• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1991년도 춘계공동학술대회 발표논문 및 초록집; 전북대학교, 전주; 26-27 Apr. 1991
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• pp.405-421
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• 1991

In this paper, faults existing in a software system is classified into three types; simple, degenerative and regenerative faults. The reliability functions and failure rates of both a software module and system which have a mixture of such faults are obtained and the expected number of failures in the system after time T is also derived. Using the formulas obtained, a cost-reliability model and an efficient algorithm for optimal software release time are proposed via nonlinear programming formulation ; minimizing the total test cost with constraints on the failure rates of each module. Application of this model to several cases are presented and it appears to be more realistic.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3835-3838
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• 2016

Background: Breast cancer is one of the most frequent cancer types within female populations. Silibinin is a chemotherapeutic agent ative against cancer. Niosomes are biodegradable, biocompatible, safe and effective carriers for drug delivery. Objective:To prepare nanoniosomal silibinin and evaluate its cytotoxicity inthe T-47D breast cancer cell line. Materials and Methods: Niosomes were prepared by reverse phase evaporation of a mixture of span 20, silibinin, PEG-2000 and cholesterol in chloroform and methanol solvent (1:2 v/v). The solvent phase was evaporated using a rotary evaporator and the remaining gel phase was hydrated in phosphate buffer saline. Mean size, size distribution and zeta potential of niosomes were measured with a Zetasizer instrument and then nanoparticles underwent scanning electron microscopy. The drug releasing pattern was evaluated by dialysis and the cytotoxicity of nanoniosomes in T-47D cells was assessed by MTT assay. Results: Particle size, size variation and zeta potential of the niosomal nanoparticles were measured as $178.4{\pm}5.4nm$, $0.38{\pm}0.09$ and $-15.3{\pm}1.3mV$, respectively. The amount of encapsulated drug and the level of drug loading were determined $98.6{\pm}2.7%$ and $22.3{\pm}1.8%$, respectively; released drug was estimated about $18.6{\pm}2.5%$ after 37 hours. The cytotoxic effects of nanoniosome were significantly increased when compared with the free drug. Conclusions: This study finding suggests that silibinin nanoniosomes could serve as a new drug formulation for breast cancer therapy.

• International Journal of Reliability and Applications
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• 제12권1호
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• pp.15-39
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• 2011

This paper deals with the reliability analysis of a complex system with three possibilities at the time of repair. The considered system consists of two subsystems A and Bin series configuration (1-out-of-2: F). Subsystem A has n units which are connected in series whereas subsystem B consists of n units in parallel configuration. The configuration of subsystem A is of 1-out-of-n: F whereas subsystem B is of k-out-of-n: D and k+1-out-of-n: F nature. System has three states: Good, degraded and failed. Supplementary variable technique has been used for mathematical formulation of the model. Laplace transform is being utilized to solve the mathematical equation. Reliability, Availability, M.T.T.F., Busy Period and Cost effectiveness of the system have been computed. The repairs from state $S_7$ to $S_0$, $S_8$ to $S_0$, $S_9$ to $S_0$ and $S_{11}$ to $S_0$ have two types namely exponential and general. Joint probability distribution of repair rate from $S_7$ to $S_0$, $S_8$ to $S_0$, $S_9$ to $S_0$ and $S_{11}$ to $S_0$ is computed by Gumbel-Hougaard family of copula. Some particular cases of the system have also been derived to see the practical importance of the model.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2000년도 춘계학술대회논문집
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• pp.1716-1720
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• 2000

To develop the code of predicting flow-field and aeroacoustic noise by a electrical cable, a combined CFD-acoustic analogy approach is selected. The two-dimensional, unsteady, incompressible Reynolds-Averaged Navier-Stokes solver with a ${\kappa}{\omega}$, ${\kappa}{\omega}$ SST turbulence modeling is used to calculate the near-field around electrical cable. Near-field results are then coupled with two-dimensional Curle's integral formulation based upon Lighthill's acoustic analogy with an assumption of acoustic compactness. To validate this code, numerical results are compared with experimental data for a circular cylinder. The simulation shows an overprediction on acoustic amplitudes, but overally speaking, the spectrum pattern of sound pressure agrees well with experiment in an acceptable amount of error. In addition, various cross sections of a cable were selected and compared with each other in terms of drag and radiated noise.

• Geomechanics and Engineering
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• 제1권3호
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• pp.259-262
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• 2009

This paper examines the potential of relevance vector machine (RVM) in prediction of pullout capacity of small ground anchors. RVM is based on a Bayesian formulation of a linear model with an appropriate prior that results in a sparse representation. The results are compared with a widely used artificial neural network (ANN) model. Overall, the RVM showed good performance and is proven to be better than ANN model. It also estimates the prediction variance. The plausibility of RVM technique is shown by its superior performance in forecasting pullout capacity of small ground anchors providing exogenous knowledge.

