• BMB Reports
• /
• v.53 no.8
• /
• pp.431-436
• /
• 2020

Alpha-fetoprotein (AFP) is one of the most commonly used and reliable biomarkers for Hepatocellular carcinoma（HCC). However, the underlying mechanism of AFP expression in HCC is poorly understood. In this study, we found that TCP10L, a gene specifically expressed in the liver, is down-regulated in HCC and that its expression inversely correlates with AFP expression. Moreover, overexpression of TCP10L suppresses AFP expression whereas knockdown of TCP10L increases AFP expression, suggesting that TCP10L might be a negative regulator of AFP. We found that TCP10L is associated with the AFP promoter and inhibits AFP promoter-driven transcriptional activity. Taken together, these results indicate that TCP10L negatively regulates AFP expression in HCC and that it could be a potential prognostic marker and therapeutic target for HCC.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.33 no.8B
• /
• pp.689-698
• /
• 2008

The performance of a TCP protocol on MANETs has been studied in a numerous researches. One of the significant reasons of TCP performance degradation on MANETs is inability to distinguish between packet losses due to congestion from those caused by nodes mobility and as consequence broken routes. This paper presents the Cluster-Label-based Routing (CLR) protocol that is an attempt to compensate source of TCP problems on MANETs - multi-hop mobile environment. By utilizing Cluster-Label-based mechanism for Backbone, the CLR is able to concentrate on detection and compensation of movement of a destination node. The proposed protocol provides better goodput and delay performance than standardized protocols especially in cases of large network size and/or high mobility rate.

• Journal of Communications and Networks
• /
• v.7 no.3
• /
• pp.385-393
• /
• 2005

In this paper, we propose a simple algorithm to adaptively adjust the value of dupthresh, the duplicate acknowledgement threshold that triggers the transmission control protocol (TCP) fast retransmission algorithm, to improve the TCP performance in a network environment with persistent packet reordering. Our algorithm uses an exponentially weighted moving average (EWMA) and the mean deviation of the lengths of the reordering events reported by a TCP receiver with the duplicate selective acknowledgement (DSACK) extension to estimate the value of dupthresh. We also apply an adaptive upper bound on dupthresh to avoid the retransmission timeout events. In addition, our algorithm includes a mechanism to exponentially reduce dupthresh when the retransmission timer expires. With these mechanisms, our algorithm is capable of converging to and staying at a near-optimal interval of dupthresh. The simulation results show that our algorithm improves the protocol performance significantly with minimal overheads, achieving a greater throughput and fewer false fast retransmissions.

• Proceedings of the Korean Information Science Society Conference
• /
• 2000.10c
• /
• pp.514-516
• /
• 2000

현재 가장 널리 쓰이는 수송계층 프로토콜인 TCP는 패킷 손실의 원인을 망의 혼잡 때문에 일어난다고 가정하고 있으므로 기존의 유선망과 고정 호스트로 이루어진 전통적인 네트워크에 적합하다. 그러나 무선 링크에서의 패킷 손실은 대부분 혼잡에 의해서가 아니라 높은 에러율과 핸드오프에 의해 발생하게 되므로 기존의 TCP를 그대로 사용하면 불필요한 혼잡제어 메커니즘의 호출로 성능의 저하를 가져온다. 현재까지 무선환경에 적합한 TCP를 위한 많은 방안이 제시되고 있지만 근본적인 해결책을 제시하지 못하고 있다. 본 논문에서 제안하는 기법은 패킷손실이 유선링크에서 일어나는 것인지, 무선링크에서 일어나는 것인지를 판별하여 패킷손실이 유선링크에서 일어난 경우는 기존의 혼잡제어 메커니즘을 호출하여 재전송하고, 무선링크에서 일어난 경우는 혼잡제어 메커니즘을 호출하지 않고 재전송 하여 성능을 개선한다.

• Proceedings of the IEEK Conference
• /
• 2000.07a
• /
• pp.117-120
• /
• 2000

As the use of real-time multimedia applications increases, a considerable amount of “greedy” UDP traffic would easily dominate network bandwidth and packet loss. As a result, bandwidth available to TCP connections is oppressed and their performance extremely deteriorates. In or-der that both TCP and UDP sessions fairly co-exist in the Internet, it is vital that we consider the fairness among both protocols. In this work, we implement a “TCP-friendly” rate control mechanism suitable to video applications and con-sider its applicability to a real system through observation of the video quality at the receiver and the connection state. It is shown that we can achieve high-quality and stable video transfer fairly sharing the network bandwidth with TCP by applying our rate control at a control interval of 32 times as long as RTT.

