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Design and Optimization of Solid Dispersed Osmotic Pump Tablets of Aceclofenac, A Better Approach to Treat Arthritis

  • Edavalath, Sudeesh;Rao, B. Prakash
    • Journal of Pharmaceutical Investigation
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    • v.41 no.4
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    • pp.217-225
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    • 2011
  • The aim of this work was to prepare porous osmotic pump tablets for controlled delivery of Aceclofenac. Aceclofenac solid dispersion was prepared to improve the solubility by using the drug - carrier (Mannitol) ratio of 1:1. The osmotic pump tablets were prepared using the solid dispersed product of Aceclofenac. The formulation contains potassium chloride as osmotic agent, cellulose acetate as semipermeable membrane, poly ethylene glycol (PEG 4000) as pore former and sodium lauryl sulphate (SLS) as solubility enhancer. The formulations were designed by the general factors such as osmotic agent and pore former. All formulations were evaluated for various physical parameters and, the in vitro release studies were conducted as per USP. The drug release kinetic studies such as zero order, first order, and Higuchi and Korsmeyer peppas were determined and compared. All the formulations gave more controlled release compared to the marketed tablet studied. Numerical optimization techniques were applied to found out the best formulation by considering the parameter of in vitro drug release kinetics and dissolution profile standards. It was concluded that the porous osmotic pump tablets (F7) composed of Aceclofenac solid dispersion/Potassium chloride/Lactose/Sodium lauryl sulphate/Magnesium Stearate (400/40/95/10/5, mg/tab) and coating composition with Cellulose acetate/ PEG 4000 (60/40 %w/w) is the most satisfactory formulation. The porous osmotic pump tablets provide prolonged, controlled, and gastrointestinal environment-independent drug release.

Awareness of Difference between Physical Therapy and Rehabilitation Therapy among Some University Students (일부 대학생의 물리치료와 재활치료의 차이점에 대한 인지도)

  • Lee, Han Suk
    • The Journal of Korean Physical Therapy
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    • v.25 no.5
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    • pp.322-329
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    • 2013
  • Purpose: This study was conducted in order to investigate the awareness of physical therapy and difference between physical therapy and rehabilitation therapy. Methods: A total of 183 subjects who gave consent to participate in the survey at five universities in Gyenggi-do were randomly selected and the survey was conducted from February 2012 to July 2013 by a questionnaire consisting of 13 questions. Frequency analysis for the awareness of the general characteristics of physical therapy, anticipated cost, awareness of difference, and cross tab analysis for correlation with each item were used. Results: Participants recognized the academic ability, and the department for management of physical therapist licensing very well. The kindness and workmanship of physical therapists were average. According to their experience of physical therapy, most participants received a hot pack and electrical therapy at a local clinic and satisfaction with treatment was high. The percentage of students who recognized a difference between physical therapy and rehabilitation therapy was high, however, they misunderstood only electrical therapy for physical therapy and they recognized the exercise method of physical therapy for rehabilitation therapy. No correlation of the awareness of difference was observed between physical therapy and rehabilitation therapy and the awareness of physical therapy, experience, and anticipated cost, except the major of students. Conclusion: We found that people can misunderstand exercise therapy for rehabilitation therapy even though they have good awareness of physical therapy. Therefore, a physical therapist has to find the ways to express their identity while working.

Comparision of Fashion Show Effectiveness Perception as a Tool of Sales Promotion between Consumers and Sponsors (프로모션 매체로서의 Fashion Show에 관한 소비자와 주최자의 인식비교)

  • Ku, Yang-Suk;Hur, Jin-Hee
    • Fashion & Textile Research Journal
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    • v.2 no.2
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    • pp.159-168
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    • 2000
  • The purpose of this study was to identify and to compare the fashion show effectiveness between consumers and sponsors. The data were analyzed by using frequency, factor analysis, cross-tab, t-test and Kruskal Wallis with utilizing SPSS for Windows. The results of this study were as follow: 1. There was a favorable attitude towards fashion show itself but negative attitude towards possibility of purchasing clothes through fashion show. 2. Possibility of purchasing clothes through fashion show was very rare. Only 7.3% of consumers showed the experience of purchasing clothes through the show. 3. There were significant differences in the perception of watching fashion show purpose between consumers and sponsors. Consumers considered fashion show as more entertaining factor but sponsors considered show as more informative and sales promotion factor. 4. There was different recognition about purpose of having fashion show between consumers and sponsors. Sponsors utilized fashion show for the sales promotion medium but consumers recognized the fashion show as publicity for the company. 5. Sponsors showed more favorable attitude towards fashion show than consumers group.