• Carbon letters
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• 제5권1호
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• pp.6-11
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• 2004

In spite of unparalleled combination of essential material properties for brake linings and clutch facings, replacement for asbestos is seriously called for since it is a health hazard. Once asbestos is replaced with other material then composition and properties of brake pad changes. In certain cases hardness of the material may be high enough to affect the rotor material. In this study, hardness of the brake pad has been controlled using suitable reinforcement materials like glass, carbon and Kevlar pulp. Brake pad formulations were made using CNSL (cashew net shell liquid) modified phenolic resin as a binder, graphite or cashew dust as a friction modifier and barium sulphate, talc and wollastonite as fillers. Influence of each component on the hardness value has been studied and a proper formulation has been arrived at to obtain hardness values around 35 on Scleroscopic scale. Friction and wear properties of the respective brake pad materials have been measured on a dynamometer and their performance was evaluated.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1996년도 추계학술대회 논문집 학회본부
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• pp.49-51
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• 1996

The z-transform method is a basic mathematical tool in analyzing and designing sampled-data control systems. However, since the z-transform method relates only the sampling-instants signals, another mathematical tool is necessary to describe the continous signals between the sampling instants. For this purpose the delayed and the modi fled z-transform methods were developed. The definition of the modi fled z-transform includes a sample in the interval [-T,0] of the original signal in its series expression, where the signal value is always zero for any physical system. From this reason one step skew of the time index always appears in its application formulas. This introduces an unnecessary operation and a gap in linking the mathematical formula and its physical interpretation. Considering the conceptual difficulty and application inconvenience, a method of using the advanced z-transform in analysis of sampled-data control systems is developed as a replacement of the modi fled z-transform. With one formulation of the advanced z-transform, now it is possible to relate both the signals of the sampling instants and those in between without any complication and conceptual difficulty.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.245.2-245.2
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• 2003

A rapid and reproducible high performance liquid chromatographic assay of prazosin in human plasma was developed. After addition of internal standard (IS, terazosin hydrochloride) and alkalization of the plasma, the drug and IS were extracted into t-butylmethylether. The organic phase was back-extracted with 0.05% phosphoric acid and 50 ${\mu}$l of the acid solution was injected into a reverse-phase C18 column with a mobile phase consisting of water: acetonitrile: triethylamine = 75 : 25 : 0.1 (pH 5.0). (omitted)

• Ocean Systems Engineering
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• 제12권2호
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• pp.247-265
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• 2022

In the present study, we focus on the CFD simulations for the performance and the rotor-generated wake of a model-scale wind turbine which was designed for wave tank experiments. The CFD simulations with fully resolved rotor geometry are performed using MARIN's community-based open-source CFD code ReFRESCO. The absolute formulation method (AFM) is leveraged to model the rotating wind turbine. The k - ω SST turbulence model is adopted in the incompressible Reynolds Averaged Navier-Stokes (RANS) simulations. First, the thrust and torque coefficients, C_T and C_P, are calculated at different Tip Speed Ratios (TSR), and the results are compared against the experimental data and previous numerical results. The pressure distribution of the turbine blades at the 70% span is obtained and compared to the results obtained by other tools. Then, a verification study aiming at quantifying the discretization uncertainty of the turbine performance with respect to the grid resolution in the wake region is performed. Last, the rotor-generated wake at the TSR of 7 is presented and discussed.

• Structural Engineering and Mechanics
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• 제15권1호
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• pp.83-114
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• 2003

A new simple 3-node triangular flat-shell element with standard nodal DOF (6 DOF per node) is proposed for the linear and geometrically nonlinear analysis of very thin to thick plate and shell structures. The formulation of element GT9 (Long and Xu 1994), a generalized conforming membrane element with rigid rotational freedoms, is employed as the membrane component of the new shell element. Both one-point reduced integration scheme and a corresponding stabilization matrix are adopted for avoiding membrane locking and hourglass phenomenon. The bending component of the new element comes from a new generalized conforming Kirchhoff-Mindlin plate element TSL-T9, which is derived in this paper based on semiLoof constrains and rational shear interpolation. Thus the convergence can be guaranteed and no shear locking will happen. Furthermore, a simple hybrid procedure is suggested to improve the stress solutions, and the Updated Lagrangian formulae are also established for the geometrically nonlinear problems. Numerical results with solutions, which are solved by some other recent element models and the models in the commercial finite element software ABAQUS, are presented. They show that the proposed element, denoted as GMST18, exhibits excellent and better performance for the analysis of thin-think plates and shells in both linear and geometrically nonlinear problems.