• IMMUNE NETWORK
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• v.23 no.1
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• pp.4.1-4.15
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• 2023

Th cells, which orchestrate immune responses to various pathogens, differentiate from naive CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as well as a variety of immune-related diseases. Decades of research have revealed that the fate decision processes are controlled by cytokines, cytokine receptor signaling, and master transcription factors that drive the differentiation programs. Since the Th1 and Th2 paradigm was proposed, many subsets have been added to the list. In this review, I will summarize these events, including the fate decision processes, subset functions, transcriptional regulation, metabolic regulation, and plasticity and heterogeneity. I will also introduce current topics of interest.

• IMMUNE NETWORK
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• v.23 no.1
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• pp.10.1-10.16
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• 2023

Memory T (Tm) cells protect against Ags that they have previously contacted with a fast and robust response. Therefore, developing long-lived Tm cells is a prime goal for many vaccines and therapies to treat human diseases. The remarkable characteristics of Tm cells have led scientists and clinicians to devise methods to make Tm cells more useful. Recently, Tm cells have been highlighted for their role in coronavirus disease 2019 vaccines during the ongoing global pandemic. The importance of Tm cells in cancer has been emerging. However, the precise characteristics and functions of Tm cells in these diseases are not completely understood. In this review, we summarize the known characteristics of Tm cells and their implications in the development of vaccines and immunotherapies for human diseases. In addition, we propose to exploit the beneficial characteristics of Tm cells to develop strategies for effective vaccines and overcome the obstacles of immunotherapy.

• Journal of the Chungcheong Mathematical Society
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• v.23 no.3
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• pp.471-479
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• 2010

For a complex regular Borel measure ${\mu}$ on ${\Omega}$ which is a subset of ${\mathbb{C}}^k$, where k is a positive integer we define the Toeplitz operator $T_{\mu}$ on a reproducing analytic space which comtains polynomials. Using every symmetric polynomial is a polynomial of elementary polynomials, we show that if $T_{\mu}$ has finite rank then ${\mu}$ is a finite linear combination of point masses.

• Journal of Convergence for Information Technology
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• v.7 no.2
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• pp.83-90
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• 2017

To launch the product recently attached to IoT consumer electronics, smart phones and healthcare products around the large companies is a trend that is growing interest in the IoT. However, the country's small business environment is what the environmental improvement process that is easily accessible to the small business environment because the IoT technologies are difficult to apply the IoT technologies than any other country environment than desperate situation. In this paper, we propose a service operating model to improve production efficiency when the fusion manufacturing process is currently operating in the country SMEs and IoT technology. Proposed model using the manufacturing product information and sensor / dabayiseu information in the entire manufacturing process has as its object to utilize the IoT technology. Performance evaluation, the proposed model is more efficient than the previous model and 23.1% of the manufacturing process. In addition, it is increasing the manufacturing process was reduced by 17.3%, the average processing time as compared to the previous model. Finally, the personnel cost to be used in the manufacturing process was found to be an average decrease of 19.8% than previous model.

• IMMUNE NETWORK
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• v.23 no.1
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• pp.3.1-3.14
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• 2023

Microvilli are outer membrane organelles that contain cross-linked filamentous actin. Unlike well-characterized epithelial microvilli, T-cell microvilli are dynamic similar to those of filopodia, which grow and shrink intermittently via the alternate actin-assembly and -disassembly. T-cell microvilli are specialized for sensing Ags on the surface of Ag-presenting cells (APCs). Thus, these finger-shaped microprotrusions contain many signaling-related proteins and can serve as a signaling platforms that induce intracellular signals. However, they are not limited to sensing external information but can provide sites for parts of the cell-body to tear away from the cell. Cells are known to produce many types of extracellular vesicles (EVs), such as exosomes, microvesicles, and membrane particles. T cells also produce EVs, but little is known about under what conditions T cells generate EVs and which types of EVs are released. We discovered that T cells produce few exosomes but release large amounsts of microvilli-derived particles during physical interaction with APCs. Although much is unanswered as to why T cells use the same organelles to sense Ags or to produce EVs, these events can significantly affect T cell fate, including clonal expansion and death. Since TCRs are localized at microvilli tips, this membrane event also raises a new question regarding long-standing paradigm in T cell biology; i.e., surface TCR downmodulation following T cell activation. Since T-cell microvilli particles carry T-cell message to their cognate partner, these particles are termed T-cell immunological synaptosomes (TISs). We discuss the potential physiological role of TISs and their application to immunotherapies.

