• Asian-Australasian Journal of Animal Sciences
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• 제16권8호
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• pp.1193-1198
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• 2003

An increase in frequency of administration of exogenous growth hormone (GH) or GH-releasing hormone was reported to be a model to increase blood circulating insulin-like growth factor-1 (IGF-1) and to improve growth performance in animals. We have investigated the effect of twice daily administration of GH-releasing peptide-2 (GHRP-2) on growth performance, GH responsiveness and plasma insulin-like growth factor IGF-1 in swine. We administered to eight swine, 3 control and 5 treatment, a twice daily s.c. injections of GHRP-2 ($30{\mu}g/kg\;BW$) for a period of 10 days. Every day blood samples immediately taken before injections of GHRP-2 or saline, at 08:00 h and 16:00 h, were measured for IGF-1 concentrations. Blood samples for GH assay were collected every 20 min on days 1, 6 and 10, from 1 hour before and 3 h after GHRP-2 or saline injections at 08:00 h. GH peak concentrations and GH area under curve (GH AUC) on day 1, 6 and 10 in treatment group of swine were higher than those in control swine (p<0.05). Twice daily administration of GHRP-2 caused a significantly attenuation (p<0.05) of GH peak concentrations ($80.25{\pm}13.87$, $39.73{\pm}5.72$ and $27.57{\pm}6.06ng/ml$ for day 1, 6 and 10, respectively) and GH AUCs ($3,536.15{\pm}738.35$, $1,310.31{\pm}203.55$ and $934.37{\pm}208.99ng/ml$ for day 1, 6 and 10, respectively). However, there was no significant difference in GH peak concentration and GH AUC between day 6 and 10. Plasma IGF-1 concentration levels were higher in treatment than control group of swine (p<0.05) after 3 days of the treatment, and the levels reached a plateau from day 3 to 10 of experiment. Growth performance did not alter by GHRP-2 administration, even though a numerical increase of body weight gain and feed efficiency was observed. These results indicate that twice daily administration of GHRP-2 for 10 days in swine did not significantly influence on growth performance, caused an overall attenuation of GH response, and that elevation of plasma GH concentrations caused by GHRP-2 administration increased plasma IGF-1 concentrations, even though an attenuation of GH response was observed.

• 한국임상약학회지
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• 제8권2호
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• pp.83-88
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• 1998

Improved knowledge of the time course of antimicrobial activity should provide useful information for designing optimal dosage regimen. In contrast to $\beta$-lactam, aminoglycosides tend to induce a prolonged postantibiotic effect against aerobic or facultative gram negative rods and clinical outcome was significantly correlated with achieving peak serum concentrations. The objective of this study was to compare the efficacy, safety of e same total daily dose of amikacin and gentamicin given either twice or thrice daily in the treatment of patients. Consecutive patients over 20 years old with a suspected or confirmed infection for which an aminoglycosides was indicated were eligible. Exclusion criteria were known allergy to aminoglycosides, renal impairment, granulocytopenia and pregnancy. Patients were treated with intravenous amikacin 15 mg/kg/day or gentamicin 4.5 mg/kg/day either in two devided or in three devided. Seventy-four patients with infection were enrolled in this study of amikacin twice daily (A2, n=29), gentamicin twice daily (G2, n=8) vs amikacin thrice daily (A3, n=30), gentamicin thrice daily (G3, n=7). Baseline characteristics were comparable in G2 and G3. The clinical cure rate (including partial improve) were $89.0\%\;and\;86.0\%$ in A2 group and A3 group respectively. The bacteriologic cure rate were $99.0\%\;and\;85.7\%$ in A2 group and in A3 group respectively. The clinical and bacteriologic effects were difficult to compare G2 with G3, because of the small numbers of patients. The serum creatinin rose in $3.44\%$ (1 in 29) of patients in the A2 group compared to $13.3\%$ (4 in 30) in e A3 group. Although audiometry was not performed, there was no clinical evidence of ototoxicity in any of the patients. In our opinion, twice-daily regimen of aminoglycosides is more effective and less nephrotoxic than thrice-daily regimen.

• 건축사
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• 통권661호
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• pp.156-157
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• 2024

• Child Health Nursing Research
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• 제14권1호
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• pp.14-21
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• 2008

Purpose: The aims of this study were to evaluate effects of massage therapy and the attachment promotion program with autistic children. Method: A quasi-experimental design was conducted with a convenience sample of 44 autistic children. The experimental group (n= 23) attended the massage therapy and the attachment promotion program for 4 months. The control group (n=21) only had the attachment promotion program. Measurements were made twice for both groups using the social maturity scale and child autism rating scale. Recording of mother-child attachment was done for 15 minutes in only the experimental group twice using video equipment. Results: After 4 months of interventions, there was significant difference on social maturity (F=9.01, p=.005) between the groups. However, there was no significant difference on CARS ((F=2.47, p=.124). The total scores of mother-child attachment between pre- and post-interventions showed a significant difference (Z=-3.42, p=.001). Conclusion: The results showed that massage therapy and the attachment promotion program might be an effective way for providing a chance to increase social maturation and to increase attachment between mother and autistic child.

