• 대한간호학회지
• /
• 제20권1호
• /
• pp.79-87
• /
• 1990

Clinical and epedemiologic studies of coronary heart disease(CHD)have from time to time over the last three decades found associations between prevalence of CHD and behavioral attributes and cigarette smoking. The main purpose of this study is reduced to major risk factor of coronary heart disease through prohibition of smoking and control of behavior pattern. The subjects consisted of 120 smokers and 90 non-smokers who were married men older than 30 years working in officers. The officers were surveyed by means of questionnaire September 26 through October 6, 1989. The Instruments used for this study was a self-administered measurement tool composed of 59 items was made through modifications of Jenkuns Activity Survery(JAS). The Data were analysed by SAS(Statistical Analsis System) program personal computer. The statistical technique used for this study were Frequency, x$^2$-test, t-test, ANOVA, Pearson Correlation Coefficient. The 15 items were chosen with items above 0.3 of the factor loading in the factor analysis. In the first factor analysis 19 factors were extracted and accounted for 86% of the total variance. However when the number of factors were limited to 3 in order to derive Jenkins classification, three factors were derived. There names are Job-Involvement, Speed & Impatience, Hard-Driving. Each of them includes 21 items, 21 and 9, respectively. The results of this study were as follow : 1. The score of the smoker group and non-smoker group in Job-Involvement(t＝5.7147, p＜0.0001), Speed & Impatience(t＝4.6756, p＜.0001), Hard-Driving(t＝8.0822, p＜.0001) and total type A behavior pattern showed statistically significant differences(t＝8.1224, p＜.0001). 2. The score of type A behavior pattern by number of cigarettes smoked daily were not statistically significant differences. 3. The score of type A behavior pattern by duration of smoking were not significant differences. It was concluded that the relationship between smokers and non - smokers of type A behavior pattern was statistically significant difference but number of cigarettes smoked daily and duration of smoking were not significant differences. Therefore this study is needed to adequate nursing intervention of type A behavior pattern in order to elevated to educational effect for prohibition of cigarette smoking.

• 생명과학회지
• /
• 제25권12호
• /
• pp.1425-1431
• /
• 2015

면역 시스템의 림프구는 B 림프구와 T 림프구 두 종류로 나눌 수 있다. B 림프구는 플라즈마 세포로 분화하여 항체를 생성하는 체액성 면역을 담당하며, T 림프구는 다른 세포나 세균을 죽이는 세포성 면역을 담당한다. 고전적으로 B 림프구와 T 림프구의 작용은 한 방향으로 이뤄졌다. T 림프구는 B 림프구의 분화를 촉진하고 면역글로불린종류의 전환을 조절한다. T 림프구가 부족한 경우 B 림프구의 부족을 초래함이 보고되어 있다. 그러나 최근에 역으로 B 림프구가 T 림프구의 분화와 활성을 조절할 수 있다는 보고가 있다. 예를 들어, B 림프구는 CD8+ T 림프구의 tolerance를 직접 조절할 수 있고, TGF-β의 분비를 통해 T 림프구의 anergy를 유도할 수 있다. 본 연구는 LPS에 의해 자극된 B 림프구가 수지상세포에서 IL-12의 분비를 억제하여 Th1 림프구의 분화를 억제할 수 있음을 보여준다. 이 억제는 B 림프구와 수지상세포의 직접적인 interaction에 의해 일어나는 것이 아니며 B 림프구가 수지상세포의 성숙을 조절하여 일어나는 것도 아니다. B 림프구에서 분비되는 soluble factor가 LPS에 의해 증가되는 수지상세포의 IL-12p35 transcription을 억제한다. 이 결과들은 B 림프구가 매개하는 새로운 면역억제 기전이 존재함을 보여준다. 이것은 고전적인 방향성을 가진 T 림프구에 의한 B 림프구 작용조절로 면역반응이 결정되는 것이 아니라 T 림프구와 B 림프구가 서로 작용을 하여 면역평형을 결정하는 기전이 존재함을 보여준다.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2001년도 춘계학술대회 논문집 유기절연재료 전자세라믹 방전플라즈마 연구회
• /
• pp.19-24
• /
• 2001

