• Proceedings of the Korean Society of Crop Science Conference
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• 2000.04a
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• pp.420-421
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• 2000

• Journal of the Korean Society for Library and Information Science
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• v.54 no.4
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• pp.317-349
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• 2020

Mental health experts warn the combination of overwhelming amounts of information, economic instability, political discontent, social injustice, and the high infection and death rates of the ongoing COVID-19 pandemic are negatively impacting mental health in ways that may worsen the pandemic and intensify our primal fear of death. Terror Management Theory (TMT) argues that self-esteem and cultural worldviews serve as defenses against the terror of our own mortality. This theory anchor paper introduces TMT to Library and Information Science (LIS) via a selected literature review on TMT's use in the field of Psychology and an extensive discussion on the conceptual connections to LIS supported with empirical research from related disciplines and contexts. The implications, applications, and usefulness of TMT for LIS research, education, and practice are discussed in relation to the COVID-19 pandemic and other contexts, and a research agenda is proposed.

• Biomolecules & Therapeutics
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• v.24 no.3
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• pp.328-337
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• 2016

We examined whether wogonin (WO) improved hippocampal neuronal activity, behavioral alterations and cognitive impairment, in rats induced by administration of trimethyltin (TMT), an organotin compound that is neurotoxic to these animals. The ability of WO to improve cognitive efficacy in the TMT-induced neurodegenerative rats was investigated using a passive avoidance test, and the Morris water maze test, and using immunohistochemistry to detect components of the acetylcholinergic system, brain-derived neurotrophic factor (BDNF), and cAMP-response element-binding protein (CREB) expression. Rats injected with TMT showed impairments in learning and memory and daily administration of WO improved memory function, and reduced aggressive behavior. Administration of WO significantly alleviated the TMT-induced loss of cholinergic immunoreactivity and restored the hippocampal expression levels of BDNF and CREB proteins and their encoding mRNAs to normal levels. These findings suggest that WO might be useful as a new therapy for treatment of various neurodegenerative diseases.

• Journal of Plant Biotechnology
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• v.35 no.4
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• pp.329-335
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• 2008

Tocopherols are essential lipophilic antioxidant in human cells, while little is known about its function in plant tissues. To study the impact of composition and content of tocopherols on stress tolerance, tobacco (Nicotiana tabacum) was transformed with a construct containing a cDNA insert encoding $\gamma$-tocopherol methyltransferase ($\gamma$-TMT/VTE4) from perilla under the control of the cauliflower mosaic virus (CaMV) 35S promoter. The transgenic tobacco was confirmed by PCR and RT-PCR. The total content and composition of tocopherols in the transgenic lines were similar with wild type controls. However, chlorophyll-a and carotenoid content in the transgenic lines were increased by up to 45% (P<0.01) and 39% (P<0.02), respectively. Also, the over-expression of $\gamma$-TMT increased the salt stress tolerance in tobacco plants. These results demonstrate that over-expression of $\gamma$-TMT gene in tocopherol bio-synthetic pathway can increase salt stress tolerance and contents of chlorophyll-a and carotenoid in transgenic tobacco plants.

• Biomolecules & Therapeutics
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• v.20 no.2
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• pp.207-213
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• 2012

The present study examined the effects of krill-derived phosphatidylserine (Krill-PS) on the learning and memory function and the neural activity in rats with trimethyltin (TMT)-induced memory deficits. The rats were administered vehicle (medium-chain triglyceride: MCT) or Krill-PS (50, 100 mg/kg, p.o.) daily for 21 days. The cognitive improving efficacy of Krill-PS in TMT-induced amnesic rats was investigated by assessing the Morris water maze test and by performing choline acetyltransferase (ChAT), acetylcholinesterase (AChE) and cAMP responsive element binding protein (CREB) immunohistochemistry. The rats with TMT injection showed impaired learning and memory of the tasks and treatment with Krill-PS produced a significant improvement of the escape latency to find the platform in the Morris water maze at the $2^{nd}$ and $4^{th}$ day compared to that of the MCT group (p<0.05). In the retention test, the Krill-PS+MCT groups showed increased time spent around the platform compared to that of the MCT group. Consistent with the behavioral data, Krill-PS 50+MCT group significantly alleviated the loss of acetylcholinergic neurons in the hippocampus and medial septum compared to that of the MCT group. Treatment with Krill-PS significantly increased the CREB positive neurons in the hippocampal CA1 area as compared to that of the MCT group. These results suggest that Krill-PS may be useful for improving the cognitive function via regulation of cholinergic marker enzyme activity and neural activity.

