• 대한한방소아과학회지
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• 제31권4호
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• pp.9-18
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• 2017

Objectives The purpose of this study is to investigate the recent Korean medicine treatment and study trends of tic disorder by reviewing clinical studies. Methods The clinical studies of Korean medicine treatment for tic disorder were obtained from National Discovery for Science Leader (NDSL), Research Information Sharing Service (RISS), Korean Traditional Knowledge Portal (KTKP) and Oriental Medicine Advanced Searching Integrated System (OASIS). Results 15 articles were analyzed to find out the most commonly used herbal medicine, acupoints, other Korean medicine treatments and evaluation methods. Conclusions This study shows some common Korean medicine treatment methods for tic disorder which can be used for further research.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제21권3호
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• pp.133-140
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• 2010

Tic disorders, including Tourette syndrome, are known as neurobiologic disorders and as such, much emphasis has been placed on isolating genetic determinants. Although previous reports involving studies of discordance among monozygotic twins have shown the importance of genetic predisposition, they have also supported a role for environmental factors in the development of tic disorders. Therefore, it is important to consider that both genetic and environmental factors contribute to their clinical expression. The goal of this article was to review recent reports regarding the role of environmental factors in development and progression of tics. Specific environmental factors associated either with a more severe course of illness or improved outcomes were discussed. Given that accumulating evidence had suggested the usefulness of behavior therapies in the suppression of tic disorders, particular emphasis was placed on the impact of several contextual factors.

• 턱관절균형의학회지
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• 제4권1호
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• pp.12-16
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• 2014

Therapeutic effect of Yinyang Balancing Appliance of functional cerebrospinal therapy (FCST) for meridian and neurologic yinyang balance was observed in chronic motor tic disorder. One chronic motor tic Disorder case was managed with the Yinyang Balancing appliance on tempromandibular joint (TMJ), combined with acupuncture. Clinical outcome measurement was based on subjective measures and clinical observations. The patient showed positive changes after the treatment and this effect maintained over the follow-up period. Although it is not clear the effect is sustaining or temporary in its nature, a positive effect was observed and further clinical and biological research on FCST is expected.

• 턱관절균형의학회지
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• 제6권1호
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• pp.19-23
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• 2016

본 임상사례에서 보는 것처럼 틱, 뚜렛장애에서도 FCST의 음양균형장치와 골반균형기법(PBT), 침치료 등 구조적 치료를 통해서도 유의한 치료변화가 나타남을 확인할 수 있었다.

• 턱관절균형의학회지
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• 제11권1호
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• pp.25-36
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• 2021

It was observed that the effectiveness of Yin-yang balancing therapy of the tempromandibular joint (YBT) or functional cerebrospinal therapy (FCS) in three cases: an acute and a chronic motor tic disorder and a Tourrette's disorder (TD). These three cases were mainly managed with cervical balancing appliance for the Yin-yang Balancing on tempromandibular joint (TMJ) and pelvic balance therapy. They were treated concurrently with acupuncture, cupping and herb-medicine. Clinical outcome measurement was based on subjective measures with visual analogue scale (VAS), Yale Global Tic Severity Scale (YGTTS) and clinical observations for 235, 279 and 273 days respectively. The patient showed positive changes after the treatment and this effect maintained over the follow-up period. Although it is not clear whether the effect is sustained afterwards or not, a positive effect on the motor tic disorders and TD was observed. And so, furthermore strict clinical and structural researches for verification on YBT is expected.

• 대한한의학회지
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• 제42권3호
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• pp.139-152
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• 2021

Objectives: The purpose of this review is to investigate the latest traditional Chinese medicine clinical studies on pediatric tic disorder with Tuina treatment and propose the directions of future studies and clinical applications. Methods: To obtain data from CNKI, set the field by '中醫學', '中藥', '中西醫結合' and used keywords '抽动障碍', '抽動穢語綜合', '小兒抽动', '兒童抽动' and '推拿', '導引', '按摩', 'Tuina', 'massage' in cross combination way. Results: 12 clinical studies were selected. These studies were analyzed by author & year, subjects, diagnostic criterion, evaluation criterion, syndrome differentiation, treatment period, methods& results, frequent acupoints and assessment of the quality of studies. All of reports achieved effective therapeutic results on the pediatric tic disorder with Tuina treatment. Conclusion: Tuina treatment has a positive effect and are easily accepted by children who have fear and rejection to traditional Korean Medicine such as acupuncture and Herbal remedy. It is also safe and simple to operate. So the Tuina treatment is worthy to disseminate potential for further development in the treatment of pediatric tic disorders.