In this study, Pb(La Ce)$TiO_3$ composition ceramics were manufactured for 20 MHz resonator application. Electromechanical coupling factor, mechanical quality factor and dynamic range of thickness vibration mode were measured as the variations of L/T(length/thickness) ratio of ceramic substrats. Mechanical quality factor and dynamic range of third overtone thickness vibration mode showed the highest value of 2,773 and 52.22 dB at specimen S4(l/t=12), respectively. The excellent temperature stability of resonant frequency suitable for resonator application was shown, regardless of thermal shock.

• Asian-Australasian Journal of Animal Sciences
• /
• 제29권10호
• /
• pp.1451-1457
• /
• 2016

A comparative study was performed to investigate the efficacy of KiFAY as a feed additive on performance parameters, thyroid, and pancreatic hormone levels in broilers. Ninety birds (Vencobb 400) were randomly divided into three groups viz., Control (no DL-methionine supplementation), Treatment1 (containing added DL-methionine) and Treatment 2 (containing KiFAY and without DL-methionine supplementation). The performance parameters (weekly body weight, body weight gain, feed intake, and feed consumption ratio) were recorded and calculated during the whole study of 4 weeks. Analyses of insulin and insulin-like growth factor (IGF 1), triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) were performed at the end of the study. The results show that birds on supplementation of KiFAY performed significantly (p<0.001) better than other treatments. The weekly body weight, body weight gain, feed in-take and feed consumption ratio improved in KiFAY treated birds. The study found an increase in insulin and IGF1 levels (p<0.001) in KiFAY compared with the other treatments. Serum T3, T4, and TSH levels in the Treatment 2 were higher than other treatments (p<0.001). The KiFAY supplementation was able to improve performance with associated responses at a hormonal level in broilers.

• 지질공학
• /
• 제7권1호
• /
• pp.37-52
• /
• 1997

본 연구는 여러 호간구조물의 안정구모물의 안정해석에 관한 실제적인 적용성에 관련된 것으로, 호안구조물의 안정해석에는 4가지 종류의 호안단면을 고려하였다. 안정해석의 결과로서, 상치블럭의 안전율은 T.T.P.피복경상제가 형식 중에서 가장 컸으며, 피복재료의 강성과 완만한 사면경사에 영향을 받는다. 제체의 직선사면 활동 및 원호활동파괴에 대한 안전율은 사석경사제가 모든 형식중에서 가장 컸으며, 완만한 사면경사와 피목재료의 강성의 증가의 영향을 받는다. 제체의 전도 및 지반지지력에 대한 안전율은 경사호안이 직립호안 보다 크며, 완만한 사면경사와 구조물 폭의 증가에 영향을 받는다.

• Preventive Nutrition and Food Science
• /
• 제11권1호
• /
• pp.1-5
• /
• 2006

Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic acid that have been used to reduce the incidence, growth and metastasis of breast, colon, prostate and gastric cancer in animals. CLA could reduce tumor growth by altering angiogenesis; a process requiring associated angiogenic factors such as vascular endothelial growth factor (VEGF). In this study, we determined whether CLA could modulate the expression of VEGF in murine mammary tumor cells and adipocytes. The c9, t11-CLA isomer reduced VEGF transcripts and protein when mammary tumor cells were stimulated with PMA. That isomer also reduced VEGF expression in un stimulated mouse 3T3-L1 adipocytes. Since VEGF can be regulated by cyclooxygenase-2 (COX-2), we determined whether CLA could alter COX-2 enzyme expression and $PGE_2$ production. The c9, t11-CLA isomer reduced not only COX-2 enzyme expression but also $PGE_2$ production. Thus, c9, t11-CLA could modulate neovascularization by alteration of VEGF expression from mammary tumor cells and adipocytes by reducing COX-2 metabolites.

