• Bulletin of the Korean Chemical Society
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• v.16 no.9
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• pp.864-869
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• 1995

Investigation of the structures of the gangliosides has proven to be very important in the understanding of their biological roles such as regulation of differentiation and growth of cells. We used nuclear magnetic resonance spectros-copy in order to investigate the structure of GA1. In order to do this, the assignment of spectra is a prerequisite. Since GA1 does not have polar sialic acid, the spectral overlap is severe. In order to solve this problem, we use 2D NMR spectroscopy and heteronuclear 1H/13C correlated spectroscopy in this study. Here, we report the complete assignment of the proton and the carbon spectra of the GA1 in DMSO-d6-D20 (98:2, v/v). These assignments will be useful for interpreting 1H and 13C NMR data from uncharacterized oligosaccharides and for determining the linkage position, the number of sugar rings, and the sequence of new ganglioside. Amide proton in ring Ⅲ shows many interring nOes and has intramolecular hydrogen bonding. This appears to be an important factor in tertiary folding of GA1. Based on this assignment, determination of three dimensional structure of GA1 will be carried out. Studies on the conformational properties of GA1 may lead to a better understanding of the molecular basis of its functions.

• Korean Medical Education Review
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• v.21 no.2
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• pp.80-91
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• 2019

The tripartite mission of 'academic medicine' is education, research, and patient care. Academic medical centers (AMCs) are carrying out the mission and ultimately aiming to improve the health of people and communities. Globally, AMCs are facing a tremendous financial risk stemming from the changes in health insurance reimbursement plans and a shortage of human resources. Innovative AMCs in the United States are trying to transform their physician-centered, and siloed structure into a patient-centered, and integrated structure. They are also building integrated systems with primary healthcare groups to provide continuous patient care from primary to tertiary levels and making strategic networks based on value-based payment and the patient-centered model. These changes have been proven to improve outcomes of patient care and increase fiscal revenues, which are both crucial in supporting education and research. To address the shortage of human resources, programs are being built to develop newly appointed faculty for the future. AMCs have different approaches to bringing changes into their organizations; however, there is a common emphasis on 'a patient-centered approach,' which helps them set more explicit organizational values and make strategic decisions based on their values. Korean AMCs are facing similar challenges to AMCs in the United States in spite of many differences between the countries' healthcare systems. The innovative efforts of AMCs in the United States to address the challenges will be helpful, well-worked examples for Korean AMCs with similar challenges.

• Economic and Environmental Geology
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• v.19 no.spc
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• pp.43-52
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• 1986

Kaolin-pyrophyllite are locally abundant in the three hydrothermal areas at Yangsan-Tongnae area, Hadong-Sancheong area and Haenam area, deposits are originally composed of acidic volcanic rocks and anorthositic rocks in Hadong-Sancheong area. The clay deposits are formed in the near shallow depths environment through acid hydrothermal alteration. Hadong-Sancheong halloysite deposits are formed by alteration of anorthosite. These differences are mainly on the various country rocks, geological structure and properties of hydrothermal solutions. Country rock is mostly underlain by rhyolitic tuffaceous and anorthositic rocks and a large number of clay deposits were formed during volcanic activity through upper Cretaceous-lower Tertiary. Intrusive rocks is broadly distributed in this area and clay deposits are variable in shapelayer and funnel typed. Zonal pattern of mineral assemblage is as follows, Yangsan-Tongnae deposits-kaolinite, pyrophyllite, dumortierite, andalusite and sericite, Hadong-Sancheong-mostly halloysite, and Haenam-dickite, pyrophyllite, alunite and diaspore. The difference in the zonal pattern of altered rock is considered to depend on differences in the initial acidity of related hydrothermal solution, initial acidity was controlled by the oxygen fugacity.

• Journal of Korean Academy of Nursing
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• v.27 no.1
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• pp.189-201
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• 1997

This study was designed to test the relationship between effectiveness of nursing organizations and structural and managerial variables of nursing organizations that are described in the Robbins Organizational theory model. The data were collected through self reported questionnaires from 605 nurses working in, and 782 patients hospitalized in, five tertiary hospitals in Seoul. Results showed that according to MANOVA there was a significant difference in nurses job satisfaction and patient satisfaction among the five hospitals. According to cluster analysis of the structural and managerial variables of nursing organizations, the five hospitals were divided into two clusters and there was no significant difference in nurses job satisfaction or patient satisfaction between the two clusters. According to canonical correlation analysis the formalization and centralization of structural variables were shown to be predicting variables for nurses job satisfaction, and the managing job design and managing Change of managerial variables were shown to be predicting variables for nurses job satisfaction.

