• BMB Reports
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• 제56권7호
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• pp.410-415
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• 2023

Breast cancer has become the most common cancer among women worldwide. Among breast cancers, metastatic breast cancer is associated with the highest mortality rate. Twist1, one of the epithelial-mesenchymal transition-regulating transcription factors, is known to promote the intravasation of breast cancer cells into metastatic sites. Therefore, targeting Twist1 to develop anti-cancer drugs might be a valuable strategy. In this study, LY-290181 dose-dependently inhibited migration, invasion, and multicellular tumor spheroid invasion in breast cancer cell lines. These anti-cancer effects of LY-290181 were mediated through the down-regulation of Twist1 protein levels. LY-290181 inhibited extracellular signal-regulated kinase and c-Jun N-terminal kinase signaling pathways. Therefore, our findings suggest that LY-290181 may serve as a basis for future research and development of an anti-cancer agent targeting metastatic cancers.

• Molecules and Cells
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• 제28권6호
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• pp.553-558
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• 2009

In the periphery, a galectin-1 receptor, CD7, plays crucial roles in galectin-1-mediated apoptosis of activated T-cells as well as progression of T-lymphoma. Previously, we demonstrated that $NF-{\kappa}B$ downregulated CD7 gene expression through the p38 MAPK pathway in developing immature thymocytes. However, its regulatory pathway is not well understood in functional mature T-cells. Here, we show that CD7 expression was downregulated by Twist2 in Jurkat cells, a human acute T-cell lymphoma cell line, and in EL4 cells, a mature murine T-cell lymphoma cell line. Furthermore, ectopic expression of Twist2 in Jurkat cells reduced galectin-1-induced apoptosis. While full-length Twist2 decreased CD7 promoter activity, a C-terminal deletion form of Twist2 reversed its inhibition, suggesting an important role of the C-terminus in CD7 regulation. In addition, CD7 expression was enhanced by histone deacetylase inhibitors such as trichostatin A and sodium butyrate, which indicates that Twist2 might be one of candidate factors involved in histone deacetylation. Based on these results, we conclude that upregulation of Twist2 increases the resistance to galectin-1-mediated-apoptosis, which may have significant implications for the progression of some T-cells into tumors such as Sezary cells.

• 대한수학회지
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• 제37권3호
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• pp.491-502
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• 2000

The disjoint union of mapping class groups g,1 gives us a braided monoidal category so that it gives rise to a double loop space structure. We show that there exists a natural twist in this category, so it gives us a ribbon category. We show that there exists a natural twist in this category, so it gives us a ribbon category. We explicitly express this structure by showing how the twist acts on the fundamental group of the surface Sg,l. We also make an explicit description of this structure in terms of the standard Dehn twists, as well as in terms of Wajnryb's Dehn twists. We show that the inverse of the twist g for the genus g equals the Dehn twist along the fixed boundary of the surface Sg,l.

• 대한기계학회논문집B
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• 제40권3호
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• pp.157-164
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• 2016

봉다발 유동에서 비틀림 혼합날개 지지격자의 대류열전달 성능을 실험적으로 평가하였다. 시험부는 $4{\times}4$ 정사각 배열의 봉다발로 제작하였고, 모의 봉다발에서 봉 중심 간 거리와 봉 외경의 비는 ~1.35이다. 대류열전달 성능 평가를 위해 혼합날개 지지격자 하류에서 봉 벽면 온도의 원주방향 및 축방향 분포를 측정하였다. 원주방향의 경우, 지지격자 하류에서 비틀림 혼합날개 끝이 향하는 벽면의 온도가 가장 낮게 나타났는데 이는 비틀림 혼합날개에 의해 왜곡된 유동 때문으로 판단된다. 반면, 축방향의 경우, 혼합날개 지지격자 근처에서 벽면의 온도가 크게 낮아졌는데, 이는 비틀림 혼합날개에 의해 대류열전달이 향상됨을 의미한다. 비틀림 혼합날개 지지격자에 의해 대류열전달 성능은 지지격자 상류에 비해 지지격자 근처 하류에서 ~35 % 향상되었고, 실험데이터를 기반으로 비틀림 혼합날개 지지격자에 대한 열전달 성능 예측 상관식을 제안하였다.

• 한국전기전자재료학회논문지
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• 제17권2호
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• pp.207-211
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• 2004

We have performed computer simulation to obtain a globa1 optimization of power consumption and viewing angle characteristic of reflective twisted nematic (R-TN) mode liquid crystal display (LCD) with sin81e polarizer and λ/4 plate. Our studies shout that with increasing the twist angle, a steepness of reflectance-voltage curve increase, operation voltages decreases, the region where contrast ratio (CR) greater than 10 increases but the reflectance of the white state starts to decrease at above the twist angle of 75$^{\circ}$. Above the twist angle of 90$^{\circ}$, the R-TN mode LCD shows the most favorable combination of low consumption and good viewing angle characteristic.

• 한국염색가공학회지
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• 제20권1호
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• pp.28-35
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• 2008

Texturing is the process of including a characteristic of a natural fiber in a synthetic fiber. The most common method of it the false twist texturing. Nylon textured yarn is primarily manufactured by the disk type. The major process parameters or the disk type false twist machine ratio, disk/yarn, and heater temperature. This study therefore investigated the effects of false twist texturing, especially speed and draw ratio, on the physical properties of nylon textured yarn. The increase of speed was proportional to the increase of unwinding tension, which could reduce the production efficiency by elevating the tension affecting to fiber during the process. In addition, the increase of speed was inversely proportional to the increase of crimp rigidity of nylon textured yarn. Draw ratio was proportionally increased with the increase of tenacity and the reductions of fineness and elongation, showing the influence or draw ratio to the ultimate physical properties of textured yarn.