• 한국지반공학회:학술대회논문집
• /
• 한국지반공학회 2005년도 춘계 학술발표회 논문집
• /
• pp.17-24
• /
• 2005

Recently construction activities increase in reclaimed onshore areas. It is therefore considered an important factor for the design of pile foundation with problems in terms of settlements due to soft grounds. Nevertheless the design of piles for negative skin friction(or downdrag forces) is probably poorly understood by many engineers. It is mainly because the most of design specification give a way to design pile foundation in bearing capacity aspect although the negative skin friction is related to settlement(downdrag). Under LRFD(load resistance factor design) approach it is to separately consider ultimate limit state and serviceability limit state. This paper discusses LRFD approach to the design of piles for negative skin friction and compares this approach to traditional design approach. And also a case history is analyzed in that point of view.

• 대한기계학회논문집A
• /
• 제20권11호
• /
• pp.3454-3462
• /
• 1996

Compared to a full three dimensional FEM, the Slab-FEM hybrid method reduces the required computation time distinctly and it can be applied to the analysis of a shape rolling process. However, the method is somewhat approximate and predictions by the method contain certain inaccuracies. In the present investigation a parameter called T-factor was introduced to compensate the inaccuracies of the method and proper values of the parameter were estimated for different widths of bars and reduction ratios. Then, the method was applied to analyze cold and hot rollings of rectangular bars and predicted results were compared to those of experiments. Nonuniform distributions of temperature in the bars were predicted by utilizing the temperature equation obtained for a semi-infinite solid under radiation and convection boundary conditions. It was found out that accuracies of spread and roll separating force predictions could be enhanced by using proper values of the T-factor.

• 한국안전학회지
• /
• 제23권5호
• /
• pp.61-66
• /
• 2008

It is important to calculate the exact crack opening area in the cracked pipe subjected to axial force and bending moment. Among many solutions for obtaining the crack opening displacement, Paris-Tada's expression, which is derived from energy method, is open used in fracture analysis for piping crack problems because of its simplicity. But Paris-Tada's equation has conservativeness when radius over thickness ratio(R/t) is ten or less, for it is based on the stress intensity factor solution having a compliance function derived from a simple shell theory. In this paper we derived a new expression using a different stress intensity factor solution which is able to consider the variation of compliance through wall thickness in a cracked pipe. Conservativeness of both equations was examined and compared to finite element analysis results. Conservativeness of the new equation is decreased when R/t > 10 and increased slightly when R/t < 10 compared with Paris-Tada's. But Both equations were highly conservative when R/t < 10 compared with finite element analysis results.

• 한국임상수의학회지
• /
• 제28권2호
• /
• pp.190-195
• /
• 2011

본 연구에서 돼지 PBMC에 t10c12-CLA 처리는 TNF-${\alpha}$생산을 증가시켰으나, LPS 자극 PBMC에서는 TNF-${\alpha}$생산을 감소시켰다. t10c12-CLA 처리는 PBMC의 inhibitory ${\kappa}B$ ($I{\kappa}B$)-${\alpha}$ 단백질 분해를 증가시키고 NF-${\kappa}B$ p65 활성 수준을 증가시켰다. 그러나 LPS 자극 PBMC에서는 상반되는 효과가 관찰되었다. 특히, LPS 비자극 PBMC에서 t10c12-CLA는 NF-${\kappa}B$ 저해제인 caffeic acid phenethyl ester (CAPE)를 처리한 경우 NF-${\kappa}B$ p65 활성 수준을 증가시켰으나 반대로 LPS로 자극한 CAPE 처리 PBMC에서는 NF-${\kappa}B$ p65 활성 수준을 억제시켰다. 이상의 결과는 t10c12-CLA가 돼지 PBMC에 있어 LPS 자극 유무에 따라 다른 효과를 가질 수 있으며, 이는 NF-${\kappa}B$ p65 활성도의 변화와 관련성이 있음을 보여주고 있다.