• Korean Journal of Biological Psychiatry
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• v.11 no.2
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• pp.136-145
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• 2004

Objectives:Genetic variations of the tryptophan hydroxylase(TPH) gene and the serotonin transporter linked polymorphic region(5-HTTLPR) polymorphism have been associated with its functional capacity. The authors investigated whether the allelic constitution of the TPH gene and 5-HTTLPR are associated in Korean panic patients. Methods:244 Korean patients with panic disorder and 227 normal healthy controls were tested for a genetic polymorphism of TPH A218C and 5-HTTLPR polymorphism. To assess the severity of panic disorder during the last one month, anticipatory anxiety, panic difficulty, panic distress, agoraphobic difficulty and agoraphobic distress were measured with visual analogue scale(VAS) score, STAI-S & T, BDI, SCL-90-R, ASI-R, CGI, PDSS, and HAMD. Results:There was no significant difference in genotype and allele frequencies of TPH A218C and 5-HTTLPR polymorphism between panic patients and controls. Although we observed some differences in genotype and allele frequencies of TPH A218C polymorphism among male subjects, these differences disappeared after Bonferroni correction. And there were no significant differences in clinical variables. Conclusion:Our results suggested that there are no association between the genetic polymorphism of TPH gene and 5-HTTLPR with panic disorder.

• Journal of Oriental Neuropsychiatry
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• v.26 no.3
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• pp.293-306
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• 2015

Objectives: The purpose of this study is to identify predictors of clinical efficacy of oriental medical treatment for patients with panic disorder. Methods: We analyzed medical records of 41 patients who were diagnosed with panic disorder through DSM-IV or ICD-10 by 2 oriental medical neuro-psychiatrists. We performed frequency analysis of demographic characteristics in patients with panic disorder, and assessed the correlation between the psychological scales by Pearson correlation. Repeated measures ANOVA were used to compare the psychological scales during the treatment; and Single regression analysis was used to analyze the factors that have correlation to improvement of panic disorder by oriental medical treatment. Psychological scales used in the study were STAI-X-1/2, STAXI-S/T, BDI2, BAI, BSQ, PAS, ASI, LOT-R, SWLS, LSES and LSMS. Results: Patients' demographic characteristics indicated that there were twice more female than male patients; furthermore, there was a high ratio of patients in their 20s and 30s, with the highest percentage of onset-age in the 20s and average duration of panic disorder from 1~5 years. More than half of the total patient cohort comprised of those who had panic disorder with agoraphobia and major depressive disorder; in addition, major accompanied symptoms were dyspepsia, chest discomfort and headache. After treatment, most scores of psychological scales were significantly reduced, and correlation between the psychological scales was significant. Furthermore, we identified some factors that were significantly correlated to improvement of panic disorder by oriental medical treatment. Conclusions: In conclusion, treatment of panic disorder with oriental medicine was clinically efficient and improved the quality of life.

• Anxiety and mood
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• v.10 no.2
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• pp.115-127
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• 2014

Objective : Existing depression rating scales do not fully reflect depressed patients' perspective of remission, which goes beyond symptom resolution. The Remission from Depression Questionnaire (RDQ) captures a broader array of domains, and the present study examines the reliability and validity of the Korean Version of the RDQ (K-RDQ). Methods : The test-retest reliability of the K-RDQ was studied in 60 depressed patients and 30 normal subjects working at a university hospital. Subjects were evaluated at baseline and again 1-2 weeks later. The validity of the K-RDQ was studied in 200 depressed patients who were rated on the 17-item HDRS and the CGI-S ; each patient also completed the QIDS-SR, STAI-S, GHQ/QL-12, and SDS. Results : The K-RDQ demonstrated excellent internal consistency, with a Cronbach's ${\alpha}$ of 0.965 for the total scale and above 0.80 for each of the 7 subscales. The test-retest reliability of the total scale was 0.951. Mean K-RDQ scores ($45.79{\pm}18.65$) of the depressed patients were significantly higher than those ($15.87{\pm}10.60$) of the mentally healthy subjects (t=12.8, p<0.001). Five factors from the K-RDQ were extracted by principal axis factoring with equimax rotation. Conclusion : These results indicate that the K-RDQ is a reliable and valid measure that evaluates multiple domains that depressed patients consider important in determining remission. Thus, the K-RDQ maybe considered an appropriate tool for use in the clinical setting.

