• Journal of Acupuncture Research
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• v.40 no.4
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• pp.344-350
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• 2023

Background: 4-carvomenthenol[4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol] is a main component of Origanum vulgare L., Zanthoxylum piperitum (L.) DC., and other plants. It has been reported to exhibit anti-inflammatory, antibacterial, and anti-tumor effects. Furthermore, it is necessary to conduct a toxicity test on 4-carvomenthenol to ensure its safety. Methods: This study included 5-week-old Institute of Cancer Research mice that were categorized into 3 treatment groups (12, 25, and 50 mg/kg 4-carvomenthenol dose levels) and a control group (10% dimethyl sulfoxide, 40% polyethylene glycol 300, 5% Tween 80, and 45% normal saline injection of the final volume), with 5 male mice and 5 female mice per group. All groups were observed for clinical symptoms and body weight in a period of 14 days and were subjected to gross necropsy after euthanasia. Results: No deaths were recorded. No test substance-related clinical signs in the female mice of the 12 mg/kg dose group were observed. Abnormal gait was observed in 1 male from day 1 to day 3 in the 12 mg/kg dose group; 1-3 males from day 1 to day 7 and 1-5 females from day 1 to day 15 in the 25 mg/kg dose group; and 2-5 males and 2-5 females from day 1 to day 15 in the 50 mg/kg dose group. No test substance-related effect on the body weight and necropsy findings was observed. Conclusion: The results of this study suggested that the lethal dose of 4-carvomenthenol could be greater than 50 mg/kg. However, further research is needed, especially repeated-dose toxicity studies, to confirm the efficacy and safety of 4-carvomenthenol.

• Korean Journal of Clinical Laboratory Science
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• v.43 no.1
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• pp.26-31
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• 2011

The genotypes of Human Papilloma Virus (HPV) are important in the carcinogenesis of uterine cervical cancer. Diagnosis of uterine cervical cancer screening has been executed using Papanicolau method (Pap) and HPV DNA Chip method. We researched the interrelation of HPV DNA genotypes in single and multiple infections and analyzed the results of Pap and HPV DNA Chip tests at Gunsan Medical Center (GMC). The correlation analysis was surveyed on collected results from 599 patients who have been tested with both Pap and HPV DNA chip tests from November 2004 to May 2010 at GMC. The inconsistency between Pap and HPV DNA Chip tests was 41.1%. The HPV DNA Chip genotype related with high risk cases were type 16 (13.5%), type 52 (10.5%), type 58 (10.1%), and type 18 (3.4%). Those related with low risk cases were type 70 (8.9%), type 6 (1.7%), type 40 (1.2%), type 11 (1.3%), and other types (14.3%). Among the 195 cases of HPV positive status, 161 cases were associated with single infection; 108 (67.1%) cases were related with high risk genotype; 19 (11.8%) cases were low risk genotype; 31 (21.1%) cases were related with other types. 29 cases were associated with double infections; 23 (79.3%) cases were high risks; 5 (17.2%) cases were mixed high and low risks; 1 (3.5%) case was low risk.

• Journal of the Korean Chemical Society
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• v.64 no.6
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• pp.360-370
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• 2020

This study explored the learning environment for promoting conceptual understanding, immersion, and situational interest in small group learning using augmented reality, according to the level of students' self-regulation. 95 ninth-grade students from a coed high school in Seoul participated in this study. Students were divided into a group of four and each group was randomly assigned to three learning environments that provide one marker and one smart device(1-1), two markers and two smart devices(2-2), and four markers and four smart devices(4-4) for a group. Small group learning using augmented reality was conducted for two class periods about the chemical bonding concept from the Integrated Science subject. Two-way ANOVA results revealed that students in the 4-4 learning environment scored significantly higher than those in the 1-1 or 2-2 learning environment in a conception test. Changes in the learning environment have affected students with a low level of self-regulation. In an immersion test, students in the 4-4 learning environment scored significantly higher than those in the 1-1 learning environment, and changes in the learning environment have affected students with a high level of self-regulation. As a result of situational interest test, students in the 4-4 and 2-2 learning environments scored significantly higher than those in the 1-1 learning environment, and changes in the learning environment have affected students with a low and a high level of self-regulation. Based on the results, the educational implications of the learning environment for promoting conceptual understanding, immersion, and situational interest in small group learning using augmented reality are discussed.

• Korean Journal of Veterinary Research
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• v.6 no.1
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• pp.1-9
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• 1966

From thse studies, the methodology of the complement fixation test for hog cholera has been described, and the application of the test for the diagnosis of hog cholera has been suggested.

• Journal of International Academy of Physical Therapy Research
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• v.6 no.2
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• pp.878-883
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• 2015

The purpose of this study compared the ability of feedback breathing training (FBT) and balloon blowing training to enhance the breathing of elderly people. The subjects were randomly and evenly divided into a feedback breathing training group (FBTG) and a balloon blowing training group (BBTG). Each group trained 3 times a week for 4 weeks, with the training suspended during the last 2 weeks. Pulmonary function measurements were obtained before the test and 2, 4 and 6 weeks after the test: forced vital capacity (FVC), forced expiratory volume at one second (FEV1), FEV1/FVC, peak expiratory flow (PEF) and vital capacity (VC). A repeated-measures ANOVA was conducted for the significance test. The FBT resulted in a significant increase in the FVC, FEV1/FVC, PEF, and VC of the elderly smokers after 4 weeks and a significant decrease in the FVC, FEV1/FVC, and PEF after 6 weeks. The BBT resulted in a significant increase in the FVC, FEV1, FEV1/FVC, PEF, and VC of the elderly smokers after 4 weeks and a significant decrease in the FVC, FEV1/FVC, and PEF after 6 weeks. In conclusion, An at home breathing rehabilitation program, in addition to balloon blowing, could increase the breathing performance of elderly people.

