• Journal of Pharmaceutical Investigation
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• v.32 no.4
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• pp.267-275
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• 2002

A self-microemulsifying drug delivery system (SMEDDS) was developed to increase the dissolution rate, solubility, and ultimately bioavailability of a poorly water soluble drug, lovastatin. SMEDDS was thε mixtures of oils, surfactants, and cosurfactants, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal (GI) tract. Various types of self-emulsifying formulations were prepared using four types of oil (Capryol 90, Lauroglycol 90, Labrafil M 1944 CS and Labrafil M 2125), two surfactants (Cremophor EL and Tween 80), and three cosurfactants (Carbitol, PEG 400 and propylene glycol). Thε efficiency of emulsification was studied using a laser diffraction size analyzer to determine particle size distributions of the resultant emulsions. Optimized formulations selected for bioavailability assessment were Carpryol 90 (40%), Cremophor EL (30%) and Carbitol (30%). SMEDDS containing lovastatin (20 mg and 5 mg) were compared to a conventional lovastatin tablet $(Mevacor^{\circledR},\;20\;mg/tab)$ by the oral administration as prefilled hard gelatin capsules to fasted beagle dogs for in vivo study. The arεa under the serum concentration-time curve from time zero to the last measured time in serum, $AUC_{0{\rightarrow}24h}$, was significantly greater in SMEDDS, suggesting that bioavailability increase 130% and 192% by the SMEDDS, respectively. The self-emulsifying formulations of lovastatin afforded the improvement in absolute oral bioavailability relative to previous data of lovastatin tablet formulation. These data indicate the utility of dispersed self-emulsifying formulations for the oral delivery of lovastatin and potentially other poorly absorbed drugs.

• Journal of Navigation and Port Research
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• v.30 no.6 s.112
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• pp.551-559
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• 2006

The purpose of this study was to find out morbidity rate and pattern of disease and affect of variables related disease and medical management of seafares'. The subjects this study were 1049 seafares' were took education in Korea Institute of Maritime and Fisheries Technology. This questionnaire was focused on finding the basic data for prevention of disease and promotion health for the seafares'. The collected data were analyzed by using descriptive statistics, Chi-square, cross tab, linear regression by SPSS 10.1 package. The result of this study are as follow. 1)The morbidity rate within recent 12 months was 69.0%. 2)there were significant differences qf occurred disease in age(p<0.05), income(p<0.01), career of ship on board(p<0.01), rank(p<.01), perceived health status(p<0.01), worry of health(p<0.01), fatigue symptoms(0.01), satisfy of job(p<0.05), rest time(p<0.05) 3) Considering disease unable to work more than 4 hour, the number of those who had oral disease 7.3%> tinea 6.6%> gastric ulcer 6.4, and musculoskeletal disease group were 20.9%, which revealed the highest rate oral disease 13.6%> skin disease> 12.4%, digestive disease> 12.1%. 4) As refer to medical management, The pain above 31days 35.7%, hospitalization and treatment below 7days were each 50.2%, 42.8%, medical service were doctor's office 27.9, which revealed the highest rate.

• Journal of architectural history
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• v.12 no.4 s.36
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• pp.7-26
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• 2003

This article works on the development process of the Buddhist Temple with two pagodas in the Eastern Asia. in 7-8th centuries. This study was motivated from the observation that why there are many the Buddhist Temple having two pagodas only around the late 7th century, roughly around 670 A.D.. This period corresponds to the Silla Dynasty(in Korean History) and Hakuho Period(in Japan History) among the Eastern Asia while the composition of the temple being changed as Buddhism spreads out from China. The results of this study are the followings. The appearance of the Buddhist Temple having two pagodas was resulted from the representation of the Ideology in Botabpum(dogma of pagoda security) of the Saddharmapundarika Sutra, that is to say, two Buddhas sit side by side and iconography of Esoteric Buddhism dogma supports the spirit for defending one's country. Buddhist Temple having two pagodas in China had separate tab-won(areas with pagodas outer temple building block). Buddhist Temple having two pagodas in Korea had begun with sacheunwangsa temple in Unified-Silla. But it had two pagodas with inner temple area instead of outer. This was different from the composition of China. It can be related to the layout of the temple haying two pagodas in East-Jin(in China History) and the sculpture of two pagodas in Ungang-stonecave(in China). Thus the layout of the Buddhist Temple having two pagodas in Silla had been originated from that of China, but was developed to the main temple layout on her own accord. As Japanese Temple having two pagodas had been influenced diplomatically, it had two pagodas inner area as like the layout in Shilla. But later under the influence of Tang it was modified to the layout having them in separate area. And this influence can be seen for example Tangchojaesa temple. For the more, We call see that the diplomatic trends according to the policies in East asia affected to Buddhism and then naturally also to the layout of the Buddhist Temple.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.17 no.6
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• pp.121-126
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• 2017

