• The Korean Journal of Malacology
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• v.26 no.2
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• pp.151-156
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• 2010

For industrialization of the hard clams, Meretrix petechiails (Lamarck), spawning was induced per spawning induction technique in the artificial maturation group administered of parent maturation control and the natural maturation group of which parents were transported for artificial spawning per time period. Then, fertilization rates, hatching rates and D-shaped larva development rates were investigated. In addition, growth and survival rates of larvae were investigated per larva breeding technique. The results of spawning induction by exposure in the artificial maturation group indicated that response rates were relatively higher at 23% and 32% respectively at the 4th hour and the 8th hour of exposure. In terms of water temperature increase, responses began only when the temperature reached $28^{\circ}C$ or higher. In the experiment group administered with both exposure and water temperature increase techniques, response rate was found to be 45% or higher at the 4th hour of exposure and the temperature of $28^{\circ}C$. At the temperatures of 29, 30 and $31^{\circ}C$, significant differences were not observed. Therefore, it was indicated that the response rates of parent hard clams were higher toward water temperature increase than exposure time. As for spawning induction per time period of the transported parent group, response rate and D-shaped larva development rate were the highest at 67.6% and 96% respectively on August 6, 2009. In terms of water temperatures during larva breeding experiment, growth was faster as water temperature was higher. In addition, growth and survival rates were relatively higher at the salinity of 25. In terms of stocking density, growth and survival rates were relatively higher at 5 inds./mL.

• Journal of Ginseng Research
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• v.35 no.2
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• pp.209-218
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• 2011

Ginseng has been used as a general tonic agent to invigorate the human body as an adaptogenic agent. In a previous report, we have shown that ginseng contains a novel glycolipoprotein called gintonin. The main function of gintonin is to transiently enhance intracellular free $Ca^{2+}$ $[Ca^{2+}]_i$ levels in animal cells. The previous method for gintonin isolation included multiple steps using organic solvents. In the present report, we developed a simple method for the preparation of crude gintonin from ginseng root as well as stem and leaf, which produced a higher yield of gintonin than the previous one. The yield of gintonin was 0.20%, 0.29%, and 0.81% from ginseng root, stem, and leaf, respectively. The apparent molecular weight of gintonin isolated from stem and leaf through sodium dodecyl sulfate polyacrylamide gel electrophoresis was almost same as that from root but the compositions of amino acids, carbohydrates or lipids differed slightly between them. We also examined the effects of crude gintonin from ginseng root, stem, and leaf on endogenous $Ca^{2+}$-activated $Cl^-$ channel (CaCC) activity of Xenopus oocytes through mobilization of $[Ca^{2+}]_i$. We found that the order of potency for the activation of CaCC was ginseng root > stem > leaf. The $ED_{50}$ was $1.4{\pm}1.4$, $4.5{\pm}5.9$, and $3.9{\pm}1.1$ mg/mL for root, stem and leaf, respectively. In the present study, we demonstrated for the first time that in addition to ginseng root, ginseng stem and leaf also contain gintonin. Gintonin can be prepared from a simple method with higher yield of gintonin from ginseng root, stem, and leaf. Finally, these results demonstrate the possibility that ginseng stem and leaf could also be utilized for ginstonin preparation after a simple procedure, rather than being discarded.

• Journal of Ginseng Research
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• v.35 no.2
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• pp.191-199
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• 2011

The human ether-a-go-go-related gene (HERG) cardiac $K^+$ channels are one of the representative pharmacological targets for development of drugs against cardiovascular diseases such as arrhythmia. Panax ginseng has been known to exhibit cardioprotective effects. In a previous report we demonstrated that ginsenoside $Rg_3$ regulates HERG $K^+$ channels by decelerating deactivation. However, little is known about how ginsenoside metabolites regulate HERG $K^+$ channel activity. In the present study, we examined the effects of ginsenoside metabolites such as compound K (CK), protopanaxadiol (PPD), and protopanaxatriol (PPT) on HERG $K^+$ channel activity by expressing human a subunits in Xenopus oocytes. CK induced a large persistent deactivatingtail current ($I_{deactivating-tail}$) and significantly decelerated deactivating current decay in a concentration-dependent manner. The $EC_{50}$ for persistent $I_{deactivating-tail}$ was $16.6{\pm}1.3$ ${\mu}M$. In contrast to CK, PPT accelerated deactivating-tail current deactivation. PPD itself had no effects on deactivating-tail currents, whereas PPD inhibited ginsenoside $Rg_3$-induced persistent $I_{deactivating-tail}$ and accelerated HERG $K^+$ channel deactivation in a concentration-dependent manner. These results indicate that ginsenoside metabolites exhibit differential regulation on Ideactivating-tail of HERG $K^+$ channel.

