• Archives of Pharmacal Research
• /
• 제13권2호
• /
• pp.180-186
• /
• 1990

A bioequivalence study of ranitidine tablets was conducted according to the Korean Guidine for the Bioequivalence Test using twelve healthy male subjects. The plasma concentration-timecurves of ranitidine from the test and reference tablets showed profound multiple peak phenomenon in each subject as reported earlier. However, the area under the plasma concentration-time curve (AUC) and the maximum ploasma concentration at the first peak ($C_{max1}$) of the two preparations was proven to be equal when analyzed satistically according to the criteria of the guidline;i. e., statistical power (1-$\beta$)was calculated to be over 0.8 under the condition of $\alpha$ = 5% and $\Delta$(minimum detectable difference) = 20%, and the confidence interval of the difference in AUC at 95% confidence level was in the range of $\pm$ 20%, which statisfied the criteria of bioequivalence. Equivalence of the peak concentration of ranitidine at the second peak ($C_{max2}$), and the time to reach the first ($T_{max1}$) and second verify the bioequivalence of $c_{max2}$ , $T_{max1}$ and $T_{max2}$ between the two tablets. However, we conclude that the test and reference tablets are bioequivalent taking the therapeutic characteristics of the ranitidine preparations into consideration.

• 대한수의학회지
• /
• 제23권1호
• /
• pp.123-128
• /
• 1983

This study was conducted to evaluate the modified drug sensitivity test for the shortening of detection time and clinical application. The results obtained were summarized as follows. 1. Inhibitory zone in 6 strains of Staphylococcus and Escherichia coli tested to sensitivity teat were reached at 100% between 2 and 6 hours. 2. The sensitivity test of Staphylococcus A, B and E. coli No. 2, No. 3 to antibacterial ointment drugs were strong positive(+++), but Staphylococcus A. A. and E. coli No. 1 were mild resistant(+). 3. The sensitivity test of Staphylococcus A. B and E. coli No. 2, No. 3 to antibacterial injection drugs in 6 hours after treatment were strong positive(+++), and Staphylococcus A. A. and E. coli No. 1 were moderate positive(++). 4. This modified method was detected 86% degree of sensitive between 7 to 12 hours after treatment. 5. We think this modified method was more practical compare to other methods.

• 한국동물위생학회지
• /
• 제14권2호
• /
• pp.127-133
• /
• 1991

The present study was conducted to investigate the biochemical properties, pathogenicity, antimicrobial test, and serotype of E-coli isolated from slaughtered cattle during the period from March 1991 to May 1991. 1. A total of 12 E-coli isolates were isolated from 132 bile juice of slaughtered cattle. 2. All isolates were resistant to Erythromycin, Cephalothin, Neomycin and Lincomycin while the majority of them were susceptible to Trimethoprimsulfamethoxazol (67%), Chloramphenicol(58％), Gentamicin(58%), Ampicillin(17%), Kanamycin(9%) and Tetracycline (9%). 3. In the test of colicinogenecity and congo-red binding capability, 4(33%) isolates produced colicin, all isolates were congo-red negative. 4. The serotypes of isolated E-coli were identified as 008： K- (2 strain), 015： K- (1 strain), 08： K87： K88ab(1 strain), 0139： Kl2(1 strain), 0147: K89(1 strain), others(6 strains ) were autoagglutination.

• Bulletin of the Korean Chemical Society
• /
• 제34권7호
• /
• pp.2131-2137
• /
• 2013

In this work, the key intermediate, 4-amino-4'-(2-amino-4-anilino-1,3,5-triazine-6-yl)-aminostilbene-2,2'-disulfonic acid, was prepared from 4-(2-amino-4-anilino-1,3,5-triazine-6-yl)amino-4'-nitrostilbene-2,2'-disulfonate by using Tin(II) chloride as the reducing agent. Using this intermediate, nineteen new asymmetrically substituted bistriazinylstilbene fluorescent brightening agents were synthesized. Chemical structures of the obtained compounds 5a-s were analyzed by proton NMR spectrum. The physical properties of the new compounds 5a-s were characterized by fastness test and whiteness measurement test and the obtained data were compared to measurements obtained from CI 86.

• 설비공학논문집
• /
• 제15권2호
• /
• pp.109-115
• /
• 2003

The performance of two vertical-blade eliminators (V1, V2) and two horizontal-blade ones (H1, H2) for absorption chillers were tested in terms of pressure drop and refrigerant entrainment. The test was carried out using a wind tunnel with a cross section of 300 mm$\times$300 mm. The pressure drop of four eliminators tested was found to be in the rage of 1.0~2.7mm $H_2O$ at the face velocity of 2m/s. In the refrigerant entrainment test the vertical-blade eliminators showed much better performance than the horizontal-blade ones. The horizontal-blade eliminators showed satisfactory results at the air velocity of 2m/s but exceeded the limit value at 3 m/s. Since the cooling capacity of a machine is lowered by about 2.5% at the pressure drop of 1 m $H_2O$, more researches are required to reduce the pressure drop in the eliminator.

• 한국정보관리학회:학술대회논문집
• /
• 한국정보관리학회 1995년도 제2회 학술대회 논문집
• /
• pp.37-40
• /
• 1995

본 연구는 자연언어시스템에서 색인어와 탐색어의 특정성에 기인하는 재현율 감소를 극복하기 위한 방법론으로써 탐색어의 확장을 통한 검색효율을 평가하였다. 이를 위하여 우리말 데이터베이스를 대상으로 주제전문가가 자연언어로 작성한 원 질의문 (Q1), 원 질의문에 사용된 탐색어와 데이터베이스내의 색인어간의 유사도를 이용하여 탐색어를 확장한 질의문 (Q2(0.2), Q2(0.3)), 주제전문가인 이용자가 Q1의 의미적인 관계를 고려해서 자연언어로 탐색어를 확장한 질의문 (Q3)을 검색효율면에서 비교하였다. 실험결과, 평균재현율은 Q2(0.2), Q2(0.3), Q3, Q1의 검색의 순이었다. 평균정확율은 Q3, Q2(0.3), Q1, Q2(0.2)검색의 순으로 나타났다.

