• Title/Summary/Keyword: T. B. Lee

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Enhancement of Immuno Modulatory Activities of Acer mono Bark from Low Temperature High Pressure Extraction Process (저온 고압 추출에 의한 고로쇠 수피의 면역활성 증진)

  • Jeong, Myoung-Hoon;Oh, Sung-Ho;Kim, Seung-Seop;Kwon, Min-Chul;Choi, Woon-Yong;Seo, Yong-Chang;Lee, Hak-Ju;Kang, Ha-Young;Lee, Hyeon-Yong
    • Journal of Korean Society of Forest Science
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    • v.99 no.1
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    • pp.16-23
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    • 2010
  • Experiments were performed for investigate the immune activities on human B and T cell growth and secretion of their cytokines. Also, antibodies in serum were investigated in female ICR mouse by feeding the extracts of Acer mono at dose of 30 and 100 mg/mL of one day orally for 15 days. The cytotoxicity of the samples on normal human cell (HEL299) was below 24.15% in adding the all extracts. Both human immune B and T cells were increased up to about 40% by the high pressure extraction process. The secretion of cytokines (IL-6, TNF-${\alpha}$) on human B and T cells were increased up to 20-50% by adding the high pressure extraction process compare to the hot water extraction process. Also, total serum IgG levels increased by feeding Acer mono extacts. It can be conclude that optimum condition for efficient extraction of Acer mono as functional materials is solvent extraction process using water with high pressure at below $100^{\circ}CA$ than typical process.

Surface Marker Analysis in Acute Leukemias (백혈병의 면역학적 표지자검사의 결과분석)

  • Moon, Jin-Young;Lee, Chae-Hoon;Kim, Kyung-Dong;Kim, Chung-Sook
    • Journal of Yeungnam Medical Science
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    • v.14 no.2
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    • pp.359-369
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    • 1997
  • We studied the expression of the cell surface antigen associated with myeloid and lymphoid leukemias on bone marrow or peripheral blood blast cells from 153 leukemic patients including 61 cases of acute myelogenous leukemias(AML), 46 of acute lymphocytic leukemias(ALL) and 12 of acute leukemias. They were analyzed by direct or indirect immunofluorescence method for reactivity with the monoclonal antibodies to B cells(CD10, CD19, SmIg), T cells(CD2, CD5, CD7, CD3, CD4, CD8), myeloid antigen(CD13, CD14, CD33, CD61) and a nonspecific antigen, HLA-DR. Lymphoid associated markers detected on AML is CD7 32.8%, CD10 14.8%, CD5 13.1%, CD2 6.6% and CD19 1.6%. TdT was positive in 4.9% of AMLs. Hybrid leukemias were 8 cases out 61 AML cases and were mainly composed of monocytic lineage, M4 and M5a. Myeloid markers detected in ALL were CD13 2.2% and CD33 2.2%. In this study, immunologically classified ALLs were composed of 65.2% of CALLA (+) B precursor type, 10.9% of CALLA (-) B precursor pattern, 8.7% of T cell type, 2.2% of B cell type, 4.5% of mixed lymphoid lineage(B&T), 2.2% of undifferentiated leukemia, and 6.5% of hybrid leukemia. Twelve cases of acute leukemias ware finally diagnosed to be 5 cases of hybrid leukemia, 3 cases of B lineage, 3 case of T lineage and 1 case of mixed lymphoid(B&T) leukemia. In summary, we think the best method for typing acute leukemias is by using a combination of FAB classification and immunophenotying.

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Trends of Converging Smart Devices with IoT Technology (스마트 디바이스와 사물인터넷 (IoT) 융합 기술 동향)

  • Ko, J.;Hong, S.G.;Lee, B.B.;Kim, N.S.
    • Electronics and Telecommunications Trends
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    • v.28 no.4
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    • pp.79-85
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    • 2013
  • 최근 스마트폰을 포함한 스마트 디바이스의 급속한 확산에 따라 모바일 통신 산업의 패러다임이 '음성통화'에서 '어플리케이션'으로 전환되고 있으며, 소비자들의 정보에 대한 인식이 "개발, 공유, 참여, 확산" 과정을 통한 개인화와 라이프 스타일의 변화 추구를 위한 용도에 많은 관심을 가지기 시작했다. 특히, 최근의 사물인터넷의 부각으로 인해 IoT(Internet of Things)와 스마트 디바이스와의 연동을 통해 주변의 센서로부터 수집된 정보를 직접 가공 처리하거나 제어하는 개인 중심의 생활밀착형 센서 앱 서비스를 제공하려는 다양한 시도가 이루어지고 있다. 본고에서는 스마트 디바이스에서의 센서와의 연동 및 적용 사례와 함께 IoT와의 융합기술 국내외 동향 등을 살펴보고자 한다.

