• Biomolecules & Therapeutics
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• 제25권3호
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• pp.249-258
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• 2017

To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidance task, ameliorated alternation behavior in the Y-maze, and increased exploration time in the Morris water maze task, indicating the improvement of cognitive behaviors against cholinergic dysfunction. The biflorin-induced reverse of latency in the scopolamine-treated group was attenuated by MK-801, an NMDA receptor antagonist. Biflorin also enhanced cognitive function in a naïve mouse model. To understand the mechanism of biflorin for memory amelioration, we performed Western blot. Biflorin increased the activation of protein kinase C-${\zeta}$ and its downstream signaling molecules in the hippocampus. These results suggest that biflorin ameliorates drug-induced memory impairment by modulation of protein kinase C-${\zeta}$ signaling in mice, implying that biflorin could function as a possible therapeutic agent for the treatment of cognitive problems.

• 한국환경보건학회지
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• 제37권2호
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• pp.102-112
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• 2011

Objectives: The purpose of this study is to analyze the effects of chronic exposure by welders to manganese (Mn) through an analysis of the degree of brain activity in different activities such as cognition and motor activities using the neuroimaging technique of functional magnetic resonance imaging (fMRI). The neurotoxic effect that Mn has on the brain was examined as well as changes in the neuro-network in motor areas, and the usefulness of fMRI was evaluated as a tool to determine changes in brain function from occupational exposure to Mn. Methods: A survey was carried out from July 2010 to October 2010 targeting by means of a questionnaire 160 workers from the shipbuilding and other manufacturing industries. Among them, 14 welders with more than ten years of job-related exposure to Mn were recruited on a voluntary basis as an exposure group, and 13 workers from other manufacturing industries with corresponding gender and age were recruited as a control group. A questionnaire survey, a blood test, and an fMRI test were carried out with the study group as target. Results: Of 27 fMRI targets, blood Mn concentration of the exposure group was significantly higher than that of the control group (p<0.001), and Pallidal Index (PI) of the welder group was also significantly higher than that of the control group (p<0.001). As a result of the survey, the score of the exposure group in self-awareness of abnormal nerve symptoms and abnormal musculoskeletal symptoms was higher than those of the control group, and there was a significant difference between the two groups (p<0.05, respectively). In the correlation between PI and the results of blood tests, the correlation coefficient with blood Mn concentration was 0.893, revealing a significant amount of correlation (p<0.001). As for brain activity area within the control group, the right and the left areas of the superior frontal cortex showed significant activity, and the right area of superior parietal cortex, the left area of occipital cortex and cerebellum showed significant activity. Unlike the control group, the exposure group showed significant activity selectively on the right area of premotor cortex, at the center of supplementary motor area, and on the left side of superior temporal cortex. In the comparison of brain activity areas between the two groups, the exposure group showed a significantly higher activation state than did the control group in such areas as the right and the left superior parietal cortex, superior temporal cortex, and cerebellum including superior frontal cortex and the right area of premotor cortex. However, in nowhere did the control group show a more activated area than did the exposure group. Conclusions: Chronic exposure to Mn increased brain activity during implementation of hand motor tasks. In an identical task, activation increased in the premotor cortex, superior temporal cortex, and supplementary motor area. It was also discovered that brain activity increase in the frontal area and occipital area was more pronounced in the exposure group than in the control group. This result suggests that chronic exposure to Mn in the work environment affects brain activation neuro-networks.

• Physical Therapy Rehabilitation Science
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• 제7권3호
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• pp.114-118
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• 2018

Objective: The left and right sides of the brain has different roles. This study investigated the differences in cognitive driving ability between stroke survivors with damage to the left brain and right brain. Therefore, the purpose of this study was to compare the driving cognitive ability of left and right hemispheric drivers following stroke. Design: Cross-sectional study. Methods: The Stroke Drivers' Screening Assessment (SDSA) from the UK was translated to the Korean Stroke Drivers' Screening Assessment (K-SDSA) to meet the specific traffic environments of Korea. The SDSA is composed of 4 tasks :1) a dot cancellation task that measures concentration and visuospatial abilities necessary for driving, 2) a directional matrix task to measure spatio-temporal executive function required for driving, 3) a compass matrix task to measure accurate direction determination ability required for driving, and 4) recognition of traffic signs and reasoning ability to understanding traffic situation. The SDSA assessment time is about 30 minutes. The K-SDSA was used to compare the cognitive driving abilities between 15 stroke survivors with left and 15 stroke survivors with right brain damage. Results: There were significant differences between the persons with stroke patients with left brain lesions (right hemiplegia) compared to the persons with stroke with right brain lesions (left hemiplegia) (p<0.05). It was found that the cognitive driving ability of those with right brain damage was lower than that of the group of left brain damage. Conclusions: This research investigated the driving cognitive ability of persons with stroke. The therapists can use this information as basis for the driving test and training purposes. It could also be used as a basis to understanding if the cognitive ability of not only stroke survivors but also those with brain damage is adequate to actually drive.