• 동의신경정신과학회지
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• 제19권2호
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• pp.141-149
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• 2008

Objective : This study was designed to analyze the herbal medicine case-control studies of tic disorder in traditional chinese medicine. Method : For this study, we searched the studies on tic disorder, which had been published 2007, through web-site CNKI(中國知識基魔設施工程) http://www.cnki.net). There were 15 herbal medicine case-control studies and we focused on those studies. Results: 1. DSM-IV(7 studies), CCMD(5 studies) and ICD-10(3 studies) were frequently used in the diagnosis of tic disorder. 2. Paeonia radix alba, Uncariae ramulus et uncus and Glycyrrhizae radix were frequently used in treatment. Moreover Scorpio, Gastrodiae rhizoma, Pinelliae rhizoma and so on were used. 3. Treatment results were assessed by improvement of symptom, YGTSS and so on. 4. Herbal medicine treatment was more effective than western medicine treatment in most studies, and side effects of herbal medicine were far less than those of western medicine. Conclusion : There have been reported many herbal medicine treatment studies of tic disorder in traditional chinese medicine. We believe that these studies can be applied to the clinical practices in Korean medicine.

• 대한토목학회논문집
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• 제31권1B호
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• pp.21-27
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• 2011

유출예측량을 모의할 때 과거와 현재의 수문자료를 이용한다는 측면에서 미래 예측결과의 불확실성을 완전히 제거할 수는 없겠지만, 다양한 기법별 분석에 의하여 불확실성을 감소시킬 수 있다. 본 연구에서는 유출예측의 정확성 향상을 위해 다양한 유출예측 기법을 적용 및 평가하였으며 확률론적 예측을 가능하게 하는 예측기법인 ESP와 관측 시계열 자료를 이용한 통계기법으로 공주지점의 유출예측을 수행하였다. 각 기법에 따른 유출예측 결과의 신뢰성 평가는 MAE(Mean Absolute Error), RMSE(Root Mean Squared Error), RRMSE(Relative Root Mean Squared Error), Mean Absolute Percentage Error (MAPE), TIC(Theil Inequality Coefficient)를 이용하였다. ESP 확률을 이용하여 예측한 유출결과와 통계적 시계열 분석에 의해 예측된 유출결과를 MAE, RMSE, RRMSE, MAPE, TIC를 이용하여 비교 분석하였으며 유출예측의 개선효과를 확인해본 결과, ESP 확률을 이용한 예측이 MAE(10.6), RMSE(15.14), RRMSE(0.244), MAPE(22.74%), TIC(0.13)으로 평가되었으며 MAE(23.2), RMSE(37.13), RRMSE(0.596), MAPE(26.69%), TIC(0.30)으로 평가된 ARMA와 MAE(26.4), RMSE(34.44), RRMSE(0.563), MAPE(47.38%), TIC(0.25)으로 평가된 Winters 에 비해 신뢰성이 높게 나타났다.

• 생물정신의학
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• 제13권4호
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• pp.299-304
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• 2006

Objectives : The purpose of the present study was to investigate whether the TaqI A polymorphism of dopamine receptor D2 gene(DRD2) is associated with Tourette syndrome(TS) and chronic motor tic disorder(CMT) in Korean population. Methods : DRD2 TaqI A RFLP genotyping was carried out with DNA extracted from blood samples of 75 patients with tic disorders(47 with TS and 28 with CMT) and 90 healthy subjects. Genotype and allelic frequencies for the DRD2 gene polymorphisms of the tic disorder group as a whole were compared to those of the control group. Separating the TS group, thereafter, the frequency of genotypes and alleles were compared to those of the controls. Results : The results demonstrated that genotype and allele distributions for the DRD2 gene polymorphism in the tic disorder as a whole, TS, and control groups were not significantly different. Conclusion : No association was found for DRD2 gene, TS and CMT. The data suggest that DRD2 gene may not be a useful marker for the prediction of the susceptibility of tic disorder.

• 한국콘텐츠학회논문지
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• 제22권10호
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• pp.861-869
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• 2022

투렛증후군 환자에게서 뮤파(Mu wave) 동기화가 깨졌을 때 틱이 발생하고, 그 반대로 뮤파 동기화를 이루면 틱이 발생하지 않는다. 연구시험 결과는 전운동피질(Frontal Cortical 3 사이트)에서 뮤파 동기화를 틱 환자가 인위적으로 하지 않고 뉴로피드백 훈련처럼 자율적으로 뇌파 조절이 이뤄진다면 마찬가지 결과로 틱이 발생하지 않는다는 사실을 시사한다. 피시험자에게 틱을 억제시켰을 때 인지 제어 반응 프로세스가 변경된다. 변경된 인지 제어를 뇌파 주파수 파워를 조절하는 뉴로피드백으로 훈련하면 환자가 인위적으로 틱을 억제하지 않아도 자율적으로 치료가 된다. 연구시험 결과는 뇌 운동영역의 뮤파 통제를 통해 틱이 발생하지 않는 생체신호 지표가 뉴로피드백 훈련의 치료프로토콜이 될 수 있는 단초를 마련하였다. 기존 뉴로피드백 치료 프로토콜인 SMR강화, 세타파-베타파 불균형 수정, 알파파 강화 등에 뮤파 강화를 추가할 수 있게 되었다. 본 연구가 투렛증후군 환자 치료법인 뉴로피드백 치료 프로토콜을 보다 과학적으로 검증하는 후속 연구와 임상시험에 활용될 것이다.