• 한국신재생에너지학회:학술대회논문집
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• 2005.06a
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• pp.674-677
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• 2005

The characteristics of geothermal resources in Korea was roughly estimated using hot springs, 580 geothermal gradients and 338 heat flow data. In the aspect of hot springs with geologic structure, location of hot springs coincide with fault zone, especially younger age of Cretaceous to Tertiary. In the aspect of geothermal gradients, Pohang area shows the highest geothermal gradient anomaly, which is covered with unconsol idated rock of low thermal conductivity preserving the residual heat from igneous activity or radioactivity elements decay. In the aspect of heat flow density, high anomaly can be found along the zone connecting Uljin-Pohang-Busan on the southeastern part of Korean peninsula at which big fault zone as Yangsan fault is well developed.

• Journal of the Korean Magnetic Resonance Society
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• v.18 no.1
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• pp.5-9
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• 2014

In last three decades, RNA molecules have been revealed to play the central roles in many cellular processes. Structural understanding of RNA molecules is essential to interpret their functions, and many biophysical techniques have been adopted for this purpose. NMR spectroscopy is a powerful tool to study structures and dynamics of RNA molecules, and it has been further applied to study tertiary interactions between RNA molecules, RNA-protein, and RNA-small molecules. This short article accounts for the general methods for NMR sample preparations, and also partially covers the resonance assignments of structured RNA molecules.

• Proceedings of the Korean Information Science Society Conference
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• 2002.10e
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• pp.373-375
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• 2002

단백질의 3차 구조를 보여주는 다양한 뷰어가 존재한다. 본 논문에서PDB(Protein Data Bank) 파일을 분석하여 단백질의 3차 구조를 보여주는 PDB 한글 뷰어단백질의 기능은 3차 구조(tertiary structure)에 의해 결정된다는 것이 밝혀짐으로써 단백질의 3차 구조에 대한 연구가 보다 활발하게 진행되고 있다. 단백질의 기능을 효과적으로 파악하기 위해서는 단백질의 3차 구조를 보여주는 도구가 필수적이며, 현재 단백질의 3차원 구조정보를 바탕으로 에 대해 기술한다. PDB 한글 뷰어는 기존 뷰어의 스테레오뷰(stereo view) 기능을 보완하여한 단백질의 2가지 구조를 동시에 보여주는 기능을 제공한다. 또한, 아미노산 원자들에 대한 분석 기능과 PDB 데이터의 이해를 돕는 도움말을 제공함으로써 효과적으로 단백질의 3차구조를 파악할 수 있다.

• Journal of the Korean Magnetic Resonance Society
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• v.13 no.1
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• pp.56-63
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• 2009

SWIRM domain, a core domain of SRG3 is well conserved in SW13, RSC8, and MOIRA family proteins. To understand structural basis for cellular functions of the SWIRM domain, we have initiated biochemical and structural studies on SWIRM domain and mutants using gelfiltration chromatography, circular dichroism and NMR spectroscopy. The structural properties of the mutant SWIRM domains (K34A and M75A) have been characterized, showing that the structures of both wild-type and mutant proteins are a-helical conformation. The data conclude that mutations at interaction sites of its binding partner protein do not affect its secondary and tertiary structure.

• Journal of the Korean Magnetic Resonance Society
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• v.14 no.2
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• pp.127-133
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• 2010

Redox-dependent conformational change of human 8-kDa Dynein light chain (LC8) plays important role in regulating NF-${\kappa}B$ signaling pathway. In this study we characterized the structural states of the oxidized and reduced forms of LC8 by using NMR spectroscopy. The $^1H-^{15}N$ 2D HSQC spectra of oxidized LC8 indicated that no significant change in tertiary structure of LC8 occurred upon oxidation. The chemical shift perturbations of LC8 upon oxidation suggest a redox-dependent quaternary structural change.

• The Journal of the Petrological Society of Korea
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• v.3 no.2
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• pp.128-137
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• 1994

The northeastern shore of the Anmyondo consists mainly of tuff, basalt, andesite and dacite. The K-Ar ages of the two mugearites are $89.4{\pm}2.4$ Ma and $91.9{\pm}2.3$ Ma which correspond to the middle Cretaceous age. Petrochemical reviews on the volanic rocks of the Cretaceous, Tertiary and Quaternary ages in the Korean Peninsula show that marked differences exist in chemical compositions according to the age of eruption.