• Journal of IKEEE
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• v.26 no.3
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• pp.475-482
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• 2022

Signal pre-processing and post-processing are some areas of study around electrical resistance tomography due to the low spatial resolution of pixel-based reconstructed images. In addition, methods that improve integrity and noise reduction are candidates for application in ERT. Lately, formulations of image processing methods provide new implementations and studies to improve the response against noise. For example, compact variational mode decomposition has recently shown good performance in image decomposition and segmentation. The results from this first approach of C-VMD to ERT show an improvement due to image segmentation, providing filtering of noise in the background and location of the target.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.77.2-77.2
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• 2019

Measurements of supermassive black hole (SMBH) masses are crucial in studying the co-evolution of SMBHs and their host galaxies. Although reverberation mapping is the most accurate method known to date, this requires spectroscopic monitoring over long periods. Thus, the current sample barely reaches three digits. The virial method, on the other hand, uses emission-line and continuum properties from a single spectrum to estimate the SMBH mass; hence the name single-epoch method. The Sloan Digital Sky Survey (SDSS) has observed spectra of almost all quasi-stellar objects (QSOs) discovered so far. Building on previous studies, using the single-epoch method, we estimate the SMBH masses of more than 500,000 QSOs from the SDSS DR14 Quasar Catalog. This increases the mass-estimated SMBH sample almost by a factor of two, and especially more for the low-mass regime, which was the main target of SDSS-IV (eBOSS).

• IMMUNE NETWORK
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• v.20 no.6
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• pp.47.1-47.13
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• 2020

Tetracyclines, which have long been used as broad-spectrum antibiotics, also exhibit a variety of nonantibiotic activities including anti-inflammatory and immunomodulatory properties. Tetracyclines bind to the 30S ribosome of the bacteria and inhibit protein synthesis. Unlike antimicrobial activity, the primary molecular target for the nonantibiotic activity of tetracycline remains to be clarified. Nonetheless, the therapeutic efficacies of tetracyclines, particularly minocycline and doxycycline, have been demonstrated in various animal models of autoimmune disorders, such as multiple sclerosis, rheumatoid arthritis, and asthma. In this study, we summarized the anti-inflammatory and immunomodulatory activities of tetracyclines, focusing on the mechanisms underlying these activities. In addition, we highlighted the on-going or completed clinical trials with reported outcomes.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.10
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• pp.1077-1083
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• 2009

To reject the Doppler frequency spectrum dispersion of clutter caused by high-speed antenna rotation of MTI radar system due to terrain characteristics, signal processing parameters(MTI filter constant, M/N detector ration, K-factor and offset of CFAR) are adjusted for the optimal elimination of the ground clutter. For this investigation, logging equipment is designed and utilized for the collection of classified ground clutter data. Test case is devised through Matlab simulation for the classified analysis and optimization of clutter rejection. Then indoor radar test and outside test in accordance with terrain characteristics are repeatedly performed for the verification of the test. This whole process is through the evolutional development model and repeated for the optimization. Final result is that ground-clutter rejection capability is 5.6 times(7.5 dB) better than that of existing radar system.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.9
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• pp.1840-1846
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• 2011

It is necessary to estimate the Doppler spectrum for each range cell for the extraction of useful information from the return echoes in radar systems used for the remote sensing purpose such as detection of moving targets and weather surveillance. The signal amplitude in the beat frequency band is the important parameter in the detection and tracking of targets. However, strong clutter echoes do exist in most radar operation environments and the system phase noise spreads both the clutter and signal echoes of the target. In this paper, the effects of this system phase noise are analyzed concerning the clutter and the signal beat spectrum. It is shown that the separation capability of adjacent beat signal depends on the degree of spread in the clutter and beat signal caused by the radar system phase noise

• Journal of Microbiology and Biotechnology
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• v.17 no.7
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• pp.1079-1082
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• 2007

Chromosome microdissection and the reverse FISH technique is one of the most useful methods for the identification of structurally abnormal chromosomes. In particular, the laser microbeam microdissection (LMM) method allows rapid isolation of a target chromosome or a specific region of chromosomes without damage of genetic materials and contamination. Isolated chromosomes were directly amplified by the degenerate oligonucleotide-primed polymerase chain reaction (DOP-PCR), and then the FISH probes labeled with spectrum green- or spectrum red-dUTP were generated by nick-translation. Whole chromosome painting (WCP) probes were successfully generated from only 5 copies of the chromosome. With this method, we produced 24 WCP probes for each human chromosome. We also tried to characterize a marker chromosome, which seemed to be originated from chromosome 11 on conventional banding technique. The marker chromosomes were isolated by the LMM method and analyzed by reverse FISH. We elucidated that the marker chromosome was originated from the short arm of chromosome 5 ($5p11{\to}pter$). A fully automated and computer-controlled LMM method is a very simple laboratory procedure, and enables rapid and precise characterization of various chromosome abnormalities.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.3003-3007
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• 2015