• Molecules and Cells
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• v.19 no.1
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• pp.16-22
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• 2005

A cDNA encoding ${\gamma}-tocopherol$ methyltransferase (${\gamma}-TMT$) from Arabidopsis thaliana was overexpressed in lettuce (Latuca sativa L.) to improve the tocopherol composition. Seven lines of lettuce ($T_0$) containing the ${\gamma}-TMT$ transgene were produced by Agrobacterium-mediated transformation. The inheritance and expression of the transgene were confirmed by DNA and RNA gel blot analyses as well as quantification of tocopherols and ${\gamma}-TMT$ activities. The ratio of ${\alpha}-/{\gamma}-tocopherol$ content (TR) varied from 0.6 to 1.2 in non-transformed plants, while the $T_0$ plants had ratios of 0.8 to 320. The ratio ranged from 0.4 to 544 in 41 $T_1$ progenies of the $T_0$ transgenic line gTM3, and the phenotypic segregation indicated monogenic inheritance of the transgene (i.e., 3:1 = dominant:wild-type classes). There was a tight relationship between the TR phenotype and ${\gamma}-TMT$ activity, and enzyme activities were affected by the copy number and transcript levels of the transgene. The TR phenotype was stably expressed in $T_2$ progenies of $T_1$ plants. The results from this study indicated that a stable inheritance and expression of Arabidopsis ${\gamma}-TMT$ transgene in lettuce results in a higher enzyme activity and the conversion of the ${\gamma}-tocopherol$ pool to ${\alpha}-tocopherol$ in transgenic lettuce.

• Journal of the Korean Society for Computer Game
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• v.31 no.4
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• pp.1-8
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• 2018

The present study investigated the validity of a serious game named 'Draw Ttoring' developed for accessment of children's attention and tried to provide the basic information about it. To this goal, we tested it to 284 elementary school students in measuring various behavior data(reaction time, total playing time, correct rate, discrepancy between type of TMT). Futhermore, the behavior data was compared with academic achievement to see the external validity. In results, 'Draw Ttoring' showed various behavior data and correlation with academic achievement. In Type A of TMT, total time and reaction time had a correlation with academic achievement, while, in Type B of TMT, total time and correct rate did. Mental flexibility calculated by the discrepancy between Type A and Type B showed also the positive correlation with academic achievement. These results showed that the serious game named 'Draw Ttoring' can provide more various information about children attention and these can't be observed by traditional paper pencil test. Finally, serious game can provide an good alternative method to access children's cognition.

• Journal of the Korean Society of Physical Medicine
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• v.17 no.3
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• pp.51-58
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• 2022

PURPOSE: This study aimed to evaluate the correlation between executive function and gait evaluations for the elderly, and validate the obstacle gait evaluation as a cognitive impairment test tool. METHODS: This study was a cross-sectional design. 79 people aged 65 years or older were selected as subjects. The Korean version of the Mini-Mental State Examination (MMSE-KC) to evaluate overall cognitive function and the Trail Making Test (TMT) A, B to measure executive function were performed. The 4-meter walking speed test and the walking speed test while crossing over an obstacle were carried out to evaluate gait. The Spearman's correlation was used to measure the correlation between cognition and gait speed. RESULTS: There was no significant correlation between the 4 m gait speed and executive function( TMT-A (p = .056), TMT-B (p = .115)). However, there was a significant correlation between the 4 m gait speed and MMSE-KC (r = .277, p < .05). There was also a significant correlation between walking speed while crossing over an obstacle and all tests (MMSE-KC (r = .382, p < .01). TMT-A (r = -.327, p < .01), TMT-B (r = -.283, p < .05)). CONCLUSION: It was found that the gait speed while crossing over an obstacle was correlated with all cognitive function tests. Therefore, we suggest the use of the gait speed test while crossing over an obstacle rather than the simple gait test to diagnose cognitive decline.

• Journal of the Korean Society for Heat Treatment
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• v.4 no.4
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• pp.24-33
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• 1991

The effects of thermomechanical treatments on microstructure and fatigue properties of 7050 Al alloy were investigated. The precipitation kinetics changed to a faster rate due to cold deformation employed in this special TAHA thermomechanical treatments including pre-aging, plastic deformation and two step final-aging. The G.P. zones in the under-aged condition were cut by dislocations and dissolved during the plastic deformation. During the low cycle fatigue, the T6' condition showed cyclic hardening behavior whereas the TMT5, TMT27 and T76 conditions showed cyclic softening at above 0.7% total strain amplitudes. The ${\Delta}K_{th}$ value of TMT27 was improved more than two times, compared with that of T76 condition. The T6' with small shearable precipitates resulted in the markedly high ${\Delta}K_{th}$ value. This is thought to be resulted from dislocation reversibility and roughness-induced crack closure due to planarity of slip.

• Journal of the Korean Society for Heat Treatment
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• v.2 no.4
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• pp.19-26
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• 1989

Fundmental fatigue crack propagation tests with C-T type specimens were conducted at various load ratios (R) such as 0.1, 0.3 and 0.5 in T6 and Thermomechanically treated (TMT) conditions of 7039 Al alloy. Better mechanical properties from monotonic test as well as fatigue crack propagation were obtained by TMT process owing to uniform distribution of fine microstructures and non-existence of precipitation free zone (PFZ). Through the measurement of Kop and ${\Delta}K$ at various R the concept of effective stress intensity factor range ratio, U was reviewed to asses the load ratio effect on fatigue crack propagation. A relationship between U and variables such as ${\Delta}K$ and R was obtained empirically. This may enable us to predict ${\Delta}K_{eff}$ that is of critical importance for prediction of fatigue crack propagation rate.