• Journal of the Korean Wood Science and Technology
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• 제21권3호
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• pp.45-52
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• 1993

Surveyed results on the slope of grain and the twist of sawn lumber of Pinus koraiensis, Larix leptolepis, and Pinus densiflora were summarized as follows: 1. The slope of grain of Pinus koraiensis has a Z-grain in the stem axis. The slope of grain was found to be the lowest at near to the pith and then constantly increased. At the height of 0.2m from the base of stem. a cross section of 35 annual rings was found to have a repeatedly increasing and decreasing slope of grain and then constantly decreased. At the height of 1.2m to 7.2m from the base of stem, the slope of grain increased conspicuously until the 10th annual ring, after which it increased near to the bark with repeatedly increasing and decreasing trends. 2. Pinus densiflora has a S-grain in the stem axis. The lowest slope of grain was found at near to the pith, and the highest in the 10 to 35 annual rings from the pith. 3. Larix leptolepis has a S-grain. At the height of 3.2m from the base of stem, the big fluctuation of the slope of grain was found without any particular trend. 4. The slope of grain and the twist between natural and reforested timber of Pinus koraiensis were found to be almost the same trend in viewpoint of the annual ring. The maximum slope of grain of imported Siberian timber of Pinus koraiensis was found at the 10 annual rings, which was quite similar to that of native species in Korea, but the big difference of the twist was found at 140 annual rings. 5. The twist was little at the mature wood of reforested Pinus koraiensis and Siberians and the duplicated part of mature and juvenile woods of those. On the contrary, the twist was great at the duplicated part of mature and juvenile woods of Pinus koraiensis. 6. The twist of Larix leptolepis showed the S-direction which coincided with that of slope of grain. The twist was greatest at the part of juvenile wood and little at the duplicated part of mature and juvenile woods, and little difference of twist was found between mature and juvenile woods. 7. Siberian larix having a minimum slope of grain showed the lowest twist, and the twist at the duplicated part of mature and juvenile woods showed a middle level of both mature and juvenile woods' portions.

• 한국기계가공학회지
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• 제15권1호
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• pp.26-33
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• 2016

In this study, a new method to develop a fixed diamond wire for silicon wafer machining by the multi-wire cutting method was developed. The new twist diamond wire has improved performance with high breaking strength and chip flutes structure. According to these characteristics, the new twist diamond wire can be used in the higher speed multi-wire cutting process with a long lifetime. Except the design of the new structure, the twist diamond wire is coating by electroless-electroplating process. It is good for reducing breakage and the falling-off of diamond grains. Based on the silicon material removal mechanism and performance of the wire-cutting machine, the optimal processing condition of the new twist diamond wire has been derived via mathematical analysis. At last, through the tensile testing and the machining experiments, the performance of the twist diamond wire has been obtained to achieve the development goals and exceed the single diamond wire.

• Journal of information and communication convergence engineering
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• 제15권2호
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• pp.97-103
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• 2017

Implementation of faster pairing calculation is the basis of efficient pairing-based cryptographic protocol implementation. Generally, pairing is a costly operation carried out over the extension field of degree $k{\geq}12$. But the twist property of the pairing friendly curve allows us to calculate pairing over the sub-field twisted curve, where the extension degree becomes k/d and twist degree d = 2, 3, 4, 6. The calculation cost is reduced substantially by twisting but it makes the discrete logarithm problem easier if the curve parameters are not carefully chosen. Therefore, this paper considers the most recent parameters setting presented by Barbulescu and Duquesne [1] for pairing-based cryptography; that are secure enough for 128-bit security level; to explicitly show the quartic twist (d = 4) and sextic twist (d = 6) mapping between the isomorphic rational point groups for KSS (Kachisa-Schaefer-Scott) curve of embedding degree k = 16 and k = 18, receptively. This paper also evaluates the performance enhancement of the obtained twisted mapping by comparing the elliptic curve scalar multiplications.

• 한국염색가공학회지
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• 제9권5호
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• pp.1-9
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• 1997

In the single yarn spinning process by the ring spinning system, the finer the fineness of yarn and the lower the twist coefficient, the lower the breaking strength and breaking elongation. The change of yarn specific volume to yarn number agreed with Peirce's formula in the range of Ne 50 to 70, but above that range the values of the experiment are higher than that of the formula. The change of diameter of yarn to the reciprocal of the square root of yarn number agreed with Peirce's formula in the range of under 0.14, but above that value the values of the experiment are higher than that of the formula. In breaking strength variation according to twist constant of single yarn, as the twist coefficient increased, breaking strength increased. At 5.8∼6.0 of twist coefficient the maximum breaking strength was shown, but above that value breaking strength decreased. Breaking elongation also showed a similar tendency. But at 6.0∼6.5 of twist coefficient the maximum breaking elongation was shown. Also spinning tension increased as twist coefficient increased. Twist coefficient, breaking strength and breaking elongation according to the number of coils stayed almost the same. Yarn spinning tension according to the number of coils at the maximum of diameter was the lowest value. The speed of the traveller at the maximum of diameter was the highest value.