• 한국경영과학회지
• /
• 제31권1호
• /
• pp.55-71
• /
• 2006

We perform a computational study on 0-1 knapsack problems generated under explicit correlation induction. A total of 2000 100-variable test problems are solved. We use two solution methods: (1) a well known heuristic and (2) a representative branch and bound type algorithm. Two different performance measures are considered: (1) the number of nodes needed to find an optimal solution and (2) the relative error of the heuristic solution. We also examine the effect of different joint probability mass functions (pmfs) for the coefficient values on the performance of the solution procedure.

• 한국표면공학회지
• /
• 제27권4호
• /
• pp.215-222
• /
• 1994

The role dispersoids has been studied in a number of researches as a key point for the high strength application of dispersion strengthened aluminum alloy. The mechanical alloying(MA) process with high mechanical properties of dispersion strengthened MA Al-8Ti-1B alloys were invested in order to evaluate their stress corrosion cracking(SCC) application. SCC properties of the mechanically alloyed Al-8Ti-1B were studied using slow strain rate test(SSRT). In this study Al-8Ti-1B alloy were more susceptible to SCC in solutions of pH=2.01 and 13.2 than pH=6.81 solution. In this study Al-8Ti-1B alloys by MA had more SCC resistance than Al-8Ti alloys or Al 7075-T73 alloys. So Al-8Ti-1B alloys by MA had more resistance in SSRT SCC susceptinility test than any other above alloying metals.

• The Korean Journal of Pain
• /
• 제18권2호
• /
• pp.124-132
• /
• 2005

Background: This study was performed to evaluate the dose-related effects of naloxone on morphine analgesia in the rat formalin test, and observe the correlation of pain behavior and spinal c-fos expression induced by a formalin injection. Methods: Fifty rats were divided into five groups; control, morphine (morphine pre-treated, intra-peritoneal injection of 0.1 mg of morphine 5 min prior to formalin injection), and three naloxone groups, which were divided according to the administered dose-ratio of naloxone to morphine 20 : 1 ($5{\mu}g$), 10 : 1 ($10{\mu}g$), and 1 : 1 ($100{\mu}g$) representing the low-, medium-, and high-dose naloxone groups, respectively, were injected intra-peritoneally 16 min after a formalin. A fifty ul of 5% formalin was injected into the right hind paw. All rats were observed for their pain behavior according to the number of flinches during phases 1 (2-3, 5-6 min) and 2 (1 min per every 5 min from 10 to 61 min). The spinal c-fos expression was quantitatively analyzed at 1 and 2 hours after the formalin injection using a real-time PCR. Results: The morphine pre-treated (morphine and three naloxone) groups during phase 1, and the morphine, low- and medium-dose naloxone groups during phase 2, showed significantly less flinches compared to those of the control (P < 0.05). In the three naloxone groups, the numbers of flinches were transiently reduced following the naloxone injection in the low- and medium-dose groups compared to those of the morphine group (P < 0.05). The duration of the reduced flinches was longer in the medium-dose group (P < 0.05). The high-dose group revealed immediate increases in flinches immediately after the naloxone injection compared to those of the morphine, low- and medium-dose groups (P < 0.05 for each). The spinal c-fos expression showed no significant patterns between the experimental groups. Conclusions: Our data suggest that relatively low-dose naloxone (1/20 to 1/10 dose-ratio of morphine) transiently potentiates morphine analgesia; whereas, high-dose (equal dose-ratio of morphine) reverses the analgesia, and the spinal c-fos expression does not always correlate with pain behavior in the rat formalin test.

• 보건교육건강증진학회지
• /
• 제11권2호
• /
• pp.18-32
• /
• 1994

The purpose of this study was to analyze the effectiveness of injury prevention education on elementary school students. We are selected two elementary school in Tejeon, one was intervention school, the other was control school. Surveys were completed before the begining of the interventions in February in 1994 and again after their completion in July 1994. Intervention group was 284 students in pre-test and 218 students in post-test. And control group was 253 students in pre-test and 208 students in post-test. The results of this study was followed. 1. In the general characteristics of subjects studied, sex, mother education, father education, economic status, number of household, and traffic environment were not significant difference between intervention and control group(p>0.05). 2. The contents of injury prevention education that subjects wished to learn, were not significant difference between intervention and control group(p>0.05). Also the mothods of that were significant difference between intervention and control group in pre-test(p<0.05) but not in post-test(p>0.05). 3. Education in knowledge, attitude and practice of injury prevention was slightly effectiveness. Change in attitude of injury prevention was higher than in knowledge and attitude of that we guess that they require a lot of education in the pedestrian prevention. 4. Reative risk between intervention and control group in injury incidence was 1.53 in hospital-care students, and 1.43 in home-care children. Also relative risk of total injury incidence was 1.38, therefore we knew that injury incidence after education was reduced. 5. In the analysis of injury causes, pedestrain injury was remarkably reduced at hospital-care students in two group. At home-care students, two groups were high proportion in play injury. 6. In the analysis of injury places, intervention group was high proportion at near-the house in pre-test(35.4%) and at school in post-test(36.4%). And control group was high at inside-the house in pre-test(31.5%) and at near-the house in post-test(28.2%).