• Journal of Sasang Constitutional Medicine
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• v.10 no.2
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• pp.111-150
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• 1998

1. Background and Purpose: I intended to understand the medical and pharmacological theory of Taeumin, through a study of the process through which Lee Je-ma discovered the Interior-Overheated-Disease of Taeumin and created the prescriptions for it. 2. Methods: I studied and analized the change in the medical and pharmacological theory, through a historical study on the quotations and prescriptions of "DongYi Soose Bowon". 3. Results: Through a literature study I could find that in the existing Oriental Medicine before Lee Je-ma, the difference of the Liver Febrile Disease of Taeumin and the Stomach Febrile Disease of Soyangin were recognized, and the prescriptions of the two diseases were a little distinguished, but the medical theories of those were not distinguished at all. And I found that the Liver Febrile Disease of Taeumin shows the pain in the eyes and the throat, and drying of the nose due to interior dry and heat, so it is different from the Stomach Febrile Disease of Soyangin that shows irritation of fever, headache, and the trouble in passing feces and urine. Also I could know that Radix Puerariae, Rhizoma Cimicifugae, Rhizoma Ligustici, Radix Angelicae Dahuricae, and Radix et Rhizoma Rhei are Taeumin's medicines because these medicines had been used for Taeumin's syndromes, and that Radix Scutellariae, Radix Platycodi, Semen Raphani, and Fructus Gleditsiae are Tae-Eum-In's medicines because these medicines are known as acting for lung.

• Food Science and Preservation
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• v.17 no.6
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• pp.826-834
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• 2010

We investigated the temperature changes during processing and quality characteristics of seven preparations of Byeok-hyang-ju described in ancient documents. During fermentation, treatments with intervals longer than 7 days to the second mashing kept temperatures below room temperature. The process with the shortest interval (2 days) between the second and third mashings maintained a preparation temperature above $28^{\circ}C$ for the longest period. As fermentation proceeded, the pH gradually decreased. Titratable acidities increased prior to the second mashing, and then decreased. Amino acid levels increased gradually during all fermentations except for that of method 5 (the lowest level of raw material addition). Ethanol content increased rapidly to the time of second mashing with all methods except method 2. This method featured a short interval between the first and second mashing. Upon sensory evaluation, the best overall acceptability was provided by method 3.

• Journal of the Korean Geographical Society
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• v.28 no.2
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• pp.163-178
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• 1993

The purpose of this paper is to provide a better understanding of the unprecedented reform movement of geographic education in the United States since 1980 and extract some implications from this movement for geographic education in Korea. For the purpose, the history to this movement was reviewed through following three stages. In the first stage(1980~1984: form :HSGP" to :"Guideline"), the voluntary improvement movement appeared at California and the orgni-zational movement began in 1982 such as the Committee on Geography and International Knowledge. The national educational refrom imperatives, presented at "A Nation at Risk", and "Back to Basics" movement provided good opportunities to resurrect geography as a basic subject. For next real resurrection movement, the very important document "Guidelines for Geographic Education" was published at 1984. In the second stage(1985~1989: from "Guide-lines" to "Public"), the "Guideline" gave power-full motives and foci for reconstructiong the contents of geography, especially by the five fundamental themes(Location, Place, Relation-ships within Places, Movement, and Region). Also GENIP as the symbol of unity of all four major geography organization(AAG, NCGE, NGS, AGS) contributed to expanding and stren-gthening geography education. Also Geography Educagtion Program of NGS was a smart and well organized program to improve geographic education through it's a five strategies: Grass-roots organization(Alliances), Teacher education, Pu-blic awareness, Educational materials develo-pment, Targeted outreach to education decision-makers. In the late 1980s, the last focus of movement was the Public awareness and Edua-ction decision-making. In the third stage(1990-present: from "Public" to "Core Subject"), the initiative pendulum swung from geography organization to nation curricu-lum. In this National Curriculum, Geography was approved as a "Core Subject" and The 1994 National Geography Assessment Framework was constructed to assess the outcome of student's education in geography in grades, 4,8, and 12. Some Implications extracted from the process and contents of renaissance movement of geogr-aphic education in the Uinted States since 1980 are as follows. First, It shows the importance of the unity and target assignment among the geography organization. Second, interactive relationship between the academic geography and school geography develops each other. Third, teacher education, including pre-service education, including pre-service education and in-service education, is a key element to improve the quality of geography. And teacher organization is a good clearing house to exchange information for good geography. Forth, the positive and active response to changes in socketies such as globalism and inter-nationalizing, national education policy, and the trend of pedagogy is needed to rejuvenate geo-graphic education. Above all, we need to establish a well organized and powerfull program, sophisticated activities strategies, and long-term implementa-tion plan if we want more and better school geography.