• Anxiety and mood
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• v.12 no.1
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• pp.34-41
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• 2016

Objective : Emotional state and emotion regulation strategies are considered to be important factors influencing the pattern and severity of somatic pain. The aim of this study is to investigate the relationship between cognitive emotional regulation strategies and somatic pain in patients with depression and/or anxiety disorders. Methods : A total of 140 outpatients, diagnosed with depression and/or anxiety disorders according to DSM-IV-TR, were evaluated using the Beck Depression Inventory (BDI), the State-Trait Anxiety Inventory (STAI), the Cognitive Emotion Regulation Questionnaire (CERQ), and the Numerical Rating Scale (NRS) for somatic pain. Pearson correlations and independent t-tests were performed to analyze the relationship between somatic pain, the severity of depression and/or anxiety and cognitive emotion regulation strategies. Results : The severity of pain was significantly correlated with depressive symptoms, but not with anxiety. Patients with somatic pain tend to use maladaptive cognitive emotion regulating strategies more frequently, especially rumination and catastrophizing. Conclusion : These findings suggest that somatic pain correlates with maladaptive cognitive emotional regulating strategies. Interventions which modulate these non-productive strategies, especially rumination and catastrophizing, would be a new approach for managing patients with depressive and/or anxiety disorders who are suffering from somatic pain.

• Journal of Korean Clinical Nursing Research
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• v.14 no.1
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• pp.187-198
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• 2008

Purpose: Music intervention has long been used in research of patients undergoing surgical operation in reducing anxiety level and improve surgical outcome. However, there are few studies that have considered a patient's music preference. We investigated the effect of the tailored music intervention which chose music according to the patient's preference on anxiety level and vital signs. Method: The subjects were 50 patients who received regional anesthesia for surgical operation at D hospital in Pohang city from April, 2006 to November, 2006. All of the subjects were randomly assigned either music group (30 subjects) or non-music group (20 subjects). As the patients arrived in the operating room, vital signs were monitored until the subjects were transferred to the recovery room, while Spielberger's STAI-KYZ questionnaires were applied twice to measure preoperative and intra-operative anxiety. The data were analyzed by 2-test, t-test, one-way ANCOVA and repeated measures ANOVA using SPSS 12.0/PC+. Results: There were no significant differences between the two groups on vital signs. All of the vital signs increased when the subjects arrived in the operating room, but decreased quickly once the operation began, regardless of the groups. However, the music group reported significantly less intra-operative anxiety, compared to the non-music group (F=15.208, p<.000), when preoperative anxiety was treated as a covariance. Conclusion: The findings support that the use of music which was chosen by patients during the surgery significantly reduced patient's intra-operative anxiety during regional anesthesia.

• Journal of Oriental Neuropsychiatry
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• v.22 no.4
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• pp.101-109
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• 2011

Objectives : The aim of this study was to evaluate the effects of EFT-I(EFT program for insomnia) for insomnia in the elderly as a preliminary study. Methods : This study was a single group pre-post comparative study that involved 10 elderly women(mean age=$76.3{\pm}4.29$), who visited a senior welfare center, complained of insomnia symptoms. Subjects received 8 sessions(twice a week for 4 weeks and 1 hour for each session) of EFT-I group training. Insomnia severity, depression, state-anxiety, and life satisfaction of each subject were evaluated twice at pre and post of EFT-I. Korean Sleep Scale, Short form of Geriatric Depression Scale(SGDS), State-Trait Anxiety Inventory(STAI), and life satisfaction scale were used as evaluation tools. The data were analyzed using paired-samples T-test. Results : Insomnia severity, life satisfaction, depression, and state-anxiety were significantly improved by EFT-I. Conclusions : Result of this study showed that EFT-I can be a useful treatment program for elderly insomnia. Larger clinical trials are needed to verify effect of EFT-I as a community based insomnia management program for the elderly.

• Sleep Medicine and Psychophysiology
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• v.21 no.2
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• pp.69-73
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• 2014

Objectives: This study was designed to assess the change of heart rate variability (HRV) at resting, upright, and psychological stress in anxiety disorder patients. Methods: HRV was measured at resting, upright, and psychological stress states in 60 anxiety disorder patients. We used visual analogue scale (VAS) score to assess tension and stress severity. Beck depression inventory (BDI) and state trait anxiety inventories I and II (STAI-I and II) were used to assess depression and anxiety severity. Differences between HRV indices were evaluated using paired t-tests. Gender difference analysis was accomplished with ANCOVA. Results: SDNN (Standard deviation of normal RR intervals) and low frequency/high frequency (LF/HF) were significantly increased, while NN50, pNN50, and normalized HF (nHF) were significantly decreased in the upright position compared to resting state (p < 0.01). SDNN, root mean square of the differences of successive normal to normal intervals, and LF/HF were significantly increased, while nHF was significantly decreased in the psychological stress state compared to resting state (p < 0.01). SDNN, NN50, pNN50 were significantly lower in upright position compared to psychological stress and nVLF, nLF, nHF, and LF/HF showed no significant differences between them. Conclusion: The LF/HF ratio was significantly increased after both physical and psychological stress in anxiety disorder, but did not show a significant difference between these two stresses. Significant differences of SDNN, NN50, and pNN50 without any differences of nVLF, nLF, nHF, and LF/HF between two stresses might suggest that frequency domain analysis is more specific than time domain analysis.

