• 한국산학기술학회논문지
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• 제22권3호
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• pp.323-332
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• 2021

본 연구의 목적은 배뇨장애 치료를 위한 실로도신과 솔리페나신 숙신산염을 함유한 새로운 복합 정제를 개발하는 것이다. 이러한 목표를 달성하기 위하여 실로도신과 솔리페나신 숙신산염의 동시 정량법을 확립하였다. 두 약물은 다양한 완충액에서 1 mg/ml 이상의 수용해도 값을 나타내었으며, 실로도신과 솔리페나신 숙신산염이 함유된 시판제품의 용출은 다양한 용출조건에서 30분 이내에 완료되었다. 시차 주사 열량계를 사용하여 부형제와 약물 간 상호 반응성을 확인하여 선정된, 약물과 반응성이 없는 부형제를 사용하여 습식 과립화 방법을 사용하여 결합제와 붕해제의 사용에 따른 다양한 처방을 제조한 후 용출시험을 진행하였다. 제조한 정제의 처방 중 실로도신, 솔리페나신 숙신산염, 유당, 미결정셀룰로오스 PH101, 소듐라우릴설페이트, 포비돈 K-30, 크로스포비돈 및 스테아린산마그네슘이 8/10/56/112/2/6/6/2(w/w)의 비율로 제조된 정제는 트루패스정(실로도신 시판 제품) 및 베시케어정(솔리페나신 숙신산염 시판 제품)과의 비교용출 시험시 동등성을 나타내는 것을 확인하였다. 따라서, 본 연구를 통해 얻어진 복합 정제는 각 약물의 시판 제품과 동등한 생체이용률을 나타낼 수 있을 것으로 판단되며, 향후 배뇨 장애 치료에 복약순응도가 우수한 의약품으로 활용될 수 있을 것으로 사료된다.

• 한국항해항만학회지
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• 제47권6호
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• pp.358-366
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• 2023

본 연구는 해양수산부의 '지능형 해상교통정보시스템' 서비스 중 '사고취약선박 모니터링 서비스'의 선박 충돌 경보를 개선하기 위한 것으로, 현재의 선박 충돌 경보는 대형 선박 위주의 데이터와 그 운항자에 기반한 설문조사 레이블을 가지고 지도 학습(SL)한 모델을 사용하고 있다. 이로 인해, 소형선박 데이터 및 운항자의 의견이 현재 충돌 지도학습 모델에 반영되지 않아, 소형선박 운항자가 느끼는 체감보다 먼 거리에서 경보가 제공되기 때문에 그 효과가 미비하다. 또한, 지도학습(SL) 방법은 레이블링 된 다수의 데이터가 필요하지만, 레이블링 과정에서 많은 자원과 시간이 필요하다. 본 논문은 이러한 한계를 극복하기 위해 준지도학습(SSL)의 알고리즘인 Label Propagation과 TabNet을 사용하여 레이블이 결정되지 않은 데이터를 활용하여 소형선박을 위한 충돌 경보의 분류 모델을 연구하였다. 충돌 경보의 분류 모델을 활용하여 소형선박 운항자를 대상으로 실해역 시험을 수행한 결과 운항자의 만족도가 증가하는 결과를 확인하였다.

• Biomolecules & Therapeutics
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• 제16권2호
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• pp.168-172
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• 2008

The present study is to determine of sensitive nicorandil analysis method using HPLC and measure the pharmacokinetics parameters (bioavailability, $C_{max}$, $T_{max}$, Ke, $T_{1/2}$) of nicorandil (5 mg, Tab; Choongwae Pharma Corporation). Plasma (500 ul) was mixed with furosemide (internal standard, 500 ug/ml). Detection wavelength was 256 nm. The mixture of 0.01 M ammonium acetate and acetonitrile 80:20 (v/v) was used mobile phase. The HPLC separation was accomplished on ODC reverse HPLC column. The nicorandil was analyzed by a HPLC system, which consists of CAPCELL PAK C18 column (5 ${\mu}$m, 4.6 × 150 mm) and a chromatography data analysis S/W, using a isocratic mobile phase (mixture of 0.01 M ammonium acetate and acetonitrile 80:20 ) at 1.0 ml/min. Its sensitivity, selectivity, accuracy and precision must be adequate for the bioavailabilty study of nicorandil, and the linearity ($r^2$ ≥ 0.9994) of nicorandil was also proved in the range of 0.05 ug/ml . 3 ug/ml. The pharmacokinetic parameters of nicorandil (5 mg) tablets were measured as the follow. AUC: 0.19 ug/ml·hr, $C_{max}$: 0.14 ug/ml, $t_{max}$: 0.58 hr, Ke: 0.11 hr., $t_{1/2\beta}$: 6.76 hrs. This method is simple and sensitive HPLC method using UV detector for determination of nicorandil in human plasma.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2006년도 추계학술발표대회 논문집
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• pp.139-143
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• 2006

