• Journal of Digital Contents Society
• /
• v.18 no.1
• /
• pp.159-165
• /
• 2017

In order to solve problems in automatic quality inspection of tablet capsules, computation-efficient image processing technique, appropriate threshold setting, edge detection and segmentation methods are required. And since existing automatic system for quality inspection of tablet capsules is of very high cost, it needs to be reduced through the realization of low-price hardware system. This study suggests a technique that uses low-cost camera module to obtain image and inspects dents on tablet capsules and sorting them by applying TLS curve fitting technique and edge-based image segmentation. In order to assess the performance, the major classifications algorithm of PCA, ICA and SVM are used to evaluate training time, test time and accuracy for capsule image area and curve fitting edge data sets.

• 한국정보교육학회:학술대회논문집
• /
• 2007.08a
• /
• pp.96-101
• /
• 2007

u-learning (Ubiquitous Learning) 환경에서는 학습자들이 언제, 어디에서나 어떤 단말기로도 자유롭게 학습할 수 있는 학습자 중심의 교육과정이 가능해야 한다. 최근 각광을 받고 있는 태블릿 (Tablet) PC는 펜을 주로 입력 매개로 활용하고, 음성을 인식하여 이를 문자로 변환하여 저장할 수 있는 기능도 가지고 있어 초등교육 현장에 적합한 단말기이다. 또한 PBL (Problem-based Learning)은 학습자들이 자기주도적으로 문제를 해결해 가는 과정에서 문제해결력과 비판적 사고 기능을 신장시킬 수 있는 학습형태로 태블릿 PC 기반의 PBL 학습시스템은 u-learning 환경에서 학습자 중심의 교육과정 실현에 적합한 시스템이다. 본 연구에서는 태블릿 PC 기반의 PBL 학습시스템의 인터페이스 설계 방안을 제시해 보았다. 본 연구에서 제시하는 사용자 인터페이스의 특징은 다음과 같다. 첫째, 학습의 프로세스를 프로젝트의 목적 및 과제 파악 단계, 학습계획 수립단계, 자료의 수집 및 정리단계, 프로젝트 마무리 단계로 구분하고, 각 단계에서의 학습자의 활동을 지원하는 시스템으로 구성한다. 둘째, 태블릿 PC 기반에서의 학습 활동에 서투른 학습자도 직관적으로 접근 할 수 있도록 인터페이스에 아이콘을 적절하게 활용한다. 셋째, 태블릿 PC에 펜이나 음성으로 입력된 자료를 문자, 도형, 이미지로 손쉽게 저장하고 축적할 수 있도록 한다. 넷째, 학습자들간의 상호작용과 교사의 피드백을 손쉽게 할 수 있도록 게시판, 자료실, 통합 메시지함의 기능을 활성화한다.

• Journal of Pharmaceutical Investigation
• /
• v.39 no.1
• /
• pp.43-49
• /
• 2009

Aspirin or acetylsalicylic acid, a member of the salicylate family, is frequently used as an analgesic, antipyretic, anti-inflammatory and antiplatelet drug. Because aspirin is chemically unstable in water and heat for tablet formulation, additives including lubricants are used in preparing aspirin tablets, using a dry-granulation process. Aspirin tablets are produced by a number of manufacturers which usually use their own unique combination of additives during the manufacturing process. In this study, we employed an NMR based metabolomics technique to identify the manufacturers of various aspirin tablets. Aspirin tablets from six different companies were analyzed by 1H 400 MHz NMR. The acquired data was then integrated and processed by principal component analysis (PCA). Based on the NMR data, we were able to identify peaks corresponding to acetylsalicylic acid in all of the six samples, whereas different NMR patterns were found in the aromatic and aliphatic regions depending on the unique additive used. These observations led to the conclusion that the differences in the NMR patterns among the different aspirin tablets were due to the presence of additives.

