• Journal of Pharmaceutical Investigation
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• v.30 no.3
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• pp.213-218
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• 2000

Ondansetron is a potent, highly selective 5-hydroxytryptamine3(5-HT3) receptor- antagonist, for the management of nausea and vomiting induced by cytotoxic chemotherapy and radiography, and the treatment of post-operative nausea and vomiting. The purpose of the present study was to evaluate the bioequivalence of two ondansetron tablets, $Zofran^{TM}$, (Glaxo Wellcome Korea Ltd.) and Hana ondansetron (Hana Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, $23.56{\pm}1.79$ year in age and $67.35{\pm}8.35\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 8 mg of ondansetron was orally administered, blood was taken at predetermined time intervals and the concentrations of ondansetron in serum were determined using HPLC with UV detector. Pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets were 7.53%, -0.23% and -3.92%, respectively when calculated against the $Zofran^{TM}$, tablet. The powers $(1-{\beta})$ for $AUC_t,\;C_{max}\;and\;T_{max}$ were above 99.00%, above 99.00% and 84.99%, respectively. Minimum detectable differences $(\Delta)\;at\;{\alpha}=0.1\;and\;1-{\beta}=0.8$ were all less than 20% (e.g., 12.25%, 10.88% and 18.37% for $AUC_t,\;C_{max}\;and\;T_{max}$, respectively). The 90% confidence intervals were all within ${\pm}20%$ (e.g., $-0.70{\sim}15.76,\;-7.53{\sim}7.08\;and\;-16.27{\sim}8.42\;for\;AUC_t,\;C_{max}\;and\;T_{max}$, respectively). All of the above parameters met the criteria of KFDA for bioequivalence, indicating that Hana ondansetron tablet is bioequivalent to $Zofran^{TM}$, tablet.

• Journal of Internet of Things and Convergence
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• v.10 no.1
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• pp.29-37
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• 2024

The purpose of this study is to investigate the impact of education applying the Havruta learning method in fundamentals nursing classes for nursing students on problem-solving ability, self-directed learning ability, critical thinking disposition, and learning commitment. One-group pretest-posttest design was used. Nursing students received training applying the Havruta learning method for 6 weeks (12 hours) in fundamentals nursing classes. The study was conducted from September 18 to November 6, 2023. Data were analyzed using SPSS/WIN 28.0 with mean, standard deviation, and paired samples t-test. problem-solving ability (t=4.52, p<.001), self-directed learning ability(t=-4.61, p<.001), critical thinking disposition(t=-4.10, p<.001) significantly increased before and after the 6-week Havruta learning method training for nursing students. However, there was no statistically significant difference in learning commitment (t=-0.28, p=.782). The Havruta learning method is an effective nursing education tool for improving problem-solving ability, self-directed learning ability, and critical thinking disposition. The results of this study can serve as basic data for nursing professors when planning teaching and learning strategies using Havruta. Research will be needed to utilize the Havruta learning method in various classes and evaluate its effectiveness.

• Radiation Oncology Journal
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• v.27 no.1
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• pp.15-22
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• 2009

Purpose: This study was designed to evaluate the effects on bone mineral density (BMD) and related factors according to the distance from the radiation field at different sites. This study was conducted on patients with uterine cervical cancer who received pelvic radiotherapy. Materials and Methods: We selected 96 patients with cervical cancer who underwent determination of BMD from November 2002 to December 2006 after pelvic radiotherapy at Kosin University Gospel Hospital. The T-score and Z-score for the first lumbar spine (L1), fourth lumbar spine (L4) and femur neck (F) were analyzed to determine the difference in BMD among the sites by the use of ANOVA and the post-hoc test. The study subjects were evaluated for age, body weight, body mass index (BMI), post-radiotherapy follow-up duration, intracavitary radiotherapy (ICR) and hormonal replacement therapy (HRT). Association between the characteristics of the study subjects and T-score for each site was evaluated by the use of Pearson's correlation and multiple regression analysis. Results: The average T-score for all ages was -1.94 for the L1, -0.42 for the L4 and -0.53 for the F. The average Z-score for all ages was -1.11 for the L1, -0.40 for the L4 and -0.48 for the F. The T-score and Z-score for the L4 and F were significantly different from the scores for the L1 (p<0.05). There was no significant difference between the L4 and F. Results for patients younger than 60 years were the same as for all ages. Age and ICR were negatively correlated and body weight and HRT were positively correlated with the T-score for all sites (p<0.05). BMI was positively correlated with the T-score for the L4 and F (p<0.05). Based on the use of multiple regression analysis, age was negatively associated with the T-score for the L1 and F and was positively correlated for the L4 (p<0.05). Body weight was positively associated with the T-score for all sites (p<0.05). ICR was negatively associated with the T-score for the L1 (p<0.05). HRT was positively associated with the T-score for the L4 and F (p<0.05). Conclusion: The T-score and Z-score for the L4 and F were significantly higher than the scores for the L1, a finding in contrast to some previous studies on normal women. It was thought that radiation could partly influence BMD because of a higher T-score and Z-score for sites around the radiotherapy field. We suggest that a further long-term study is necessary to determine the clinical significance of these findings, which will influence the diagnosis of osteoporosis based on BMD in patients with cervical cancer who have received radiotherapy.