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Design of V/UHF-Band SP3T Transmitting/Receiving Switch (V/UHF 대역 SP3T 송수신 스위치 설계)

  • Lee, Byeong-Nam;Park, Dong-Chul
    • Journal of the Korea Institute of Military Science and Technology
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    • v.11 no.5
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    • pp.34-41
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    • 2008
  • This paper describes the design of SP3T PIN diode switch which has a 500W high power handling capability in $20{\sim}400MHz$ frequency range. Design factors were investigated and it was confirmed by simulation that the characteristics of insertion loss, VSWR, and isolation met design goal. Also, the capability to handle 500W high power with very fast switching speed of less than $26{\mu}s$ was confirmed and insertion loss of less than 1dB, VSWR of less than 1.4:1, and isolation of higher than 60dB were obtained by experiments.

Design of Gap-Coupled NRD Duplexer using T-junction (T-junction을 이용한 gap-coupled NRD 듀플렉스 설계)

  • Kim, Ki-Don;Kim, So-Young;Lee, Jeong-Hae
    • Proceedings of the KIEE Conference
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    • 2002.07c
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    • pp.1915-1918
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    • 2002
  • 본 논문에서는 non-radiative dielectric (NRD) guide를 이용한 듀플렉서를 설계하였다. 설계된 듀플렉스는 두 개의 gap-coupled 필터와 T-junction으로 구성되어 있다. Gap-coupled 필터의 설계에는 차단 주파수 영역 등가회로를 이용하였으며 T-junction은 30dB 이상의 반사손실을 갖도록 최적화하여 두 가지의 형태로 설계하였다 위의 설계과정을 통하여 1% 대역폭, 0.1dB ripple, 37.7 및 38.3 GHz의 중심주 파수를 갖는 듀플렉서를 설계하였다. 두 가지 형태의 결합부를 갖는 듀플렉서에 대해 시뮬레이션하여 응답특성을 비교한 결과 듀플렉서의 응답특성이 원하는 결과에 근접하게 나옴을 확인하였다.

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IDEALS IN THE UPPER TRIANGULAR OPERATOR ALGEBRA ALG𝓛

  • Lee, Sang Ki;Kang, Joo Ho
    • Honam Mathematical Journal
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    • v.39 no.1
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    • pp.93-100
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    • 2017
  • Let $\mathcal{H}$ be an infinite dimensional separable Hilbert space with a fixed orthonormal base $\{e_1,e_2,{\cdots}\}$. Let $\mathcal{L}$ be the subspace lattice generated by the subspaces $\{[e_1],[e_1,e_2],[e_1,e_2,e_3],{\cdots}\}$ and let $Alg{\mathcal{L}}$ be the algebra of bounded operators which leave invariant all projections in $\mathcal{L}$. Let p and q be natural numbers($p{\leqslant}q$). Let $\mathcal{B}_{p,q}=\{T{\in}Alg\mathcal{L}{\mid}T_{(p,q)}=0\}$. Let $\mathcal{A}$ be a linear manifold in $Alg{\mathcal{L}}$ such that $\{0\}{\varsubsetneq}{\mathcal{A}}{\subset}{\mathcal{B}}_{p,q}$. If $\mathcal{A}$ is an ideal in $Alg{\mathcal{L}}$, then $T_{(i,j)}=0$, $p{\leqslant}i{\leqslant}q$ and $i{\leqslant}j{\leqslant}q$ for all T in $\mathcal{A}$.

Energy Consumption Model of LoRa Class B in LoRaWAN (LoRaWAN에서 LoRa Class B의 에너지 소비 모델)

  • Hong, Jiyeon;Lee, Gyeongheon;youn, Joosang
    • Proceedings of the Korean Society of Computer Information Conference
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    • 2019.07a
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    • pp.105-107
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    • 2019
  • 최근 몇 년간 소량의 데이터를 송수신하는 Massive IoT 네트워크에 많은 관심을 가지고 있다. 이러한 환경을 구축하기 위해서 저전력 광역 네트워크(LPWAN) 기술 중 LoRa(Long Range) 네트워크를 사용하고 있다. 대부분의 IoT 응용 서비스는 디바이스가 장시간 안정적으로 작동해야 하므로 에너지 효율성을 중점으로 두고 LoRa 디바이스의 수명을 최대화하기 위한 디바이스의 여러 동작들을 설계하는 에너지 소비 모델링이 중요하다. 따라서 본 논문에서는 LoRa Class B 통신 방식의 에너지 소비 모델을 정의하고 성능을 평가한다.

