• The Korean Journal of Physiology and Pharmacology
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• v.15 no.1
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• pp.17-22
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• 2011

Quercetin mainly exists in the skin of colored fruits and vegetables as one of flavonoids. Recent studies show that quercetin, like other flavonoids, has diverse pharmacological actions. However, relatively little is known about quercetin effects in the regulations of ligand-gated ion channels. In the previous reports, we have shown that quercetin regulates subsets of homomeric ligand-gated ion channels such as glycine, 5-$HT_{3A}$ and ${\alpha}7$ nicotinic acetylcholine receptors. In the present study, we examined quercetin effects on heteromeric neuronal ${\alpha}3{\beta}4$ nicotinic acetylcholine receptor channel activity expressed in Xenopus oocytes after injection of cRNA encoding bovine neuronal ${\alpha}3$ and ${\beta}4$ subunits. Treatment with acetylcholine elicited an inward peak current ($I_{ACh}$) in oocytes expressing ${\alpha}3{\beta}4$ nicotinic acetylcholine receptor. Co-treatment with quercetin and acetylcholine inhibited $I_{ACh}$ in oocytes expressing ${\alpha}3{\beta}4$ nicotinic acetylcholine receptors. The inhibition of $I_{ACh}$ by quercetin was reversible and concentration-dependent. The half-inhibitory concentration ($IC_{50}$) of quercetin was $14.9{\pm}0.8\;{\mu}M$ in oocytes expressing ${\alpha}3{\beta}4$ nicotinic acetylcholine receptor. The inhibition of $I_{ACh}$ by quercetin was voltage-independent and non-competitive. These results indicate that quercetin might regulate ${\alpha}3{\beta}4$ nicotinic acetylcholine receptor and this regulation might be one of the pharmacological actions of quercetin in nervous systems.

• Journal of Astronomy and Space Sciences
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• v.31 no.3
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• pp.225-233
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• 2014

The first Korean satellite laser ranging (SLR) system, Daedeok SLR station (DAEK station) was developed by Korea Astronomy and Space Science Institute (KASI) in 2012, whose main objectives are space geodesy researches. In consequence, Korea became the $25^{th}$ country that operates SLR system supplementing the international laser tracking network. The DAEK station is designed to be capable of 2 kHz laser ranging with precision of a few mm both in daytime and nighttime observation of satellites with laser retro-reflector array (LRA) up to the altitude of 25,000 km. In this study, characteristics and specifications of DAEK station are investigated and its data quality is evaluated and compared with International Laser Ranging Service (ILRS) stations in terms of single-shot ranging precision. The analysis results demonstrated that the DAEK station shows good ranging performance to a few mm precision. Currently, the DAEK station is under normal operations at KASI headquarters, however, it will be moved to Sejong city in 2014 to function as a fundamental station for space geodesy researches in combination with other space geodesy systems (GNSS, VLBI, DORIS, etc.).

• Microbiology and Biotechnology Letters
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• v.40 no.4
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• pp.319-324
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• 2012

Production of liquid starters using wheat bran as a medium for Rhizopus oryzae N174 and the changes in their characteristics noted during storage were investigated in this study. The optimal culture conditions of the liquid starters were determined to be 5~15% (w/v) wheat bran and 48~72 hrs of incubation. The effects of liquid starters with different storage periods and temperatures (-18, 4, 10 and $25^{\circ}C$) on the quality of wheat nuruk were evaluated. According to the results of the pH, acidity, reducing sugar and enzyme activities, it was found that liquid starter using wheat bran preserved for one day, at any temperature, is the best method of storage for seed cultures for R. oryzae N174.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.4
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• pp.195-201
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• 2011