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A Study on the Performance of Ramp Tabs Asymmetrically Installed in the Supersonic Nozzle Exit (초음속 노즐 출구에 비대칭적으로 설치한 램프 탭의 성능 연구)

  • Kim, Kyoung-Rean;Ko, Jae-Myoung;Park, Jong-Ho
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.35 no.10
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    • pp.934-939
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    • 2007
  • Thrust vector control(TVC) is the method which generates the side force and moment by controlling the exhausting gas directly from the supersonic nozzle to change the trajectory of a missile quickly. In this paper, performance study on the tapered ramp tabs asymmetrically installed in the supersonic nozzle exhaust for the thurst vector control has been carried out using the supersonic cold flow system. To study the shock wave structure and location of the oblique shock wave produced by the ramp tab, the flow field visualization using the schlieren system is conducted. This paper provides the thrust spoilage, three directional forces and moments and distribution of surface pressure on the region enclosed by the tapered ramp tabs.

A study on hamburger button UI of smart phone (스마트 폰의 햄버거 버튼 UI 연구)

  • Kim, Hwoikwang;Lee, Youngju
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.13 no.4
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    • pp.171-178
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    • 2017
  • The controversy about the burger button triggered in 2013 is that it is difficult to know what the hamburger button itself means and that it is difficult to predict what will happen when the button is clicked, Could. This controversy was found to be fundamentally out of touch, and it could be seen that it caused conflict with Apple's navigation structure with iOS. Therefore, in the case of Apple, it is often used in the form of a tab at the bottom instead of using the slide menu, but it is preferable to be used for the purpose of the hamburger button. I've looked through a variety of documents and found that the amount of content you want to offer on your app or the web is large, and there are five or more categories. And if a sub-category needs to exist in the main category like a large shopping mall, the hamburger button could provide the best UI. Apps and webs that can be curated, such as news and pinterest, are better used to enhance the search filter than to place a hamburger button, and for apps or the web that has a longer amount of content on a page Scrolling was available as an alternative to the burger button. In other words, depending on the amount of content to be provided, it is possible to decide whether to use the hamburger menu from the time of designing the information architecture.

An analysis of ground supported farm silo with variable thickness (I) -Part I mechanical characteristics of shell with Variable thickness- (지반과 구조물사이의 상호작용을 고려한 변단면 도통형쉘의 해석 (I) -변단면 쉘의 역학적 특성 (I)-)

  • 조진구;조현영
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.31 no.4
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    • pp.58-71
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    • 1989
  • This study aims to develop a computerized program for analysis of the ground-supported cylindrical shell structure with step varied section and to find out its mechanical characteri- stics through application of the developed program to the analysis of a ensiled farm silo as a model structure. The thickness of wall and bottom-plate of farm silo is assumed to be step-varied and its detailed structural dimensions are presented in Tab. 1 and 2. Several numerical case studies show that sectional stresses of the sample structures are largely reduced by adopting "varied section" design technique. And, other major results ob- tained from this study are summarize4 as follows ; 1. The variation of wall-thickness has a great influence on bending stresses of wall. Ho- wever, the larger the relative thickness of bottom-plate is, the smaller the influence is. 2. The magnitude of thickness of projecting toe of bottom-plate has negligible effect on sectional stresses 3. The conventional design methodology, which assumes the bottom edge of wall as clam- ped on ground, is proved to be discarded through the numerical analysis. 4. It is found that the "varied section" design technique should get similar effects as in the case of thick bott6m-plate having uniform thickness. 5. The variation of wall-thickness has a considerable effect on the bending stresses of bo- ttom-plate. Especially, this phenomenon is very remarkable in its projecting toe. In some cases. the negative bending moment may be acted on.