Objective: To explore the application of multiplex nested methylated specific polymerase chain reaction (PCR) in the early diagnosis of epithelial ovarian carcinoma (EOC). Materials and Methods: Serum and fresh tissue samples were collected from 114 EOC patients. RUNX3, TFPI2 and OPCML served as target genes. Methylation levels of tissues were assessed by multiplex nested methylated specific PCR, the results being compared with those for carcinoma antigen 125 (CA125). Results: The serum free deoxyribose nucleic acid (DNA) methylation spectrum of EOC patients was completely contained in the DNA spectrum of cancer tissues, providing an accurate reflection of tumor DNA methylation conditions. Serum levels of CA125 and free DNA methylation in the EOC group were evidently higher than those in benign lesion and control groups (p<0.05). Patients with early EOC had markedly lower serum CA125 than those with advanced EOC (p<0.05), but there was no significant difference in free DNA methylation (p>0.05). The sensitivity, specificity and positive predicative value (PPV) of multiplex nested methylated specific PCR were significantly higher for detection of all patients and those with early EOC than those for CA125 (p<0.05). In the detection of patients with advanced EOC, the PPV of CA125 detection was obviously lower than that of multiplex nested methylated specific PCR (p>0.05), but there was no significant difference in sensitivity (p>0.05). Conclusions: Serum free DNA methylation can be used as a biological marker for EOC and multiplex nested methylated specific PCR should be considered for early diagnosis since it can accurately determine tumor methylation conditions.

• Journal of the Earthquake Engineering Society of Korea
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• v.5 no.6
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• pp.47-54
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• 2001

Unbond brace hysteretic dampers are generally used to prevent or decrease structural damage in building structures subjected to strong earthquake by its energy dissipating hysteretic behavior. In the study, a straightforward design procedure for unbond brace hysteretic dampers was developed. The required amount of equivalent damping to satisfy given performance acceptance criteria was obtained conveniently based on the capacity spectrum method without carrying out time-consuming nonlinear dynamic time history analysis. Then the size of the unbond braces is determined from the required equivalent damping. Parametric study has been performed for the design variables such as natural period, yield strength, the stiffness after the first yield stress of the unbond brace. The procedure was applied to 5-story and 10-story steel frames for verification of the proposed method. According to the earthquake time history analysis results, the maximum displacement of the model structure with unbond braces supplied in accordance with the proposed method corresponds well with the given target displacement.

• Journal of the Korean Society of Radiology
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• v.5 no.6
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• pp.421-426
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• 2011

This research was accomplished to assess dose effects on image quality at computed radiography (CR). The ultimate target of the research was finding optimized exposure that provides necessary image quality for the clinical chest diagnosis. Modulation transfer function (MTF), normalized noise power spectrum (NNPS), and Noise equivalent quanta (NEQ) corresponding to the different doses were measured for the assessment of image quality. The preparation of "edge test device" used in MTF measurement and experimental geometry setup were followed by the recommendations of International Electrotechnical Commission (IEC). The experimental results show the necessary image quality can be achieved even at a half of the automatic exposure control (AEC) setting dose for chest diagnosis. It means that the patient exposure can be reduced dramatically by using optimized dose.

• Earthquakes and Structures
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• v.13 no.3
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• pp.267-277
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• 2017

Base-isolation is now being adopted as a retrofitting strategy to improve seismic behaviour of reinforced concrete (r.c.) framed structures subjected to far-fault earthquakes. However, the increase in deformability of a base-isolated framed building may lead to amplification in the structural response under the long-duration horizontal pulses of high-magnitude near-fault earthquakes, which can become critical once the strength level of a fire-weakened r.c. superstructure is reduced. The aim of the present work is to investigate the nonlinear seismic response of fire-damaged r.c. framed structures retrofitted by base-isolation. For this purpose, a five-storey r.c. framed building primarily designed (as fixed-base) in compliance with a former Italian seismic code for a medium-risk zone, is to be retrofitted by the insertion of elastomeric bearings to meet the requirements of the current Italian code in a high-risk seismic zone. The nonlinear seismic response of the original (fixed-base) and retrofitted (base-isolated) test structures in a no fire situation are compared with those in the event of fire in the superstructure, where parametric temperature-time curves are defined at the first level, the first two and the upper levels. A lumped plasticity model describes the inelastic behaviour of the fire-damaged r.c. frame members, while a nonlinear force-displacement law is adopted for the elastomeric bearings. The average root-mean-square deviation of the observed spectrum from the target design spectrum together with a suitable intensity measure are chosen to select and scale near- and far-fault earthquakes on the basis of the design hypotheses adopted.