The flavonoid quercetin is a low molecular weight compound generally found in apple, gingko, tomato, onion and other red-colored fruits and vegetables. Like other flavonoids, quercetin has diverse pharmacological actions. However, relatively little is known about the influence of quercetin effects in the regulation of ligand-gated ion channels. Previously, we reported that quercetin regulates subsets of nicotinic acetylcholine receptors such as ${\alpha}3{\beta}4$, ${\alpha}7$ and ${\alpha}9{\alpha}10$. Presently, we investigated the effects of quercetin on muscle-type of nicotinic acetylcholine receptor channel activity expressed in Xenopus oocytes after injection of cRNA encoding human fetal or adult muscle-type of nicotinic acetylcholine receptor subunits. Acetylcholine treatment elicited an inward peak current ($I_{ACh}$) in oocytes expressing both muscle-type of nicotinic acetylcholine receptors and co-treatment of quercetin with acetylcholine inhibited $I_{ACh}$. Pre-treatment of quercetin further inhibited $I_{ACh}$ in oocytes expressing adult and fetal muscle-type nicotinic acetylcholine receptors. The inhibition of $I_{ACh}$ by quercetin was reversible and concentration-dependent. The $IC_{50}$ of quercetin was $18.9{\pm}1.2{\mu}M$ in oocytes expressing adult muscle-type nicotinic acetylcholine receptor. The inhibition of $I_{ACh}$ by quercetin was voltage-independent and non-competitive. These results indicate that quercetin might regulate human muscle-type nicotinic acetylcholine receptor channel activity and that quercetin-mediated regulation of muscle-type nicotinic acetylcholine receptor might be coupled to regulation of neuromuscular junction activity.

• Journal of Korean Society of Environmental Engineers
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• v.36 no.12
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• pp.865-872
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• 2014

The study was conducted to evaluate the effect of addition of food waste in brown water for anaerobic hydrogen production. Batch experiment was carried out to determine appropriate food waste to brown water mixing ratio. Maximum hydrogen yield of $6.92mmol\;H_2/g\;COD_{removed}$ was obtained at 70% food waste and 30% brown water. Semi-pilot scale reactor was operated based on result of batch experiment. Semi-pilot reactor operated, mixing 70% food waste and 30% brown water showed significant increment in butyric acid concentration. B/P (Butyric to propionic acid ratio) which is considered as governing factor for hydrogen production was found high (52.64). Maximum hydrogen yield of $25.03mmol\;H_2/g\;COD_{removed}$ was obtained. Result of this study concluded that mixing of food waste to brown water at appropriate ratio assists in enhanced hydrogen fermentation.

• Journal of the Korean Society of Hazard Mitigation
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• v.8 no.4
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• pp.135-143
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• 2008

During the last decades several devastating tsunamis have been occurred. Recently, there have been increasingly concerned about tsunamis around the Korean Peninsula since the 2004 Sumatra Tsunami occurred on December 26, 2004. In general, the Korean Peninsula is not safe against potential tsunami attacks. The 1983 Central East Sea Tsunami and the 1993 Hokkaido Tsunami caused considerable damage to the Eastern Part of the Peninsula. Thus, a prediction of damage due to tsunamis must be required at the Eastern Part of the Peninsula. In this study, numerical simulation of tsunamis at Pohang New Port, one of the most important ports in the Eastern Part of Korea, is conducted for three different tsunami events. Numerical simulation is focused on inundation on the port and run-down around an intake structure which supplies cooling water to the porthinterland. The computed results show that Pohang New Port is damaged by the most dangerous tsunami which can be generated in the East Sea. Thus, it is required to set up a counter-measure against tsunami attacks at Pohang New Port.

• Korean Journal of Soil Science and Fertilizer
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• v.42 no.3
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• pp.152-159
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• 2009

This study was carried out to investigate optimum application rate with mixed organic fertilizer for chemical fertilizer alternative where the paddy rice (Chucheong) was cultivated in clay loam of paddy field. The mixed organic fertilizer were applied at 0, 50, 100 and 150% levels of recommended nitrogen by soil testing plot compared with plot of chemical fertilizer (nitrogen, phosphate and potash), respectively. The ammonium nitrogen content in paddy soil and surface water of mixed organic fertilizer 100% plot were higher than chemical fertilizer plot. The absorbed amount of nitrogen and nitrogen use efficiency by rice plant in mixed organic fertilizer 100% plot were higher than chemical fertilizer plot. The number of tillers on rice at 30 days and 60 days after transplanting mixed organic fertilizer 100% plot were many more than chemical fertilizer plot. The milled rice yield of mixed organic fertilizer 100% plot was increased by 4% than chemical fertilizer plot. The optimum application rate of mixed organic fertilizer was as follows ; $OAR_{MOF}(Mg\;ha^{-1})=[(NAR_{ST}{\div}NC_{MOF}/1,000{\times}0.93)/1,000]$ ($OAR_{MOF}$ : Optimum application rate of mixed organic fertilizer, NARST : Nitrogen application rate($kg\;ha^{-1}$) by soil testing, $NC_{MOF}$ : Nitrogen content($g\;kg^{-1}$) of mixed organic fertilizer, and $0.93:124.3kg\;ha^{-1}/133.0kg\;ha^{-1}$, respectively).