• The Journal of Information Systems
• /
• v.23 no.4
• /
• pp.169-196
• /
• 2014

This study investigates how information and communication technology (ICT) can damage intellectual property rights (IPR) in the movie industry. Utilizing a survey questionnaire to gather information about the extensive use of ICT devices, including tablet PCs and smartphones, we demonstrate how digital piracy behavior is associated with various socio-demographic characteristics. Econometrically, since a large number of people do not engage in piracy activities, we adopt a zero-inflated negative binomial model. We find that people with tablet PCs are more likely to engage in the piracy of movies from peer-to-peer (P2P) sites. In particular, when we categorize ICT devices based on whether they are portable and allow downloads, we find that people with devices equipped with both functions are most likely to engage in movie piracy.

• Journal of the Korean Graphic Arts Communication Society
• /
• v.29 no.3
• /
• pp.143-153
• /
• 2011

Digital leader caught seat by modern's everyday life tool now by popularization of smart device such as Smart phone and Tablet PC. Therefore, desire of readers about electronic book practical use is increasing based on convenience and economic performance of electronic book. 1971, Michael S. Hart established Project Gutenberg to produced first electronic book because inputs American Independence Declaration Statement by computer and produce more electronic books. After that, an electronic book technology repeats several times development and American electronic book take is increasing rapidly. Sales volume of electronic books is dramatically increasing in Korea since digital device such as Smart phone and Tablet PC became popular. This research attempts to analyze factors influencing on shifting from paper book to electronic book. Results of this research proposed grounds for building business strategy. Finding is the factor of social influence is only significant to acceptability intention. It means user of e-Book enhance their acceptability intention along social phenomena.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2019.05a
• /
• pp.230-231
• /
• 2019

As we move into the aging society, social efforts to improve the IADL of the elderly are getting bigger. In this study, elderly people were taught using tablet PC - based contents in order to make ATM more convenient. The ATM contents used are the educational contents for the tablet PC developed in the same way as the ATM interface used in the actual bank. After the elderly used the content, they evaluated the usability of the content.

• Journal of Microbiology and Biotechnology
• /
• v.27 no.4
• /
• pp.739-746
• /
• 2017

As alternatives to antibiotics in livestocks, probiotics have been used, although most of them in the form of liquid or semisolid formulations, which show low cell viability after oral administration. Therefore, suitable dry dosage forms should be developed for livestocks to protect probiotics against the low pH in the stomach such that the products have higher probiotics survivability. Here, in order to develop a dry dosage forms of probiotics for poultry, we used hydroxypropyl methylcellulose phthalate 55 (HPMCP 55) as a tablet-forming matrix to develop probiotics in a tablet form for poultry. Here, we made three different kinds of probiotics-loaded tablet under different compression forces and investigated their characteristics based on their survivability, morphology, disintegration time, and kinetics in simulated gastrointestinal fluid. The results indicated that the probiotics formulated in the tablets displayed higher survival rates in acidic gastric conditions than probiotics in solution. Rapid release of the probiotics from the tablets occurred in simulated intestinal fluid because of fast swelling of the tablets in neutral pH. As a matrix of tablet, HPMCP 55 provided good viability of probiotics after 6 months under refrigeration. Moreover, after oral administration of probiotics-loaded tablets to chicken, more viable probiotics were observed, than with solution type, through several digestive areas of chicken by the tablets.

• Journal of Pharmaceutical Investigation
• /
• v.31 no.2
• /
• pp.131-136
• /
• 2001