• Advances in Traditional Medicine
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• v.7 no.2
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• pp.205-210
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• 2007

The objectives of the study were (1) To evaluate the safety and tolerability of Damtab. (2) To characterize hypoglycemic effect of Damtab, if any. (3) To evaluate insulin sensitivity effect of Damtab, if any. Hypoglycemic effect of Damtab (700 mg and 1,400 mg) were examined. Gliclazide (80 mg) was used as an active control. Placebo was used as control. Breakfast was given, half an hour before dosing whereas lunch, snacks and dinner were given at 6, 10 and 14 h post dose. An oral glucose tolerance test was conducted to calculate the insulin sensitivity index from the values of glucose and insulin during oral glucose tolerance test. Both giclazide 80 mg and Damtab 1,400 mg significantly lowered plasma glucose level up to 6 h. Insulin sensitivity index of Damtab (1,400 mg) was found to be similar to that of placebo. A significant increase in insulin level at 1 h post dose of Damtab (1,400 mg) was observed. Damtab 700 mg shows placebo like effect whereas Damtab 1,400 mg possesses hypoglycemic effect.

• The Korean Journal of Applied Statistics
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• v.27 no.7
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• pp.1163-1170
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• 2014

The concepts and structure of intermittent panel time series data are introduced. We suggest a Wald test statistic for the test of homogeneity for intermittent panel first order autoregressive model and its limit distribution is derived. We consider the fitting the model with pooling data using sample mean at the time point if homogeneity for intermittent panel AR(1) is satisfied. We performed simulations to examine the limit distribution of the homogeneity test statistic for intermittent panel AR(1). In application, we fit the intermittent panel AR(1) for panel Mumps data and investigate the test of homogeneity.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.254-263
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• 2017

This study was conducted to identify the relationship between negative emotion and obesity and provide adequate information to enable effective nursing intervention in elderly. Participants were 216 elderly who had been attending two geriatric welfare facilities in Chungbuk. The data were collected between 14 and 30 August, 2017 with a structured questionnaire and body measurement. The questionnaires were CES-D, RULS, BPS and collected data were analyzed using descriptive statistics, t-tests, ${\chi}^2-test$, Fisher' exact tests, Pearson's correlation, and logistic regression with SPSS/WIN 22.0. The mean BMI of participants was $23.59{\pm}3.48$ and the prevalence of obesity was 31.9%. Significant differences were observed in age (${\chi}^2=8.16$, p=.003), gender (${\chi}^2=9.27$, p=.002), smoking (${\chi}^2=7.78$, p=.004), depression (t=2.54, p=.012) and social isolation (t=2.98, p=.003) between the normal and obesity groups. Depression (OR,1.04; 95% CI, 1.00-1.09) and social isolation (OR, 1.06; 95% CI, 1.02-1.11) was associated with an increased risk obesity. Therefore, it was necessary to measure and quantify the depression and social isolation for weight management among the elderly. Moreover, it is necessary to develop health promotion programs and nursing intervention, including the need for physical, mental, and social relationships.

• Proceedings of the Korea Concrete Institute Conference
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• 1995.10a
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• pp.198-203
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• 1995

The objective of this study is to provide the information on the techniques of manufacturing and experiment in small scale modeling of precast concrete(P.C.)large panel structures. The adopted scale was 1/5th 4types of experiments were performed : material tests for model concrete and model reinforcement, compressive test of horizontal joint, shear test of vertical joint and cyclic static test of 2-story subassemblage structure. Based on the experimental results, the following conclusions are drawn: (1)Model concrete may have in general larger compressive strength than expected. (2) Model reinforcement can show less ductility if the annealing processes were performed without using vaccuum tube. (3) Failure modes of horizontal and vertical joints were almost same for both prototype and model. But the strength of model appears to be higher than required by similitude law. (4)Hysteretic behavior of 1/5 scale subassemblage model can be made quite similar to prototype's if the ductility of model reinforcement and compressive strength of model concrete could be representative of those of prototype.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.1
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• pp.767-780
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• 2021

The purpose of this research is to analyze the effect of financial elements (asset growth, liability growth, equity growth, revenue growth, and profit growth) on stock price performance and to analyze the growth of Corporate Social Responsibility (CSR) costs as a moderating effect. The technique analysis used is regression analysis. Samples in this analysis are manufacturing firms listed on the Indonesian Stock Exchange (IDX) for the period 2014-2018. The use of regression models for hypothesis testing must fulfill several applicable assumptions such as Normality Test, Heteroscedasticity Test, Multicollinearity Test, Autocorrelation Test, Model Fit Test, Determination Coefficient Test, and Hypothesis Test. Data analysis used two research models, namely model 1 and model 2. Model 1 is without the moderating variable, and model 2 is with the moderating variable, that is, CSR cost growth. Based on the result of the regression analysis, it can be inferred that the asset, revenue, and profit growth have a positive impact on stock price results. Liabilities and equity growth do not affect stock price performance. Operating expense growth has a significant effect on price performance. CSR cost growth can moderate the effect of growth in financial statement elements on stock price performance but is not significant.