• The Journal of the Korea Contents Association
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• v.11 no.3
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• pp.477-486
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• 2011

In this paper, I had tried to analyze the relationship between the time assigned for computer usage and weakening eyesight. First of all, students classified by gender, school year, eyesight, and wearing glasses along demographic characters took part in a poll, and The questionnaire included questions about computer time, factors of weakening eyesight, and purpose of computer use. The finding in this analysis composed of a cross-tabulations between annual eyesight change and the factors to change their eyesight is that 63.6 % of 165 students participated in this survey weakened their eyesight within a year. To show a correlation between computer usage duration and worsening eyesight in this paper, regression analysis indicated weakened vision by computer usage duration per day and week instead of a year. In addition, according to the analysis between computer usage duration and weakened vision for the people who wear glasses or not trough Independent-Samples T test, weakened vision was shown in computer usage duration per day and week, but not shown in the duration by the year. Therefore, weakening vision was also worse for the people who didn't wear glasses than the others. This study indicated 24..5% of teenagers had poor eyesight by using their computer. According to the frequency analysis on purposes of computer usage, the biggest purpose accounting for 36.4% of the total was the computer usage as a game consol, and the computer as a learning tool was the next biggest purpose at 32.1%. This paper showed the correlation between computer usage time and a factor of weakened eyesight through an analysis of the factor. Therefore, schoolchildren's parents should be more interested in their computer usage.

• Journal of Korean Home Economics Education Association
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• v.13 no.1
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• pp.13-24
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• 2001

The purpose was to identify the middle and high school students'clothing gift purchasing behavior according to the consumption orientation. Self-administered questionnaires were distributed to 585 middle and high school students who had an experience of purchasing a clothing gift more than one time during recent one year in Chonbuk province from Mar. 6 to Mar. 15 2000. Frequency. percentage. mean. standard deviation. factor analysis. $\varkappa$$_2$-test. t-test. one way ANOVA were used for data analysis. Duncan's Multiple Range test was followed. The results of this study were as follows ; 1. The student's consumption orientation factors were consisted of plan, practicality. and pleasure. and they were divided into the practicality pursuit. the convenience pursuit. and the feeling pursuit. 2. The practicality pursuit considered practical aspects more. but considered external aspects of gifts less. gift purchasing frequencies was less. and selected cheaper gifts. The convenience pursuit considered practical aspects less. purchased gift more frequently. and selected ore expensive ones. The feeling pursuit considered practical aspects and external aspects of gift important. 3. Girls considered the external aspects of clothing gift more important than boys. and patronized the specialty store or discount outlet. The students in high schools or with more pocket money considered more criteria when selecting gifts. and selected more expensive ones. 4. Middle and high school students game and took gifts 1-3 times a year. and the common price rage was 10,000-30,000 won. Girls with more pocket money and in older ages selected more expensive gifts. On birthday or parents day. they used to select clothing as a gift more frequently. and the rank order of the favorite items were socks or stockings. handkerchiefs. and upper outer wears. They patronized specially store or opposite sexes.

• Journal of the Korea Fashion and Costume Design Association
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• v.19 no.2
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• pp.79-90
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• 2017

The main purpose of the study was to explore effects of selection criteria of collaborating fashion companies on the partnership growth of collaborating artists with those companies. Secondly was to find differences in the selection criteria of collaborating fashion companies and the partnership growth of collaborating artists according to the characteristics of artists including gender, age, frequency and time period of collaboration. The questionnaire was developed by the researchers and was collected from 50 artists with experience in collaboration with fashion companies. The questionnaire was composed of three parts including the selection criteria of fashion companies, partnership growth measured by a Likert-type scale, and characteristics of artists measured by a nominal scale. Data were analyzed by a frequency test, factor analysis, reliability test, regression analysis, and independent sample t-test using SPSS Win 18.0. The results of the study showed that significant effects of the selection criteria of collaborating fashion companies on the partnership growth of collaborating artists with the companies. Also, there were differences in the selection criteria of collaborating fashion companies and the partnership growth of collaborating artists between artist groups according to the characteristics of the artists including gender, age, frequency and time period of collaboration.