• Journal of the Korean Ceramic Society
• /
• v.30 no.11
• /
• pp.905-910
• /
• 1993

$\alpha$-tricalcium phosphate($\alpha$-TCP) powders were synthesized and their hydration properties were investigated in Tris. solution. Two kinds of $\alpha$-TCP powder samples were prepared; the one is reaction product of CaHPO4.2H2O and CaCO3, and another is that of hydroxyapatite(HAp) and $\beta$-Ca2P2O7. They were satisfied with Ca/P mole ratio 1.5 and were heated at 150$0^{\circ}C$ for 5 hours. In the hydration of $\alpha$-TCP samples the powder which was synthesized from HAp and $\beta$-Ca2P2O7 was hydrated faster than that from CaHPO4.2H2O and CaCO3. The hydration reaction of $\alpha$-TCP powder transformed rapidly into HAp accompanying setting and hardening. It was realized that the hydration reaction of $\alpha$-TCP was due to the solution-precipitation mechanism and the hydrates from the reaction were Ca-deficient HAp having funtional group HPO42-.

• Journal of KIISE:Information Networking
• /
• v.32 no.3
• /
• pp.382-390
• /
• 2005

As today's networks evolve towards an If-based integrated network, the role of transmission control protocol(TCP) has been increasing as well. As a well-known issue, the performance of TCP is affected by its loss recovery mechanism that is comprised of two algorithms; fast retransmit and fast recovery. Although retransmission timeout(RTO) caused by multiple packet losses can be avoided by using selective acknowledgement(SACK) option, RTO cannot be avoided if a retransmitted packet is lost. Therefore, we propose a simple modification to make it possible for a TCP sender using SACK option to detect a lost retransmission. In order to evaluate the proposed algorithm, simulations have been performed for two scenarios where packet losses are random and correlated. Simulation results show that the proposed algorithm can improve TCP performance significantly.

• Tribology and Lubricants
• /
• v.4 no.1
• /
• pp.43-55
• /
• 1988

A Study on the effect of the additives in lubricating oil was investigated on the basis of the thermal activated wear theory in terms of their wear behaviours, using four ballwear machine. The sample oils, which included diethyl-3, 5-di-t-butyi-4-hydroxy-benzyl phosphonate (DEP), ZDDP and TCP additives respectively, showed distinct wear characteristics depending upon the bulk oil temperature and the sliding velocity. The newly synthesized additive, viz., DEP showed excellent antiwear performance cornpared with the conventional additives, ZDDP and TCP. On the basis of the experimental results, it is reduced that the wear mechanism of the conventional additives, viz., ZDDP and TCP is the protective film formation and their antiwear capability is depending upon the shearing strength of the film formed. On the other hand, the new additive, DEP showed that the secondary activation energy was much eliminated and so, the thermal instability was reduced by the hydrogen scavenging reaction of the new additive, which was virtually an endothermic reaction process.In conclusion, a new concept of antiwear mechanism is estabilished and testified. And new chemical, which showed the function of hydrogen and free radical scavenging role, is synthesized and introduced as the new, highly antiwear effective lubricating oil additive.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.27 no.4C
• /
• pp.308-315
• /
• 2002

Guaranteed frame rate (GFR) service has been defied to provide minimum cell rate (MCR) guarantees for virtual connections (VCs) carrying Internet traffic in ATM networks and allow them to fairly share residual bandwidth. The simplest switch implementation mechanism to support the GFR service in ATM networks consists of the frame-based generic cell rate algorithm (F-GCRA) frame classifier and the early packet discard (EPD)-like buffer acceptance algorithm in a single FIFO buffer. This mechanism is simple, but has foiled to guarantee the same bandwidth as an MCR to a VC that has reserved a relatively large MCR. This paper applies the packet spacing scheme to TCP traffic to alleviate its burstness, so as to guarantee a larger MCR to a VC. In addition, the random early detection (RED) scheme is added to the buffer acceptance algorithm in order to improve fairness in use of residual bandwidth. Simulation results show that the applied two schemes improve a quality of service (QoS) in the GFR service for the TCP traffic.

• Journal of Korea Society of Industrial Information Systems
• /
• v.22 no.1
• /
• pp.33-40
• /
• 2017

In this Paper, Analyse the Steady State Behavior of TCP and TFRC with Packet Error when both TCP and TFRC Flows Co-exist in the Network. First, Model the Network with TCP and TFRC Connections as a Discrete Time System. Second, Calculate Average Round Trip Time of the Packet Between Source and Destination on Packet Loss Environment. Then Derive the Steady State Performance i.e. Throughput of TCP and TFRC, and Average Buffer Size of RED Router Based on the Analytic Network Model. The Throughput of TCP and TFRC Connection Decrease Rapidly with the Growth of Sending Window Size and Their Transmission Rate but Their Declines become Smoothly when the Number of Sending Window Arrives on Threshold Value. The Average Queue Length of RED Router Increases Slowly on Low Transmission Rate but Increases Rapidly on High Transmission Rate.