Recently, a lot of people use touch-pen devices such as smart phones and tab computers. To generate the picture and text, a user can give input or control the touch-pen device through simple or multi-touch gestures by touching the screen with a special stylus pen and/or one or more fingers. The accuracy and response time from the moment of contact with the touch board is very important to the touch device. Therefore, research is needed to find a way of removing the noise included in the touch signal quickly and efficiently. In this paper, we propose a method for removing a noise mixed in with a touch point coordinate which has been caused by a input pen on the touch screen. For effective filtering, the fast sampling of the coordinate corresponding to the noise from the input signal is required primarily. Secondly the total compensation of the touch coordinates using the characteristics of the B-Spline curve is applied to correct coordinates of the points. This method can ensure a real-time response than other algorithms. The applied performance evaluation method is comparing error pixels with evaluation values by dividing 10 intervals on the touch pad diagonally. Usually the average error is 7.1 pixels but our proposed method shows an average 4.1 errors. Therefore, our proposed touch pen method can express the input signal on the coordinates more correctly.

• The Journal of Korean Academy of Prosthodontics
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• v.50 no.3
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• pp.191-197
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• 2012

Esthetics is important in restoring maxillary anterior area. Alveolar bone resorption and loss of interdental papilla may be minimized by immediate implantation. Previous studies showed successful results with the immediate implantation in healthy extraction socket, while many of these studies objected the immediate implantation into extraction sites with periapical lesions. Recent studies, however, reported successful results of the immediate implantation into extraction sites with periapical lesions with careful debridement of extraction sockets and general medication of antibiotics prior to implantation. A 73-year-old female visited the department of Prosthodontics in ${\bigcirc}{\bigcirc}$ University Dental Hospital with the chief complaint of fallen post-core and crown on left maxillary incisor. Although the incisor was with vertical root fracture and periapical lesion, the immediate implantation following the extraction of tooth was planned. Thorough socket debridement, irrigation with chlorhexidine, and tetracycline soaking were followed by immediate implantation. The general medication of antibiotics (Moxicle Tab.$^{(R)}$, 375 mg) was prescribed before and after the surgery. Immediate provisional restoration was delivered two days after the surgery, and the definitive metal-ceramic restoration was placed about six months later after reproducing the emergence profile from the provisional restoration. This case presents satisfying result esthetically and functionally upto two years after the placement of prosthesis with the harmonious gingival line and no loss of marginal bone.

• Journal of Technologic Dentistry
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• v.32 no.4
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• pp.341-350
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• 2010

Purpose: This study focused on achieving desired shades by combining zirconia core with different thickness porcelain in order to make dental prostheses effectively. Methods: White and colored $LAVA^{TM}$ All Ceramic (3M-ESPE, Seefeld, Germany), and Zirkonzahn (Bruneck, Italy) Trans and prettau were used to have Zirconia. LAVATM Ceram (3M-ESPE, Germany) and ICE (Zirkonzahn, Italy) powder were used to have the porcelain. We made quadrilateral specimen of thickness 0.3mm, 0.5mm, 0.7mm and diameter 10 to use zirconia ceramics system of 2 kinds that color tone reappearance way is different and produced total 120 specimens to 4 experimental groups. We used Spectrophotometer to analyze color tone. Data's value getting by dispersal colorimetry period found L*, a*, b* value using Excel program. We used one-way ANOVA to use SPSS WIN 12.0 program. Results: All L*, a*, b* indexes of zirconia core and porcelain veneer in LAVA group and Zirkonzahn group were different. When you combine the white zirconia core of LAVA group with a porcelain veneer, the thickness of the porcelain must be more than 0.5mm to meet the standard target. When all the colored zirconia cores of LAVA group were combined with porcelain veneers, there was no significant difference from the standard target. When the zirconia cores of Zirkonzahn group are combined with porcelain veneers, the thinner thicknesses were closer to the standard tab than thicker thicknesses; however, there was a significant difference in all combinations, with Delta E* value indicating more than 3. Conclusion: When it comes to colored zirconia, which is the most popular, the thicknesses of both a core and a dentin veneer must be more than 0.3mm to get an appropriate shade. There is more possibility to get desirable shades when the thicknesses of a white core are thinner; however, they would be vulnerable to the environment and lose their color. When combine a zirconia core with a dentin veneer, using Zirkonzahn group needs more considerations in order to meet the standard target.

• Korean Journal of Food Science and Technology
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• v.31 no.4
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• pp.1057-1064
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• 1999

Cortex Mori radicis has been used in the treatment of diabetes mellitus. In this study, the antihyperglycemic effect of Cortex Mori radicis was observed in obese diabetic mice(C57BLKsJ db/db). Cold water extract of Cortex Mori radicis was supplied in tab water(500, 1000 mg/kg/day) with normal chow for 5 weeks. Food intake and body weight gain were decreased significantly in experimental group. Also experimental group exhibited lower fasting serum glucose level when compaired to control group. Hb Alc level and triglyceride level were lowered in a dose-dependent manner. The activity of small intestinal disaccharidases was decreased at most segments. In conclusion, Cortex Mori radicis has anti-obesity effect to reduce food intake and body weight gain. And it is able to decrease the activity of small intestinal disaccharides and thus it can reduce serum glucose level and triglyceride level.

