• The Korean Journal of Pain
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• 제37권3호
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• pp.218-232
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• 2024

Background: Cynara scolymus has bioactive constituents and has been used for therapeutic actions. The present study was undertaken to investigate the mechanisms underlying pain-relieving effects of the hydroethanolic extract of C. scolymus (HECS). Methods: The antinociceptive activity of HECS was assessed through formalin and acetic acid-induced writhing tests at doses of 50, 100 and 200 mg/kg intraperitoneally. Additionally, naloxone (non-selective opioid receptors antagonist, 2 mg/kg), atropine (non-selective muscarinic receptors antagonist, 1 mg/kg), chlorpheniramine (histamine H₁-receptor antagonist, 20 mg/kg), cimetidine (histamine H₂-receptor antagonist, 12.5 mg/kg), flumazenil (GABA_A/BDZ receptor antagonist, 5 mg/kg) and cyproheptadine (serotonin receptor antagonist, 4 mg/kg) were used to determine the systems implicated in HECS-induced analgesia. Impact of HECS on locomotor activity was executed by open-field test. Determination of total phenolic content (TPC) and total flavonoid content (TFC) was done. Evaluation of antioxidant activity was conducted employing 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Results: HECS (50, 100 and 200 mg/kg) significantly indicated dose dependent antinociceptive activity against pain-related behavior induced by formalin and acetic acid (P < 0.001). Pretreatment with naloxone, atropine and flumazenil significantly reversed HECS-induced analgesia. Antinociceptive effect of HECS remained unaffected by chlorpheniramine, cimetidine and cyproheptadine. Locomotor activity was not affected by HECS. TPC and TFC of HECS were 59.49 ± 5.57 mgGAE/g dry extract and 93.39 ± 17.16 mgRE/g dry extract, respectively. DPPH free radical scavenging activity (IC₅₀) of HECS was 161.32 ± 0.03 ㎍/mL. Conclusions: HECS possesses antinociceptive activity which is mediated via opioidergic, cholinergic and GABAergic pathways.

• 구강회복응용과학지
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• 제35권1호
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• pp.20-26
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• 2019

목적: Wire를 꼬아서 제조한 twisted file (TF)이 개발된 이래, 최근에는 기존 twisted file의 내구성 및 절삭 효과를 증진시키기 위하여 구동방식의 변형을 준 TF-adaptive movement가 소개되었다. 본 연구의 목적은 TF-adaptive movement가 twisted file의 내구성에 미치는 영향을 조사하는 것이다. 연구 재료 및 방법: J자 모양의 근관 형태를 가지는 레진 모형 근관에 twisted file을 이용하여 근관 형성 시 adaptive movement (TFA군)와 continuous rotation movement (TFC군)의 두 가지 구동 방식 하에서 파일의 내구성을 비교하고, 각각의 모형 근관을 형성하는데 소요된 시간을 측정하였다. TF 파일을 사용할 때마다 치과용 현미경으로 TF의 날풀림(unwind) 또는 변형 및 파절 여부를 관찰하여 그때까지 TF로 형성한 모형 근관의 수를 기록하고, 사진을 촬영하였다. 또한 twisted file의 첨단(D0)에서 날풀림이 발생한 지점까지의 직선 거리를 측정했다. 실험 결과는 0.05의 유의수준에서 Mann-Whitney U test로 분석했다. 결과: 파일의 파절은 두 실험군 모두에서 발생하지 않았으며, TFC군은 TFA군에 비하여 날풀림이 발생하기 전까지 형성한 모형 근관의 수가 통계적으로 유의하게 적었으며, 모형 근관을 작업장까지 성형, 확대하는데 걸린 시간은 TFA군이 TFC군에 비해 유의하게 길었다. 날풀림이 발생한 지점의 위치는 TFC군과 TFA군 사이에 유의한 차이가 발견되지 않았다. 결론: Twisted file을 adaptive movement mode로 사용하여 근관을 형성하면 날풀림이 발생하기 전까지 확대할 수 있는 근관의 수가 증가했으나, 작업장까지 근관을 형성하는데 필요한 시간이 유의하게 증가했다. Adaptive movement와 continuous rotary movement 간에 기구의 날풀림이 발생하는 위치에는 유의한 차이가 발견되지 않았다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2002년도 하계학술대회 논문집 B
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• pp.860-863
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• 2002

Recently, main nozzle and inner nozzle for EHV class gas circuit breakers were made by PTFE(Poly Tetra Fluoro Ethylen) for the basic material composite. But, nowadays strengthened PTFE was demanded because the supply of electric power increased. This paper shows the research results for nozzles according to the filler materials.

• 동아시아식생활학회지
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• 제21권6호
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• pp.871-876
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• 2011

In the present study, we investigated the compositions, antioxidant activities and anti-tumor effects of Artemisia princeps Pampanini (APD) as well as blanched leaves (CNBD) and dried leaves (CND) from Cirsium setidens Nakai on HepG2 cells. Water and ash contents were increased in CND. Protein and lipid contents were increased in CNBD. K, Ca, Mg, Fe and Cu contents of CND were higher than those of CNDB and APD. P contents was significantly decreased in CND. Yields of CND was reached high levels, but TPC, TFC, acacetin, apigenin, cynarin contents, and antioxidant activity were higher in APD. Viability of HepG2 liver cells was significantly decreased in APD. Therefore, extracts of APD are more effective preventing the liver cancer than extracts of CND and CNBD.