• Journal of Digital Convergence
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• v.15 no.6
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• pp.481-491
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• 2017

The purpose of this study was to investigate the degrees of life quality, anger expression and suicidal ideation of Korean special mission national merit(Performer), and to identify the effects of life quality and anger expression on suicidal ideation of the subjects. The general characteristics as well as life quality, anger expression and suicidal ideation of 362 Korean veterans were collected from March 2016 to May 2016, and the collected data were analyzed with SPSS 23.0 Statistics Program. The result showed that life quality was inversely correlated with anger expression(r=-.151, p<.001) and suicidal ideation(r=-.539, p<.001), and anger expression was positively correlated with suicidal ideation(r=.601, p<.001). Life quality and anger expression were significant predictors of suicidal ideation with 42.9% explanatory power. In order to prevent the suicide of the Korean special mission national merit(Performer), it is necessary to develop a national adaptation program to improve the life quality and to develop an effective anger control education program considering the characteristics of them.

• Journal of the Microelectronics and Packaging Society
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• v.18 no.4
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• pp.33-38
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• 2011

The p-type $(Bi_{0.2}Sb_{0.8})_2Te_3$ powers were fabricated by mechanical alloying and hot-pressed at temperatures of $350{\sim}550^{\circ}C$. Themoelectric properties of the hot-pressed $(Bi_{0.2}Sb_{0.8})_2Te_3$ were characterized as a function of the hot-pressing temperature. With increasing the hot-pressing temperature from $350^{\circ}C$ to $550^{\circ}C$, the Seebeck coefficient and the electrical resistivity decreased from 237 ${\mu}V/K$ to 210 ${\mu}V/K$ and 2.25 $m{\Omega}-cm$ to 1.34 $m{\Omega}-cm$, respectively. The power factor of the hot-pressed $(Bi_{0.2}Sb_{0.8})_2Te_3$ became larger from $24.95{\times}10^{-4}W/m-K^2$ to $32.85{\times}10^{-4}W/m-K^2$ with increasing the hot-pressing temperature from $350^{\circ}C$ to $550^{\circ}C$. Among the specimens hot-pressed at $350{\sim}550^{\circ}C$, the $(Bi_{0.2}Sb_{0.8})_2Te_3$ hot-pressed at $500^{\circ}C$ exhibited the maximum dimensionless figure-of-merit of 1.09 at $25^{\circ}C$ and 1.2 at $75^{\circ}C$.

• Journal of the Korean Geotechnical Society
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• v.33 no.3
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• pp.5-15
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• 2017

In this study, the liquid and plastic limit tests were conducted on Paju clay with Casagarande method (dynamic) and the fall cone test method (static) to find out the effects of test methods and testers on their values. Six testers, who already have the experience of test, participated. As a results of liquid limit tests, the fall cone test method showed 4% smaller liquid limit compared to the value determined by Casagrande method. As the number of tests increased, the fall cone test method showed less variation between testers and the variation range of level of proficiency was also more stable. In the case of one point method, the liquid limit determined by the fall cone test method varied with smaller range compared to the Casagrande. Consequently, the fall cone test provided more stable liquid limit value than that of Casagrande method. For the results of plastic limit tests, there were no difference between Casagrande method and the fall cone test unlike liquid limit test results. In other words, both methods showed that plastic limit reached the average value as the number of tests increased, and the tendency level of proficiency also showed to get better.