• Nuclear Engineering and Technology
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• v.8 no.2
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• pp.89-99
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• 1976

The grafting of acrylic acid in aqueous solution to polyvinyl chloride fibers tab been studied in the presence of ferrous, ferric, and cupric salts, The mutual irradiation technique was adopted using a Co-60 source or a Van do Graaff accelerator. The grafting and homopolymerization were suppressed by the cations. Particularly the grafting was suppressed by the cations in the following order of effectiveness : $Cu^{2+}$>$Fe^{2+}$>$Cu^{3+}$. The rate of grafting (in %/hr) was proportional to the 0.76th power of the dose rate over the range from 8.5f $10^3$ rad/hr to $1.4\times10^5$ rad/dr. The apparent activation energy for the grafting was determined to be 6.1 Kcal/mole between $25^{\circ}$ and $75^{\circ}C$ for the mixture of AA-HaO-$(CH_2Cl)_2$, containing Mohr's salt, $4\times10^{-3}$ mole/l. The increase of the grafting was observed when total dose and dose intensity were raised, or when ethylene dichloride as a swelling agent was saturated in the monomer mixture. The grafted polyvinyl chloride fibers showed considerable improvement in moisture regain, heat shrinkage, and melting properties, but tensile properties were not significantly affected by grafting.

• The Journal of the Petrological Society of Korea
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• v.8 no.3
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• pp.149-170
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• 1999

The volcanic lavas in the Janggi area are plotted on basalt, basaltic andesite and andesite field (SiO$_2$; 48-61 wt.%) in the TAS diagram and belong to subalkaline series. Nineteen chenmical analyses of lavas show two distinct differentiation trends; tholeiitic and calc-alkaline. Calc-alkaline basaltic andesites composed of plagioclase and two-pyroxenes (cpx, opx) in their phenocrysts. Tholeiitics basaltic lavas can be classified into two sub-types. The one is porphyritic basalts composed of plagioclase, clinopyroxene and olivine phenocryst, and the other is aphyric basalt and more evolved lavas (aphyric basaltic andesite) with the same mineral phases. Incompatible elements and REE patterns show the enrichment of LILE and depletion of HFSE. This characteristics indicate that these lavas are evolved from the magmas related to subduction. Howeverm calc-alkaline basaltic andesite lavas show that slightly higher enrichment of LILE and the depletion of HFSE than those of tholeiitic basaltic lavas. On the tectonic discriminant diagram such as Ba/Th and La/Th ratios, calc-alkaline basaltic andesite lavas belong to orogenic medium to high-K suites, whereas tholeiitic basaltic lavas belong to medium-K suites and MORB. On the other diagram, such as La/Yb vs. Th/Yb, the volcanic lavas in the study area plotted in the field of oceanic arc basalt. Tholeiitic basaltic lavas are located in more prinitive environment than calc-alkaline andesitic lavas.

• Journal of the Korean Society of Food Science and Nutrition
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• v.23 no.6
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• pp.986-993
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• 1994

As a part of development of traditional foods, mugwort boogag and dry laver boogag were fried insoybean oil, and BHA or tocopherol-added soybean oil. They were wrapped up in opp vinyl film, and preserved at $4^{\circ}C(RH{\;}40{\pm}5%){\;}and{\;}25^{\circ}C(RH{\;}80{\pm}5%)$. During the storage of bobogags, acid value, peroxide value, and TBA value were investigated. Changes of sensory evaluation and texture profile were also examined. Boogags were manufactured by washing the raw materials. drying in the shade, mixing them with glutinous rice flour, and hot-air drying up it to 13 % of moisture contents after dryed it up to 80% of moisture contents on dry table for 23days, in order. These boogags were packaged to manufacture goods with dryed state or fried at $160^{\circ}C$ for 10 sec. Acid value, peroxide value, and TBA value of boogags which preserved at $4^{\circ}C$ generally appeared lower than at $25^{\circ}C$. As storage time goes by, moisture contents of bobogagas preserved at $25^{\circ}C$ increased and its quality were gradually deteriorated. When the boogags were fried in BHA(0.01%) and tocopherol (0.01%) added soybean oil, changes of acid value, peroxide value, TBA value were generally low. During the storage of bobogagas antioxidant effect of BHA was higher than that of tocopherol. Texture was inclined to decrease as storage time goes, by that of boogags preserved at $4^{\circ}C$ was a little more satisfactory. Hardness was also high.