• Nuclear Engineering and Technology
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• v.51 no.2
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• pp.453-462
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• 2019

Mental workload (MWL) is a major consideration for the user interface design in nuclear power plants (NPPs). However, each MWL evaluation method has its advantages and limitations, thus the evaluation and control methods based on multi-index methods are needed. In this study, fuzzy comprehensive evaluation (FCE) theory was adopted for assessment of interface designs in NPP based on operators' MWL. An evaluation index system and membership functions were established, and the weights were given using the combination of the variation coefficient and the entropy method. The results showed that multi-index methods such as performance measures (speed of task and error rate), subjective rating (NASA-TLX) and physiological measure (eye response) can be successfully integrated in FCE for user interface design assessment. The FCE method has a correlation coefficient compared with most of the original evaluation indices. Thus, this method might be applied for developing the tool to quickly and accurately assess the different display interfaces when considering the aspect of the operators' MWL.

• Journal of Minimally Invasive Surgery
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• v.21 no.4
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• pp.168-176
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• 2018

Purpose: Robotic-associated minimally invasive surgery is a novel method for overcoming some limitations of laparoscopic surgery. This study aimed to evaluate the outcomes (postoperative pain, cosmesis, surgeon's workload) of single-incision robotic cholecystectomy (SIRC) vs. single-incision laparoscopic cholecystectomy (SILC) vs. conventional three-port laparoscopic cholecystectomy (3PLC). Methods: 134 patients who underwent laparoscopic or robotic cholecystectomy at a single center during 2016~2017 were enrolled. Prospectively collected data included demographics, operative outcomes, questionnaire regarding pain and cosmesis, and NASA-Task Load Index (NASA-TLX) scores for surgeon's workload. Results: 55 patients underwent SIRC, 29 SILC, and 50 3PLC during the same period. 3PLC patient group was older than the others (SIRC vs. SILC vs. 3PLC: 48.1 vs. 42.2 vs. 54.1 years, p<0.001). Operative time was shortest with 3PLC (44.1 vs. 38.8 vs. 25.4 min, p<0.001). Estimated blood loss, postoperative complications, and postoperative stay were similar among the groups. Pain control was lowest in the 3PLC group (98.2% vs. 100% vs. 84.0%, p=0.004), however, at 2 weeks postoperatively there were no differences among the groups (p=0.374). Cosmesis scores were also worst after 3PLC (17.5 vs. 18.4 vs. 13.3, p<0.001). NASA-TLX score was highest in the SILC group (21.9 vs. 44.3 vs. 25.2, p<0.001). Conclusion: Although SIRC and SILC take longer than 3PLC, they produce superior cosmetic outcomes. Compared with SILC, SIRC is more ergonomic, lowering the surgeon's workload. Despite of higher cost, SIRC could be an alternative for treating gallbladder disease in selected patients.

• Anatomy and Cell Biology
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• v.56 no.1
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• pp.94-108
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• 2023

Cancer cell heterogeneity is a serious problem in the control of tumor progression because it can cause chemoresistance and metastasis. Heterogeneity can be generated by various mechanisms, including genetic evolution of cancer cells, cancer stem cells (CSCs), and niche heterogeneity. Because the genetic heterogeneity of CSCs has been poorly characterized, the genetic mutation status of CSCs was examined using Exome-Seq and RNA-Seq data of liver cancer. Here we show that different surface markers for liver cancer stem cells (LCSCs) showed a unique propensity for genetic mutations. Cluster of differentiation 133 (CD133)-positive cells showed frequent mutations in the IRF2, BAP1, and ERBB3 genes. However, leucine-rich repeat-containing G protein-coupled receptor 5-positive cells showed frequent mutations in the CTNNB1, RELN, and ROBO1 genes. In addition, some genetic mutations were frequently observed irrespective of the surface markers for LCSCs. BAP1 mutations was frequently observed in CD133-, CD24-, CD13-, CD90-, epithelial cell adhesion molecule-, or keratin 19-positive LCSCs. ASXL2, ERBB3, IRF2, TLX3, CPS1, and NFATC2 mutations were observed in more than three types of LCSCs, suggesting that common mechanisms for the development of these LCSCs. The present study provides genetic heterogeneity depending on the surface markers for LCSCs. The genetic heterogeneity of LCSCs should be considered in the development of LCSC-targeting therapeutics.