Tofisopam is a new type of tranquilizer valuable for the relief of anxiety and tension in a wide range of emotional disorders. Tofisopam has the therapeutic characteristics of a minor tranquilzer and a mild stimulatory effect. The purpose of the present study was to evaluate the bioequivalence of two tofisopam tablets, $Grandaxin^{TM}$ (Hwan In Pharmaceutical Co., Ltd.) and $Tofim^{TM}$ (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, $23.11\;{\pm}\;2.83$ years in age and $65.43\;{\pm}\;7.64\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 50 mg of tofisopam was orally administered, blood was taken at predetermined time intervals and the concentrations of tofisopam in serum were determined using HPLC method with UV detector. The pharmacokinetic parameters such as $AUC_t$, $C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t$, C_{max}\;and\;T_{max}$ between two tablets based on the $Grandaxin^{TM}$ were -5.59%, 2.22% and -13.18%, respectively. Minimum detectable differences $({\Delta})$ at ${\alpha}=0.10$ and $1-{\beta}=0.8$ were less than 20% (e.g., 14.95% and 19.34% for $AUC_t\;and\;C_{max}$, respectively). The powers $(1-{\beta})$ at ${\alpha}=0.10$, ${\Delta}=0.2$ for $AUC_t$ and $C_{max}$ were 95.21% and 81.93%, respectively. The 90% confidence intervals were within {\pm}20%$ (e.g., $-15.64{\sim}4.45$ and $-10.77{\sim}15.21$ for $AUC_t\;and\;C_{max}$, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that $Tofim^{TM}$ tablet is bioequivalent to $Grandaxin^{TM}$ tablet.

• Journal of Pharmaceutical Investigation
• /
• v.36 no.3
• /
• pp.201-207
• /
• 2006

Acetaminophen (paracetamol), a para-aminophenol derivative, has analgesic and antipyretic properties and weak anti-inflammatory activity. The purpose of the present study was to evaluate the bioequivalence of two acetaminophen tablets, $Tylenol^{\circledR}$ ER (Janssen Korea Ltd.) and Tylicol ER (Hana Pharmaceutical Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of acetaminophen from the two acetaminophen formulations in vitro was tested using KP VIll Apparatus II method with pH 1.2 buffer solution. Twenty six healthy male subjects, $22.8{\pm}1.99$ years in age and $65.6{\pm}8.03$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single tablet containing 650 mg as acetaminophen was orally administered, blood samples were taken at predetermined time intervals and the concentrations of acetaminophen in serum were determined using HPLC with UV detector. The dissolution profiles of two formulations were similar in pH 1.2 buffer solution. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Tylenol^{\circledR}$ ER, were 2.84, 1.89 and -1.36% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log $0.987{\sim}log$ 1.08 and log $0.944{\sim}log$ 1.17 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Tylicol ER tablet was bioequivalent to $Tylenol^{\circledR}$ ER tablet.

• Journal of Pharmaceutical Investigation
• /
• v.32 no.3
• /
• pp.223-229
• /
• 2002

Metformin is an oral antihyperglycemic agent used in the therapy of noninsulin-dependent diabetes mellitus and does not cause hypoglycemia at the therapeutic dose. Its mechanism of action may involve an increased binding of insulin to its receptors and glucose uptake at the post-receptor level. The purpose of the present study was to evaluate the bioequivalence of two metformin tablets, Glucophage (Daewoong Pharmaceutical Co., Ltd.) and Glycomin (Ilsung Pharmaceuticals Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The metformin release from the two metformin tablets in vitro was tested using KP VII Apparatus II method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four normal male volunteers, $23.75{\pm}1.96$ years in age and $68.77{\pm}10.41\;kg$ in body weight, were divided into two groups with a randomized $2{\times}2$ cross-over study. After one tablet containing 500 mg as metformin was orally administered, blood was taken at predetermined time intervals and the concentrations of metformin in serum were determined using HPLC with UV detector. Besides, the dissolution profiles of two metformin tablets were very similar at 떠1 dissolution media. The pharmacokinetic parameters such as $AVC_t,\;C_{max}\;and\;T_{max}$ were calculated. The ANOVA test was performed for the statistical analysis of the logarithmically transformed $AVC_t\;and\;C_{max}$, untransformed $T_{max}$. The results showed that the differences in $AVC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on the Glucophage were 0.09%, 6.09% and -8.22%, respectively. There were no sequence effects between two tablets in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.94){\sim}log(1.09)\;and \;log(1.01){\sim}log(1.15)$\;for\;AVC_t\;and\;C_{max},\;respectively)$, indicating that Glycomin tablet is bioequivalent to Glucophage tablet.