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The Grades Classification of Burley Stems and Scraps using Cluster Analysis by Nicotine and Nitrate Contents (버어리주맥과 엽설의 니코틴과 nitrate함량에 의한 등급별 군집분석)

  • Han, Young-Rim;Sung, Yong-Joo;Kwon, Young-Ju;Kim, Sam-Kon;Lee, Kyeong-Ku;Kim, Kun-Soo;Rhee, Moon-Soo
    • Journal of the Korean Society of Tobacco Science
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    • v.28 no.2
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    • pp.124-129
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    • 2006
  • The grades of burley tobacco stems and scraps were classified followed by the nicotine and nitrate contents by using the cluster analysis. The chemical components of the burley tobacco stems and scraps gathered from 2002 to 2005 were analyzed with auto analyzer. According to the nicotine contents and the nitrate contents, the burley stems and scraps could be classified three groups, respectively. In case of the burley scraps, the AB3T, AB4TR, B1T and B2T grades belonged to the $1^{st}$ a group. The C1W and C2W grades belonged to the $2^{nd}$ group and the CD3W and CD4TR belonged to the $3^{rd}$. In case of the burley stems, the AB3T and AB4TR grades belonged to the $1^{st}$ group. The B1T, B2T, C1W and C2W grades belonged to the $2^{nd}$ group and the CD3W and CD4TR belonged to the $3^{rd}$ group. This classification of raw materials depending on the similarity in the chemical components might be helpful to control the properties of the Reconstituted Tobacco sheet.

Studies on the Synthesis of 1-Hydroxycarbapenems (1-히드록시카르바페넴의 합성에 관한 연구)

  • You, Jong Hyeon;Park, Jeong Ho;Goo, Yang Mo;Lee, Yun Yeong
    • Journal of the Korean Chemical Society
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    • v.42 no.1
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    • pp.69-77
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    • 1998
  • (3S,4S)-1-(t-Butoxycarbonylmethyl)-3-[(S)-1-(t-butyldimethylsilyloxy)ethyl]-4-(2-diazo-2-ethoxycarbonyl-1-oxoethyl)-2-azetidinone (14) was prepared from 4-styryl-2-azetidinone 7b via a sequence of reactions involving N-alkylation with bromoacetate, ozonolysis, oxidation, condensation with magnesium ethyl malonate, and diazo transfer reaction. (3S,4S)-3-[(S)-1-(t-Butyldimethylsilyloxy)ethyl]-4-(3-diazo-3-ethoxycarbonyl1-hydroxypropyl)-2-azetidinone (21) was also prepared from 4-formyl-2-azetidinone 5b via a sequence of reactions involving Wittig reaction, 1,3-dipolar cycloaddition with ethoxycarbonylformonitrile oxide, catalytic hydrogenation, and diazotization. However, the final cyclization of 14 or 21 to 1-hydroxycarbapenem or 1-hydroxycarbapenam by treating with $Rh_2(OAc)_4$ was unsuccessful.

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Swiprosin-1 Expression Is Up-Regulated through Protein Kinase $C-{\theta}$ and $NF-{\kappa}B$ Pathway in T Cells

  • Kim, Young-Dae;Kwon, Min-Sung;Na, Bo-Ra;Kim, Hye-Ran;Lee, Hyun-Su;Jun, Chang-Duk
    • IMMUNE NETWORK
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    • v.13 no.2
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    • pp.55-62
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    • 2013
  • Swiprosin-1 exhibits the highest expression in $CD8^+$ T cells and immature B cells and has been proposed to play a role in lymphocyte biology through actin remodeling. However, regulation of swiprosin-1 gene expression is poorly understood. Here we report that swiprosin-1 is up-regulated in T cells by PKC pathway. Targeted inhibition of the specific protein kinase C (PKC) isotypes by siRNA revealed that $PKC-{\theta}$ is involved in the expression of swiprosin-1 in the human T cells. In contrast, down-regulation of swiprosin-1 by A23187 or ionomycin suggests that calcium-signaling plays a negative role. Interestingly, swiprosin-1 expression is only reduced by treatment with $NF-{\kappa}B$ inhibitors but not by NF-AT inhibitor, suggesting that the $NF-{\kappa}B$ pathway is critical for regulation of swiprosin-1 expression. Collectively, these results suggest that swiprosin-1 is a $PKC-{\theta}$-inducible gene and that it may modulate the late phase of T cell activation after antigen challenge.