The purpose of this study is to analyze the characteristic of living environment on nursing homes and to examine the current status and problems of the nursing homes by looking into the differences in the spatial uniqueness of living environment in relation to the characteristics of the nursing home. This study utilized a mail survey during July 29 - August 31, 2006 that included a structured questionnaire. The questionnaire largely dealt with the general feature of the facility and the elderly who live there, and the spatial feature of the facility. The study limited its survey to those facilities that were registered to the Ministry of Health and Welfare, which opened after 1995 and that had the capacity of more than 30 people. As a result, the questionnaire was sent to the directors of 344 facilities who were in charge of the nursing home operation and planning. 182 facilities returned the questionnaire and the study used'182 questionnaires for data analysis. The study used the SPSS 12 program to draws the frequency, percentage of the answers and utilized the cross-tab, t-test, ANOVA to analyze the differences.

• 한국산림과학회지
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• 제5권1호
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• pp.27-32
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• 1966

Taking an opportunity of the application of clearcutting method, 140 red pine (Pinus densiflora Sieb. et Zucc.) trees grown at Chon-nam province, the southern part of South Korea, were fellen and the tree height, clear-bole length, D.B.H. diameter at base(0.2m above from the ground line) and the length of the longest branch were measured. The correlation between factors mentioned were analysed. The results are summarized as follows: 1. The correlation between crown length and tree height (r=0.821) was sinificant. 2. The correlation between the diameter at base and D.B.H. was highly significant (r=0.961). D.B.H. can be calculated from multiplying the diameter at base by 0.88. 3. A weak relation between D.B.H and tree height was abserved. 4. The positive correlation between tree height and clear-bole-length was calculated, but it was not sharp between D.B.H. and the length of the longest branch. 5. The height, basal area, D.B.H. and volume increment by tree class calculated from the data of the stem analysis are presented (Tab. 3~10).

• 농촌지도와개발
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• 제12권2호
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• pp.231-241
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• 2005

The objectives of this study were to explore leadership program participation of rural leaders and to analyze needs assessment for leadership program. The data were collected from 273 rural leaders by stratified random sampling. The SPSSWIN/ver.10 program was used for analyzing data with frequency and cross-tab analysis. The major findings of this study were as follows; 1) Rural leaders should effectively use leadership competency after leadership program. 2) Major problems of leadership program were lecturers' speciality and rather vague educational purpose. 3) Rural leaders wanted to learn more about rural and agricultural policies, conflict resolution among residents, specific and specialized leadership skills, and organizational activities. 4) Rural leaders responded that they need more programs on developing logical thinking, organizational competency, creative thinking, and positive attitude. 5) Characteristics of rural leaders should be considered in developing and implementing leadership programs.

• 대한기계학회논문집B
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• 제28권10호
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• pp.1139-1146
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• 2004

The effect of triangular tabs attached at the perimeter of jet nozzle on heat transfer enhancement was investigated experimentally. The modified flow structure was visualized using a smoke-wire method. Four different types of jet nozzle having 0, 4, 6 and 8 tabs were tested at jet Reynolds number Re=15,000 to investigate the effect of tabs on the variation of heat transfer rate. The local and average Nusselt numbers are increased with increasing the number of tabs. At nozzle-to-plate distance of L/D=4, the average Nusselt number was increased about 9.9% at Re=15,000 in the impingement region for the case of 8 tabs attachment. As the nozzle-to-plate distance increases, however, the heat transfer enhancement effect of triangular tabs is reduced. For the case of 4 tabs, the heat transfer enhancement is not so distinctive at L/D=8. As the protrusion depth of tabs into the jet flow increases, the heat transfer rate is also enhanced when the nozzle-to-plate distance is smaller than L/D=6.