• Journal of fish pathology
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• v.23 no.1
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• pp.57-67
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• 2010

Effects of temperature ($13{\pm}1.5^{\circ}C$, $23{\pm}1.5^{\circ}C$) on the pharmacokinetic properties of nalidixic acid (NA), piromidic acid (PA) and oxolinic acid (OA) were studied after oral administration to cultured olive flounder, Paralichthys olivaceus. Serum concentrations of these antimicrobials were determined after oral administration of a single dosage of 60 mg/kg body weight (average 700 g). At $23{\pm}1.5^{\circ}C$, the peak serum concentrations of NA, PA and OA, which attained at 10 h, 24 h and 30 h post-dose, were 11.55, 3.79 and $1.12{\mu}g/m\ell$, respectively. At $13{\pm}1.5^{\circ}C$, the peak serum concentrations of NA, PA and OA, which attained at 10 h, 15 h and 30 h post-dose, were 6.36, 1.4 and $1.01{\mu}g/m\ell$, respectively. Better absorption of NA and PA was noted at $23{\pm}1.5^{\circ}C$ compared to $23{\pm}13^{\circ}C$. The elimination of NA from serum of olive flounder was considerably faster at $23{\pm}1.5^{\circ}C$ than at $13{\pm}1.5^{\circ}C$. However, both absorption and elimination of OA were not affected significantly by temperature. The kinetic profile of absorption, distribution and elimination of these antimicrobials in serum were analyzed by fitting to a one- and two compartment model, with WinNonlin program. In the one compartment model for NA, AUC, Tmax and Cmax at $23{\pm}1.5^{\circ}C$ were $258.26{\mu}g{\cdot}h/m\ell$, 10.67 h and $8.91{\mu}g/m\ell$, respectively. The AUC, $T_{max}$ and $C_{max}$ at $13{\pm}1.5^{\circ}C$ were $341.45 {\mu}g{\cdot}h/m\ell$, 7.72 h and $6.23{\mu}g/m\ell$, respectively. In the one compartment model for PA, AUC, $T_{max}$ and $C_{max}$ at $23{\pm}1.5^{\circ}C$ were $248.12{\mu}g{\cdot}h/m\ell$, 21.15 h and $3.09{\mu}g/m\ell$, respectively. The AUC, $T_{max}$ and $C_{max}$ at $13{\pm}1.5^{\circ}C$ were $103.89{\mu}g{\cdot}h/m\ell$, 12.89 h and $1.22{\mu}g/m\ell$, respectively. In the two compartment model for OA, AUC, $T_{max}$ and $C_{max}$ at $23{\pm}1.5^{\circ}C$ were $138.20{\mu}g{\cdot}h/m\ell$, 23.95 h and $1.06{\mu}g/m\ell$, respectively. The AUC, $T_{max}$ and $T_{max}$ at $13{\pm}1.5^{\circ}C$ were $159.10{\mu}g{\cdot}h/m\ell$, 28.03 h and $1.02{\mu}g/m\ell$, respectively.

• The Mathematical Education
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• v.18 no.1
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• pp.21-23
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• 1980

In [3], an extension of B. Brosowski s T-invariant Point Theorem is given where the linearity of the function and the convexity of the set are relaxed. In this paper, our main purpose is to generalize S. P. Singh's T-invariant Point Theorem to Approximation Theory.

• East Asian mathematical journal
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• v.23 no.2
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• pp.207-212
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• 2007

We describe the class of invertible matrices T such that $TAT^{-1}$ is EPr, for a given EPr matrix A of order n. Necessary and sufficient condition is determined for $TAT^{-1}$ to be EP for an arbitrary matrix A of order n.

• Transportation Technology and Policy
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• v.12 no.3
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• pp.14-23
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• 2015

• Korean Journal of Ecology and Environment
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• v.33 no.2 s.90
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• pp.80-108
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• 2000

This paper deals with floristic and taxonomic accounts of 47 taxa of the genus Trachelomonas collected from 58 waters in Korea. Of these, 19 taxa are added to the Korean Trachelomonas flora, and 4 taxa, T. curta var. reticulata, T. koreana, T. planctonica var. papillosa, and T. spina are newly recorded in the world flora of the euglenoids. Detailed description and illustrations are given for each species. Since 23 taxa are previously reported in the Korean freshwaters, a total of 70 taxa are listed up in the Korean Trachelomonas flora. Trachelomonas species are abundant and diverse in old or stagnant swamps or ponds, where is enriched with organic matters and nutrient salts. T. bacillifera, T. hispida, and T. volvocina formed water blooming in the natural swamps or fishery ponds in spring and summer.