• 천문학회보
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• 제40권2호
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• pp.55.3-55.3
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• 2015

We study the possibility of new approach for identifying instrumental noise artifacts and sources of gravitational wave (GW) data such as LIGO and CLIO using various correlation analyses.To improve the quality of data for the GW signal search, the instrumental noises should be reduced in an appropriate way. Furthermore, it is important to understand the correlation between auxiliary channels of the GW detector. In this study, we investigate the possible way of identifying glitch triggers by generating time-frequency-correlation (TFC) maps between the related channels and compare the result to the current conventional schemes.

• Natural Product Sciences
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• 제19권2호
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• pp.186-191
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• 2013

Screenings of potential antioxidant activities of Crataegus pinnatifida BUNGE Major. fruits extracted 80% methanol were performed using four antioxidant assays. Significant differences were observed both in total phenolic contents (TPC) and total flavonoid contents (TFC), DPPH radical scavenging activity, nitric oxide scavenging activity, ABTS radical scavenging assay, and reducing power assay. The total polyphenol content and total flavonoid content in the extract were measured to be $224.4{\pm}0.52$ mg GAE/100 g and $12{\pm}0.25$ mg QE/100 g, respectively. When the tested concentration was $500{\mu}g/mL$, DPPH and ABTS radical-scavenging activities of methanolic extracts were 84.15% and 88.8%, respectively. The reducing power and nitric oxide scavenging activity were increased at the manner of dose-dependently. These results suggest that methanolic extracts of Crataegus pinnatifida Bge. fruits possess excellent radical scavenging activities and may serve as a potential source of natural antioxidant.

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 2008년도 추계학술발표회 발표논문집
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• pp.198-201
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• 2008

매생이의 에탄올 추출물의 기능적 특성과 추출액의 플라보노이드와 페놀함량과의 상관성을 검토하고, 아질산염 분해능과 효소의 영향 등을 측정하였다. 매생이 에탄올 추출액의 클로로필 함량은 물추출보다 에탄올 추출의 경우가 높았으나, 플라보노이드 함량은 물추출액에서 약간 높게 나타났다. 추출액의 TPC함량은 TFC함량이 높을수록 높게 나타났으나 직접 비례하지는 않았다. 그리고 매생이에 함유된 아질산염 함량 측정결과와 아질산염 분해능 결파 비교로부터 에탄올 추출의 경우에는 아질산염 분해능이 시료자체의 아질산염 함량과 직접적인 영향이 없는 것으로 보였으며, 매생이 에탄올 추출액이 나타내는 아질산염 분해작용은 낮은 pH에서 높게 나타났으나, 매생이 자체에 존재하는 효소의 관여는 극히 미약하였다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.1833-1838
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• 2003

In the nuclear power plant, emergency core coolant system(ECCS) is furnished at reactor coolant system(RCS) in order to cool down high temperature water in case of emergency. However, in this coolant system, thermal stratification phenomenon can be occurred due to coolant leaking in the check valve. The thermal stratification produces excessive thermal stresses at the pipe wall so as to yield thermal fatigue crack(TFC) accident. In the present study, when the turbulence penetration occurs in the branch piping, the maximum temperature differences of fluid at the pipe cross-sections of the T-branch with thermal stratification are examine

• Advances in Traditional Medicine
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• 제8권1호
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• pp.32-38
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• 2008

Galgeuntang water extract exhibited a strong free radical scavenging activity and reducing power determination. However, a gradual increase in the free radical scavenging activity and reducing power determination was obtained with increasing concentrations. The highest radical scavenging activity was shown by the water extract from Galgeuntang (116.93 ${\mu}g$/mL) and the water extract from Cinnamonum cassia Presl. (95.01 ${\mu}g$/mL). These results of phenolic and flavonoid contents of the extracts indicated that the strong radical scavenging activity of the Cinnamonum cassia Presl. extract might be in part due to the phenolic compounds. The correlation coefficient between TPC and DPPH ($r^2$ = 0.9312), TFC and DPPH ($r^2$ = 0.9677), showed positive correlation among total phenolic/flavonoid contents and antioxidant activity. These results suggest that Galgeuntang has a potential antioxidant activity.

• 설비공학논문집
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• 제18권3호
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• pp.202-210
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• 2006

In the nuclear power plant, emergency core coolant system (ECCS) is furnished at reactor coolant system (RCS) in order to cool down high temperature water in case of emergency. However, in this coolant system, thermal stratification phenomenon can be occurred due to coolant leaking in the check valve. The thermal stratification produces excessive thormal stresses at the pipe wall so as to yield thermal fatigue crack (TFC) accident. In the present study, when the turbulence penetration occurs in the branch pipe, the maximum temperature differences of fluid at the pipe cross-sections of the T-branch with thermal stratification are examine.