• Journal of the Korean Institute of Landscape Architecture
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• v.42 no.2
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• pp.41-51
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• 2014

A self-administered questionnaire survey and face-to-face interviews were conducted on 150 local residents belonging to seven villages, 160 visitors and 86 experts in order to analyze the attitudes of groups of local residents, visitors as well as experts toward the development plan of Sobaeksan Jarak-gil. Reliability analysis and one-way ANOVA were performed on the data collected by a questionnaire survey using IBM SPSS Statistics 20.0 after coding. The Duncan Test was conducted as a post-hoc test. Based on the analytical results, in economic terms, the expert group expected an increase in income, improvement in living standards and increase in expenditure for the maintenance of local infrastructure. In environmental terms, the visitor group was highly concerned about the disruption of the local natural environment and ecosystem, destruction of local properties and landscape, increase in water/soil/air pollution and increase in solid waste and noise. In social and cultural terms, the expert group had higher expectation for excavation of traditional cultural properties, instillation of local patriotism and pride, and the visitor group was highly concerned about a rise in crime, destruction of indigenous culture/increase in imitations, and induction of conflicts between residents. It is estimated that these results will be used as basic data for establishing the development plan of the mountainous ecological trail reflecting opinions of various groups.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.36 no.2
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• pp.38-45
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• 2018

Baekdudaegan is Korea's traditional geographic system which incorporates the mountains and water to constitute an organism. In this system, the mountain ranges of the Korean peninsula is categorized into one Daegan, one Jeonggan and thirteen Jeongmaek: a classification that follows the principle that 'a mountain range separates watercourse (山自分水嶺).' Among them, the scope of this study encompasses one Daegan and nine Jeongmaek which fall in South Korea. As for the methodology, this study interviewed the visitors to Baekdudaegan in South Korea and analyzed 2,519 responses. Among the interviewee, a very low proportion of 5.1% answered that they 'know' the traditional geographic system and those who 'know' Baekdudaegan were merely 39%. Only 11.8% said they 'know' Jeongmaek. Meanwhile, more than 60% answered that the natural environment of Baekdudaegan was 'well conserved,' and this can lead to the judgment that the environment is well conserved. Many answered that it was desirable to include Baekdudaegan in the curriculum, most effectively from the primary school, for promoting the awareness of Baekdudaegan. Currently, the traditional geological system is not included in the promulgated curriculum of the Ministry of Education. Therefore, the lessons from this study lead to a suggestion that the curriculum by the Ministry of Education shall allot courses on this traditional geological system. This policy will inculcate the identity of the Korean nationality and the fundamental concept of conservation by stimulating the affection to our territory and environment.

• The Journal of Engineering Geology
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• v.13 no.4
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• pp.457-474
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• 2003

This study aims to elucidate characteristics of groundwater level fluctuation at riverbank filtration sites in Daesan-myeon, Changwon City. Groundwater level fluctuation, river water level change and stream-aquifer interaction are very important to estimate optimal discharge rate of the pumping well. Water level contours from February 2003 to October 2003 show normal decreasing trend toward the Nakdong river with the hydraulic gradient of 0.008. However, flow reversion occurs when groundwater is discharged at the pumping wells or rise of the Nakdong river by rainfall. The fluctuation of the Nakdong river ranges 0 - 10 m msl. Autocorrelation analysis was conducted to the groundwater levels measured on the six monitoring wells (DS1, DS2, DS3, DS4, DS6 and DS7). The analyzed waterlevel data can be grouped into three: group 1 (DS1 and DS3) represents strong linearity and long memory effect, group 2 (DS1 and DS6) intermediate linearity and memory, and group 3 (DS4 and DS7) weak linearity and memory. Waterlevels of group 1 wells are relatively closely related to the change of river-water level. Those of group 2 wells are largely affected by the pumping and the river-water level, and those of group 3 wells are strongly linked to pumping.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.1
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• pp.81-88
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• 2020

Flight data recorder is a equipment that records data required for investigation of aircraft accidents and should be developed in compliance with the ED-112A standard. Unlike general data storage device, flight data recorder must be able to recover data after an aircraft accident, requiring a housing and a memory board to protect data in extreme environments. To attain this performance, we designed a housing that can withstand the test by analyzing the physical environment of the impact, shear/tensile, penetration resistance and static crush test of the crash survival test and minimized the size and weight compared to the existing one in consideration of the installation of the aircraft in this paper. Insulation material and thermal block material were applied to endure high and low temperature fire so that the internal temperature does not rise above 150℃ even in 260℃, 10 hour environment. In addition, the memory board is designed to minimize the size and we devise a hoping programming method to prevent continuous data loss of more than 16 seconds. Through this, Crash protected memory module that satisfies ED-112A was completed.