• 월간 기계설비
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• 통권232호
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• pp.50-70
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• 2009

T.A.B란 공기조화설비에 대한 종합시험조정으로 시험, 조정 및 균형(Testing, Adjusting & Balancing)이라는 뜻이다. 이는 설계 목적에 부합되도록 모든 빌딩의 환경시스템을 검토하고, 조정하는 과정이다. 따라서 T.A.B기술은 공기 및 물이라는 유체의 흐름과 온 습도에 관련된 분야이기 때문에 시각적으로 그 성과를 알아보기 힘들고, T.A.B를 적용한 후 결과치를 정밀 분석해 판단할 수 있으며 T.A.B기술을 적용하지 않은 건물과 간접비교하는 방법으로 그 효과를 쉽게 알 수 있다. T.A.B기술을 적용할 경우 시공 중인 건물에 설계도서가 완료되기 전, 또는 장비의 구매발주 전에 T.A.B측면에서 모든 기술 도서를 면밀히 검토하게 된다. 그 중 일부에서 발견되는 문제점들 즉, 적정치 못한 용량 선정, 시스템 구성상 미비점, 불필요한 장비 선정, 누락 사항을 발견할 수 있다. 따라서 T.A.B 기술을 적용할 경우 향상된 품질의 시공이 가능해 준공 후 빈번히 대두되는 하자 문제가 현격히 줄게 되며 또한 운전경비 절감, 쾌적한 실내환경 조성, 장비수명 연장 등 효율적인 운전관리 효과를 얻을 수 있다. 우리나라 공기조화설비기술은 꾸준한 발전을 이루었고, 최근에는 도입 초기단계시 전혀 고려되지 않던 공조공간의 쾌적성 및 소음 방지 대책 등의 문제가 주요사항으로 부각되고 있다. 이에 따라 공조설비에 T.A.B실행의 표준화 정착과정에 있으며, 국내 학계 및 연구기관에서 공조설비에 대한 연구 및 T.A.B용역업체의 기술축적 등 T.A.B분야 발전을 위해 노력하고 있다. 본지는 T.A.B의 수행절차 및 수행계획, TAB 수행업체 등에 대해 알아본다.

• 한국의류학회지
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• 제35권1호
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• pp.13-25
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• 2011

This study investigates the factors influencing consumer's channel selection for luxury fashion items, specifically the effect of (i) perceived luxury benefits, (ii) perceived online shopping risks, (iii) demographics, and (iv) purchasing behavior. A survey questionnaire was developed and implemented to measure the perceived luxury benefits, perceived online shopping risks, purchasing behaviors, and consumer demographics. A total of 396 responses were analyzed by one-way ANOVA, cross-tab, and multinomial logit analysis with SPSS18.0. The results are as follows. First, those who shop in offline shopping channels tend to be heavy buyers that look for product quality and conspicuousness. They perceive low risks from online shopping and purchase few bag items offline. Second, those who shop online tend to be men and perceive the high benefits of economic value. Third, those who shop in multi channels tend to be men, search for information via the Internet, and purchase few accessory items. Implications for multichannel strategies are suggested.

• Journal of Pharmaceutical Investigation
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• 제41권4호
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• pp.217-225
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• 2011

The aim of this work was to prepare porous osmotic pump tablets for controlled delivery of Aceclofenac. Aceclofenac solid dispersion was prepared to improve the solubility by using the drug - carrier (Mannitol) ratio of 1:1. The osmotic pump tablets were prepared using the solid dispersed product of Aceclofenac. The formulation contains potassium chloride as osmotic agent, cellulose acetate as semipermeable membrane, poly ethylene glycol (PEG 4000) as pore former and sodium lauryl sulphate (SLS) as solubility enhancer. The formulations were designed by the general factors such as osmotic agent and pore former. All formulations were evaluated for various physical parameters and, the in vitro release studies were conducted as per USP. The drug release kinetic studies such as zero order, first order, and Higuchi and Korsmeyer peppas were determined and compared. All the formulations gave more controlled release compared to the marketed tablet studied. Numerical optimization techniques were applied to found out the best formulation by considering the parameter of in vitro drug release kinetics and dissolution profile standards. It was concluded that the porous osmotic pump tablets (F7) composed of Aceclofenac solid dispersion/Potassium chloride/Lactose/Sodium lauryl sulphate/Magnesium Stearate (400/40/95/10/5, mg/tab) and coating composition with Cellulose acetate/ PEG 4000 (60/40 %w/w) is the most satisfactory formulation. The porous osmotic pump tablets provide prolonged, controlled, and gastrointestinal environment-independent drug release.