No Association between Genetic Polymorphism of Tryptophan Hydroxylase A218C and Serotonin Transporter Linked Polymorphic Region and Panic Disorder

한국인 공황장애 환자의 트립토판 가수분해 효소와 세로토닌 전달체 유전자 다형성

  • Choi, Young Hee (Department of Neuropsychiatry, Inje University Seoul Paik Hospital) ;
  • Woo, Jong Min (Department of Neuropsychiatry, Inje University Seoul Paik Hospital) ;
  • Park, Hun Ku (Department of Neuropsychiatry, Inje University Seoul Paik Hospital) ;
  • Yoon, Kyung Sik (Department of Biochemistry, Kyunghee University School of Medicine) ;
  • Cho, Dae Yeon (LabGenomics Clinical Research Institute, LabGenomics) ;
  • Lee, Min Soo (Department of Psychiatry, Korea University College of Medicine)
  • 최영희 (인제대학교 의과대학 서울백병원 신경정신과학교실) ;
  • 우종민 (인제대학교 의과대학 서울백병원 신경정신과학교실) ;
  • 박헌구 (인제대학교 의과대학 서울백병원 신경정신과학교실) ;
  • 윤경식 (경희대학교 의과대학 생화학교실) ;
  • 조대연 ;
  • 이민수 (고려대학교 의과대학 정신과학교실)
  • Published : 2004.11.30

Abstract

Objectives:Genetic variations of the tryptophan hydroxylase(TPH) gene and the serotonin transporter linked polymorphic region(5-HTTLPR) polymorphism have been associated with its functional capacity. The authors investigated whether the allelic constitution of the TPH gene and 5-HTTLPR are associated in Korean panic patients. Methods:244 Korean patients with panic disorder and 227 normal healthy controls were tested for a genetic polymorphism of TPH A218C and 5-HTTLPR polymorphism. To assess the severity of panic disorder during the last one month, anticipatory anxiety, panic difficulty, panic distress, agoraphobic difficulty and agoraphobic distress were measured with visual analogue scale(VAS) score, STAI-S & T, BDI, SCL-90-R, ASI-R, CGI, PDSS, and HAMD. Results:There was no significant difference in genotype and allele frequencies of TPH A218C and 5-HTTLPR polymorphism between panic patients and controls. Although we observed some differences in genotype and allele frequencies of TPH A218C polymorphism among male subjects, these differences disappeared after Bonferroni correction. And there were no significant differences in clinical variables. Conclusion:Our results suggested that there are no association between the genetic polymorphism of TPH gene and 5-HTTLPR with panic disorder.

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