• Journal of Sasang Constitutional Medicine
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• v.17 no.2
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• pp.74-84
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• 2005

1. Objectives The purpose of this study is to find out effects of Choeongsimyeonja-tang and Taeumjowi-tang on the against decline of physical function as aging. 2. Methods In Wistar rat 10, 30, 50 week and 40 week Choeongsimyeonja-tang & Taeumjowi-tang between 10 weeks form condition change of weight, change of intestine weight, hematology, blood chemistry, research result about serum content following conclusion get. 3. Results and Conclusions 1. Observed gain in weight than control group form of Cheongsimyeonja-tang & Taeumjowi-tang to aged Wistar rat. 2. Is thought to promote activation of living body action gaining intestine weight along with gain in weight. 3. Displayed decrease of MDA's content of serum than control group form of Cheongsimyeonja-tang & Taeumjowi-tang to aged Wistar rat. 4. Change that is Wistar rat's hematological value by aging according to 10, 30, 50 week WBC, RBC, Hgb, monocyces, eosinophil ere. increase, and HCT, PLT ere. showed tendency that decrease accorcling to old-week, and observed improvement that is hematological value than control group form of Cheongsimyeonja-tang & Taeumjowi-tang.5. Change that is Wistar rat's biochemical value by aging was measured highest in 50 week because ALT, AST, BUN, CRN, T-bili., T-chol., TG, TP, ALB, A/G. P ete. increase according to 10, 30, 50 week, and observed improvement that is biochemical value than control group form of Cheongsimyeonja-tang & Taeumjowi-tang. Is considered by being effect that Cheongsimyeonja-tang & Taeumjowi-tang living body function decline by aging by this result.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.4
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• pp.848-852
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• 2009

Taeumjowi-tang is originated in Donguisusebowon edited by Lee Je-Ma. The objective of this study was to investigate the subacute toxicity of Taeumjowi-tang in rats. Several doses(0, 125, 250, 500, 1,000, and 2,000 mg/kg) of Taeumjowi-tang were administered to rats for 4 weeks. The mortality, clinical signs, body weights and gross findings were examined for experimental period. No dead animals were found during the experimental period. In addition, any differences were not found between control and treated groups in clinical signs, hematology, serum biochemistry, and other findings. In conclusion, the no observed adverse effect level(NOAEL) for Taeumjowi-tang was over 2,000 mg/kg/day in rats.

• Journal of Society of Preventive Korean Medicine
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• v.16 no.3
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• pp.129-137
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• 2012

Objective : Herb-drug interactions have become an important issue because of the consumption of herbal remedies has increased in the world. Yangguksanhaw-tang (Liang ge san huo-tang) and Taeumjowi-tang (Tai yin tiao wei-tang) are typical herbal formulas on Sasang constitution medicine (four-constitution medicine). This study was aimed at evaluating the effects of Yangguksanhaw-tang and Taeumjowi-tang on drug metabolizing enzymes, cytochrome P450 (CYP450) isozymes. Methods : Vivid$^{(R)}$ CYP450 Screening Kits were used to measure of CYP3A4, CYP2C19, CYP2D6 and CYP2E1 activities. This method is based on the use of fluorescent CYP450 substrates that are efficiently metabolized by specific CYP450 isozymes to yield a product with altered fluorescent properties. The percent inhibitions of CYP450s by herbal formulas were calculated. Results : Yangguksanhaw-tang inhibited CYP2C19 and CYP2E1 activities higher than that other CYP450 isozymes. The $IC_{50}$ values of CYP2C19 and CYP2E1 were 159.83 ${\mu}g/mL$ and 261.40 ${\mu}g/mL$, respectively. The CYP2E1 activity was inhibited ($IC_{50}=215.17{\mu}g/mL$) higher than that other CYP450 isozymes by Taeumjowi-tang. Conclusions : These results suggest that Yangguksanhaw-tang may inhibit the metabolism of co-administered drugs whose primary route of metabolism is via CYP2C19 or CYP2E1. Taeumjowi-tang could inhibit the metabolism of co-administered drugs, which are substrates for CYP2E1. Therefore, co-administration of the herbal formulas and other conventional drugs should be undertaken with care.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1439-1443
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• 2008

The objective of this study was to evaluate the acute toxicity of Taeumjowi-tang in rats. SPF Sprague-Dawley male and female rats were administered orally with Taeumjowi-tang extract of 2,500 mg/kg(low dosage group), and 5,000 mg/kg(high dosage group). We daily examined number of deaths, clinical signs, body weights and gross findings for 14 days. No dead animal and no significant changes of body weights were found during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, hematology, serum biochemistry, and other findings. In conclusion, Taeumjowi-tang extract did not show any toxic effects, and oral LD50 value was over 5,000 mg/kg in SD rats.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.2
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• pp.481-486
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• 2008

Hiccup is one of common symptoms clinically and caused by various etiologies. We have tried researching the effect of herbal medicines(Taeumjowi-tang) to treat a Taeumin patient with severe hiccup, who is presumed cerebral vascular disease, and evaluated hiccup's a time in a minute and hiccup's total time in a day. The symptoms, not only the patient's hiccup, also his general condition including the dysphagia and right side hemiparesisis, are improved considerably. The constitutional treatment with Taeumin herbal medicines(Taeumjowi-tang) may have an effect on the management of hiccup by control of Qi and Fluid Metabolism.