• Physical Therapy Korea
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• v.19 no.3
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• pp.98-104
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• 2012

The aim of this study was to examine the effects of repeated passive movement (RPM) of different velocities on the improvement of knee joint position sense (JPS) in post-stroke patients with hemiplegia, thereby investigate the possibility of clinical application in the initial stage of rehabilitation for patients with post-stroke hemiplegia. Thirteen hemiplegic patients participated in this study. For the subjects' knee JPS tests, a passive angle reproduction test and an active angle reproduction test were performed prior to and after the intervention, which involved 30 repetitions of passive full-range-of-motion flexion and extension exercise of the knee joints at randomized degrees of $0^{\circ}/s$, $45^{\circ}/s$, and $90^{\circ}/s$. Paired t-test analysis was done in order to compare changes in the pre- and post-intervention knee JPS. One-way repeated analysis of variance was used in order to compare changes in JPS after intervention at three different movement velocities. The level of significance was set at .05. The result was that the subjects' post-intervention knee JPS significantly improved after the RPM exercise at a $45^{\circ}/s$ and a $90^{\circ}/s$ relative to the RPM exercise $0^{\circ}/s$ (p<.05). JPS changes with RPM intervention at the rapid velocity of $90^{\circ}/s$ were most increased, suggesting the most effective enhancement in knee JPS is with intervention at the velocity (p<.05). Therefore, RPM intervention at a half or higher velocity improved stroke patients' knee JPS. During the initial stage of rehabilitation for patients with post-stroke hemiplegia, the efficient application of the RPM exercise at a half or higher velocity will be possible.

• Journal of Korean Public Health Nursing
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• v.4 no.2
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• pp.5-13
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• 1990

The purpose of this study was to investigate physical self concept between high school boys and girls and to find various factors affecting them. For the Survey, 331 respondents for boys and 347 for girls were randomly selected from one coeducational high school in Seoul, from May 16 to May 19, 1990. The instrument used in this questionaire survey method was a part of Won Shik Jung's Physical Self Concept Scale for measuring Self Concept, it's reliability was' Cronbach a = 0.718. For the analysis. descriptive statistics were used by calculating frequencies, percentages and mean scores. $X^2-test$, t-test, and analysis of variance were employed to test the differences and statistical significance. The relationship between physical self concept and area variables was analysed by use of Pearson's correlation coiefficients. For the examine of various factors affecting physical self concept, multiple stepwise regression method was employed. The results of this study are summarized as follows: 1. There was no significant difference in physical self concept between male and female students. 2. The scores of physical self concept among the students were negatively correlated with their academic year, even though statistical signification was not found. 3. Physical self concept was classified into two areas; health area and appearance area. There was no significant difference in health area between boys and girls. But, the difference of health area was significant in accordance with the academic years. That, the scores of the health area are dropped as academic year going up. 4. Significant relationship was revealed among health area, appearance area, and physical self concept. The correlation between health area and physical self concept was the highest relationship (r = 0.71) The main factors affecting the physical self concept were (1) father's educational background (2) year (3) number of brother (4) religion (5) father's age. 5. As academic year going up, the rate of counseling with parents are dropped. In conclusion, the result of the study indicate that, a person managed the school health and parents can help students to promote their physical, mental, and emotional health by means of health education and counseling.

• Journal of the Korea Fashion and Costume Design Association
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• v.9 no.2
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• pp.1-13
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• 2007

Black has played a more important role in the history of fashion than other colors. In general, black was regarded as a color of negative images. However, as people have recognized the aesthetic value of black color, they have expressed unique and various images of black through the medium of clothes. This study was based on both theory research and actual survey, where survey sheets were distributed to collect data. For data analysis, SPSS 10.0, a statistics software, was used, and frequency, pecentage, t-test, ANOVA test, and Duncan test were adopted and analyzed. The survey was conducted on 608 men over 20 in Seoul, Gyeonggi Province, Gangwon Province, and other areas for two months from May 20, 2005 to July 25, 2005. The analysis showed the following results. First, Dignity was the mostly cited image of black color among men followed by modernity, sorrow, feminineness, abstinence, and sensuality. Second, Men showed different responses according to their age. In sum, men more strongly recognize abstinence and sensuality in black dress as they become older. Marital status significantly affected men's recognition of black dress in terms of abstinence and sensuality. Abstinence was more strongly recognized by married men than single men. In addition, married men pointed out sensuality of black dress more frequently than single men. In short, married men tended to recognize abstinence and sensuality more easily than single men. Education level clearly affected men's recognition of dignity, modernity, and abstinence in black dress. In sum, as men got higher education, they tended to increasingly recognize dignity and modernity in black dress. In conclusion, this study has proved that black dress has unique aesthetic values and reflects various images according to age, marital status, education level.

• The Journal of the Korea Contents Association
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• v.17 no.2
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• pp.1-12
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• 2017

This study investigated the effect of parental attachment on interpersonal competence and psychological well-being of college students. 625 college students completed self-administered questionnaires. Reliability test, ANOVA, Duncan ex-post analysis, and hierarchical regression analysis on data were used. Study results showed that parental attachement and interpersonal competence had significant effects on college students' psychological well-being. Results also depicted gender differences in the relationship of study variables; students' interpersonal competence demonstrated partial mediation effect in the relation of attachment with the same-sex parent and psychological well-being, while complete mediation effect in that of attachment with the opposite-sex parent and psychological well-being, These findings suggest that gender-conscious university policies to promote interpersonal competence among students are greatly needed to ensure psychological well-being of the student population.