• 한국치위생학회지
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• 제16권2호
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• pp.241-248
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• 2016

Objectives: The purpose of the study is to evaluate the dental website usability in Korea. The dental website included dental university hospital, network dental hospital and dental office. Methods: The study was carried out by three age groups including twenties, thirties, and forties. Each group consisted of ten customers and evaluated twelve websites of dental hospitals. Each was assigned to four hospitals and three tasks including easiness of online reservation, preventive information, and treatment information. They filled out the self-administered questionnaire. The questionnaire included the easiness of on-line reservation, satisfaction on the quality and quantity of preventive informations, satisfaction on the quality and quantity of treatment informations, predictiveness on the sub-menu, usefulness of site map, information on the main page of web site, usefulness of decision on visit to dentistry, and revisit intention. Results: The easiness of on-line reservation was the highest in the private dental office, and university dental hospital and network dental hospitals followed in conducting task(1). The anticipated value and measurement on the usefulness of web site were the lowest in network dental hospitals and the time interval between two values was 57 seconds. This discrepancy showed the largest difference. The satisfaction on treatment information in task(3) was higher than that of the satisfaction on preventive information in task (2). The revisit intention was the highest in dental university hospitals. Conclusions: This study showed the comparison in usefulness of web site of university dental hospitals, network dental hospitals and private dental office. The web site focused on the treatment information rather than preventive information. This study suggested that the most important function of dental web site would be the preventive information that was mainly operated by the role of dental hygienists rather than treatment information in the future.

• 한국응용과학기술학회지
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• 제37권3호
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• pp.409-417
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• 2020

본 연구는 서로 다른 운동유형이 당뇨처치 그룹의 베타 아밀로이드, BDNF 및 인지기능에 미치는 영향을 알아보기 위하여 24마리의 C57BL/6 쥐를 당뇨처치를 하지 않은 그룹 6마리(통제그룹: 6)와 당뇨처치 그룹 18마리로 무작위 할당하여, 이를 다시 당뇨처치 그룹의 경우 통제그룹 6마리, 유산소 운동그룹 6마리, 저항운동 그룹 6마리로 나누었고 운동그룹은 8주간 주 5회 저강도로 각각 트레드밀 운동과 사다리 운동을 실시하였다. 그 결과 베타아밀로이드는 8주 후 당뇨처치 그룹의 통제그룹(DM.G.)이 나머지 세 그룹에 비하여 높은 수준을 나타내었으나 통계적으로 유의한 차이는 나타나지 않았다. BDNF의 경우는 당뇨통제그룹이 나머지 세 그룹에 비하여 낮은 수준을 나타냈으며 통계적으로 유의한 차이를 나타냈다(p<.05). 인지기능을 알아보기 위한 Y-미로 검사에서도 당뇨통제 그룹이 나머지 세그룹에 비하여 낮은 수준을 보였으며 통계적으로도 유의한 차이를 나타냈다(p<.05).

• 한국통신학회논문지
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• 제28권12B호
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• pp.1081-1090
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• 2003

차세대 인터넷은 QoS(Quality of Service)의 보장과 초고속 전송을 특징으로 하는데 그 대표적인 구조가 DiffServ(Differentiated Service)와 MPLS(Multi-Protocol Label Switching)이다. 차세대 인터넷에서 종단간 QoS를 보장하기 위해서 DiffServ와 MPLS를 연동하기 위한 기술에 관한 연구가 필수적이고, 현재 이에 관한 연구가 활발하게 진행되고 있다. IETF(Internet Engineering Task Force)의 MPLS WG(Working Group)에서는 이를 위하여 E-LSP(EXP inferred-PSC LSPs)와 L-LSP(Label-Only-Inferred-PSC LSPs) 방안을 제안했는데, 두 가지 방법 모두 MPLS에서 DiffServ의 서비스 클래스를 지원하는데 문제점을 가지고 있다. 본 논문에서는 기존의 E-LPS를 확장하여 DiffServ의 이론적인 모든 클래스와 ECN(Explicit Congestion Notification)을 비롯한 실험적인 기능을 지원하는 확장 E-LSP를 제안한다. 제안된 확장 E-LSP를 이용한 MPLS망에서 보다 세분화된 DiffServ 클래스를 지원할 경우 서비스 품질을 시뮬레이션을 통하여 검증하였다.