• Journal of Korean Society of Transportation
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• v.35 no.4
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• pp.332-347
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• 2017

Analysis of the interaction between the automated vehicles and manual vehicles is very important in analyzing the performance of automated cooperative driving environments. In particular, the automated vehicle platooning can affect the driving behavior of adjacent manual vehicles. The purpose of this study is to analyze the lane change behavior of the manual vehicles in automated vehicle platonning environment and to conduct the experiment and questionnaire surveys in three stages. In the first stage, a video questionnaire survey was conducted, and responsive behaviors of manual vehicles were investigated. In second stage, the driving simulator experiments were conducted to investigate the lane change behaviors of in automated vehicle platonning environments. To analyze the lane change behavior of the manual vehicles, lane change durations and acceleration noise, which are indicators of traffic flow stability, were used. The driving behavior of manual vehicles were compared across different market penetration rates (MPR) of automated vehicles and human factors. Lastly, NASA-TLX (NASA Task Load Index) was used to evaluate the workload of the manual vehicle drivers. As a result of the analysis, it was identified that manual vehicle drivers had psychological burdens while driving in automated vehicle platonning environments. Lane change durations were longer when the MPR of the automated vehicles increased, and acceleration noise were increased in the case of 30-40 years old or female drivers. The results from this study can be used as a fundamental for more realistic traffic simulations reflecting the interaction between the automated vehicles and manual vehicles. It is also expected to effectively support the establishment of valuable transportation management strategy in automated vehicle environments.

• Journal of information and communication convergence engineering
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• v.11 no.3
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• pp.147-152
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• 2013

A novel balun being the structure of a Wilkinson power divider is suggested and fabricated. One of the power dividing paths in the suggested balun uses a conventional ${\lambda}/4$ transmission line for $-90^{\circ}$ phase shifting, and the other path uses a composite right/left-handed -${\lambda}/4$ transmission line for $+90^{\circ}$ phase shifting with four series capacitors and three parallel inductors. In addition, the suggested balun uses two $50-{\Omega}$ resistors and a conventional $50-{\Omega}$ transmission line of ${\lambda}/2$ electrical length between the two output ports, achieving good isolation and reflection values of two balanced ports. The suggested balun is simulated by the advanced design system simulation program and fabricated on TLX-9 20-mil substrate. The fabricated balun has a very good values of $S_{11}$ = -27.46 dB, $S_{21}$ = -3.40 dB, and $S_{31}$ = -3.28 dB, a phase difference of $-179.5^{\circ}$, a magnitude difference of 0.12 dB, and a delay difference of 0.1 ns, with $S_{22}$ = -36.28 dB, $S_{33}$ = -27.19 dB, and $S_{32}$ = -25.2 dB at 1 GHz, respectively.

• Journal of Korean Society of Transportation
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• v.15 no.2
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• pp.35-48
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• 1997

항법장치 인간-기계 인터페이스(HUMAN-Machine Interface)는 운전자의 편안함과 안전, 수행도 및 시스템의 사용성, 도로, 안전의 향상 등을 위한 중요한 요소로 인식되고 있 다. 그러므로 항법장치 인간-기계 인터페이스 체계가 운전자와 교통에 미치는 영향은 직접 적인 항법장치의 시장성 확보와 첨단교통체계의 전개와 성공에 영향을 미치는 중요한 기술 로 떠오르고 있으며, 특히 선진국의 인간-기계 인터페이스 표준의 연구 및 제정의 노력으로 인해 항법장치의 인간-기계 인터페이스 설계 및 평가를 위한 가이드라인과 효율적인 평가 방법의 개발이며, 이들의 데이터베이스화 역시 설계 및 평가 효율향상을 위한 기본적으로 중요하게 여겨지는 연구과제이다. 본 논문은 기존 항법장치 인간공학적 평가 방법들의 비교 평가를 통해서 적합한 항법장치의 평가방법론과 추출된 항법장치 인간-기계 인터페이스 설 계 변수를 제시하며, 이들을 가이드라인화하여 데이터베이스화 할 수 있도록 설계된 Navi HEGS(Navigation HMI Evaluation & Guideline System)에 대하여 기술한다. 또한 실험을 통하여 본 논문에서 제시된 주관적 평가 방법인 RNASA-TLX(Revision of NASA-Task Load Index)와 운전자의 시각분석의 결과를 본 시스템을 사용하여 분석 제시하며, 이들을 통해 국내 항법장치 인간-기계 인터페이스 연구의 기반을 제시하고자 한다.