• Journal of Sasang Constitutional Medicine
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• v.27 no.2
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• pp.254-269
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• 2015

Objectives This study aimed to observe the effect of Taeumjowi-tang on the cisplatin-induced gastrointestinal dysfunctions in rats. Methods Four groups, each of 8 rats per group, were used in this study. Saline and distilled water treated control rats were intact vehicle control group. Delayed gastrointestinal motility was induced by intraperitoneal treatment of cisplatin 2mg/kg, once a week for 5 weeks(Cisplatin control group). Taeumjowi-tang aqueous extracts(TJ) were orally administered in a volume of 5ml/kg, once a day for 14 days from 4th cisplatin treatment(TJ group). Ondansetron 1mg/kg was subcutaneously treated, in a volume of 1ml/kg, as same as TJ(ondansetron group). We measured the body weights, intestinal charcoal transit ratio, fecal parameters, fundus MDA(malondialdehyde), GSH(glutathione) contents and SOD(superoxide dismutase), CAT(catalase) activities, TPH(tryptophanhydroxylase) and MAO(monoamine oxidase) activities, pyloric gastrin and serotonin contents with their immunoreactive cells, colonic serotonin-immunoreactive cells, the histopathology of pylorus, fundus mucosa and colon. Results 1) The body weight gains, the small intestinal charcoal transfer rates, the fecal parameters(numbers, weights and water contents) were increased in TJ, ondansetron group. 2) The inhibit of fundus antioxidant defense systems by cisplatin were decreased in TJ, ondansetron group. 3) The pyloric TPH activities were increased and the pyloric MAO activities were decreased in TJ group. 4) The pyloric gastric contents and the gastrin-immunoreactive cells were increased and the pyloric serotonin contents and the pyloric and colonic serotonin-immunoreactive cells were decreased in TJ group. 5) The pylorus atrophic changes and the gastric surface erosive damage regions by cisplatin were favorably inhibited by treatment of TJ group. Conclusions The results obtained in this study suggest that TJ favorably retarded the cisplatin related GI(gastrointestinal) dysfunctions and constipation through modulations of GI enterochromaffin cells, serotonin and gastrin-producing cells and antioxidative systems.

• Journal of Sasang Constitutional Medicine
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• v.19 no.1
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• pp.193-202
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• 2007

1. Objectives These cases are to report that Taeumin patients suffering from positional vertigo treated by Constitutional medications. 2. Methods These patients were treated by Taeumin's Constitutional medications and acupuncture treatment according to the result of Sasang Constitutional diagnosis. We used Visual analogue scale(VAS) for the assessment of vertigo. 3. Results & Conclusions Three patients have been suffering from Positional Vertigo were treated by Taeumin's Constitutional medications(especially Taeumjowi-tang and Jowisungcheng-tang) and showed positive responses about their problems.

• Journal of Sasang Constitutional Medicine
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• v.16 no.3
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• pp.124-128
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• 2004

1. Objectives The purpose of this study was to investigate the effects of administration of Taeumjowi-tang on the Taeumin bronchiectasis 2. Methods Consulting her Cheyungkisang(體形氣像) and QSCC, we had diagnosed her as Taeumin and treated her with Taeumjowi-tang(太陰調胃湯). 3. Results After the treatment, she felt her symptoms, cough, sputum, dyspnea, dizziness, general weakness, flushing sign, improved. 4. Conclusions We have concluded that these effects must be useful in the clinical study of the Sasang constitutional treatment on Bronchiectasis.

• Journal of Sasang Constitutional Medicine
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• v.29 no.2
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• pp.116-127
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• 2017

Objectives The purpose of this study was to survey changes in symptoms caused by Sasang medicines. Methods We recruited 45 subjects who were classified 15 typical Soeumin, Soyangin, Taeumin and did a survey about symptoms. We split Soeumin into 3 groups and prescribed medicines Palmulgunja-tang, Yanggyuksanhwa-tang, Taeumjowi-tang. We did same process in Soyangin and Taeumin. After taking medicines for 4 weeks, we did a survey about physical changes. Results There was no consistent changes in symptoms. But medicines which were not suitable to their Sasang constitution induced known reactions. And medicines which were suitable to their Sasang constitution induced reactions. Conclusions Changes in symptoms appeared after taking medicine, but they can be induced by medicine.

• Journal of Sasang Constitutional Medicine
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• v.19 no.3
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• pp.270-276
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• 2007

1. Objectives We introduced a case of postoperation stomach cancer patient with metastasis to peritoneum and colon who suffered from repetitive diarrhea and abdominal pain. 2. Methods Stomach cancet is the most common cancer in Korea. Eventhough the 5-year survival rate of stomach cancer is increasing recently, metastasized stomach cancer does not show good prognosis, especially when the surgical operation is not applicable. After partial resection of stomach, most of patients experienced gastrointestinal disorders like dyspepsia, reduced meal size, abdominal discomfort, loose stool, and constipation. 3. Results and Conclusions Taeumjowi-tang, a Sasang Constitutional Medicine, improved the diarrhea and abdominal pain.