• 한국전문물리치료학회지
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• 제14권3호
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• pp.48-56
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• 2007

Environmental Enrichment (EE) alone is not capable of enhancing the fine digit and the forelimb functions. Therefore, we applied modified constraint-induced movement therapy (mCIMT) under the influence of EE to assess its effect on promoting improved forelimb sensorimotor functions. Focal ischemic brain injury was produced in Sprague-Dawley rats (60 rats, $250{\pm}50$ g) through middle cerebral artery occlusion (MCAO). Before MCAO induction, all rats were trained in modified limb placing tests and reaching tasks for 1 week. Then they were randomly divided into three groups: Group I: application of standard environment (SE) after MCAO induction (n=20), Group II: application of EE after MCAO induction (n=20), Group III: MCAO+EE, mCIMT and task-oriented training that was initiated at 10th day after MCAO induction (n=20). We also applied mCIMT (between 9 AM and 5 PM/daily) which included restraining the forelimb ipsilateral to the lesion using the 'Jones & Schallert' method. We assessed the change of modified limb placing, single pellet reaching test and the immunoreactivity of BDNF by immunohistochemistry (pre, 1st, 5th, 10th and 20th day). Group I showed no improved outcome, whereas group II and III significantly improved on the use of the forelimb and the immunoreactivity. The qualitative analysis of the skilled reaching test, of group III showed the greatest improvement in the fine digit and the forelimb function. These results suggest that EE combined with mCIMT is more functional in promoting enhanced fine digit and forelimb functional movements.

• 감성과학
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• 제22권4호
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• pp.31-44
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• 2019

본 연구의 목적은 노화에 따른 작업기억능력의 저하에 영향을 받는 자막인식위치에 대해 탐구하는 것이다. 이를 위해, 본 연구에는 주니어 집단(평균 나이: 26세, 표준편차: 3.06, N=27)과 시니어 집단(평균 나이: 61.69세, 표준편차: 4.18, N=26)이 참여했으며, 실험 과제로는 실험 참가자들의 작업기억능력을 측정하기 위한 N-back 과제와 자막인식위치를 측정하기 위한 동영상자막확인 과제가 사용되었다. N-back 과제 수행 결과, 시니어 집단이 주니어 집단보다 과제에 대한 반응속도가 느리고 정답률이 낮게 나타나, 시니어 집단은 주니어 집단에 비해 작업기억능력의 저하가 나타났다는 것을 의미했다. 또한, 동영상자막확인 과제 수행 결과, 노화에 따른 작업기억능력의 저하에 부정적인 영향을 받는 자막위치는 화면의 '좌측-아래'이고 긍정적인 영향을 받는 자막위치는 화면의 '좌측-가운데'으로 나타났다. 나머지 화면 위치에서는 노화에 따른 작업기억능력의 저하에 영향을 받지 않았다. 결과적으로 본 연구 결과를 통해서 연령의 증가에 따른 작업기억능력의 저하에 부정적 혹은 긍정적 영향을 받는 영상 속 자막인식위치에 대해서 살펴볼 수 있었으며, 이는 영상에 자막을 제시해야할 경우 시청자의 연령을 고려하여 자막위치를 선정하면 효율적으로 시청자에게 정보를 제공할 수 있다는 것을 의미했다.

• 한국멀티미디어학회논문지
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• 제10권12호
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• pp.1726-1732
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• 2007

The rapid proliferation of wireless networks and mobile computing applications has changed the landscape of network security. Anomaly detection is a pattern recognition task whose goal is to report the occurrence of abnormal or unknown behavior in a given system being monitored. This paper presents an efficient rough set based anomaly detection method that can effectively identify a group of especially harmful internal attackers - masqueraders in cellular mobile networks. Our scheme uses the trace data of wireless application layer by a user as feature value. Based on this, the used pattern of a mobile's user can be captured by rough sets, and the abnormal behavior of the mobile can be also detected effectively by applying a roughness membership function with the age of the user profile. The performance of the proposed scheme is evaluated by using a simulation. Simulation results demonstrate that the anomalies are well detected by the proposed scheme that considers the age of user profiles.

• Journal of information and communication convergence engineering
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• 제6권2호
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• pp.228-232
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• 2008

In recent years, wireless ad hoc networks have become increasingly popular in both military and civilian applications due to their capability of building networks without the need for a pre-existing infrastructure. Recently, IEEE 802.11 Task Group e has been working on a new mechanism, the Enhanced Distributed Coordination Function (EDCF), to enhance the performance of 802.11 DCF. However, EDCF only reduces the internal collisions within a station, and external collisions between stations remain high in ad-hoc networks. In this paper, we propose to adopt an adaptive backoff window control technique, based on a dynamic value of the initial value of the range in which the backoff is chosen, so the backoff timer is randomly chosen in the range (InitRng, CW-1). We use ns-2 simulation to evaluate the throughput of our scheme. Results show that the throughput is improved for our scheme compared to the original DCF due to the reduced the number of collisions.