• Asian-Australasian Journal of Animal Sciences
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• 제2권4호
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• pp.571-574
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• 1989

Five multiparous and four nulliparous cross-bred cows were administered s/c with oestradiol-$17{\beta}$ and progesterone 0.1 mg and 0.25 mg/kg. b.w./day for 7 days and 2 mg s/c twice daily of reserpine on days 9 to 12. Lactation was successfully induced in all animals for periods from 258 to 476 days. All animals were dried off for a minimum of 2 months. Subsequently, they were injected s/c with oestradiol valerate and hydroxyprogesterone caproate at 0.1 mg and 0.25 mg/kg. b.w./day on days 1 to 3 and 2 mg twice daily of reserpine on days 8 to 11. Lactation was successfully reinduced in all the cows for a period varying from 228 to 426 days.

• Tuberculosis and Respiratory Diseases
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• 제79권4호
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• pp.241-247
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• 2016

Bronchodilators are the cornerstone of symptomatic chronic obstructive pulmonary disease (COPD) treatment. They are routinely recommended for symptom reduction, with a preference of long-acting over short-acting drugs. Bronchodilators are classified into two classes based on distinct modes of action, i.e., long-acting antimuscarinics (LAMA, once-daily and twice-daily), and long-acting ${\beta}2$-agonists (LABA, once-daily and twice-daily). In contrast to asthma management, evidence supports the efficacy of both classes of long-acting bronchodilators as monotherapy in preventing COPD exacerbations, with greater efficacy of LAMA drugs versus LABAs. Several novel LAMA/LABA fixed dose combination inhalers are currently approved for COPD maintenance treatment. These agents show superior symptom control to monotherapies, and some of these combinations have also demonstrated superior efficacy in exacerbation prevention versus monotherapies, or combinations of inhaled corticosteroids plus LABA. This review summarizes the current data on clinical effectiveness of bronchodilators alone or in combination to prevent exacerbations of COPD.

• 한국조리학회지
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• 제8권3호
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• pp.1-20
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• 2002

The rapidly changing environments of today's hospitality industry lays more and more emphasis on the management of food & beverage sector. Hotel restaurants changes their menus 2 times a year. But they tend to modify or complement old items, or imitate other restaurants'menus, rather than try new ones. In addition, the change cycles are determined without any systematic and scientific criteria. Based on the survey, a plan for managing menu change cycles is proposed. The proposed plan is summarized as follows: First, the survey result demonstrates that the appropriate frequency of menu changes is: twice a year for the fixed menu; four times for the seasonal menu; four times for the promotion menu; twice for the business menu; and, three times for the event menu. Second, under the management maintained by consistent monitoring of menu change. Third, menu change should be managed through the menu analyses on its profitability, popularity, and the potential for further growth. Fourth, menu change should be managed through the periodic investigations of the tastes and preferences of the customers. fifth, a unique system for the menu change should be constructed by analyzing of other competitive restaurants or restaurant chain stores.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제21권1호
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• pp.51-64
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• 2007

본 연구에서는 유추를 바탕으로 삼각형의 코사인정리를 n각형으로 일반화시키고, 이를 벡터를 이용하여 증명할 것이다. 이를 통해, 수학교과의 내용을 유추를 통해 확장하는 한 예를 제시할 것이며, 수학 영재 교육에서 수학적 사고(특히 일반화, 유추)를 계발 육성하기 위한 교수-학습 자료로 활용할 수 있을 것으로 기대된다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 1996년도 춘계학술대회논문집; 부산수산대학교, 10 May 1996
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• pp.322-327
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• 1996

Dynamic stability of an axially oscillating cantilever beam is investigated in this paper. The equations of motion are derived and transformed into non-dimensional ones. The equations include harmonically oscillating parameters which originate from the motion-induced stiffness variation. Using the equations, the multiple scale perturbation method is employed to obtain a stability diagram. The stability diagram shows that relatively large unstable regions exist around the frequencies of the first bending natural frequency, twice the first bending natural frequency, and twice the second bending natural frequency. The validity of the diagram is proved by direct numerical simulations of the dynamic system.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2005년도 춘계학술대회논문집
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• pp.877-882
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• 2005

Dynamic stability of an axially accelerating beam stucture is investigated in this paper. The equations of motion of a fixed-free beam are derived using the hybrid deformation variable method and the assumed mode method. Unstable regions due to periodical acceleration are obtained by using the Floquet's theory. Stability diagrams are presented to illustrate the influence of the dimensionless acceleration, amplitude, and frequency. Also, buckling occurs when the acceleration exceeds a certain value. It is found that relatively targe unstable regions exist around the first bending natural frequency, twice the first bending natural frequency, and twice the second bending natural frequency. The validity of the stability diagram is confirmed by direct numerical integration of the equations of motion.