• Sleep Medicine and Psychophysiology
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• v.26 no.2
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• pp.111-124
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• 2019

Objectives: Healthy sleep is important and can have a positive effect on resilience. The aim of the present study was to compare the differences in resilience between two group nurses in rotating shift and daytime fixed work schedules and to investigate stress perception, coping factors, social and psychological health, and sleep factors that may affect resilience. Methods: A total of 400 female nurses having rotating shift and daytime fixed work schedules at two hospitals was surveyed from June 12, 2017 to June 12, 2018. All participants completed perceived stress scale (PSS), stress coping short form (Brief COPE), psycho-social wellbeing Index short form (PWI-SF) or general health questionnaire-18 (GHQ-18), center for epidemiologic studies depression scale (CES-D), STAI-X-1 in state-trait anxiety inventory (STAI), Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), insomnia severity index (ISI), Conner Davidson resilience scale (CD-RISC). Independent t-test, paired t-test, Pearson correlation analysis, and multiple regression analysis were applied to the results of the final 373 questionnaires of 400 nurses in two general hospitals. Results: Comparing the variable statistics between the two groups of rotating shift and daytime fixed work nurses, showed statistically significant differences in all variables except perceived stress, sleep quality, and daytime sleepiness. Factors that had a significant correlation with resilience were stress coping strategies, depression, and insomnia severity (p < 0.001). In multiple regression analysis, larger positive reframing1 (β = 0.206, p < 0.001), severe less depression (β = -3.45, p < 0.001), and higher psychosocial health (β = 0.193, p < 0.001). As acceptance coping2 increased (β = 0.129, p < 0.05), as daytime sleepiness decreased (β = -1.17, p < 0.05), and as active coping2 increased (β = 0.118, p < 0.05), as the positive reframing2 increases (β = 0.110, p < 0.05), the resilience increased. Conclusion: This study, it was found that resilience was higher in daytime fixed workers than in shift workers. In addition, specific stress coping strategies, psycho-social health, sleep, and depression factors were associated with resilience.

• Sleep Medicine and Psychophysiology
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• v.25 no.1
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• pp.15-20
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• 2018

Objectives: This study was designed to assess the change of heart rate variability (HRV) at resting, upright, and psychological stress states in depressive disorder patients. Methods: HRV was measured at resting, upright, and psychological stress states in 62 depressive disorder patients. We used visual analogue scale (VAS) score to assess tension and stress severity. Beck depression inventory (BDI) and state trait anxiety inventories I and II (STAI-I and II) were used to assess depression and anxiety severity, respectively. Differences between HRV indices and VAS score were evaluated using paired t-tests. Gender difference analysis was conducted with ANCOVA. Results: SDNN (standard deviation of normal to normal intervals), LF/HF (low frequency/high frequency), and VLF (very low frequency) were significantly increased, while NN50 and pNN50 were significantly decreased in the upright position compared to resting state. SDNN, RMSSD (root mean square of the differences of successive normal to normal intervals), and VLF were significantly increased, while pNN50 was significantly decreased in the psychological stress state compared to resting state. SDNN, NN50, and pNN50 were significantly lower in an upright position compared to a state of psychological stress, and LF, HF, and LF/HF showed no significant differences Conclusion: The LF/HF ratio was significantly increased after physical stress in depressive disorder. However, the LF/HF ratio was not significantly increased after psychological stress, and the change in LF/HF ratio after physical stress and psychological stress did not significantly differ from each other. Significant increase in SDNN, NN50, and pNN50 in an upright posture compared to psychological stress suggests that depressive patients react more sensitively to physical stress than psychological stress.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.8 no.1
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• pp.83-91
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• 1997

Objects：This study investigated whether depression, anxiety and perceived parental rearing patterns of the conduct disorder patients are different from those of the normal control group. The correlations were also assessed between perceived parenting style and depression, anxiety, severity of conduct problems and age at onset of conduct disorder in adolescents with conduct disorder. Methods：Thirty hospitalzed patients who met the DSM-Ⅳ criteria of conduct disorder, and 30 normal control subjects completed self-report questionnaires containing the Children’s Depression Inventory(CDI), the State-Trait Anxiety Inventory for Children(STAIC) and the Parental Bonding Instrument(PBI). Results：In the conduct disorder group, the results were as follows：1) The mean scores of CDI and STAIC-T(Trait) were not significantly different from those of the control group, but STAIC-S (State) showed significantly higher scores. 2) Parenting style was perceved to be less caring and more overprotective than in the control subjects. 3) There were negative correlations between maternal care and CDI and between maternal care and severity of conduct problems. 4) There were positive correlations between maternal overprotection and STAIC-T(Trait). 5) There were no correlations between paternal rearing patterns and depression, anxiety, severity of conduct problems, or age at onset of conduct disorder. Conclusion：We failed to identify depression and anxiety as common comorbid disorders in conduct disorder. Parental rearing patterns are thought to be significantly negativistic in conduct disorder group. It is guessed that less caring and more overprotective rearing style of parents, especially of mothers, could have much influence on depression and anxiety, more severe conduct problems and earlier age at onset of conduct disorder in the adolescents with conduct disorder.