated renally with minimal hepatic metabolism. The purpose of the present study was to evaluate the bioequivalence of Samchundang Atenolol (Samchundang Pharmaceutical Co., Korea.) to Tenolmin(Hyundai Pharmaceutical Ind. Co., Korea). The atenolol release from the two atenolol tablets in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four normal male volunteers, 22.83$\pm$1.99 years in age and 65.82$\pm$7.15 kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 50 mg of atenolol was orally administered, blood was taken at predetermined time intervals and the concentrations of atenolol in serum were determined using HPLC method with fluorescence detector. The dissolution profiles of two atenolol tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AUC_{t}$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_{t}$ and $C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AUC_{t}$, $C_{max}$ and $T_{max}$ between two tablets based on the Tenolmin were 3.74％, 4.38％ and 17.77％, respectively. There were no sequence effects between two tablets in these parameters. The 90％ confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.98)∼log(1.l1) and log(0.95)∼log(1.l5) for $AUC_{t}$ and $C_{max}$ respectively), indicating that Samchundang Atenolol tablet is bioequivalent to Tenolmin tablet.

• Journal of the Korean Geotechnical Society
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• v.19 no.2
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• pp.65-74
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• 2003

Most of land reclamation projects are being implemented along the south and west coastal lines of the Korean Peninsula. The earth structures and in-ground LNG tank, and buildings can be constructed using artificial freezing method on the reclaimed land to control the uplift pressure caused by capillary forces. In this study, upon freezing a saturated soil in a closed-system from the top, a considerable frost heaving pressure was developed. Decomposed granite soils, silty soil, and sandy soil were used in the laboratory freeze test which is sometimes subjected to thermal gradients under closed-systems. A major concern has been the ability to predict the frost heaving pressure over the results of relatively short-term laboratory tests. The frost heaving pressure arising within the soil samples and the temperature of the samples inside were monitored with time elapse. The degree of saturation versus heaving pressure curve is presented for each soil sample and the maximum pressure is closely related to this curve. TDR apparatus was used to measure the volumetric water content by the measurement of unfrozen water contents of frozen soils. Unfrozen water increased in soils containing a high percentage of fine-grained particles. In fine-grained soils with strong attractive farces between soil grains and water molecules, additional water is attracted into the pores leading to further volume changes and ice segregation.