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Performance Study of Supersonic Nozzle with Asymmetric Entrance Shape (유입부 비대칭 노즐의 성능연구)

  • Lee Ji-Hyung;Kim Joug-Keun;Lee Do-Hyung
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2005.11a
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    • pp.40-45
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    • 2005
  • Techniques used for throcket motors are mainly classified as fixed nozzles with mechanical exhaust jet interferences on the expansion region (such as jet tabs and jet vanes) and movable nozzles(such as ball&socket md flexible seal). Using the numerical analysis and the cold-flow test, this paper evaluates the performance of supersonic nozzle for asymmetric entrance shape at tilted position of ball&socket nozzle. Numerical results show that the asymmetric effects in the flow fields are gradually diminished up to the nozzle throat and are not noticeable downstream of the nozzle throat. Although the calculated thrust and the lateral force are less than those of cold-flow test, two results show a flirty good agreement.

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Evaluation on Usability of Space in Leed-Certified Office Building (친환경 인증 오피스 건축물의 공간 이용성 평가)

  • Kang, Inho;Park, Jung-A
    • KIEAE Journal
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    • v.14 no.4
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    • pp.103-109
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    • 2014
  • The purpose of this study was to evaluate the usability and satisfaction of space to which positive elements in Leed-Certified Office Building are applied. The study was conducted using the three-step approach. The first step was to understand the building and identify the issues which included the analysis of floor plans, documentations, and the interview with designers and facility managers. The second step was FGI(Focus Group Interviews), which were conducted with mixed employees of rank and location of workplace. Finally, a web-based questionnaire survey was conducted on the 319 executives and employees. Methods of analysis used were quantitative analysis of questionnaire, qualitative analysis of open ended free-answer, and FGI in the second step. Satisfaction, preference, and comfort level were studied using cross tab, co-relation, ANOVA for quantitative analysis. The results of this study are as follows: First, lobby and atrium are representative elements that are functioning positively and it is recognized as sustainable spaces being utilized by users. Second, there are several dead spaces like green shaft, roof garden and sunken space although they can contribute to Leed-certification. Third, there are some problematic spaces such as the O.A. room and the urinals even though they contribute to the Leed-certification.

An implementation of the hybrid SoC for multi-channel single tone phase detection (다채널 단일톤 신호의 위상검출을 위한 Hybrid SoC 구현)

  • Lee, Wan-Gyu;Kim, Byoung-Il;Chang, Tae-Gyu
    • Proceedings of the KIEE Conference
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    • 2006.10c
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    • pp.388-390
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    • 2006
  • This paper presents a hybrid SoC design for phase detection of single tone signal. The designed hybrid SoC is composed of three functional blocks, i.e., an analog to digital converter module, a phase detection module and a controller module. A design of the controller module is based on a 16-bit RISC architecture. An I/O interface and an LCD control interface for transmission and display of phase measurement values are included in the design of the controller module. A design of the phase detector is based on a recursive sliding-DFT. The recursive architecture effectively reduces the gate numbers required in the implementation of the module. The ADC module includes a single-bit second-order sigma-delta modulator and a digital decimation filter. The decimation filter is designed to give 98dB of SNR for the ADC. The effective resolution of the ADC is enhanced to 98dB of SNR by the incorporation of a pre FIR filter, a 2-stage cascaded integrator- comb(CIC) filter and a 30-tab FIR filter in the decimation. The hybrid SoC is verified in FPGA and implemented in 0.35 CMOS Technology.

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Balancing air flow at terminal in CAV duct system with DPM method (정풍량방식 덕트에서 이중압력측정방법을 이용한 취출구 풍량조정)

  • 이대우;박명식;박영우
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.10 no.1
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    • pp.66-78
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    • 1998
  • Adequate ventilation with the proper amount of air to the right place is important factor to achieve a good Indoor air climate. Thus it is of prime importance that the ventilation system is working properly. This requires reliable pressure loss calculation to balance the air flow through duct systems. So a computer program for balancing CAV duct system is developed In this study. The results of CAV duct system is compared with the "Balans" code developed by Larsen from Norway. To obtain the pressure drop characteristics of damper at duct terminal, some experiments are performed using DPM(Dual Pressure Measurement) system. To adjust the resistance of damper, present study suggests that some special diffusers should be designed and damper producers should give the data of air flow vs. pressure drop to the customs when they manufacture the damper. One of the results concludes that the working time can be reduced from several minutes to several seconds per damper in the present experimental site, if the DPM system and the air volume adjusting process are used.

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